Search Results for grade

INTERMEDIATE-GRADE CHONDROSARCOMA Figure 6-105 INTERMEDIATE-GRADE CHONDROSARCOMA Intermediate-grade (grade 2) chondrosarcoma shows myxoid stromal changes and increased cellularity, spindle cell changes, nuclear pleomorphism, and clustering of tumor cells. More about this image found in INTERMEDIATE-GRADE CHONDROSARCOMA Intermediate-grade (grade 2) chondrosarc...

LOW-GRADE CHONDROSARCOMA Figure 6-102 LOW-GRADE CHONDROSARCOMA Low-grade chondrosarcoma is a nodular, basophilic tumor arising from the cricoid cartilage and projecting posteriorly. More about this image found in LOW-GRADE CHONDROSARCOMA Low-grade chondrosarcoma is a nodular, basophilic...

LOW-GRADE CHONDROSARCOMA Figure 6-103 LOW-GRADE CHONDROSARCOMA This low-grade chondrosarcoma is a circumscribed tumor with abnormally clustered chondrocytes, multiple per lacunae, in a densely basophilic nodular stroma. More about this image found in LOW-GRADE CHONDROSARCOMA This low-grade chondrosarcoma is a circumscribed ...

LOW-GRADE CHONDROSARCOMA Figure 6-104 LOW-GRADE CHONDROSARCOMA At high magnification, this low-grade chondrosarcoma shows round to oval, hyperchromatic chondrocytes with clustering and binucleation, but lacking nucleoli, pleomorphism, or mitotic activity. More about this image found in LOW-GRADE CHONDROSARCOMA At high magnification, this low-grade chondrosarc...

LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA Figure 1-48 LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A,B: At low power, there are far more seromucinous glands than normal for the sinonasal contents. C,D: At high power, there is architectural atypia in the form of gland fusion More about this image found in LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A,B: At low power, there ...

LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA Figure 1-49 LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA In addition to the typical findings of this tumor type, cases harboring CTNNB1 mutations also commonly exhibit squamous morules (A) and ghost cells (B) as well as nuclear More about this image found in LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA In addition to the typica...

LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA Figure 1-50 LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A: Cases harboring BRAF p.V600E mutation have an unusual appearance, frequently with micropapillary growth and two cell types: an inner ductal cell and an outer myoepithelial More about this image found in LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A: Cases harboring

RENAL CELL CARCINOMA-LIKE LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA Figure 1-51 RENAL CELL CARCINOMA-LIKE LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A: The tumor grows as follicles lined by polygonal cells with well-defined cell borders and optically clear cytoplasm, resembling More about this image found in RENAL CELL CARCINOMA-LIKE LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA ...

HIGH-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA Figure 1-52 HIGH-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A: The tumor is partially gland forming, but is also partly solid and lacks intestinal-like features. B: The tumor glands are lined by mitotically active cells with marked nuclear More about this image found in HIGH-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A: The tumor is partiall...

LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA Figure 1-53 LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A–C: Many cases show serous differentiation in the form of expression with S-100 protein (A), SOX10 (B), and DOG1 (C). D: Mucinous areas are negative for these markers, as demonstrated More about this image found in LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A–C: Many cases show sero...

LOW-GRADE NASOPHARYNGEAL PAPILLARY ADENOCARCINOMA Figure 3-14 LOW-GRADE NASOPHARYNGEAL PAPILLARY ADENOCARCINOMA A–C: Papillary arrangement of crowded, elongated to cuboidal tumor cells mimics papillary thyroid carcinoma. D: There is a loose central fibrovascular core. E: Nuclei are oval More about this image found in LOW-GRADE NASOPHARYNGEAL PAPILLARY ADENOCARCINOMA A–C: Papillary arrangeme...

LOW-GRADE NASOPHARYNGEAL PAPILLARY ADENOCARCINOMA Figure 3-15 LOW-GRADE NASOPHARYNGEAL PAPILLARY ADENOCARCINOMA The adenocarcinoma has a distinctive immunoprofile showing diffuse positive staining for CK7 (A) and TTF-1 (B); immunostains are negative for PAX8 (C) and thyroglobulin (D). More about this image found in LOW-GRADE NASOPHARYNGEAL PAPILLARY ADENOCARCINOMA The adenocarcinoma has a...

LOW-GRADE SQUAMOUS DYSPLASIA Figure 6-35 LOW-GRADE SQUAMOUS DYSPLASIA A: The mucosa shows mild architectural disorganization in the lower third as well as a focal dyskeratotic cell. B: The architectural disorganization and atypia are confined to the lower portion of the mucosa. More about this image found in LOW-GRADE SQUAMOUS DYSPLASIA A: The mucosa shows mild architectural disorg...

HIGH-GRADE SQUAMOUS DYSPLASIA Figure 6-36 HIGH-GRADE SQUAMOUS DYSPLASIA A,B: The mucosa shows architectural disorganization (A) and nuclear atypia involving two thirds or more of the epithelium (B); occasional mitoses are present. More about this image found in HIGH-GRADE SQUAMOUS DYSPLASIA A,B: The mucosa shows architectural disorgan...

NEUROENDOCRINE TUMOR, GRADE 1 Figure 6-72 NEUROENDOCRINE TUMOR, GRADE 1 At low magnification, neuroendocrine tumor, grade 1 is a submucosal tumor with cords and nests of bland cells with modest cytoplasm and round, regular nuclei. More about this image found in NEUROENDOCRINE TUMOR, GRADE 1 At low magnification, neuroendocrine tumor, ...

NEUROENDOCRINE TUMOR, GRADE 1 Figure 6-73 NEUROENDOCRINE TUMOR, GRADE 1 At higher power, the cells are monotonous with round nuclei, speckled chromatin, and lack nucleoli, and have no appreciable mitotic activity or necrosis. More about this image found in NEUROENDOCRINE TUMOR, GRADE 1 At higher power, the cells are monotonous wi...

NEUROENDOCRINE TUMOR, GRADE 1 Figure 6-74 NEUROENDOCRINE TUMOR, GRADE 1 This tumor is strongly and diffusely positive for chromogranin-A. More about this image found in NEUROENDOCRINE TUMOR, GRADE 1 This tumor is strongly and diffusely positiv...

NEUROENDOCRINE TUMOR, GRADE 1 Figure 6-75 NEUROENDOCRINE TUMOR, GRADE 1 Ki-67 immunohistochemistry shows little positive nuclear staining (less than 5 percent of cells). More about this image found in NEUROENDOCRINE TUMOR, GRADE 1 Ki-67 immunohistochemistry shows little posi...

NEUROENDOCRINE TUMOR, GRADE 2 Figure 6-76 NEUROENDOCRINE TUMOR, GRADE 2 A–F: The neuroendocrine tumor is present directly beneath the surface squamous epithelium (A–C) as loose nests (D,E) and as solid arrangements of cells (F). G,H: Scattered mitoses are present (G) as well as focal areas More about this image found in NEUROENDOCRINE TUMOR, GRADE 2 A–F: The neuroendocrine tumor is present dir...

NEUROENDOCRINE TUMOR, GRADE 2 Figure 6-77 NEUROENDOCRINE TUMOR, GRADE 2 The neuroendocrine tumor is immunohistochemically positive for keratins (A), synaptophysin (B), and chromogranin (C). More about this image found in NEUROENDOCRINE TUMOR, GRADE 2 The neuroendocrine tumor is immunohistochemi...