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gonad

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EMBRYOLOGY OF TESTIS  The <span class="search-highlight">gonad</span> is first recognized at 4 to 5 weeks of gest...
Published: 01 August 2022
EMBRYOLOGY OF TESTIS Figure 2-1 EMBRYOLOGY OF TESTIS The gonad is first recognized at 4 to 5 weeks of gestation as a thickening of the intermediate mesoderm of the ventromedial aspect of the mesonephros, forming the genital, or gonadal, ridge. At 6 weeks, and simultaneously with the arrival of th... More
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EMBRYOLOGY OF TESTIS  Early in development, the configuration of the <span class="search-highlight">gonad</span> ...
Published: 01 August 2022
EMBRYOLOGY OF TESTIS Figure 2-2 EMBRYOLOGY OF TESTIS Early in development, the configuration of the gonad (in red) is elongated between the root of the dorsal mesentery and the mesonephros. (Fig. 16-17 from Sadler TW. Langman’s medical embryology, 12th ed. Philadelphia: Wolters Kluwer; 2011:243.)... More
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GONADOBLASTOMA  Left: In this dissecting pattern (or undifferentiated <span class="search-highlight">gonad</span>...
Published: 01 August 2022
GONADOBLASTOMA Figure 7-8 GONADOBLASTOMA Left: In this dissecting pattern (or undifferentiated gonadal tissue) small nests and cords of germ cells and sex cord cells closely resemble the infiltrative growth pattern of germinoma. Right: Cords of germ cells with sex cord cells surround two discret... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... to a mutation in the hydroxysteroid dehydrogenase 32 gene; and a deficiency of all adrenal and gonadal steroid hormones causing congenital lipoid adrenal hyperplasia, the rarest form of congenital hyperplasia. These patients have low cortisol and aldosterone secretion rates and increased activity of ACTH...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... transplantation for hematological disorders during childhood: a study by the Working Party for Late Effects-EBMT . Blood   1999 ; 93 : 4109 - 15 . 253. Couto-Silva   AC , Trivin   C , Esperou   H , et al . Final height and gonad function after total body irradiation during childhood . Bone...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-3
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... in general immune suppression because of the effects of glucocorticoids and corticotropin-releasing hormone on the immune system ( 504 , 505 ); the immune system overcompensates for the stress, leading to autoimmune disease. The role of gonadal steroid hormones in the initiation of Graves disease has been...
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FIBROTHECOMA  An intratesticular <span class="search-highlight">gonadal</span> fibrothecoma is well circumscribed...
Published: 01 August 2022
FIBROTHECOMA Figure 6-143 FIBROTHECOMA An intratesticular gonadal fibrothecoma is well circumscribed, with a homogeneous gray-white cut surface. (Fig. 1A from Zhang M, Kao CS, Ulbright TM, Epstein JI. Testicular fibrothecoma: a morphologic and immunohistochemical study of 16 cases. Am J Surg Path... More
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MYOID <span class="search-highlight">GONADAL</span> STROMAL TUMOR  A circumscribed, nonencapsulated tumor with pr...
Published: 01 August 2022
MYOID GONADAL STROMAL TUMOR Figure 6-166 MYOID GONADAL STROMAL TUMOR A circumscribed, nonencapsulated tumor with prominent blood vessels is seen in the testis. More
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MYOID <span class="search-highlight">GONADAL</span> STROMAL TUMOR  Spindled tumor cells are organized in short in...
Published: 01 August 2022
MYOID GONADAL STROMAL TUMOR Figure 6-167 MYOID GONADAL STROMAL TUMOR Spindled tumor cells are organized in short intersecting fascicles, with small, ectatic blood vessels. More
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MYOID <span class="search-highlight">GONADAL</span> STROMAL TUMOR  Strong and diffuse smooth muscle actin reactiv...
Published: 01 August 2022
MYOID GONADAL STROMAL TUMOR Figure 6-168 MYOID GONADAL STROMAL TUMOR Strong and diffuse smooth muscle actin reactivity in the tumor as well as in peritubular myoid cells. More
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MYOID <span class="search-highlight">GONADAL</span> STROMAL TUMOR  Strong staining for S-100 protein.
