1-20 of 128 Search Results for

germ

Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-04
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...Table 4-1 RISK FACTORS FOR GERM CELL NEOPLASIA IN SITU (GCNIS) AND GCNIS-DERIVED TUMORS Condition Magnitude of Increased Risk (Estimated RR a ) Disorders of sex development Variable, often extreme (see Table 4-2 ), up to 150X b Prior testicular germ cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-05
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...-power fields; LVI = lymphovascular invasion; YST = yolk sac tumor. Table 5-5 CONTRASTING FEATURES OF SPERMATOCYTIC TUMOR AND SEMINOMA a Spermatocytic Tumor Seminoma Proportion of germ cell tumors 0.6% 40 to 50% Sites testis only testis, ovary (dysgerminoma), mediastinum...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-07
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...GONADOBLASTOMA Figure 7-2 GONADOBLASTOMA Nests of gonadoblastoma are present at left, above the rete testis (bottom left), with immature seminiferous tubules on the right. GONADOBLASTOMA Figure 7-3 GONADOBLASTOMA Discrete nests are composed of dark sex cord cells that surround germ cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-5
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... and the gastrointestinal tract ( 1 ), while PC4 is expressed in testicular germ cells ( 85 , 87 ). Within the central nervous system, PC5 is detected in neurons while PACE4 is found in neural and non-neural cells ( 88 ). Synaptophysin is an integral membrane protein of the presynaptic vesicles of neurons. Unlike...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... for multiple endocrine neoplasia-type 1 . Science   1997 ; 276 : 404 - 7 . 80. Pellegata   NS , Quintanilla-Martinez   L , Siggelkow   H , et al . Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans . Proc Natl Acad Sci U S A , 2006 ; 103 : 15558...
Images
HISTOGENETIC DIAGRAM OF TESTICULAR <span class="search-highlight">GERM</span> CELL TUMORS  For those tumors deriv...
Published: 01 August 2022
HISTOGENETIC DIAGRAM OF TESTICULAR GERM CELL TUMORS Figure 4-15 HISTOGENETIC DIAGRAM OF TESTICULAR GERM CELL TUMORS For those tumors derived from germ cell neoplasia in situ (GCNIS), malignant transformation occurs at a stage between maturation delay and GCNIS. Seminoma, the direct invasive deriv... More
Images
PROGNOSTIC GROUPS DEFINED BY THE INTERNATIONAL <span class="search-highlight">GERM</span> CELL CANCER COLLABORATI...
Published: 01 August 2022
PROGNOSTIC GROUPS DEFINED BY THE INTERNATIONAL GERM CELL CANCER COLLABORATIVE GROUP Figure 1-3 PROGNOSTIC GROUPS DEFINED BY THE INTERNATIONAL GERM CELL CANCER COLLABORATIVE GROUP (Modified from fig. 4 from International Germ Cell Cancer Collaborative Group. International germ cell consensus class... More
Images
EMBRYOLOGY OF TESTIS  The primordial <span class="search-highlight">germ</span> cells (left, red dots) derive fro...
Published: 01 August 2022
EMBRYOLOGY OF TESTIS Figure 2-6 EMBRYOLOGY OF TESTIS The primordial germ cells (left, red dots) derive from the yolk sac mesoderm and then migrate along the hindgut and its mesentery (right) to reach the gonadal (genital) ridges. (Fig. 16-18 from Sadler TW. Langman’s medical embryology, 12th ed. ... More
Images
PRIMORDIAL <span class="search-highlight">GERM</span> CELL/GONOCYTE  A gonocyte in the central portion of a solid...
Published: 01 August 2022
PRIMORDIAL GERM CELL/GONOCYTE Figure 2-7 PRIMORDIAL GERM CELL/GONOCYTE A gonocyte in the central portion of a solid seminiferous tubule has an appearance identical to a primordial germ cell, with a large nucleus, two prominent nucleoli, and clear cytoplasm. There are two adjacent smaller spermato... More
Images
MATURATION-DELAYED <span class="search-highlight">GERM</span> CELLS  A testis in an infant with a disorder of sex...
Published: 01 August 2022
MATURATION-DELAYED GERM CELLS Figure 4-14 MATURATION-DELAYED GERM CELLS A testis in an infant with a disorder of sex development shows gonocyte-like germ cells (blue arrows) in the central and parabasal portion of seminiferous tubules. These cells stained for OCT3/4. More
Images
DEVELOPMENT OF INVASIVE TUMORS IN PATIENTS WITH <span class="search-highlight">GERM</span> CELL NEOPLASIA IN SITU...
Published: 01 August 2022
DEVELOPMENT OF INVASIVE TUMORS IN PATIENTS WITH GERM CELL NEOPLASIA IN SITU Figure 4-16 DEVELOPMENT OF INVASIVE TUMORS IN PATIENTS WITH GERM CELL NEOPLASIA IN SITU This graph shows the proportion of testes with invasive germ cell tumors with time following a biopsy showing GCNIS. At 5 years, abou... More
Images
<span class="search-highlight">GERM</span> CELL NEOPLASIA IN SITU  Left: Clear cells with enlarged nuclei, some w...
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-17 GERM CELL NEOPLASIA IN SITU Left: Clear cells with enlarged nuclei, some with flattened edges, are aligned along the basal aspect of seminiferous tubules lacking spermatogenesis and having thickened basement membranes. Sertoli cells are present on the adlum... More
Images
<span class="search-highlight">GERM</span> CELL NEOPLASIA IN SITU  Patchy distribution of GCNIS. The tubules in t...
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-18 GERM CELL NEOPLASIA IN SITU Patchy distribution of GCNIS. The tubules in the central portion of this image are involved and surrounded by uninvolved tubules with normal spermatogenesis. More
Images
Images
Images
Images
<span class="search-highlight">GERM</span> CELL NEOPLASIA IN SITU  The tumor nuclei are highlighted by an immunos...
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-22 GERM CELL NEOPLASIA IN SITU The tumor nuclei are highlighted by an immunostain directed against OCT3/4. More
Images
<span class="search-highlight">GERM</span> CELL NEOPLASIA IN SITU  An immunostain directed against placental alka...
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-23 GERM CELL NEOPLASIA IN SITU An immunostain directed against placental alkaline phosphatase (PLAP) highlights the cytoplasmic membranes of the malignant cells. More
Images
<span class="search-highlight">GERM</span> CELL NEOPLASIA IN SITU  An immunostain directed against podoplanin hig...
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-24 GERM CELL NEOPLASIA IN SITU An immunostain directed against podoplanin highlights the cytoplasmic membranes of the malignant cells. More
Images
MATURATION-DELAYED <span class="search-highlight">GERM</span> CELLS  An immunostain directed against OCT3/4 nicel...
Published: 01 August 2022
MATURATION-DELAYED GERM CELLS Figure 4-27 MATURATION-DELAYED GERM CELLS An immunostain directed against OCT3/4 nicely demonstrates the central location of the cells in the tubules. More