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Figure 1-104
Published: 01 June 2025
GLOMANGIOPERICYTOMA Figure 1-104 GLOMANGIOPERICYTOMA A: Tumor multinucleated giant cells are an uncommon finding. B: The lower portion of the field shows glomangiopericytoma, while the upper part shows a juxtaposed solitary fibrous tumor (positive with STAT6 [not shown]). More about this image found in GLOMANGIOPERICYTOMA A: Tumor multinucleated giant cells are an uncommon fi...
Images
Figure 4-55
Published: 01 June 2025
PERIPHERAL GIANT CELL GRANULOMA Figure 4-55 PERIPHERAL GIANT CELL GRANULOMA A: Exophytic, liver-colored mucosa on the mandibular gingiva. B: Unencapsulated cellular lesion with extravasated red blood cells. C: The vascularized stroma supports multinucleated giant cells. D: Multinucleated More about this image found in PERIPHERAL GIANT CELL GRANULOMA A: Exophytic, liver-colored mucosa on the ...
Images
Figure 5-216
Published: 01 June 2025
CENTRAL GIANT CELL GRANULOMA (CGCG) Figure 5-216 CENTRAL GIANT CELL GRANULOMA (CGCG) A: The aggressive variant can grow rapidly. B: Cephalometric radiograph of the lesion shows the extent of involvement, with bowing of the mandible. C: The anterior mandible is the most common location for CGCG More about this image found in CENTRAL GIANT CELL GRANULOMA (CGCG) A: The aggressive variant can grow rap...
Images
Figure 5-217
Published: 01 June 2025
CENTRAL GIANT CELL GRANULOMA Figure 5-217 CENTRAL GIANT CELL GRANULOMA A: Scattered multinucleated cells within a vascular stroma composed of plump spindled cells, woven bone (arrows), and extravasated erythrocytes. B: Clusters of multinucleated cells are adjacent to areas of hemosiderin More about this image found in CENTRAL GIANT CELL GRANULOMA A: Scattered multinucleated cells within a va...
Images
Figure 1-154
Published: 01 June 2025
MUCOSAL MELANOMA Figure 1-154 MUCOSAL MELANOMA A: The cells are enlarged with prominent nucleoli and isolated multinucleated giant cells. B: Numerous intranuclear cytoplasmic inclusions are noted. C: Multinucleated neoplastic giant cells are present in this melanoma. More about this image found in MUCOSAL MELANOMA A: The cells are enlarged with prominent nucleoli and iso...
Images
Figure 1-143
Published: 01 June 2025
with fibrosis and a giant cell reaction. D: Reverse-polarized basaloid nuclei are adjacent to areas of stellate reticulum and ghost cells. A foreign body giant cell reaction (black arrow) is seen. More about this image found in CRANIOPHARYNGIOMA A: Columnar basaloid cells are palisaded at the peripher...
Images
Figure 5-219
Published: 01 June 2025
CHERUBISM Figure 5-219 CHERUBISM A: Vascular fibrous tissue with scattered multinucleated osteoclast-like giant cells and hemorrhage. B: Eosinophilic cuff-like perivascular deposits (arrow) within the monotonous edematous spindle cell stroma. More about this image found in CHERUBISM A: Vascular fibrous tissue with scattered multinucleated osteocl...
Images
Figure 8-32
Published: 01 June 2025
FIBROUS HISTIOCYTOMA Figure 8-32 FIBROUS HISTIOCYTOMA A: There is a well-circumscribed border to the neoplasm, seeming to displace the adnexal structures. B: The storiform appearance of the neoplastic spindled cells is well developed, lacking any pleomorphism or atypia. Multinucleated giant More about this image found in FIBROUS HISTIOCYTOMA A: There is a well-circumscribed border to the neopla...
Images
Figure 8-128
Published: 01 June 2025
ENDOLYMPHATIC SAC TUMOR Figure 8-128 ENDOLYMPHATIC SAC TUMOR A: Fibrosis and hemorrhage are noted in this tumor, a consequence of intratumoral bleeding based on the tumor’s size. B: Cholesterol clefts and giant cells are seen in association with fibrosis and hemorrhage, part of tumor More about this image found in ENDOLYMPHATIC SAC TUMOR A: Fibrosis and hemorrhage are noted in this tumor...
Images
Figure 8-86
Published: 01 June 2025
CHOLESTEROL GRANULOMA Figure 8-86 CHOLESTEROL GRANULOMA A: A heavily inflamed stroma with a foreign-body giant cell reaction to breakdown products (blood or keratin). B: Cholesterol clefts are seen adjacent to the epithelium; keratin flakes are seen (top of field) in a cholesteatoma More about this image found in CHOLESTEROL GRANULOMA A: A heavily inflamed stroma with a foreign-body gia...
Images
Figure 1-131
Published: 01 June 2025
NEUROGLIAL HETEROTOPIA Figure 1-131 NEUROGLIAL HETEROTOPIA A: Glial tissue lacks atypia and is not aggregated to suggest a neoplasm. B: Heavy fibrosis nearly completely obscures the glial tissue (lighter pink cytoplasm). C: Giant cell reaction is noted adjacent to minor mucoserous glands. D More about this image found in NEUROGLIAL HETEROTOPIA A: Glial tissue lacks atypia and is not aggregated ...
Images
Figure 5-222
Published: 01 June 2025
include multinucleated giant cells. C: The histiocytes show strong immunoreactivity for CD1a. D: Mild to moderate immunoreactivity for CD68. More about this image found in LANGERHANS CELL HISTIOCYTOSIS A: The mixed inflammatory cell infiltrate in...
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Images
Figure 1-137
Published: 01 June 2025
, including tumor giant cells (black arrow) in grade 3 tumors (C), and marked pleomorphism and anisonucleosis in grade 4 tumors (D). More about this image found in OLFACTORY NEUROBLASTOMA The appearance of the nuclei changes over the arc ...
Images
Figure 6-33
Published: 01 June 2025
: Blastomycosis-associated pseudoepitheliomatous hyperplasia at high power shows rare thick-walled, large yeast forms in the epithelium (organisms in circle). C: Thick-walled, budding yeast in a submucosal giant cell. More about this image found in PSEUDOEPITHELIOMATOUS HYPERPLASIA A: Blastomycosis-associated pseudoepithe...
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Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... the central nucleus appears missing ( fig. 5-89 ). The ghost cells frequently show dystrophic calcification. Cytologically, the cells are bland and the mitotic rate is low. Frequently, clusters of ghost cells show inflammation and the keratin induces a foreign body giant cell reaction. DENTINOGENIC GHOST CELL...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
..., and fascicular, with low to intermediate cellularity ( fig. 4-14B,C ). SpSCC is mitotically active and atypical forms are readily identified. Other findings include tumor giant cells, tumor necrosis, and desmoplastic stromal fibrosis. SPINDLE SQUAMOUS CELL CARCINOMA Figure 4-14 SPINDLE SQUAMOUS CELL CARCINOMA...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... areas and dystrophic calcifications or giant cell reaction associated with it. None of the latter features are present in vocal cord nodules and polyps. Vocal cord nodules and polyps are usually associated with hemorrhage, and, as previously mentioned, almost always are associated with other patterns...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... tissue varies greatly in the literature, probably dependent on the thoroughness of the evaluation ( fig. 7-24 ). Overall, it is present in about 70 percent of patients. In 65 percent of patients, there is evidence of rupture with fibrosis, foamy macrophages, giant cell reaction, and cholesterol clefts...