Published: 01 August 2022
MYOID GONADAL STROMAL TUMOR Figure 6-169 MYOID GONADAL STROMAL TUMOR Strong staining for S-100 protein. More
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GONADOBLASTOMA AND UNDIFFERENTIATED <span class="search-highlight">GONADAL</span> TISSUE  A: Confluent nests of g...
Published: 01 August 2022
GONADOBLASTOMA AND UNDIFFERENTIATED GONADAL TISSUE Figure 7-7 GONADOBLASTOMA AND UNDIFFERENTIATED GONADAL TISSUE A: Confluent nests of gonadoblastoma (diffuse or expansile pattern), resembling germinoma on low power, are associated with classic nests of gonadoblastoma (top and bottom right). B: ... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-07
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... gonadoblastomas with pink-tan cut surfaces contain white, “gritty” calcifications throughout; the gonad on the right also shows a solid white area of germinoma. Bilateral fallopian tubes are present. (Fig. 8 from Ulbright TM, Young RH. Gonadoblastoma and selected other aspects of gonadal pathology in young...
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GONADOBLASTOMA  Bilateral gonadoblastomas with pink-tan cut surfaces contai...
Published: 01 August 2022
GONADOBLASTOMA Figure 7-1 GONADOBLASTOMA Bilateral gonadoblastomas with pink-tan cut surfaces contain white, “gritty” calcifications throughout; the gonad on the right also shows a solid white area of germinoma. Bilateral fallopian tubes are present. (Fig. 8 from Ulbright TM, Young RH. Gonadoblas... More
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HAMARTOMATOUS NODULES  There are several discrete tan nodules measuring up ...
Published: 01 August 2022
HAMARTOMATOUS NODULES Figure 6-81 HAMARTOMATOUS NODULES There are several discrete tan nodules measuring up to 2 cm in this gonad from a patient with androgen insensitivity syndrome. More
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TESTICULAR “TUMOR” OF THE ADRENOGENITAL SYNDROME  The lesional cells (top) ...
Published: 01 August 2022
TESTICULAR “TUMOR” OF THE ADRENOGENITAL SYNDROME Figure 11-64 TESTICULAR “TUMOR” OF THE ADRENOGENITAL SYNDROME The lesional cells (top) are negative for androgen receptor whereas the nuclei of gonadal stromal cells and adjacent Sertoli cells are strongly positive (antiandrogen receptor immunostai... More
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EMBRYOLOGY OF TESTIS  The primordial germ cells (left, red dots) derive fro...
Published: 01 August 2022
EMBRYOLOGY OF TESTIS Figure 2-6 EMBRYOLOGY OF TESTIS The primordial germ cells (left, red dots) derive from the yolk sac mesoderm and then migrate along the hindgut and its mesentery (right) to reach the gonadal (genital) ridges. (Fig. 16-18 from Sadler TW. Langman’s medical embryology, 12th ed. ... More
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RUPTURED CORPUS LUTEUM IN AN OVOTESTIS  A hemorrhagic corpus luteum is pres...
Published: 01 August 2022
RUPTURED CORPUS LUTEUM IN AN OVOTESTIS Figure 11-96 RUPTURED CORPUS LUTEUM IN AN OVOTESTIS A hemorrhagic corpus luteum is present in the upper pole of an ovotestis of a patient with 46,XY ovotesticular disorder of sex development. The patient, a 14-year-old boy, presented with “testicular” pain a... More
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POLYEMBRYOMA  This tumor predominantly consists of polyembryoma. It is most...
Published: 01 August 2022
POLYEMBRYOMA Figure 4-201 POLYEMBRYOMA This tumor predominantly consists of polyembryoma. It is mostly solid, with a few cysts, and has a lobulated and prominently hemorrhagic cut surface with occasional fibrous bands. (fig. 4-1 from Stall JN, Young RH. Polyembryoma of the testis: a report of two... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-02
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
....) (Courtesy of Dr. B. Ljung, San Francisco, CA) EMBRYOLOGY OF TESTIS Figure 2-1 EMBRYOLOGY OF TESTIS The gonad is first recognized at 4 to 5 weeks of gestation as a thickening of the intermediate mesoderm of the ventromedial aspect of the mesonephros, forming the genital, or gonadal, ridge. At 6 weeks...