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hepatocyte

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch33
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... are present mostly within hepatic veins within the parenchyma. Histologically, there is hepatocellular dropout and sinusoidal dilatation affecting centrilobular areas, zones 2 and 3. In acute cases with massive liver cell necrosis, viable hepatocytes are restricted to a rim around the portal triads...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-06
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... , Kalloger   SE , Carrick   J , et al   A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary . Am J Surg Pathol   2009 ; 33 : 14 - 21 . 31. Kato   N , Sasou   S , Motoyama   T . Expression of hepatocyte nuclear...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... antigen (EMA), p16, PAX8, and WT1 ( 13 , 40 , 41 ). Estrogen and progesterone receptors (ER and PR) are frequently expressed, often with variable intensity of staining. High-grade serous carcinomas generally do not stain for carcinoembryonic antigen (pCEA), CK20, hepatocyte nuclear factor 1 (HNF1)-beta...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-07
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
..., aids in accurate diagnosis. When in doubt, immunohistochemistry for hepatocyte nuclear factor 1-β and ER/PR is informative. The immunophenotype of these sex cord-stromal tumors is distinctive and with only a couple of important exceptions, does not overlap with endometrioid neoplasms. Adult granulosa...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... repair . Stem Cell Res   2015 ; 15 : 190 - 202 . 70. Jacquemin   P , Durviaux   SM , Jensen   J , et al   Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3 . Mol Cell Biol   2000...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... is common in the mucosa, suggesting that a pancreatic differentiation program may recapitulate in gastric carcinogenesis. The liver and pancreas developmentally both arise from outpouchings from the foregut, and the expression of hepatocyte markers in acinar cell carcinoma (see below) provides further...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... haphazardly arranged pleomorphic eosinophilic cells. Immunohistochemical Findings. Immunohistochemical labeling for hepatocyte paraffin-1 (HepPar-1), polyclonal CEA, arginase-1, CD10, and alpha-fetoprotein can help establish hepatocellular differentiation ( 53 , 54 , 59 ), as can the demonstration of albumin...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... , 206 ). IOPNs label strongly with antibodies against mitochondrial antigens such as 111.3 ( 5 ). IOPNs usually label for B72.3; however, most label inconsistently for CEA and CA19-9 ( 5 ). Interestingly, about 60 percent immunolabel with hepatocyte-1 (Hep-Par-1) antibodies ( 206 ). Most IOPNs...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ductal adenocarcinomas. These include epidermal growth factor receptor (EGFR), receptor tyrosine-protein kinase erbB-2 (ERRB2, also known as HER2), HER3, hepatocyte growth factor receptor (HGFR), fibroblast growth factor receptor 1 (FGFR1), nerve growth factor, and transforming growth factors α and β...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... be immunoreactive with TTF1 and hepatocyte nuclear factor 1-b . Am J Surg Pathol   2012 ; 36 : 799 - 807 . 174a. Turashvili   G , Park   KJ . Cervical glandular neoplasia: classification and staging . Surg Pathol Clin   2019 ; 12 : 281 - 313 . 175. Howitt   BE , Emori   MM , Drapkin...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
.... Rare examples have reportedly contained cells resembling hepatocytes ( 211 ), as has been reported in gonadal yolk sac tumors. Ancillary Studies. Vaginal yolk sac tumors have immunohistochemical features similar to those of gonadal yolk sac tumors, specifically, cytokeratin, AFP, glypican-3, and SALL4...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-04
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... trophoblastic tumor; Ter = teratoma; ENT = embryonic-type neuroectodermal tumor; NBT = nephroblastoma; ST = spermatocytic tumor; AFP = alpha-fetoprotein; βhCG = beta subunit human chorionic gonadotropin; CC = choriocarcinoma; GPC3 = glypican 3; HNF1β = hepatocyte nuclear factor 1β; HPL = human placental...
Images
BALLOONED <span class="search-highlight">HEPATOCYTE</span>  Located in the center of the image, the ballooned hep...
Published: 01 January 2022
BALLOONED HEPATOCYTE Figure 1-41 BALLOONED HEPATOCYTE Located in the center of the image, the ballooned hepatocyte is larger than adjacent hepatocytes and has rarified cytoplasm with condensation of cytoplasmic proteins to create Mallory hyaline. More about this image found in BALLOONED HEPATOCYTE Located in the center of the image, the ballooned hep...
Images
Images
BUDD-CHIARI SYNDROME  Sinusoidal fibrosis with <span class="search-highlight">hepatocyte</span> atrophy in zone 3...
Published: 01 January 2022
BUDD-CHIARI SYNDROME Figure 12-3 BUDD-CHIARI SYNDROME Sinusoidal fibrosis with hepatocyte atrophy in zone 3 (Masson trichrome). More about this image found in BUDD-CHIARI SYNDROME Sinusoidal fibrosis with hepatocyte atrophy in zone 3...
Images
Images
ACUTE FATTY LIVER OF PREGNANCY  <span class="search-highlight">Hepatocyte</span> swelling and microvesicular stea...
Published: 01 January 2022
ACUTE FATTY LIVER OF PREGNANCY Figure 13-20 ACUTE FATTY LIVER OF PREGNANCY Hepatocyte swelling and microvesicular steatosis in zone 3 hepatocytes, with relative sparing of zone 1. More about this image found in ACUTE FATTY LIVER OF PREGNANCY Hepatocyte swelling and microvesicular stea...
Images
Images
MACROVESICULAR STEATOSIS  The <span class="search-highlight">hepatocyte</span> cytoplasm contains a large droplet...
Published: 01 January 2022
MACROVESICULAR STEATOSIS Figure 9-2 MACROVESICULAR STEATOSIS The hepatocyte cytoplasm contains a large droplet of fat that pushes aside the nucleus. More about this image found in MACROVESICULAR STEATOSIS The hepatocyte cytoplasm contains a large droplet...
Images
MICROVESICULAR STEATOSIS  The <span class="search-highlight">hepatocyte</span> cytoplasm is filled with numerous ...
Published: 01 January 2022
MICROVESICULAR STEATOSIS Figure 9-3 MICROVESICULAR STEATOSIS The hepatocyte cytoplasm is filled with numerous tiny droplets of fat that give the cell a bubbly appearance. More about this image found in MICROVESICULAR STEATOSIS The hepatocyte cytoplasm is filled with numerous ...