MIMICS OF FUNGAL ORGANISMS Figure 19-5 MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic sections are frequently large and irregular, and appear superimposed on the tissue. C,D: Suspected broad fungal hyphae on a skin biopsy (C), which turned out to be an incompletely sectioned Demodex spp mite on deeper levels (D). E,F: Extraneous and plant material on cytology smears and preparates can be confused with fungal hyphae (E) or yeasts (F) by the unwary. These deposits are usually larger, more irregular in outline, and poorly defined, and often appear in a different plane to the cellular material. G: The multipolar bud-like appearance can mimic Paracoccidioides spp. More about this image found in MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic section...

MIMICS OF FUNGAL ORGANISMS Figure 19-5 MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic sections are frequently large and irregular, and appear superimposed on the tissue. C,D: Suspected broad fungal hyphae on a skin biopsy (C), which turned out to be an incompletely sectioned Demodex spp mite on deeper levels (D). E,F: Extraneous and plant material on cytology smears and preparates can be confused with fungal hyphae (E) or yeasts (F) by the unwary. These deposits are usually larger, more irregular in outline, and poorly defined, and often appear in a different plane to the cellular material. G: The multipolar bud-like appearance can mimic Paracoccidioides spp. More about this image found in MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic section...

BLASTOMYCOSIS Figure 21-3 BLASTOMYCOSIS Suppurative granulomas with isolated pale fungal yeasts in the cytoplasm of a giant cell (A), which are often identified due to their weakly birefringent cell wall and central nuclei on a hematoxylin and eosin (H&E) stain (B,C). More about this image found in BLASTOMYCOSIS Suppurative granulomas with isolated pale fungal yeasts in t...

MOLECULAR TARGETS USED IN THE DIAGNOSIS OF FUNGAL INFECTIONS Figure 21-12 MOLECULAR TARGETS USED IN THE DIAGNOSIS OF FUNGAL INFECTIONS Ribosomal genes (marked with shaded arrows) are used. More about this image found in MOLECULAR TARGETS USED IN THE DIAGNOSIS OF FUNGAL INFECTIONS Ribosomal gen...

INVASIVE FUNGAL INFECTION BY HYALINE SEPTATE HYPHAE Figure 21-28 INVASIVE FUNGAL INFECTION BY HYALINE SEPTATE HYPHAE Coagulative necrosis and thrombosis illustrated at low (A) and high (B) power. More about this image found in INVASIVE FUNGAL INFECTION BY HYALINE SEPTATE HYPHAE Coagulative necrosis a...

ALLERGIC FUNGAL RHINOSINUSITIS Figure 21-31 ALLERGIC FUNGAL RHINOSINUSITIS There is mucin with abundant eosinophils (A). Fungal hyphae are typically scant (B). More about this image found in ALLERGIC FUNGAL RHINOSINUSITIS There is mucin with abundant eosinophils (A...

PAROTID GLAND MYCOSIS Figure 21-33 PAROTID GLAND MYCOSIS Hyaline septate fungal hyphae are seen on histology (stained with H&E [A] and GMS [B]). Microbiologic culture grew Candida albicans. More about this image found in PAROTID GLAND MYCOSIS Hyaline septate fungal hyphae are seen on histology ...

MUCORMYCOSIS Figure 21-38 MUCORMYCOSIS Angioinvasion by fungal organisms (A), with secondary thrombosis, necrosis, and hemorrhage (B,C), is characteristic. More about this image found in MUCORMYCOSIS Angioinvasion by fungal organisms (A), with secondary thrombo...

DUAL FUNGAL INFECTION BY MUCORALES ORGANISMS AND CANDIDA SPP Figure 21-44 DUAL FUNGAL INFECTION BY MUCORALES ORGANISMS AND CANDIDA SPP Striking difference in hyphal diameter and morphology of Mucorales (top) and Candida (bottom right). More about this image found in DUAL FUNGAL INFECTION BY MUCORALES ORGANISMS AND C...

ESOPHAGEAL CANDIDIASIS Figure 22-9 ESOPHAGEAL CANDIDIASIS These fungal organisms were only identified after careful examination of numerous PAS-stained levels, due to their scant and focal nature. More about this image found in ESOPHAGEAL CANDIDIASIS These fungal organisms were only identified after c...

EUMYCETOMA Figure 24-13 EUMYCETOMA Colonies of pigmented fungal hyphae, with background neutrophilic and granulomatous inflammatory response, are seen. More about this image found in EUMYCETOMA Colonies of pigmented fungal hyphae, with background neutrophil...

EUMYCETOMA Figure 24-15 EUMYCETOMA PAS stain highlights the fungal hyphae in a granular colony, which is contained within a suppurative granuloma. (Courtesy of Prof. P. McKee, Boussais, France) More about this image found in EUMYCETOMA PAS stain highlights the fungal hyphae in a granular colony, wh...

EUMYCETOMA Figure 24-16 EUMYCETOMA High-power view with a GMS stain shows a colony of fungal hyphae. More about this image found in EUMYCETOMA High-power view with a GMS stain shows a colony of fungal hypha...

DEMATIACEOUS FUNGAL CONIDIA Figure 24-29 DEMATIACEOUS FUNGAL CONIDIA Characteristic conidia are seen with a lactophenol cotton blue preparation. (Courtesy of the CDC PHIL) More about this image found in DEMATIACEOUS FUNGAL CONIDIA Characteristic conidia are seen with a lactoph...

KERION Figure 24-38 KERION PAS stain shows hair shaft invasion by fungal arthrospores and mildly distended follicular ostium containing scattered surrounding neutrophils. More about this image found in KERION PAS stain shows hair shaft invasion by fungal arthrospores and mild...

TINEA CORPORIS Figure 24-39 TINEA CORPORIS Fungal hyphae are demonstrated in the stratum corneum in an HIV-infected individual with florid disease. Note the mild acanthosis, focal parakeratosis, and intracorneal serum containing admixed neutrophils. More about this image found in TINEA CORPORIS Fungal hyphae are demonstrated in the stratum corneum in an...

TINEA CORPORIS Figure 24-40 TINEA CORPORIS PAS stain highlights a large number of fungal hyphae within the focally parakeratotic stratum corneum. More about this image found in TINEA CORPORIS PAS stain highlights a large number of fungal hyphae within...

PITYRIASIS VERSICOLOR Figure 24-50 PITYRIASIS VERSICOLOR PAS highlights the admixture of small fungal yeasts and hyphae in the stratum corneum. More about this image found in PITYRIASIS VERSICOLOR PAS highlights the admixture of small fungal yeasts ...

PITYRIASIS VERSICOLOR Figure 24-51 PITYRIASIS VERSICOLOR GMS stain shows intimately admixed fungal hyphae and yeasts (“spaghetti and meatballs”) within a mildly hyperkeratotic stratum corneum. More about this image found in PITYRIASIS VERSICOLOR GMS stain shows intimately admixed fungal hyphae and...