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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... block or the presence of Q waves is associated with a worse outcome, including death. Echocardiography can define the ventricular function and help in ruling out other causes of a similar clinical presentation. Cardiac magnetic resonance imaging (MRI) helps uncover inflammation, by identifying cardiac...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-02
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... and yeasts, and their function varies ( 5 ). Table 2-1 CLASSIFICATION AND EPIDEMIOLOGY OF DIFFERENT HUMAN PRION DISEASES Disease Epidemiology Kuru Last documented case occurred between 2005 and 2009 Disease was due to cannibalism in a Papua New Guinea tribe and occurred more frequently...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-01
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... admission to the hospital, she developed a headache and symptoms of sinusitis. Physical exam reveals hepatomegaly, with elevated liver function tests and a bilirubin of 9.6 mg/dL. The complete blood count shows increased white blood cells, primarily due to elevated neutrophils. An abdominal computerized...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-11
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... organisms disrupt the normal cellular processes by altering mitochondrial shape and function, degrading endoplasmic reticulum, and secreting nucleomodulins. The nucleomodulins increase cyclic-di-AMP levels, which leads to the release of pathogen-associated molecular patterns and decreased production...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... For this, as for all the lymphocytic pulmonary syndromes illustrated above, the management is HAART which removes the driving HIV stimulus of the inflammation, and leads to resolution of normal lung structure and function. HIV DESTRUCTIVE PNEUMONITIS Figure 9-14 HIV DESTRUCTIVE PNEUMONITIS A: Gross lung slice...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-29
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Indeterminate phase: asymptomatic with normal organ function 70% Can last for years or decades after acute infection Immune suppression can precipitate clinical disease Chronic Chagas disease: asymptomatic with organ dysfunction 20% Heart dysfunction, megaesophagus, and megacolon, which are usually only...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... function rather than viral-induced apoptosis and inflammation. Clinical Features Rabies infection progresses through several stages: incubation, prodrome, neurologic symptoms, coma, and death. During the prodrome, infected individuals may experience neuropathic pain or itching at the site of the bite...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-17
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... their function and inhibiting the respiratory burst, decreasing acidification, inhibiting lysosomal fusion, and excluding entry of cathepsin D. The organisms then translocate from the phagosome to the cytoplasm and multiply. This replication in the cytosol is dependent on the Francisella pathogenicity...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... undergo changes as they interact, acquiring membrane portions and functions of the endoplasmic reticulum and Golgi apparatus. The VirB T4SS (type 4 secretion system) plays a pivotal role in regulating these changes by producing a variety of factors that facilitate the intracellular life cycle...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., the bacteria are able to evade phagocytosis and manipulate host cell functions to facilitate their replication. The host response includes innate immunity, which is mediated by neutrophils and associated with the release of proinflammatory cytokines (particularly the production of interferon-γ). The adaptive...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...: a public health concern . J Med Virol 2018 ; 90 : 1003 - 9 . 47. Muyangwa M , Martynova E , Khaiboullina S , Morzunov S , Rizvanov A . Hantaviral proteins: structure, functions, and role in hantavirus infection . Front Microbiol 2015 ; 6 : 1326 . 48...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... the function of lung surfactant but do not invade tissue or cause pneumocyte or cell injury. In the alveoli, the trophic forms undergo cell wall remodeling and mating, and eventually form cysts. The latter are the infectious form of the organism, larger (8 to 10 μm) than the trophic forms and have a rigid cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-05
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... with the mild and nonspecific microscopic changes that may be present on biopsy material. Diarrheal disease caused by enteric viruses most often affects the small bowel and is usually associated with disruption of the intestinal brush border and enzymes, direct epithelial cytotoxic effects, and functional...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-26
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of acute and chronic giardiasis are likely caused by the organism’s interference with normal enterocyte and intestinal brush border function, as well as increased intestinal permeability. Clinical Features Giardiasis has a variable clinical presentation, which depends on the geographic region, parasite...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... >72 hours, and evidence of metastatic infection Devices/foreign bodies Pain, fever, chills, tachycardia (with cardiac devices), malaise, anorexia, and presence of pus Impaired function of the device, such as prosthetic joints, valves, and ventricular assist devices Acute infections reveal erythema...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... demonstrated differences in the toxin produced by M. ulcerans strains in diverse geographic locations, which results in varying toxin potency. The toxin functions by altering cellular scaffolding proteins, such as the Wiskott-Aldrich syndrome protein (WASP). This inhibits actin filaments anchoring...
Images
Published: 15 November 2023
FIBROCALCIFIC AORTIC VALVE DISEASE Figure 9-9 FIBROCALCIFIC AORTIC VALVE DISEASE The functional status of this fibrocalcific aortic valve (yellow arrowhead) is inferred by evaluating the left ventricle in explant or autopsy specimens. Concentric hypertrophy (yellow double-headed arrows) indicates... More about this image found in FIBROCALCIFIC AORTIC VALVE DISEASE The functional status of this fibrocalc...
Images
Published: 15 November 2023
SINGLE FUNCTIONAL VENTRICLES Figure 38-1 SINGLE FUNCTIONAL VENTRICLES Left: Hypoplastic left heart syndrome with aortic valve atresia and a hypoplastic but competent mitral valve. The ductal artery (*) is patent. Right: Hypoplastic right heart syndrome with pulmonary valve atresia and a hypoplas... More about this image found in SINGLE FUNCTIONAL VENTRICLES Left: Hypoplastic left heart syndrome with ao...
Images
Published: 15 November 2023
SINGLE FUNCTIONAL VENTRICLES: UNIVENTRICULAR ATRIOVENTRICULAR CONNECTIONS Figure 38-2 SINGLE FUNCTIONAL VENTRICLES: UNIVENTRICULAR ATRIOVENTRICULAR CONNECTIONS A: Double inlet ventricle of left ventricular type. B: Single inlet ventricle of left ventricular type (tricuspid atresia). C: Common i... More about this image found in SINGLE FUNCTIONAL VENTRICLES: UNIVENTRICULAR ATRIOVENTRICULAR CONNECTIONS ...
Images
Published: 15 November 2023
SINGLE FUNCTIONAL VENTRICLES: FIRST-STAGE PALLIATIVE PROCEDURES Figure 38-3 SINGLE FUNCTIONAL VENTRICLES: FIRST-STAGE PALLIATIVE PROCEDURES A: Right modified Blalock-Taussig shunt, for inadequate pulmonary blood flow. B: Pulmonary artery banding, for excessive pulmonary blood flow. C,D: Norwood... More about this image found in SINGLE FUNCTIONAL VENTRICLES: FIRST-STAGE PALLIATIVE PROCEDURES A: Right m...
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