BECKWITH-WIEDEMANN SYNDROME Figure 2-19 BECKWITH-WIEDEMANN SYNDROME Chromaffin cells forming a nodule protruding from the fetal cortex are inappropriately mature for this stage of development and have clear cytoplasm. There is a morphologic resemblance of the nodule to normal extra-adrenal paraga... More about this image found in BECKWITH-WIEDEMANN SYNDROME Chromaffin cells forming a nodule protruding f...

TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY Figure 2-15 TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY A: Tumor cells are arranged in lobules and solid sheets, with some intervening fibrous stroma. A ... More about this image found in TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDR...

PHEOCHROMOCYTOMA Figure 8-28 PHEOCHROMOCYTOMA Some tumor cells are large, with multinucleated forms and striking nuclear atypia. More about this image found in PHEOCHROMOCYTOMA Some tumor cells are large, with multinucleated forms and...

ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Figure 6-28 ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin pattern as highlighted by silver staining techniques, either in the form of “quantitative” changes (large nests disrupting the regular alveolar pattern typ... More about this image found in ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin...

BILATERAL ORCHIECTOMY SPECIMENS FROM A 25-YEAR-OLD MALE WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY Figure 2-14 BILATERAL ORCHIECTOMY SPECIMENS FROM A 25-YEAR-OLD MALE WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY Both testes were grossly nearly identical and were almost completely re... More about this image found in BILATERAL ORCHIECTOMY SPECIMENS FROM A 25-YEAR-OLD MALE WITH SALT-LOSING FO...

ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A Figure 8-60 ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A A: The adrenal medulla is mildly, diffusely thickened and extends into the alae of the gland. A single grossly discernible nodule (arrow) is the clue to the hereditary disease. ... More about this image found in ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A A: The adrenal medul...

PHEOCHROMOCYTOMA: ANASTOMOSING CORDS Figure 8-15 PHEOCHROMOCYTOMA: ANASTOMOSING CORDS In some pheochromocytomas the tumor cells form anastomosing cords rather than well-defined nests. More about this image found in PHEOCHROMOCYTOMA: ANASTOMOSING CORDS In some pheochromocytomas the tumor c...

CYTOMEGALY IN REGRESSING FETAL CORTEX FROM A STILLBORN Figure 1-27 CYTOMEGALY IN REGRESSING FETAL CORTEX FROM A STILLBORN The nuclei are extremely large and occasional nuclear pseudoinclusions are formed by invagination of cytoplasm (arrow). More about this image found in CYTOMEGALY IN REGRESSING FETAL CORTEX FROM A STILLBORN The nuclei are extr...

ZONA FASCICULATA Figure 1-48 ZONA FASCICULATA Features associated with steroidogenesis include abundant smooth endoplasmic reticulum (top arrow), which may form a complex network of anastomosing tubules, mitochondria with tubular cristae (bottom arrow), and lipid droplets (bottom of field). More about this image found in ZONA FASCICULATA Features associated with steroidogenesis include abundant...

DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Figure 1-45 DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Distinctive arcades of interrupted smooth muscle form the wall of the central adrenal vein and its tributaries. The vein is surrounded by chromaffi... More about this image found in DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Disti...

UNDIFFERENTIATED NEUROBLASTOMA Figure 11-12 UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuroblasts form solid sheets. Patterns such as this may cause confusion with other childhood neoplasms such as malignant lymphoma. Most nuclei have a single, small nucleolus. The tumo... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuro...

PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Figure 1-46 PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Where smooth muscle is deficient, chromaffin or cortical cells may come into close proximity with the vascular space and can form intravascular... More about this image found in PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Whe...

PERINATAL ADRENAL GLAND SHOWING DEFINITIVE AND PROVISIONAL ZONES BEFORE INVOLUTION Figure 1-25 PERINATAL ADRENAL GLAND SHOWING DEFINITIVE AND PROVISIONAL ZONES BEFORE INVOLUTION Definitive cortex forms a thin rim of subcapsular cells, which have a high nuclear to cytoplasmic ratio. Most of the co... More about this image found in PERINATAL ADRENAL GLAND SHOWING DEFINITIVE AND PROVISIONAL ZONES BEFORE INV...

CONGENITAL ADRENAL HYPERPLASIA Figure 2-11 CONGENITAL ADRENAL HYPERPLASIA Autopsy of an infant who died of the severe salt-losing form of 21-hydroxylase deficiency shows enlargement of both adrenal glands (arrows). The glands have a convoluted or cerebriform surface and are darker than normal due... More about this image found in CONGENITAL ADRENAL HYPERPLASIA Autopsy of an infant who died of the severe...

SDH-DEFICIENT PARAGANGLIOMA Figure 10-5 SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient with a pathogenic SDHB variant has round nesting architecture, oncocytic cytology with abundant eosinophilic cytoplasm, and focal tendency to form pseudorosettes. B: SDHB immunohistochemistry is negative, with retained positivity in vascular endothelium serving as an internal positive control. More about this image found in SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient w...

LATE GESTATION ADRENAL GLAND FROM A PREMATURE STILLBORN Figure 1-7 LATE GESTATION ADRENAL GLAND FROM A PREMATURE STILLBORN Most of this adrenal gland is composed of provisional cortical cells with abundant eosinophilic cytoplasm. There is a vague suggestion of columns resembling zona fasciculata,... More about this image found in LATE GESTATION ADRENAL GLAND FROM A PREMATURE STILLBORN Most of this adren...

ONCOCYTIC ADRENAL CORTICAL ADENOMA Figure 5-48 ONCOCYTIC ADRENAL CORTICAL ADENOMA A: Cells of this oncocytic adrenal cortical adenoma contain numerous round to elongated mitochondria. There are a few small lipid droplets. The nuclear folds and clefts may form nuclear pseudoinclusions, detectable ... More about this image found in ONCOCYTIC ADRENAL CORTICAL ADENOMA A: Cells of this oncocytic adrenal cort...

ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND Figure 9-4 ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND A: Normal paraganglia are fully formed before the adrenal medulla exists. This adrenal gland shows only provisional cortex and a small cluster of primitive adrenal me... More about this image found in ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND A: Normal para...

ADRENAL HISTOPLASMOSIS Figure 12-21 ADRENAL HISTOPLASMOSIS A: Transverse section of an enlarged adrenal gland from a patient with disseminated histoplasmosis. There are broad zones of caseous necrosis and small areas of hemorrhage. B: Numerous intracellular organisms typical for Histoplasma capsulatum are present in macrophages within sinusoids of the adrenal cortex (hematoxylin and eosin [H&E] stain). C: Organisms typical for H. capsulatum are sharply delineated with periodic acid–Schiff (PAS) stain. D: Gomori methenamine silver stain of a cell block prepared from fine needle aspiration biopsy of enlarged adrenal gland shows numerous round to ovoid yeast forms of H. capsulatum. Some organisms are isolated and single while others have a budding configuration. More about this image found in ADRENAL HISTOPLASMOSIS A: Transverse section of an enlarged adrenal gland ...

MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Figure 1-1 MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gonadal pathways are shown. Functions distinguishing the adrenal cortical zones from each other and from the gonads are determined by differential expression of steroi... More about this image found in MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gon...