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PRIMARY ADRENAL ANGIOSARCOMA  A: There is well-developed vasoformative arch...
Published: 01 December 2024
PRIMARY ADRENAL ANGIOSARCOMA Figure 12-10 PRIMARY ADRENAL ANGIOSARCOMA A: There is well-developed vasoformative architecture with sinusoidal growth between cords of vacuolated cortical cells. Acute inflammatory cells and eosinophils are also present. B: Primary adrenal angiosarcoma (same case as... More about this image found in PRIMARY ADRENAL ANGIOSARCOMA A: There is well-developed vasoformative arch...
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HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND  A: Hepatocellular car...
Published: 01 December 2024
HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-26 HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular carcinoma metastatic to the adrenal gland can simulate a primary adrenal cortical carcinoma. This metastasis has a prominent trabecular pattern with delicate si... More about this image found in HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular car...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... at the time of diagnosis. Common sites of metastasis are lung, liver, and lymph nodes, and less frequently, bone ( 39 ). Systemic symptoms also may be present ( 40 ), including prominent weight loss, intermittent low-grade fever (possibly related to extensive tumor necrosis), and anorexia. Hypoglycemia...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...: ATYPICAL MITOSES Figure 8-49 PHEOCHROMOCYTOMA: ATYPICAL MITOSES A–C: The presence of atypical mitoses should prompt careful examination for other features suggestive of aggressive behavior. Another proposal, the Grading System for Adrenal Phaeochromocytoma and Paraganglioma (GAPP), was designed to also...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-grade tumor with epithelioid features. Residual adrenal cortical cells are also present. C: High-grade epithelioid angiosarcoma of adrenal gland surrounds small nests of residual cortical cells. Tumor cells have prominent nucleoli and small clear spaces, suggesting primitive vascular lumen formation...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., with a consequently worse prognosis ( 42 ). Table 11-3 THE INTERNATIONAL NEUROBLASTOMA RISK GROUP STAGING SYSTEM (INRGSS) a INRG Stage Age (months) Histologic Category Grade of Tumor Differentiation MYCN 11q Aberration Ploidy Pretreatment Risk Group L1/L2 GN maturing; GNB intermixed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... histologic feature is a robust predictor of metastases. Various features proposed as risk factors have been combined into scoring systems. The two major scoring systems are Pheochromocytoma of Adrenal Medulla Scaled Score (PASS) ( 88 ) and Grading of Adrenal Pheochromocytoma and Paraganglioma (GAPP) ( 114...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... , Ezzat   S , Mete   O , Kim   RH . FLCN-driven functional adrenal cortical carcinoma with high mitotic tumor grade: extending the endocrine manifestations of Birt-Hogg-Dubé syndrome . Endocr Pathol   2023 ; 34 ; 257 - 64 . 71. Malkin   D , Li   FP , Strong   LC , et al . Germ...
Images
COLPOSCOPIC FEATURES OF LOW-<span class="search-highlight">GRADE</span> AND HIGH-<span class="search-highlight">GRADE</span> SQUAMOUS INTRAEPITHELIAL L...
Published: 01 September 2024
COLPOSCOPIC FEATURES OF LOW-GRADE AND HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESIONS (LSIL, HSIL) AND CARCINOMA Figure 9-35 COLPOSCOPIC FEATURES OF LOW-GRADE AND HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESIONS (LSIL, HSIL) AND CARCINOMA A: LSIL. B: HSIL. C: Squamous cell carcinoma. (Courtesy of Dr. L.... More about this image found in COLPOSCOPIC FEATURES OF LOW-GRADE AND HIGH-GRADE SQUAMOUS INTRAEPITHELIAL L...
Images
PRIMARY EFFUSION LYMPHOMA (PEL)  A: Cytologic cell block preparation of ple...
Published: 01 September 2024
PRIMARY EFFUSION LYMPHOMA (PEL) Figure 8-22 PRIMARY EFFUSION LYMPHOMA (PEL) A: Cytologic cell block preparation of pleural effusion fluid shows sheets of dyscohesive atypical lymphoid cells at low power. B: High power illustrates the typical high-grade cytomorphology, prominent single nucleoli, ... More about this image found in PRIMARY EFFUSION LYMPHOMA (PEL) A: Cytologic cell block preparation of ple...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... b Skin, lung, liver, brain + + Herpesvirus 8 (Kaposi sarcoma virus) Skin, lymphoid tissues, lung, gut + + Herpes varicella-zoster Skin, brain, cerebral arteries + Human papillomavirus, high grade Skin, genital tract Human papillomavirus, low grade Skin, genital tract + JC...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-05
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... disease typically presents with dark urine and jaundice. There may be associated right upper quadrant abdominal pain/discomfort, low-grade fever, urticaria, and pruritis. Fulminant disease is characterized by a rapid and severe course due to extensive hepatocellular injury, leading to liver...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... typical punctate nuclear staining. PEL is frequently diagnosed on cytology (due to its characteristic presentation). There is high-grade morphology, with dyscohesive sheets of large pleomorphic cells showing immunoblastic, RS-like, or rarely, plasmablastic features ( fig. 8-22A-C ) ( 30 ). The neoplastic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-11
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in individuals with prosthetic valves or prior rheumatic heart disease Mortality 25-30% Cutaneous Abattoir workers Low-grade fever and papulopustular skin lesions Eye involvement can also occur Gastroenteritis During outbreaks Diarrhea, fever, fatigue, chills, and myalgia, usually 24 hours...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., corneal opacities, and eventually, blindness. The corneal opacities are the result of eyelash-induced trauma and superinfections. The WHO has stratified the stages of trachoma on a grading scale, from five or more lymphoid follicles to cicatricial and healed trachoma. Table 18-3 CLINICAL MANIFESTATIONS...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Similar to Shigella spp, with prominent mucosal neutrophil infiltration and occasional severe mucosal injury EAEC Acute nonmucoid, nonbloody/watery diarrhea, vomiting, abdominal pain, and low-grade fever Can be associated with chronic diarrhea, wasting, and postinfectious irritable bowel...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-26
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... oocysts. The spectrum and severity of symptoms depend on the patient’s immune status. In the immune competent, infection usually presents as self-limiting nonbloody diarrhea. Steatorrhea, headache, malaise, abdominal pain, vomiting, low-grade fever, dehydration, and weight loss also occur occasionally...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... are determined by numerous factors, including patient age, immune status, and coinfection with other respiratory pathogens ( 35 ). Typically, symptomatic individuals progress through three stages. The first, the catarrhal stage, which begins 1 to 2 weeks after exposure, is characterized by low-grade...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... individual. This is also the form of disease most likely to be used as a potential biological weapon. Primary pneumonic plague presents with a sudden onset of high-grade fever, cough, dyspnea, pleuritic chest pain, and bloody sputum. Mortality is approximately 90 to 100 percent. Imaging typically shows...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of lower tract infection in children include poor feeding, lethargy, irritability, and sometimes, low-grade fever. Chest X-rays show lung hyperinflation and patchy atelectasis. On peripheral blood examination there is a leukocytosis with a predominance of lymphocytes, many appearing reactive. Approximately...