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Book Chapter
Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... , Healey CS , et al . Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A . Nature 1993 ; 363 : 458 - 60 . 26. Donis-Keller H , Dou S , Chi D , et al . Mutations in the RET proto-onocogene are associated with MEN 2A and FMTC . Hum Mol...
Book Chapter
Hereditary Predisposition to Adrenal Cortical Lesions
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... adenomatous polyposis; PPNAD = primary pigmented micronodular adrenal disease. Beyond the pathologic and clinical features of these diseases, the identification of a germ-line mutation is of paramount importance for patient management and follow-up. The implementation of next-generation sequencing...
Book Chapter
Other Adrenal Neoplasms and Tumor-Like Lesions
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... but has also been suggested to have a myofibroblastic origin ( 64 ). Tumors possibly related by proximity of their developmental precursors include teratoma ( 65 , 66 ), a malignant mixed germ cell tumor ( 67 ), and a primary tumor with the morphologic features of an extrarenal Wilms tumor reported in a 4...
Book Chapter
Pheochromocytoma and Adrenal Medullary Hyperplasia
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of germ-line mutations providing genetic susceptibility to multifocal disease, it has become apparent that some of the previous literature may have confused metastasis and multifocal primary lesions, which occasionally occur in unusual locations, such as lung and liver ( 10 ). Therefore, some...
Book Chapter
Paraganglia and Paragangliomas
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... , Michalski W , et al . Growth rate of paragangliomas related to germ-line mutations of the SDHX genes . Endocr Pract 2017 ; 23 : 342 - 52 . 66. Jansen JC , van den Berg R , Kuiper A , van der Mey AG , Zwinderman AH , Cornelisse CJ . Estimation of growth rate...
Book Chapter
Adrenal Cortical Carcinoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-melanomatous) as well as testicular germ cell tumors, melanomas, lymphomas, and sarcomas. PRECURSOR LESIONS ACC is generally considered to arise de novo. However, data from patients with Carney complex ( 15 , 16 ) and multiple endocrine neoplasia 1 (MEN1)-associated ACC suggest that there may be progression...
Book Chapter
Cardiac Germ Cell Tumors
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch49
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...: Pancreatic acinar tissue is within the cardiac teratoma. REFERENCES REFERENCES 1. Billmire D , Vinocur C , Rescorla F , et al . Malignant mediastinal germ cell tumors: an intergroup study . J Pediatr Surg 2001 ; 36 : 18 - 24 . 2. Tollens T , Casselman F , Devlieger...
Book Chapter
Germ Cell Tumors
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-13
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... of the figure). Bottom: Rosettes and tubules are the simplest immature elements to identify. Primitive neuroectoderm is required for the diagnosis ( fig. 13-6 ). Yolk sac tumor is not acceptable in an otherwise immature teratoma and should result in a diagnosis of mixed germ cell tumor. A clinically elevated...
Book Chapter
Metastatic Disease
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch52
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... . 61. Vohra A , Saiz E , Davila E , Burkle J . Metastatic germ cell tumor to the heart presenting with syncope . Clin Cardiol 1999 ; 22 : 429 - 33 . 62. Kinebuchi Y , Ogawa T , Kato H , Igawa Y , Nishizawa O , Miyagawa S . Testicular...
Images
MIXED GERM CELL TUMOR This gross image of a mixed germ cell tumors shows t...
Available to PurchasePublished: 01 August 2023
MIXED GERM CELL TUMOR Figure 13-16 MIXED GERM CELL TUMOR This gross image of a mixed germ cell tumors shows the heterogeneity typical of these tumors. There is hemorrhage and necrosis present. More about this image found in MIXED GERM CELL TUMOR This gross image of a mixed germ cell tumors shows t...
Images
MIXED GERM CELL TUMOR This tumor consists of immature teratoma (bottom) an...
