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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI:
10.55418/9781933477220-04
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...Table 4-1 RISK FACTORS FOR GERM CELL NEOPLASIA IN SITU (GCNIS) AND GCNIS-DERIVED TUMORS Condition Magnitude of Increased Risk (Estimated RR a ) Disorders of sex development Variable, often extreme (see Table 4-2 ), up to 150X b Prior testicular germ cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI:
10.55418/9781933477220-05
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...-power fields; LVI = lymphovascular invasion; YST = yolk sac tumor. Table 5-5 CONTRASTING FEATURES OF SPERMATOCYTIC TUMOR AND SEMINOMA a Spermatocytic Tumor Seminoma Proportion of germ cell tumors 0.6% 40 to 50% Sites testis only testis, ovary (dysgerminoma), mediastinum...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI:
10.55418/9781933477220-07
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...GONADOBLASTOMA Figure 7-2 GONADOBLASTOMA Nests of gonadoblastoma are present at left, above the rete testis (bottom left), with immature seminiferous tubules on the right. GONADOBLASTOMA Figure 7-3 GONADOBLASTOMA Discrete nests are composed of dark sex cord cells that surround germ cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI:
10.55418/9781933477251-5
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... and the gastrointestinal tract ( 1 ), while PC4 is expressed in testicular germ cells ( 85 , 87 ). Within the central nervous system, PC5 is detected in neurons while PACE4 is found in neural and non-neural cells ( 88 ). Synaptophysin is an integral membrane protein of the presynaptic vesicles of neurons. Unlike...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI:
10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... for multiple endocrine neoplasia-type 1 . Science 1997 ; 276 : 404 - 7 . 80. Pellegata NS , Quintanilla-Martinez L , Siggelkow H , et al . Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans . Proc Natl Acad Sci U S A , 2006 ; 103 : 15558...
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
HISTOGENETIC DIAGRAM OF TESTICULAR GERM CELL TUMORS Figure 4-15 HISTOGENETIC DIAGRAM OF TESTICULAR GERM CELL TUMORS For those tumors derived from germ cell neoplasia in situ (GCNIS), malignant transformation occurs at a stage between maturation delay and GCNIS. Seminoma, the direct invasive deriv... More
Images
in Testicular Tumors: General Considerations
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
PROGNOSTIC GROUPS DEFINED BY THE INTERNATIONAL GERM CELL CANCER COLLABORATIVE GROUP Figure 1-3 PROGNOSTIC GROUPS DEFINED BY THE INTERNATIONAL GERM CELL CANCER COLLABORATIVE GROUP (Modified from fig. 4 from International Germ Cell Cancer Collaborative Group. International germ cell consensus class... More
Images
in Normal Testicular Development, Structure, and Function
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
EMBRYOLOGY OF TESTIS Figure 2-6 EMBRYOLOGY OF TESTIS The primordial germ cells (left, red dots) derive from the yolk sac mesoderm and then migrate along the hindgut and its mesentery (right) to reach the gonadal (genital) ridges. (Fig. 16-18 from Sadler TW. Langman’s medical embryology, 12th ed. ... More
Images
in Normal Testicular Development, Structure, and Function
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
PRIMORDIAL GERM CELL/GONOCYTE Figure 2-7 PRIMORDIAL GERM CELL/GONOCYTE A gonocyte in the central portion of a solid seminiferous tubule has an appearance identical to a primordial germ cell, with a large nucleus, two prominent nucleoli, and clear cytoplasm. There are two adjacent smaller spermato... More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
MATURATION-DELAYED GERM CELLS Figure 4-14 MATURATION-DELAYED GERM CELLS A testis in an infant with a disorder of sex development shows gonocyte-like germ cells (blue arrows) in the central and parabasal portion of seminiferous tubules. These cells stained for OCT3/4. More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
DEVELOPMENT OF INVASIVE TUMORS IN PATIENTS WITH GERM CELL NEOPLASIA IN SITU Figure 4-16 DEVELOPMENT OF INVASIVE TUMORS IN PATIENTS WITH GERM CELL NEOPLASIA IN SITU This graph shows the proportion of testes with invasive germ cell tumors with time following a biopsy showing GCNIS. At 5 years, abou... More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-17 GERM CELL NEOPLASIA IN SITU Left: Clear cells with enlarged nuclei, some with flattened edges, are aligned along the basal aspect of seminiferous tubules lacking spermatogenesis and having thickened basement membranes. Sertoli cells are present on the adlum... More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-18 GERM CELL NEOPLASIA IN SITU Patchy distribution of GCNIS. The tubules in the central portion of this image are involved and surrounded by uninvolved tubules with normal spermatogenesis. More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-19 GERM CELL NEOPLASIA IN SITU A granulomatous reaction is seen. More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-20 GERM CELL NEOPLASIA IN SITU There is pagetoid spread into the rete testis. More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-21 GERM CELL NEOPLASIA IN SITU PAS highlights the neoplastic cells. More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-22 GERM CELL NEOPLASIA IN SITU The tumor nuclei are highlighted by an immunostain directed against OCT3/4. More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-23 GERM CELL NEOPLASIA IN SITU An immunostain directed against placental alkaline phosphatase (PLAP) highlights the cytoplasmic membranes of the malignant cells. More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-24 GERM CELL NEOPLASIA IN SITU An immunostain directed against podoplanin highlights the cytoplasmic membranes of the malignant cells. More
Images
in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
MATURATION-DELAYED GERM CELLS Figure 4-27 MATURATION-DELAYED GERM CELLS An immunostain directed against OCT3/4 nicely demonstrates the central location of the cells in the tubules. More
