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CYTOLOGY OF NON-NEOPLASTIC <span class="search-highlight">GASTROINTESTINAL</span> EPITHELIUM  Left: Duodenal epit...
Published: 01 March 2023
CYTOLOGY OF NON-NEOPLASTIC GASTROINTESTINAL EPITHELIUM Figure 6-38 CYTOLOGY OF NON-NEOPLASTIC GASTROINTESTINAL EPITHELIUM Left: Duodenal epithelium contains regularly spaced goblet cells. Right: Gastric epithelium has mucin cytoplasm and uniformly spaced, bland nuclei (both: hematoxylin and eosi... More
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<span class="search-highlight">GASTROINTESTINAL</span> STROMAL TUMOR (GIST)  The cut surface of the tumor abut ti...
Published: 01 March 2023
GASTROINTESTINAL STROMAL TUMOR (GIST) Figure 13-13 GASTROINTESTINAL STROMAL TUMOR (GIST) The cut surface of the tumor abut ting the pancreatic tail is firm and white to tan. More
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<span class="search-highlight">GASTROINTESTINAL</span> STROMAL TUMOR (GIST)  Characteristic features of spindle c...
Published: 01 March 2023
GASTROINTESTINAL STROMAL TUMOR (GIST) Figure 13-14 GASTROINTESTINAL STROMAL TUMOR (GIST) Characteristic features of spindle cell GIST (A) are small perinuclear vacuoles and finely stippled chromatin (B), however, they are not consistently present. The epithelioid pattern is characterized by small... More
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<span class="search-highlight">GASTROINTESTINAL</span> STROMAL TUMOR (GIST)  Left: Aspiration cytology of a spind...
Published: 01 March 2023
GASTROINTESTINAL STROMAL TUMOR (GIST) Figure 13-15 GASTROINTESTINAL STROMAL TUMOR (GIST) Left: Aspiration cytology of a spindle cell GIST reveals a cellular proliferation of spindle cells with oval nuclei with tapered ends and delicate cytoplasmic processes. Right: Epithelioid GIST can be confus... More
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MUCINOUS CYSTIC NEOPLASM  Cytologically, thick colloid-like mucin-containin...
Published: 01 March 2023
MUCINOUS CYSTIC NEOPLASM Figure 5-23 MUCINOUS CYSTIC NEOPLASM Cytologically, thick colloid-like mucin-containing degenerative inflammatory cells define the cyst as a mucin-producing cystic neoplasm and distinguish the mucin from contaminating gastrointestinal mucin (Diff Quik stain). More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-02
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...The classification of neoplasms of the pancreas presented here is based on the classification systems employed in the fourth edition of this Fascicle ( 1 ) and the 2019 World Health Organization (WHO) “blue book” for gastrointestinal malignancies ( 2 , 3 ). This classification system is presented...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ). Jaundice, gastrointestinal bleeding, and palpitations have also been reported. A major source of morbidity in infants is consumptive coagulopathy (Kasabach-Merritt syndrome) ( 11 , 12 ). Vascular neoplasms are typically strongly contrast-enhancing in the arterial phase of CT imaging; however, the absence...
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HPV-ASSOCIATED ADENOCARCINOMA, MUCINOUS TYPE  In this tumor type, most cell...
Published: 01 February 2023
HPV-ASSOCIATED ADENOCARCINOMA, MUCINOUS TYPE Figure 3-41 HPV-ASSOCIATED ADENOCARCINOMA, MUCINOUS TYPE In this tumor type, most cells (50% or more) contain intracytoplasmic mucin. Mucin can be of endocervical-type (left) or feature intestinal differentiation (right). Rarely, signet ring cell morph... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... distinctive cytologic features, but there is intratumoral heterogeneity and many lesions yield few cells. Also, EUS-FNA is commonly contaminated by gastrointestinal tract epithelium and mucin, which can obscure the diagnosis. The clinical context is crucial when approaching these specimens. Cytologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-15
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... as heterotopia. Clinical Features. Most microscopic foci of heterotopic pancreas are incidental and asymptomatic. Larger foci produce a range of symptoms depending upon their location ( 106 , 107 ). In the tubular gastrointestinal tract, bleeding, bowel obstruction, biliary obstruction, and intussusception may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...Like most organs in the gastrointestinal tract, the pancreas gives rise to two distinct families of neuroendocrine neoplasms: pancreatic neuroendocrine tumors (PanNETs), which are well differentiated, and pancreatic neuroendocrine carcinomas (PanNECs), which are poorly...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-04
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... seen with a Diff Quik stain and is granular or “stringy.” A background of histiocytes or siderophages is an infrequent finding. Contaminating mucin is common and fortunately is usually admixed with contaminating bland gastrointestinal epithelium. Microcystic and macrocystic serous cystadenomas may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-14
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of patients are symptomatic, most commonly with abdominal pain followed by jaundice or vague nonspecific symptoms ( 6 , 8 , 10 ). Other symptoms include gastrointestinal hemorrhage (10 percent), early satiety, weight loss, and pancreatitis. Most patients with metastases to the pancreas have a clinical history...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... cancer ( 70 , 80 , 103 , 107 – 112 ). Most, but not all patients with this gene mutation have a family or personal history of melanoma ( 80 , 113 , 114 ). The Peutz-Jeghers syndrome (PJS) is characterized by mucocutaneous melanocytic macules and hamartomatous polyps of the gastrointestinal tract...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... viscous mucin dominates cytology specimens from colloid carcinoma and may obscure a limited, deceptively well-differentiated epithelial component ( fig. 8-10 ) ( 46 ). Due to the frequent association with intestinal-type IPMNs, papillary features may also be present (see chapter 5 ). Gastrointestinal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-03
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of the pancreas is based on the degree to which the neoplastic cells resemble corresponding non-neoplastic cells in the normal pancreas, and follows that of other gastrointestinal tract carcinomas ( Table 3-9 ). The histopathologic grading of neuroendocrine neoplasms of the pancreas is based solely...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-05
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... Cytologically, thick colloid-like mucin-containing degenerative inflammatory cells define the cyst as a mucin-producing cystic neoplasm and distinguish the mucin from contaminating gastrointestinal mucin (Diff Quik stain). MUCINOUS CYSTIC NEOPLASM Figure 5-24 MUCINOUS CYSTIC NEOPLASM Mucin appears thinner...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
..., pericardium, and gastrointestinal system ( 157 – 160 ). Other rare genetic defects leading to pancreatic agenesis include germline mutations in the two genes for key transcription factors in pancreatic determination, PDX1 and PTF1A ( 41 , 157 , 161 – 163 ). Hypoplasia Pancreatic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-11
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... receptors, glypican-3, FLI-1, and α-methylacyl-CoA racemase (AMACR) are also consistently expressed ( 129 , 158 – 161 ). According to some studies, over half of cases share with gastrointestinal stromal tumors expression of cKIT and DOG1, although no mutations in cKIT have been found ( 162 – 164...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... . 181. Lee   YH , Chong   GO , Hong   DG . Is gastrointestinal stromal tumor (GIST) originating from the rectovaginal septum GIST or extra-GIST (EGIST)? A case report with literature review . Eur J Gynaecol Oncol   2015 ; 36 : 750 - 4 . 182. Liu   S , Pan   P , Han   B...