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hematologic

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch52
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
..., such as sarcoma, developing in a teratoma ( 64 ). Primary germ cell tumors of the mediastinum may invade the heart by direct extension ( 65 , 66 ). Hematologic Malignancies. Hematologic malignancies are especially prone to involve the heart. Approximately 35 to 40 percent of patients with leukemia have cardiac...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch24
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... and contains a predominance of B lymphocytes and plasma cells, differentiating it from rejection or Quilty effect ( fig. 24-17B ). Nevertheless, there is sufficient morphologic overlap to warrant ancillary studies (immunophenotyping or EBV studies) for definitive distinction ( fig. 24-17C ). This hematologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch57
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... to nonspecific symptoms. Chemotherapy may produce remission in some cases ( 64 ). In patients with acquired immunodeficiency syndrome (AIDS), HAART and tumor chemotherapy together may result in rare long-term survival ( 65 ). Immunohistochemical Findings. As with other hematologic processes, immunophenotyping...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch34
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...  Gallstones and cholecystitis Hematologic  Erythrocytosis  Polycythemia  Hyperviscosity syndrome  Thrombocytopenia  Platelet dysfunction  Bleeding and thrombotic disorders  Coagulation abnormalities  Iron deficiency Genitourinary  Menorrhagia  Glomerular abnormalities...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-11
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
..., the capillary vascular network seen in endometrioid stromal sarcomas is distinctive. Hematologic malignancies, like lymphoma, occasionally involve the ovaries, and these can be keratin negative and CD10 positive. However, hematologic malignancies typically show a more infiltrative growth pattern...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-14
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... , et al   Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma . J Clin Oncol   2004 ; 22 : 454 - 63 . 61. Benning   TL , Silverman   JF , Berns   LA , Geisinger   KR . Fine needle aspiration of metastatic and hematologic malignancies...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... in half of patients, despite there being minimal exocrine tissue. Histologically, the pancreatic lobules are replaced nearly entirely by mature adipose tissue with normal islets and rare isolated lobules of acinar cells. Although neutropenia is the most common hematologic abnormality, all cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... prognosis, with most dying of their disease within 3 years and a 5-year overall survival rate of only 10 percent ( 307 – 309 ). Tumor stage is the main prognostic factor. Lymphoma and Myeloid Sarcoma Definition.  Lymphoma is a hematologic malignancy that in the cervix may represent the primary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... that includes p63, synaptophysin, chromogranin, and INSM1, is helpful. The importance of SATB2 is unclear ( 204 ). Consideration may also be given to small round blue cell sarcomas, melanoma, and hematologic malignancies; in these cases, broader immunohistochemical panels may be required. Treatment. Most...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... surgical excision is now considered the standard of care given the extremely high response rate, even without any surgical resection ( 212 ). The prognosis is excellent when chemotherapy is administered ( 209 , 212 ). Hematologic Disorders Some lymphomas present with vaginal involvement...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... bone marrow transplantation in children . J Pediatr   1996 ; 129 : 544 - 50 . 252. Cohen   A , Rovelli   A , Bakker   B , et al . Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the Working Party for Late...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... of solid organ tumors, cutaneous neoplasms, and hematologic malignancies are now treated with these antibodies, which act by blocking key immune checkpoint proteins, such as CTLA4 or PD1, and promoting immune-mediated elimination of tumor cells ( 199 ). It has become apparent, however, that ICI-induced...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-09
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... sarcoma developing after a hematologic disorder found that the disease course and therapy response were not affected by the patient’s age or gender, anatomic location of tumor, clinical presentation, previous clinical history, morphologic classification, immunophenotype, and cytogenetic findings ( 67...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-11
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... studied in the tunica vaginalis ( 89 ). Rare instances of hematologic malignancies and metastases in hydroceles have been reported. These should be kept in mind whenever unexpected cellularity is encountered in a hydrocele resection ( 90 – 95 ). SPERMATOCELE Spermatocele, also known...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
10.55418/9781933477190-7
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... increase with age, starting at 30 to 40 years, but reaching a peak in the 60s or 70s, reflecting the epidemiology of the underlying cancer. For example, patients with carcinomas have an average age over 60, while some hematologic malignancies are seen in younger patients. No sex predilection is reported...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
10.55418/9781933477190-3
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
...   A , Roggli   VL . Malignant (diffuse) mesothelioma in patients with hematologic malignancies: a clinicopathologic study of 45 cases . Arch Pathol Lab Med   2015 ; 139 : 1129 – 36 . 73. Cavazza   A , Travis   LB , Travis   WD , et al . Post-irradiation malignant mesothelioma . Cancer...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-2
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... hepatitis B and there is a strong correlation with polyarteritis nodosa( 10 ). More than one third of patients with polyarteritis nodosa have chronic hepatitis B. Dermatologic, joint, neurologic, cardiopulmonary, hematologic, and gastrointestinal manifestations also occur. Serologic and Molecular Diagnosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-13
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... respiratory tracts. The organs most commonly affected are lung, gastrointestinal tract, liver, and the hematologic system ( 5 ). Autoimmune manifestations, such as thyroid dysfunction, pernicious anemia, autoimmune hemolytic anemia, autoimmune thrombocytopenia, and rheumatoid arthritis, are common...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-10
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
..., hematologic conditions, chronic liver disease, and chronic disorders such as the anemia of chronic disease; these disorders disrupt iron trafficking and lead to misdistribution of iron stores ( 2 ). Mammalian species have limited capacity for iron excretion, and there is no active mechanism for excretion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-8
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... years of therapy and usually leads to steatosis ( 75 ). Steatohepatitis is thought to occur only in patients with underlying metabolic risk factors ( 77 ). Methotrexate is used for the treatment of bladder, gynecologic, pulmonary, and hematologic malignancies, as well as an immunomodulatory...