Available to PurchasePublished: 01 August 2023
MIXED GERM CELL TUMOR Figure 13-14 MIXED GERM CELL TUMOR This tumor consists of immature teratoma (bottom) and yolk sac tumor (top). More about this image found in MIXED GERM CELL TUMOR This tumor consists of immature teratoma (bottom) an...
Images
MIXED GERM CELL–SEX CORD-STROMAL CELL TUMOR, UNCLASSIFIED Left: There is a...
Available to PurchasePublished: 01 August 2023
MIXED GERM CELL–SEX CORD-STROMAL CELL TUMOR, UNCLASSIFIED Figure 13-23 MIXED GERM CELL–SEX CORD-STROMAL CELL TUMOR, UNCLASSIFIED Left: There is a sex cord stromal tumor component on the left and a mixed germ cell-sex cord-stromal tumor component on the right. Right: Inhibin highlights the sex More about this image found in MIXED GERM CELL–SEX CORD-STROMAL CELL TUMOR, UNCLASSIFIED Left: There is a...
Images
GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE A...
Available to PurchasePublished: 01 August 2023
GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE Figure 16-49 GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE A,B: Choriocarcinoma in a patient with a significantly elevated serum hCG. C: Complete hydatidiform mole. (Courtesy of Dr. S. Stolnicu More about this image found in GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE A...
Images
EMBRYONAL CARCINOMA A: Medium power image of pure embryonal carcinoma show...
Available to PurchasePublished: 01 August 2023
EMBRYONAL CARCINOMA Figure 13-12 EMBRYONAL CARCINOMA A: Medium power image of pure embryonal carcinoma showing relatively dyscohesive high grade tumor cells. B: Higher power image of embryonal carcinoma growing in a glandular pattern. C: A mixed malignant germ cell tumor containing embryonal More about this image found in EMBRYONAL CARCINOMA A: Medium power image of pure embryonal carcinoma show...
Book Chapter
Normal Ovary
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-01
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... of the chromosomes migrating to the cell periphery and forming the first polar body. This is expelled from the cell and this secondary oocyte enters secondary meiotic division, resting in meiotic metaphases until fertilization occurs. The tumors that arise from ovarian germ cells are related to the potency states...
Book Chapter
General Features of Ovarian Cancer
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-02
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... epithelial and mesenchymal, sex cord-stromal, germ cell, miscellaneous, tumor-like lesions, and metastases to ovary. Information specific to each entity is found in the relevant chapters in this book. DIAGNOSIS AND SCREENING Other than the obvious metastases to extrapelvic and extra-abdominal sites...
Book Chapter
Clear Cell Tumors
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-06
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... serous carcinoma, and clear cell carcinomas if germ cell tumors and metastases are excluded. A bilateral tumor with multilayering and tufting of pleomorphic tumor cells and mitotic rates in excess of 10 mitotic figures per 10 high-power fields (as well as abnormal mitotic figures) are findings...
Book Chapter
Sex Cord-Stromal Tumors
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-12
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... primitive proliferating sex cords that extend into the medulla of the gonadal ridge. The sex cords then dissociate into irregular cell clusters that contain primitive germ cells (oogonia), while the surrounding cells, derived from the primitive gonadal epithelium, develop into follicular cells (granulosa...
Book Chapter
Neoplasms of the Fallopian Tube and Broad Ligament
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-16
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... nuclei and very low mitotic indices in typical cases ( Table 16-6 ), although STK11 adnexal tumors may demonstrate atypia. In typical cases, ependymoma arises in the broad ligament ( 143 – 145 ) or ovary ( 143 , 146 , 147 ). Although it is speculated to be a type of germ cell tumor, it is almost...
Book Chapter
High-Grade Serous Carcinoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... in these tumors ( 26 , 28 ). The phenomenon of transdifferentiation, in which there is convincing evidence, morphologically and immunohistochemically, of a somatically-derived germ cell-like component, can occur in high-grade serous carcinoma, but is more common in endometrial carcinoma and endometriosis-related...
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