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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... infiltrates (see figs. 4-3 , 4-6 ) ( 8 – 10 ), and features of partial regression (see fig. 4-7 ). Many pathologists who use the term “dysplastic” nevus tend to grade the lesions as mild, moderate, and severe. The authors of the 2018 WHO classification of melanocytic tumors recommend a two-tiered grading...
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EAR NEVUS  A: Compound nevus with some asymmetry and ill-defined peripheral...
Published: 01 February 2024
EAR NEVUS Figure 5-11 EAR NEVUS A: Compound nevus with some asymmetry and ill-defined peripheral lentiginous growth. B: The center of the lesion contains pigmented spindle and epithelioid melanocytes with architectural disorder and low-grade atypia. There is evidence of maturation. More about this image found in EAR NEVUS A: Compound nevus with some asymmetry and ill-defined peripheral...
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MELANOMA ARISING IN ASSOCIATION WITH AND SIMULATING A MELANOCYTIC NEVUS  A:...
Published: 01 February 2024
MELANOMA ARISING IN ASSOCIATION WITH AND SIMULATING A MELANOCYTIC NEVUS Figure 17-8 MELANOMA ARISING IN ASSOCIATION WITH AND SIMULATING A MELANOCYTIC NEVUS A: Most of the melanocytes are intradermal and display architectural disorder and atypia, but also some suggestion of maturation. Junctional ... More about this image found in MELANOMA ARISING IN ASSOCIATION WITH AND SIMULATING A MELANOCYTIC NEVUS A:...
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DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN  High-<span class="search-highlight">grade</span> DCIS undermin...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN Figure 3-25 DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN High-grade DCIS undermines an attenuated layer of residual normal epithelium with spindled nuclei. More about this image found in DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN High-grade DCIS undermin...
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DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR <span class="search-highlight">GRADE</span>  Lobular involvement b...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Figure 3-26 DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Lobular involvement by DCIS. More about this image found in DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Lobular involvement b...
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DUCTAL CARCINOMA IN SITU: HIGH NUCLEAR <span class="search-highlight">GRADE</span> WITH MICROINVASION  A: Interme...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: HIGH NUCLEAR GRADE WITH MICROINVASION Figure 3-27 DUCTAL CARCINOMA IN SITU: HIGH NUCLEAR GRADE WITH MICROINVASION A: Intermediate-power view illustrates high nuclear grade DCIS with involvement of lobules (top of field). The inflammatory cell infiltrate is prominent. Sin... More about this image found in DUCTAL CARCINOMA IN SITU: HIGH NUCLEAR GRADE WITH MICROINVASION A: Interme...
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LOBULAR CARCINOMA IN SITU AND LOW NUCLEAR <span class="search-highlight">GRADE</span> DUCTAL CARCINOMA IN SITU AN...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU AND LOW NUCLEAR GRADE DUCTAL CARCINOMA IN SITU AND/OR ATYPICAL DUCTAL HYPERPLASIA (SOLID PATTERN) Figure 4-11 LOBULAR CARCINOMA IN SITU AND LOW NUCLEAR GRADE DUCTAL CARCINOMA IN SITU AND/OR ATYPICAL DUCTAL HYPERPLASIA (SOLID PATTERN) These can be difficult to distinguish... More about this image found in LOBULAR CARCINOMA IN SITU AND LOW NUCLEAR GRADE DUCTAL CARCINOMA IN SITU AN...
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INVASIVE CARCINOMA  A: Low-<span class="search-highlight">grade</span> invasive ductal carcinoma with a relativel...
Published: 01 January 2024
INVASIVE CARCINOMA Figure 6-10 INVASIVE CARCINOMA A: Low-grade invasive ductal carcinoma with a relatively circumscribed growth pattern can be misinterpreted as sclerosing adenosis. B: At higher power, the glands appear more disorganized than would be expected in sclerosing adenosis. In addition... More about this image found in INVASIVE CARCINOMA A: Low-grade invasive ductal carcinoma with a relativel...
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INTRADUCTAL PAPILLOMA WITH HIGH-<span class="search-highlight">GRADE</span> DUCTAL CARCINOMA IN SITU  A: Even at ...
Published: 01 January 2024
INTRADUCTAL PAPILLOMA WITH HIGH-GRADE DUCTAL CARCINOMA IN SITU Figure 7-19 INTRADUCTAL PAPILLOMA WITH HIGH-GRADE DUCTAL CARCINOMA IN SITU A: Even at low power the cytologic atypia is apparent. Focal necrosis is also present. B,C: At intermediate (B) and high (C) power, the myoepithelial cell lay... More about this image found in INTRADUCTAL PAPILLOMA WITH HIGH-GRADE DUCTAL CARCINOMA IN SITU A: Even at ...
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INVASIVE BREAST CARCINOMA, NO SPECIAL TYPE (NST), <span class="search-highlight">GRADE</span> 1  This low-power i...
Published: 01 January 2024
INVASIVE BREAST CARCINOMA, NO SPECIAL TYPE (NST), GRADE 1 Figure 8-1 INVASIVE BREAST CARCINOMA, NO SPECIAL TYPE (NST), GRADE 1 This low-power image shows a tumor composed of well-formed tubules with cells that have round, regular nuclei; no mitoses are present. More about this image found in INVASIVE BREAST CARCINOMA, NO SPECIAL TYPE (NST), GRADE 1 This low-power i...
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INVASIVE BREAST CARCINOMA, NST, <span class="search-highlight">GRADE</span> 2  This tumor is composed of a mix of...
