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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch49
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... and cystic components, common in a cardiac teratoma. REFERENCES REFERENCES 1. Billmire   D , Vinocur   C , Rescorla   F , et al . Malignant mediastinal germ cell tumors: an intergroup study . J Pediatr Surg   2001 ; 36 : 18 - 24 . 2. Tollens   T , Casselman   F , Devlieger   H...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-13
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
...The understanding of the cell of origin, molecular pathogenesis, and clinical characteristics of germ cell tumors at all sites has undergone enormous changes in the last decade. Research into stem cells and their biology has established that human germ cell tumors are derived from stem...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch52
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... . 61. Vohra   A , Saiz   E , Davila   E , Burkle   J . Metastatic germ cell tumor to the heart presenting with syncope . Clin Cardiol   1999 ; 22 : 429 - 33 . 62. Kinebuchi   Y , Ogawa   T , Kato   H , Igawa   Y , Nishizawa   O , Miyagawa   S . Testicular...
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MIXED <span class="search-highlight">GERM</span> CELL TUMOR  This gross image of a mixed <span class="search-highlight">germ</span> cell tumors shows t...
Published: 01 August 2023
MIXED GERM CELL TUMOR Figure 13-16 MIXED GERM CELL TUMOR This gross image of a mixed germ cell tumors shows the heterogeneity typical of these tumors. There is hemorrhage and necrosis present. More about this image found in MIXED GERM CELL TUMOR This gross image of a mixed germ cell tumors shows t...
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MIXED <span class="search-highlight">GERM</span> CELL TUMOR  This tumor consists of immature teratoma (bottom) an...
Published: 01 August 2023
MIXED GERM CELL TUMOR Figure 13-14 MIXED GERM CELL TUMOR This tumor consists of immature teratoma (bottom) and yolk sac tumor (top). More about this image found in MIXED GERM CELL TUMOR This tumor consists of immature teratoma (bottom) an...
Images
MIXED <span class="search-highlight">GERM</span> CELL–SEX CORD-STROMAL CELL TUMOR, UNCLASSIFIED  Left: There is a...
Published: 01 August 2023
MIXED GERM CELL–SEX CORD-STROMAL CELL TUMOR, UNCLASSIFIED Figure 13-23 MIXED GERM CELL–SEX CORD-STROMAL CELL TUMOR, UNCLASSIFIED Left: There is a sex cord stromal tumor component on the left and a mixed germ cell-sex cord-stromal tumor component on the right. Right: Inhibin highlights the sex co... More about this image found in MIXED GERM CELL–SEX CORD-STROMAL CELL TUMOR, UNCLASSIFIED Left: There is a...
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GESTATIONAL TROPHOBLASTIC DISEASE AND <span class="search-highlight">GERM</span> CELL TUMORS IN FALLOPIAN TUBE  A...
Published: 01 August 2023
GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE Figure 16-49 GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE A,B: Choriocarcinoma in a patient with a significantly elevated serum hCG. C: Complete hydatidiform mole. (Courtesy of Dr. S. Stolnicu, T... More about this image found in GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE A...
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EMBRYONAL CARCINOMA  A: Medium power image of pure embryonal carcinoma show...
Published: 01 August 2023
EMBRYONAL CARCINOMA Figure 13-12 EMBRYONAL CARCINOMA A: Medium power image of pure embryonal carcinoma showing relatively dyscohesive high grade tumor cells. B: Higher power image of embryonal carcinoma growing in a glandular pattern. C: A mixed malignant germ cell tumor containing embryonal ca... More about this image found in EMBRYONAL CARCINOMA A: Medium power image of pure embryonal carcinoma show...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-01
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... and underlying mesenchyme, the gonadal anlage forms ( 1 ). Primordial germ cells migrate to the gonad from the yolk sac endoderm to enter meiosis at 12 to 15 weeks of gestation, with arrest in meiotic prophase ( 2 , 3 ). These cells are now referred to as primary oocytes. By 7 to 9 weeks’ gestation, the outer...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-02
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... of the information in this chapter represents a snapshot or an impressionistic view of ovarian cancers in general. The World Health Organization (WHO) classifies ovarian tumors into these categories: epithelial, mesenchymal, mixed epithelial and mesenchymal, sex cord-stromal, germ cell, miscellaneous, tumor-like...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-06
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... serous carcinoma, and clear cell carcinomas if germ cell tumors and metastases are excluded. A bilateral tumor with multilayering and tufting of pleomorphic tumor cells and mitotic rates in excess of 10 mitotic figures per 10 high-power fields (as well as abnormal mitotic figures) are findings...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-12
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... that extend into the medulla of the gonadal ridge. The sex cords then dissociate into irregular cell clusters that contain primitive germ cells (oogonia), while the surrounding cells, derived from the primitive gonadal epithelium, develop into follicular cells (granulosa and theca cells). In the male, the sex...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-16
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... ). Although it is speculated to be a type of germ cell tumor, it is almost never found in association with other germinal tumors. Age at presentation is reported to range from 13 to 48 years. The lesions are usually low stage at presentation and unilateral. Tumors range from 1 cm to more than 10 cm...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... in these tumors ( 26 , 28 ). The phenomenon of transdifferentiation, in which there is convincing evidence, morphologically and immunohistochemically, of a somatically-derived germ cell-like component, can occur in high-grade serous carcinoma, but is more common in endometrial carcinoma and endometriosis-related...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-07
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... diagnosis with the wolffian tumor, female adnexal tumor of probably wolffian origin (FATPWO) ( 106 ), is discussed in chapter 21 . Several types of germ cell tumors have appearances that overlap with endometrioid neoplasms: immature teratoma, tubular carcinoid, struma ovarii, and yolk sac...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-15
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... for gastrointestinal markers, such as CK7, CK20, and CDX2, and negative for germ cell markers, such as SALL4 ( 54 ). Note that the degree of SALL4 positivity depends on the degree of immaturity. If immunohistochemistry is applied to the areas that are suspicious for yolk sac tumor, these components should show...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-03
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
..., approximately 15 percent of patients with high-grade serous carcinomas are BRCA1 or BRCA2 carriers, many of whom are unaware of their hereditary predisposition. There are several practices that help identify the presence of germline mutations in affected patients: germ line mutational testing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... includes undifferentiated carcinoma with osteoclast-like giant cells, metastatic melanoma, and essentially all poorly differentiated epithelial, mesenchymal, germ cell, and hematopoietic neoplasms. In contrast to the dramatic pleomorphism seen in the larger cells in undifferentiated carcinomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-05
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... - 51 . 60. Elias   KM , Tsantoulis   P , Tille   JC , et al   Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors . J Pathol   2018 ; 246 : 459 - 69 . 61. Scourtas   A , Dudley   JC...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... , Vance   A , Finelli   D , Williams   G , Ravi-chandran   P . Dermoid cyst of the pancreas: a case report with literature review . J Radiol Case Rep   2012 ; 6 : 17 - 25 . 173. Wang   J , Zheng   Z , Qiu   Y , et al   Primary mixed germ cell tumor arising in the pancreatic...