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hepatocyte

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch33
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... are present mostly within hepatic veins within the parenchyma. Histologically, there is hepatocellular dropout and sinusoidal dilatation affecting centrilobular areas, zones 2 and 3. In acute cases with massive liver cell necrosis, viable hepatocytes are restricted to a rim around the portal triads...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-06
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... , Carrick   J , et al   A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary . Am J Surg Pathol   2009 ; 33 : 14 - 21 . 31. Kato   N , Sasou   S , Motoyama   T . Expression of hepatocyte nuclear factor-1beta (HNF...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
.... High-grade serous carcinomas generally do not stain for carcinoembryonic antigen (pCEA), CK20, hepatocyte nuclear factor 1 (HNF1)-beta, napsin, or show loss of PTEN expression. Immunohistochemical staining profiles for these antibodies are similar in the ovary and omentum ( 42 ). CYTOLOGIC FINDINGS...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-07
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... carcinoma, clear cell carcinoma expresses hepatocyte nuclear factor 1-β and lacks expression of ER and PR in most cases. Clear cell carcinoma does not express WT1 and shows p53 ( 79 – 81 ) overexpression in less than 10 percent of cases. ENDOMETRIOID ADENOCARCINOMA Figure 7-24 ENDOMETRIOID ADENOCARCINOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... repair . Stem Cell Res   2015 ; 15 : 190 - 202 . 70. Jacquemin   P , Durviaux   SM , Jensen   J , et al   Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3 . Mol Cell Biol   2000...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... is common in the mucosa, suggesting that a pancreatic differentiation program may recapitulate in gastric carcinogenesis. The liver and pancreas developmentally both arise from outpouchings from the foregut, and the expression of hepatocyte markers in acinar cell carcinoma (see below) provides further...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... haphazardly arranged pleomorphic eosinophilic cells. Immunohistochemical Findings. Immunohistochemical labeling for hepatocyte paraffin-1 (HepPar-1), polyclonal CEA, arginase-1, CD10, and alpha-fetoprotein can help establish hepatocellular differentiation ( 53 , 54 , 59 ), as can the demonstration of albumin...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... , 206 ). IOPNs label strongly with antibodies against mitochondrial antigens such as 111.3 ( 5 ). IOPNs usually label for B72.3; however, most label inconsistently for CEA and CA19-9 ( 5 ). Interestingly, about 60 percent immunolabel with hepatocyte-1 (Hep-Par-1) antibodies ( 206 ). Most IOPNs...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ductal adenocarcinomas. These include epidermal growth factor receptor (EGFR), receptor tyrosine-protein kinase erbB-2 (ERRB2, also known as HER2), HER3, hepatocyte growth factor receptor (HGFR), fibroblast growth factor receptor 1 (FGFR1), nerve growth factor, and transforming growth factors α and β...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... that are commonly PAX8, CA125, and HMGA2 positive and that may be immunoreactive with TTF1 and hepatocyte nuclear factor 1-b . Am J Surg Pathol   2012 ; 36 : 799 - 807 . 174a. Turashvili   G , Park   KJ . Cervical glandular neoplasia: classification and staging . Surg Pathol Clin   2019 ; 12 : 281...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
.... Tumor cells typically have moderate amounts of palely eosinophilic or clear cytoplasm. Nuclei are irregular and vesicular, and contain prominent nucleoli. Rare examples have reportedly contained cells resembling hepatocytes ( 211 ), as has been reported in gonadal yolk sac tumors. Ancillary Studies...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-04
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...; AFP = alpha-fetoprotein; βhCG = beta subunit human chorionic gonadotropin; CC = choriocarcinoma; GPC3 = glypican 3; HNF1β = hepatocyte nuclear factor 1β; HPL = human placental lactogen; ND = no data; PLAP = placental alkaline phosphatase. c + = usual reactivity in >80% of cases...
Images
MACROVESICULAR STEATOSIS  The <span class="search-highlight">hepatocyte</span> cytoplasm contains a large droplet...
Published: 01 January 2022
MACROVESICULAR STEATOSIS Figure 9-2 MACROVESICULAR STEATOSIS The hepatocyte cytoplasm contains a large droplet of fat that pushes aside the nucleus. More about this image found in MACROVESICULAR STEATOSIS The hepatocyte cytoplasm contains a large droplet...
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MICROVESICULAR STEATOSIS  The <span class="search-highlight">hepatocyte</span> cytoplasm is filled with numerous ...
Published: 01 January 2022
MICROVESICULAR STEATOSIS Figure 9-3 MICROVESICULAR STEATOSIS The hepatocyte cytoplasm is filled with numerous tiny droplets of fat that give the cell a bubbly appearance. More about this image found in MICROVESICULAR STEATOSIS The hepatocyte cytoplasm is filled with numerous ...
Images
BALLOONED <span class="search-highlight">HEPATOCYTE</span>  Ballooned cells are seen near the center of the image...
Published: 01 January 2022
BALLOONED HEPATOCYTE Figure 9-9 BALLOONED HEPATOCYTE Ballooned cells are seen near the center of the image (left). Several ballooned hepatocytes are evident (right). More about this image found in BALLOONED HEPATOCYTE Ballooned cells are seen near the center of the image...
Images
BALLOONED <span class="search-highlight">HEPATOCYTE</span> WITH MALLORY HYALINE  Two of the ballooned <span class="search-highlight">hepatocytes</span>...
Published: 01 January 2022
BALLOONED HEPATOCYTE WITH MALLORY HYALINE Figure 9-10 BALLOONED HEPATOCYTE WITH MALLORY HYALINE Two of the ballooned hepatocytes near the center of this image have abundant Mallory hyaline. More about this image found in BALLOONED HEPATOCYTE WITH MALLORY HYALINE Two of the ballooned hepatocytes...
Images
BALLOONED <span class="search-highlight">HEPATOCYTE</span> WITH MALLORY HYALINE: UBIQUITIN IMMUNOSTAIN  The Mallo...
Published: 01 January 2022
BALLOONED HEPATOCYTE WITH MALLORY HYALINE: UBIQUITIN IMMUNOSTAIN Figure 9-11 BALLOONED HEPATOCYTE WITH MALLORY HYALINE: UBIQUITIN IMMUNOSTAIN The Mallory hyaline in the ballooned cells is highlighted. More about this image found in BALLOONED HEPATOCYTE WITH MALLORY HYALINE: UBIQUITIN IMMUNOSTAIN The Mallo...
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EQUIVOCAL BALLOONED <span class="search-highlight">HEPATOCYTE</span>  Left: There is an equivocal ballooned cell ...
Published: 01 January 2022
EQUIVOCAL BALLOONED HEPATOCYTE Figure 9-12 EQUIVOCAL BALLOONED HEPATOCYTE Left: There is an equivocal ballooned cell in the center. Many pathologists would not count this as a ballooned hepatocyte, but some would. Right: Another example of some equivocal ballooned hepatocytes. More about this image found in EQUIVOCAL BALLOONED HEPATOCYTE Left: There is an equivocal ballooned cell ...
Images
MIMIC OF BALLOONED <span class="search-highlight">HEPATOCYTE</span>  The <span class="search-highlight">hepatocytes</span> show glycogen accumulation t...
Published: 01 January 2022
MIMIC OF BALLOONED HEPATOCYTE Figure 9-13 MIMIC OF BALLOONED HEPATOCYTE The hepatocytes show glycogen accumulation that can mimic ballooned hepatocytes. More about this image found in MIMIC OF BALLOONED HEPATOCYTE The hepatocytes show glycogen accumulation t...
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