Published: 01 January 2024
INVASIVE BREAST CARCINOMA, NST, GRADE 2 Figure 8-2 INVASIVE BREAST CARCINOMA, NST, GRADE 2 This tumor is composed of a mix of tubules and solid nests. The tumor cell nuclei display greater variability than the prior case. More about this image found in INVASIVE BREAST CARCINOMA, NST, GRADE 2 This tumor is composed of a mix of...
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INVASIVE BREAST CARCINOMA, NST, <span class="search-highlight">GRADE</span> 3  There are sheets of tumor cells wi...
Published: 01 January 2024
INVASIVE BREAST CARCINOMA, NST, GRADE 3 Figure 8-3 INVASIVE BREAST CARCINOMA, NST, GRADE 3 There are sheets of tumor cells with large pleomorphic nuclei. Zones of necrosis are present; while not a criterion of grading, necrosis is more likely to be seen in grade 3 and triple-negative breast cance... More about this image found in INVASIVE BREAST CARCINOMA, NST, GRADE 3 There are sheets of tumor cells wi...
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INVASIVE BREAST CARCINOMA, NST, <span class="search-highlight">GRADE</span> 1  A: Over 75 percent of this tumor i...
Published: 01 January 2024
INVASIVE BREAST CARCINOMA, NST, GRADE 1 Figure 8-10 INVASIVE BREAST CARCINOMA, NST, GRADE 1 A: Over 75 percent of this tumor is composed of tubules. B: The tumor cell nuclei are of low nuclear grade; no mitotic figures are seen. C: As would be anticipated, the tumor is strongly and diffusely es... More about this image found in INVASIVE BREAST CARCINOMA, NST, GRADE 1 A: Over 75 percent of this tumor i...
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INVASIVE BREAST CARCINOMA, NST, <span class="search-highlight">GRADE</span> 2  A: This tumor is composed of an ad...
Published: 01 January 2024
INVASIVE BREAST CARCINOMA, NST, GRADE 2 Figure 8-11 INVASIVE BREAST CARCINOMA, NST, GRADE 2 A: This tumor is composed of an admixture of glands and solid nests. B,C: The tumor cell nuclei are intermediate grade (B) and scattered mitotic figures are appreciated at high (C) power. More about this image found in INVASIVE BREAST CARCINOMA, NST, GRADE 2 A: This tumor is composed of an ad...
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INVASIVE BREAST CARCINOMA, NST, <span class="search-highlight">GRADE</span> 3  A: This tumor is composed of solid...
Published: 01 January 2024
INVASIVE BREAST CARCINOMA, NST, GRADE 3 Figure 8-12 INVASIVE BREAST CARCINOMA, NST, GRADE 3 A: This tumor is composed of solid sheets of highly atypical cells. B: At high power, the tumor cell nuclei are large and pleomorphic; mitotic figures are readily identified. More about this image found in INVASIVE BREAST CARCINOMA, NST, GRADE 3 A: This tumor is composed of solid...
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INFILTRATING MARGIN  A: H&amp;E stain of a <span class="search-highlight">grade</span> 1 invasive breast carcinom...
Published: 01 January 2024
INFILTRATING MARGIN Figure 8-14 INFILTRATING MARGIN A: H&E stain of a grade 1 invasive breast carcinoma, NST. The infiltrative margin is a helpful clue to the malignant nature of a proliferation composed of small glands. B: In problematic cases, myoepithelial cell markers, such as p63, are h... More about this image found in INFILTRATING MARGIN A: H&E stain of a grade 1 invasive breast carcinom...
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PUSHING MARGIN  Some carcinomas, particularly <span class="search-highlight">grade</span> 3, triple-negative tumo...
Published: 01 January 2024
PUSHING MARGIN Figure 8-15 PUSHING MARGIN Some carcinomas, particularly grade 3, triple-negative tumors are characterized by a more circumscribed or “pushing” margin. More about this image found in PUSHING MARGIN Some carcinomas, particularly grade 3, triple-negative tumo...
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LOW-<span class="search-highlight">GRADE</span> ADENOSQUAMOUS CARCINOMA  A: At low power, subtle cords, glands, a...
Published: 01 January 2024
LOW-GRADE ADENOSQUAMOUS CARCINOMA Figure 8-59 LOW-GRADE ADENOSQUAMOUS CARCINOMA A: At low power, subtle cords, glands, and nests of epithelial cells are seen haphazardly placed in the stroma. Scattered lymphoid aggregates are present. B,C: Some nests have a squamoid appearance (B) and others are... More about this image found in LOW-GRADE ADENOSQUAMOUS CARCINOMA A: At low power, subtle cords, glands, a...
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INVASIVE DUCTAL CARCINOMA, <span class="search-highlight">GRADE</span> 1, ARISING IN A MALE BREAST
Published: 01 January 2024
INVASIVE DUCTAL CARCINOMA, GRADE 1, ARISING IN A MALE BREAST Figure 10-6 INVASIVE DUCTAL CARCINOMA, GRADE 1, ARISING IN A MALE BREAST More about this image found in INVASIVE DUCTAL CARCINOMA, GRADE 1, ARISING IN A MALE BREAST
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INVASIVE CARCINOMA, <span class="search-highlight">GRADE</span> 2, WITH SOLID PAPILLARY FEATURES
Published: 01 January 2024
INVASIVE CARCINOMA, GRADE 2, WITH SOLID PAPILLARY FEATURES Figure 10-7 INVASIVE CARCINOMA, GRADE 2, WITH SOLID PAPILLARY FEATURES More about this image found in INVASIVE CARCINOMA, GRADE 2, WITH SOLID PAPILLARY FEATURES