PHEOCHROMOCYTOMA: ANGIOINVASION Figure 8-47 PHEOCHROMOCYTOMA: ANGIOINVASION A,B: The presence of vascular invasion is a worrisome finding, but unlike in other neoplasms, it is not reliably associated with the development of metastatic disease. More about this image found in PHEOCHROMOCYTOMA: ANGIOINVASION A,B: The presence of vascular invasion is ...

ADRENAL CORTICAL “FIBROMA” Figure 12-20 ADRENAL CORTICAL “FIBROMA” A: This tumor measured about 7 mm and was an incidental finding in a patient undergoing radical nephrectomy for a clear cell renal cell carcinoma. B: The tumor is densely fibrotic with bland spindle cells and resembles an ovarian... More about this image found in ADRENAL CORTICAL “FIBROMA” A: This tumor measured about 7 mm and was an in...

ADRENAL CORTICAL NEOPLASM ASSOCIATED WITH CONGENITAL ADRENAL HYPERPLASIA Figure 2-13 ADRENAL CORTICAL NEOPLASM ASSOCIATED WITH CONGENITAL ADRENAL HYPERPLASIA A: A large adrenal cortical tumor present on the right is seen next to hyperplastic lipid-depleted adrenal cortex and a normal adrenal medu... More about this image found in ADRENAL CORTICAL NEOPLASM ASSOCIATED WITH CONGENITAL ADRENAL HYPERPLASIA A...

PULMONARY PARAGANGLIOMA Figure 9-32 PULMONARY PARAGANGLIOMA A: This paraganglioma was a solitary lesion initially interpreted as an epithelial pulmonary NET. The patient was found to have a hereditary SDHC mutation. No other primary tumors were found and this tumor contained abundant sustentacular cells. In view of the clinical and histologic findings and the low metastasis frequency associated with SDHC mutation, the tumor was consistent with a primary pulmonary paraganglioma. B: High magnification shows nested architecture and cells of varied sizes. C: S-100 protein highlights sustentacular cells. More about this image found in PULMONARY PARAGANGLIOMA A: This paraganglioma was a solitary lesion initia...

MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Figure 1-9 MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Coronal section of fetal adrenal gland shows close association with developing sympathetic plexus (on far left). Small nests of primitive sympathetic cells (white arrows) a... More about this image found in MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Coronal section o...

VIRAL ENCEPHALITIS Figure 3-49 VIRAL ENCEPHALITIS The histopathologic findings are nonspecific and include perivascular cuffing by mononuclear cells and glial nodules, as seen in this mild case of herpes simplex encephalitis (A: courtesy of the CDC PHIL) and enterovirus encephalitis (B: courtesy ... More about this image found in VIRAL ENCEPHALITIS The histopathologic findings are nonspecific and includ...

PNEUMOCOCCAL MENINGITIS Figure 12-4 PNEUMOCOCCAL MENINGITIS A: Gross findings show a purulent subarachnoidal exudate. (Courtesy of the CDC PHIL) B,C: Microscopy shows a dense leptomeningeal neutrophil infiltration (B) and immunohistochemical staining (C) confirms the presence of large numbers of S. pneumoniae organisms in the infiltrate. (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in PNEUMOCOCCAL MENINGITIS A: Gross findings show a purulent subarachnoidal e...

INTESTINAL SPIROCHETOSIS Figure 13-9 INTESTINAL SPIROCHETOSIS EAEC findings on endoscopic biopsy are closely mimicked by Brachyspira spp organisms (A) and may be confused with an exaggerated colonic epithelial brush border in mild cases. The bacteria in intestinal spirochetosis are also gram negative (B), but unlike EAEC have a more wiry, spiralled morphology and are positive with silver staining (such as Warthin-Starry) (C). A novel finding is the cross reactivity of Brachyspira spp with T. pallidum immunohistochemistry (D). (Courtesy of Dr. E. Montgomery, University of Miami, Miami, FL) More about this image found in INTESTINAL SPIROCHETOSIS EAEC findings on endoscopic biopsy are closely mi...