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hamartomatous

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Peutz-Jeghers Syndrome: aut dom, STK11/LKB1 mutation  Mucosal (usually oral/labial) and cutaneous lentigines  Hamartomatous gastrointestinal polyps Carney Complex: aut dom, PRKAR1A mutation  1. Carcinocutaneous type (LAMB syndrome)   Lentigines   Atrial Myxomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch47
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... 47-4 ). There is little or no background fibrosis or other tissue elements. Mitotic figures are rare, but Ki-67 shows focal reactivity (1 to 20 percent of cells), helping to discriminate this tumor from hamartomatous lesions like cardiac rhabdomyoma. Muscle markers such as desmin show reactivity...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch45
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... CARDIAC MYOCYTES MESENCHYMAL CARDIAC HAMARTOMA CONDUCTION SYSTEM HAMARTOMA Definition.  Conduction system hamartoma is a congenital, hamartomatous lesion consisting of multicentric Purkinje cells throughout the heart with a predilection for the specialized conduction system (sinoatrial node...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch43
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... of rapamycin (mTOR), which is a highly conserved protein kinase that regulates protein synthesis, and cellular metabolism, differentiation, growth, and migration. Constitutive activation of mTOR results in the abnormal cellular proliferation and differentiation that is thought responsible for the hamartomatous...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch46
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... proposed that LHAS represents a hamartomatous process while others have suggested that it represents ectopia resulting from misplaced embryonic mesenchyme during atrial septation ( 27 ). This is a particularly attractive theory that may also explain some associations with adiposity as these fat cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch13
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... often presents primarily because of dysrhythmia, histiocytoid cardiomyopathy, is a peculiar entity that some consider a hamartomatous proliferation while others contend that it represents a cardiomyopathy ( 5 ). This entity is discussed in chapter 45 as conduction system hamartoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-03
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... and the cumulative risk of ovarian tumors is 21 percent ( 34 ). Symptoms at presentation include abdominal pain, intestinal bleeding, and intussusception during the first two decades of life ( 35 ). These symptoms, in addition to the typical hamartomatous intestinal polyps with mucocutaneous pigmentation, are keys...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ( 80 , 113 , 114 ). The Peutz-Jeghers syndrome (PJS) is characterized by mucocutaneous melanocytic macules and hamartomatous polyps of the gastrointestinal tract. PJS is caused by germline mutations in the STK11 gene and patients with PJS have a remarkable 75- to 125-fold increased...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... lipomatosis superficialis is a benign congenital hamartomatous lesion only rarely reported in the vulva or clitoris. It presents as a soft nodular or plaque-like mass with unremarkable overlying skin. Histologically, it is characterized by mature adipose tissue present in the dermis without direct...
Images
<span class="search-highlight">HAMARTOMATOUS</span> NODULES  There are several discrete tan nodules measuring up ...
Published: 01 August 2022
HAMARTOMATOUS NODULES Figure 6-81 HAMARTOMATOUS NODULES There are several discrete tan nodules measuring up to 2 cm in this gonad from a patient with androgen insensitivity syndrome. More about this image found in HAMARTOMATOUS NODULES There are several discrete tan nodules measuring up ...
Images
<span class="search-highlight">HAMARTOMATOUS</span> NODULE  Left: A circumscribed nodule in a patient with the an...
Published: 01 August 2022
HAMARTOMATOUS NODULE Figure 6-82 HAMARTOMATOUS NODULE Left: A circumscribed nodule in a patient with the androgen insensitivity syndrome consists of small tubules lined by immature Sertoli cells with numerous intervening Leydig cells. Right: Higher magnification shows the typical small tubules l... More about this image found in HAMARTOMATOUS NODULE Left: A circumscribed nodule in a patient with the an...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-03
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... Tumor-Like Lesions  Leydig cell hyperplasia  Sertoli cell nodules  Hamartomatous nodules  Pseudomalignant normal morphologic variants  Nodular testicular parenchymal maturation, including precocious maturation  Adrenal cortical rests  Torsion/infarct (of testis, of appendix testis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-06
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... common hamartomatous nodules that are also seen in AIS patients, but we consider these two entities as distinct. Whether Sertoli cell adenoma is a true neoplasm, as its nomenclature implies, or a peculiar form of hyperplastic nodule, is not entirely clear, but since it may be confused with Sertoli cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-11
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... IN SITU (GCNIS) A portion of this Sertoli cell nodule has been colonized by GCNIS cells, thereby resembling gonadoblastoma. Uninvolved tubules are at the left. HAMARTOMATOUS NODULES Hamartomatous testicular nodules are a virtually exclusive feature of the androgen insensitivity syndrome (AIS...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 9
Published: 01 November 2021
10.55418/9781933477176-4
ISBN-10: 1-933477-17-2
ISBN: 978-1-933477-17-6
... vascularity is seen in this polypoid lesion. Prostatic polyps (ectopic prostate, adenomatous polyp, papillary adenoma) are reactive lesions that are often associated with urethral injury, although hamartomatous and even neoplastic etiologies cannot be completely excluded ( 97 , 104...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 7
Published: 01 September 2021
10.55418/9781933477121-1
ISBN-10: 1-933477-12-1
ISBN: 978-1-933477-12-1
... stage sebaceous trichofolliculoma showing overlapping features with folliculosebaceous cystic hamartoma . Ann Dermatol   2016 ; 28 : 511 - 2 . 214. Wu   YH . Folliculosebaceous cystic hamartoma or trichofolliculoma? A spectrum of hamartomatous changes inducted by perifollicular stroma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 6
Published: 01 August 2021
10.55418/9781933477091-ch04
ISBN-10: 1-933477-09-1
ISBN: 978-1-933477-09-1
... ) or the fetus ( 23 ). The etiology is unclear and could be hamartomatous ( 24 ), neoplastic, reactive, or due to a primary malformation of the umbilical cord vessels. UMBILICAL CORD HEMANGIOMA Figure 4-5-6 UMBILICAL CORD HEMANGIOMA Markedly thickened umbilical cord, especially near the marginal placental...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 6
Published: 01 August 2021
10.55418/9781933477091-ch09
ISBN-10: 1-933477-09-1
ISBN: 978-1-933477-09-1
... ). Etiology. Chorangiomas are considered hamartomatous; the genesis of chorangiomatosis is less clear. Both, if sizable enough, have the capacity to induce congenital heart failure as a result of fetal cardiac output requirements needed to perfuse the excess placental capillary bed. Gross Findings...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 6
Published: 01 August 2021
10.55418/9781933477091-ch08
ISBN-10: 1-933477-09-1
ISBN: 978-1-933477-09-1
... and intermediate villi. Demography . CM is rare, and only limited demographic data are available. CM was diagnosed in approximately 0.55 percent of placentas examined in one study ( 2 ). Etiology . As localized CM shares many characteristics with chorangiomas (CA), they may have the same, likely hamartomatous...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 4
Published: 01 April 2021
10.55418/9781933477930-06
ISBN-10: 1-933477-93-8
ISBN: 978-1-933477-93-0
... POLYPOSIS SYNDROMES A short synopsis of the hamartomatous syndromes is presented. The reader is referred to reference 70 for a comprehensive discussion of this topic. Sporadic Hamartomatous Polyps Gastrointestinal hamartomas contain a combination of nondysplastic mucosal elements, lymphoid...