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in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
Ki-67 IN FETAL ADRENAL GLAND Figure 1-15 Ki-67 IN FETAL ADRENAL GLAND Immunoreactivity for Ki-67 is abundant in the definitive zone, which is the major site of cortical cell generation. Scattered individual stained cortical cells are also present in the provisional zone, along with aggregates of ... More about this image found in Ki-67 IN FETAL ADRENAL GLAND Immunoreactivity for Ki-67 is abundant in the...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and function of multiple tissues ( fig. 3-1 ). The most obvious changes include weight gain that causes truncal obesity, moon facies, and increased fat around the neck and between the scapulae (so called “buffalo hump”); unlike in generalized weight gain, there is peripheral wasting, with thin extremities...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... appears frequently in physiology papers. Extra-adrenal paraganglia are now identified using the same immunohistochemical markers commonly applied to chromaffin cells and sustentacular cells in the adrenal medulla (see chapter 1 ). Usually these are chromogranin A or synaptophysin as a generic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... symptoms such as failure to thrive, fever, or weight loss. When there is extensive skeletal localization, bone pain and the consequences of impaired bone marrow function, such as anemia and thrombocytopenia, may occur. Table 11-1 SIGNS AND SYMPTOMS OF NEUROBLASTOMA General Abdominal distension...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-melanomatous) as well as testicular germ cell tumors, melanomas, lymphomas, and sarcomas. PRECURSOR LESIONS ACC is generally considered to arise de novo. However, data from patients with Carney complex ( 15 , 16 ) and multiple endocrine neoplasia 1 (MEN1)-associated ACC suggest that there may be progression...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... IN FETAL ADRENAL GLAND Immunoreactivity for Ki-67 is abundant in the definitive zone, which is the major site of cortical cell generation. Scattered individual stained cortical cells are also present in the provisional zone, along with aggregates of labeled medullary progenitors. WEIGHT AND GROSS ANATOMY...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... into clusters based on the transcriptome and signaling pathways involved in their development, which generally correlate with the biochemical profile of the catecholamines they produce ( 5 ). Table 10-1 FAMILIAL PARAGANGLIOMA SYNDROMES Chromosome Gene Location Syndrome Most Common Paraganglioma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... Although there are some microscopic features that are more likely to be associated with tumors producing a particular endocrine syndrome, it is in general difficult to predict the associated endocrine syndrome based upon histologic features alone in individual cases, without correlation with clinical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical hyperplasia is a general term for a condition characterized by an increased number of cortical cells leading to an increase in size and weight of the gland. However, this term is currently considered a misnomer for almost all diseases that are defined as primary of the adrenal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and cytoplasmic staining for S-100 protein but not SOX10 is seen in both cell types, making SOX10 the more specific marker, but it is generally more selective for the Schwann cell lineage. Unusual examples include a composite pheochromocytoma in which the neural component consists of mature neurons and bundles...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... adenomatous polyposis; PPNAD = primary pigmented micronodular adrenal disease. Beyond the pathologic and clinical features of these diseases, the identification of a germ-line mutation is of paramount importance for patient management and follow-up. The implementation of next-generation sequencing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... in the general white population; and 3) a “cryptic” form in which biochemical abnormalities may exist, but the patients are asymptomatic. In two thirds of patients with the classic form of CAH, biosynthesis of aldosterone is blocked, resulting in “salt wasting”; the remaining one third have a simple virilizing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... Lymphangioma of the adrenal gland is exceedingly rare. A review of 53 reported cases showed a mean patient age of 39.5 years, and a female predominance ( 35 ). The lining can be highlighted by immunohistochemical staining for the generic endothelial markers CD31 or CD34. Lymphangiomas are distinguished from...
Images
Published: 01 September 2024
PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) Figure 9-2 PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregularly shaped reactive follicles. B: PGL lymph node follicle in center with macrophage phagocytosis and apoptotic debris. C: HIVp24 stains HIV virus in follicular dend... More about this image found in PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregul...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-30
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...TRICHOMONIASIS General Considerations, Including Etiology and Synonyms Trichomoniasis is a human venereal disease caused by Trichomonas vaginalis, a facultative anaerobic protozoan parasite that colonizes the epithelium of the human urogenital tract. Two other trichomonads...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-16
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...INFECTIVE ENDOCARDITIS General Considerations, Including Etiology and Synonyms Endocarditis is defined as inflammation of the endocardial tissue, which may involve the heart valves, chordae tendineae, and septum. The inflammatory process in infective endocarditis is characterized...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...HUMAN IMMUNODEFICIENCY VIRUS INFECTION General Considerations, Including Etiology and Synonyms Human immunodeficiency virus (HIV) is a single-stranded, positive-sense RNA virus surrounded by a conical capsid, with a peripheral matrix protein and lipid bilayer, measuring approximately 100...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-11
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...LISTERIOSIS General Considerations, Including Etiology and Synonyms Listeria monocytogenes is a facultative anaerobic, gram-positive bacillus that causes almost all cases of human listeriosis. Rarely, two other species, L. ivanovii and L. grayi, are implicated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...BRUCELLOSIS General Considerations, Including Etiology and Synonyms Brucella species are facultative intracellular, fastidious, gram-negative bacilli or coccobacilli that cause the zoonosis known as brucellosis ( fig. 14-1 ). In humans, the disease is also known as Malta...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...SPOROTRICHOSIS General Considerations, Including Etiology and Synonyms Sporotrichosis is a subacute to chronic invasive fungal infection caused by members of the Sporothrix schenckii sensu lato complex. The latter consists of five clades: S. brasiliensis, S. schenckii, S...
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