HURLER DISEASE Figure 19-15 HURLER DISEASE Low- (left) and high-power (right) views of type I mucopolysaccharidosis showing foamy histiocytes (“Hurler cells”) aggregating throughout the mitral valve. More about this image found in HURLER DISEASE Low- (left) and high-power (right) views of type I mucopoly...

PENETRATIVE INJURY: GUNSHOT WOUND Figure 23-15 PENETRATIVE INJURY: GUNSHOT WOUND This high-velocity weapon caused extensive morcellation of the right and left ventricles. More about this image found in PENETRATIVE INJURY: GUNSHOT WOUND This high-velocity weapon caused extensi...

POLYARTERITIS NODOSA Figure 30-22 POLYARTERITIS NODOSA A high-power view shows a mixed inflammatory infiltrate with extensive fibrinoid necrosis of the vessel wall. More about this image found in POLYARTERITIS NODOSA A high-power view shows a mixed inflammatory infiltra...

CARDIAC RHABDOMYOMA Figure 43-6 CARDIAC RHABDOMYOMA At high-power microscopy, plump eosinophilic central bodies are seen throughout the tumor (left), but not all tumor cells have the central cellular body, making some of the tumor look a bit like adipose tissue (right). More about this image found in CARDIAC RHABDOMYOMA At high-power microscopy, plump eosinophilic central b...

METASTASIS BY RETROGRADE LYMPHATIC SPREAD Figure 52-2 METASTASIS BY RETROGRADE LYMPHATIC SPREAD Left: Metastatic high-grade urothelial carcinoma forms a microscopic metastasis that cannot be seen grossly, but the intense fibrinous pericarditis is a direct consequence of the lymphatic involvement.... More about this image found in METASTASIS BY RETROGRADE LYMPHATIC SPREAD Left: Metastatic high-grade urot...

PULMONARY ARTERY INTIMAL SARCOMA Figure 55-5 PULMONARY ARTERY INTIMAL SARCOMA A: At high magnification, the tumor consists of a proliferation of pleomorphic spindle cells with a vague storiform pattern and a mild inflammatory background. B: There is variable cellularity, with the malignant cells... More about this image found in PULMONARY ARTERY INTIMAL SARCOMA A: At high magnification, the tumor consi...

AORTIC INTIMAL SARCOMA Figure 55-12 AORTIC INTIMAL SARCOMA Left: The cellular pleomorphism is evident at high power, with tumor necrosis seen in the lower left quadrant. Right: Scattered atypical mitotic figures are also present throughout. More about this image found in AORTIC INTIMAL SARCOMA Left: The cellular pleomorphism is evident at high ...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-9 ARRHYTHMOGENIC CARDIOMYOPATHY The admixture of fat and fibrosis throughout the wall is evident at high-power magnification. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY The admixture of fat and fibrosis throughout...

ELECTRICAL LEADS Figure 25-12 ELECTRICAL LEADS Left: Histologically, there is striking inflammation along the endocardial tract in some cases. Right: On high-power magnification, the infiltrate consists of a combination of lymphocytes and eosinophils. More about this image found in ELECTRICAL LEADS Left: Histologically, there is striking inflammation alon...

HYPOPLASTIC LEFT HEART SYNDROME Figure 38-15 HYPOPLASTIC LEFT HEART SYNDROME The epicardial coronary vessels are dilated, due to high left ventricular pressure, in aortic atresia and mitral stenosis in a newborn. More about this image found in HYPOPLASTIC LEFT HEART SYNDROME The epicardial coronary vessels are dilate...

HAMARTOMA OF MATURE CARDIAC MYOCYTES Figure 45-3 HAMARTOMA OF MATURE CARDIAC MYOCYTES Nodular proliferation of disorganized myocytes with central stellate vascular channels seen at low- (left) and high-power (right) magnification. More about this image found in HAMARTOMA OF MATURE CARDIAC MYOCYTES Nodular proliferation of disorganized...

CARDIAC CRYSTAL-STORING HISTIOCYTOSIS Figure 57-19 CARDIAC CRYSTAL-STORING HISTIOCYTOSIS Left: There is an infiltrate of small lymphocytes surrounded by histiocytes. Right: At high-power magnification, the crystalline structures are evident within the histiocytes. More about this image found in CARDIAC CRYSTAL-STORING HISTIOCYTOSIS Left: There is an infiltrate of smal...

MILD CELL-MEDIATED REJECTION (GRADE 1R) Figure 24-3 MILD CELL-MEDIATED REJECTION (GRADE 1R) Perivascular lymphocytic infiltrates are usually obvious at both low-power (left) and high-power (right) microscopy. More about this image found in MILD CELL-MEDIATED REJECTION (GRADE 1R) Perivascular lymphocytic infiltrat...

CARDIAC ALLOGRAFT Figure 24-21 CARDIAC ALLOGRAFT Left: Pericardial adhesions may be numerous, complicating dissection. Above: Ischemic injury, in the form of replacement-type fibrosis, is common because of the high incidence of cardiac allograft vasculopathy. More about this image found in CARDIAC ALLOGRAFT Left: Pericardial adhesions may be numerous, complicatin...

GRANULOMATOSIS WITH POLYANGIITIS: LUNG Figure 30-27 GRANULOMATOSIS WITH POLYANGIITIS: LUNG Above: This wedge biopsy shows a cavitary lesion with intense inflammation. Right: High-power magnification shows the geographic basophilic necrosis typical of granulomatosis with polyangiitis. More about this image found in GRANULOMATOSIS WITH POLYANGIITIS: LUNG Above: This wedge biopsy shows a ca...

LEUKOCYTOCLASTIC VASCULITIS: SKIN Figure 30-41 LEUKOCYTOCLASTIC VASCULITIS: SKIN Left: Low-power magnification shows patchy inflammation in the superficial dermis. Above: High-power magnification demonstrates leukocytoclasia, fibrinoid necrosis, and mild endothelial swelling. More about this image found in LEUKOCYTOCLASTIC VASCULITIS: SKIN Left: Low-power magnification shows patc...

FEMORAL ENDARTERECTOMY Figure 29-15 FEMORAL ENDARTERECTOMY Top: Low-power magnification of a plaque involved by extensive, nodular calcification shows circumferential but discrete nodular calcifications. Bottom: High-power magnification of one of the calcifications, which result from calcified f... More about this image found in FEMORAL ENDARTERECTOMY Top: Low-power magnification of a plaque involved b...

SEGMENTAL ARTERIAL MEDIOLYSIS Figure 31-20 SEGMENTAL ARTERIAL MEDIOLYSIS Left: Elastic staining shows patchy medial loss around the circumference of this muscular epicardial coronary artery. Right: High-power view shows large vacuoles of myxoid matrix throughout the media. More about this image found in SEGMENTAL ARTERIAL MEDIOLYSIS Left: Elastic staining shows patchy medial l...

INFECTIVE ENDOCARDITIS: SUBACUTE (HEALING) Figure 12-14 INFECTIVE ENDOCARDITIS: SUBACUTE (HEALING) Left: At low power, the infected valve is injured and inflamed, with shallow surface fibrin/vegetation. Right: At high power, the chronic nature of the inflammation is evident, along with organizat... More about this image found in INFECTIVE ENDOCARDITIS: SUBACUTE (HEALING) Left: At low power, the infecte...