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Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA Figure 1-44 VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure shows a single VIP-expressing neuron, a myelinated nerve containing VIP-positive axons (arrow), and branching VIP-positive terminal fibers between chr... More about this image found in VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure s...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
IMMUNOHISTOCHEMISTRY WITH PHOX2B Figure 11-36 IMMUNOHISTOCHEMISTRY WITH PHOX2B The same tumor as figure 11-35 shows nuclear reactivity for PHOX2B, a nuclear transcription factor specific for sympathetic neurons and chromaffin cells. More about this image found in IMMUNOHISTOCHEMISTRY WITH PHOX2B The same tumor as figure 11-35 shows nu...
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Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES Figure 6-19 ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES A–C: Atypical mitotic figures in varied shapes are a pathologic hallmark of ACC. More about this image found in ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES A–C: Atypical mitotic figures...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Figure 11-34 NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Area of undifferentiated NB with numerous apoptotic bodies and a few potential mitotic figures, illustrating the approach to mitosis karyorrhexis counting. More about this image found in NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Area of undiffer...
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in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PRIMARY ADRENAL LEIOMYOMA Figure 12-12 PRIMARY ADRENAL LEIOMYOMA Primary adrenal leiomyoma is composed of interlacing fascicles of spindle cells in various planes of section. No mitotic figures were identified and there is no necrosis. More about this image found in PRIMARY ADRENAL LEIOMYOMA Primary adrenal leiomyoma is composed of interla...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: PERIPHERY Figure 8-17 PHEOCHROMOCYTOMA: PERIPHERY The periphery of these tumors is extremely variable, with some showing clear encapsulation (A) and others lacking a capsule, and instead showing interdigitation with the surrounding adrenal cortex (B). Both patterns are seen in t... More about this image found in PHEOCHROMOCYTOMA: PERIPHERY The periphery of these tumors is extremely var...
Images
Published: 01 December 2024
BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Figure 6-34 BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic beta-catenin expression in ACC may be focal with a “clonal” pattern or more frequently, diffuse as in the figure. Membrane pattern is visible in peritumoral non-neopla... More about this image found in BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic...
Images
Published: 01 December 2024
PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Figure 4-16 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Heterogeneous architectural patterns with diffuse and pseudonodular lesions from the adrenal lesion... More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTI...
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Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-2 ADRENAL CORTICAL CARCINOMA This adrenal cortical carcinoma shows a gross nodule-in-nodule appearance (A). Peripheral areas are well circumscribed with oncocytic features (B). A thin capsule (C) separates the peripheral areas from a central component with an a... More about this image found in ADRENAL CORTICAL CARCINOMA This adrenal cortical carcinoma shows a gross n...
Images
Published: 01 December 2024
PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Figure 4-17 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Heterogeneity of cellular features from the same adrenal lesion seen in figures 4-12 and 4-16 . ... More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTI...
Images
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL CARCINOMA Figure 6-42 PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and vascular invasion (B,C). Increased mitotic activity and rare atypical mitotic figures were also found. Cytologic atypia was mild as it is usually in pediatric adrenal cortical ... More about this image found in PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and va...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Figure 8-53 PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Immunohistochemical stain for S-100 protein shows intratumoral variation in density of sustentacular cells in a pheochromocytoma from a patient with MEN2A (same patient as figure 8-3... More about this image found in PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Immunohistochemical sta...
Images
Published: 01 December 2024
NORMAL PERITHYROIDAL PARAGANGLION Figure 9-10 NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered incidentally in peri-thyroidal soft tissue in an adult patient with a multinodular goiter, is architecturally similar to the carotid body in figure 9-7 . The intimate association of n... More about this image found in NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered inciden...
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Published: 01 December 2024
SITES OF PARAGANGLIOMA DEVELOPMENT Figure 9-1 SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distribution of extra-adrenal chromaffin tissue in neonates (A) and prevalent sites of sympathetic paragangliomas reported up to 1965 (B) in a classic illustration. Arrow added in A indic... More about this image found in SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distributi...
Images
in Congenital Disorders of the Adrenal Gland
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
BECKWITH-WIEDEMANN SYNDROME Figure 2-18 BECKWITH-WIEDEMANN SYNDROME A: Transverse sections of adrenal gland from a 3-week-old infant with Beckwith-Wiedemann syndrome are enlarged and show redundant cerebriform folds of cortex with demarcation between adult or definitive cortex and regressing and ... More about this image found in BECKWITH-WIEDEMANN SYNDROME A: Transverse sections of adrenal gland from a...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA Figure 11-44 MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at 13 months as an unresectable abdominal NB and was treated with abdominal mega-voltage irradiation. At age 17 years, the patient presented again with an abdominal tu... More about this image found in MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at...
Images
Published: 01 December 2024
NORMAL ABDOMINAL PARAGANGLION Figure 9-5 NORMAL ABDOMINAL PARAGANGLION A: Low magnification shows proximity of this paraganglion to adjacent developing ganglia, adrenal gland, and kidney in a mid-second trimester fetus. B: Higher magnification of paraganglion in a mid-second trimester fetus. Thi... More about this image found in NORMAL ABDOMINAL PARAGANGLION A: Low magnification shows proximity of this...
Images
Published: 01 December 2024
ABDOMINAL PARAGANGLIOMA Figure 9-39 ABDOMINAL PARAGANGLIOMA Immunohistochemical staining for somatostatin receptor 2A, an inexpensive stain, can triage patients for somatostatin receptor imaging and peptide receptor radionuclide therapy (PRRT). This very sensitive positron emission tomography (PET)/computerized tomography (CT) imaging uses 68Ga, a positron emitter, chelated to a bifunctional “DOTA” compound that is also linked to a somatostatin analog. The most widely used analog is octreotate, which has high affinity for SSTR type 2, hence, the term “DOTAtate” scan. This modality is more sensitive and faster than octreotide scans, which have been available for decades and use 111in, a single photon emitter, as the radioactive tracer. For PRRT, 68Ga is replaced by 177Lu, which emits cytotoxic medium energy beta particles, or by 90Y, a high energy beta emitter that may be preferable for larger tumors [ ref. 111 ]. The immunohistochemical stain for SSTR2A in this figure corresponds to one of the lesions in the PET/CT image. More about this image found in ABDOMINAL PARAGANGLIOMA Immunohistochemical staining for somatostatin rece...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROBLASTOMA Figure 8-57 COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROBLASTOMA More about this image found in COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROBLASTOMA
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: MITOSES Figure 8-29 PHEOCHROMOCYTOMA: MITOSES Mitoses are prominent in this tumor. More about this image found in PHEOCHROMOCYTOMA: MITOSES Mitoses are prominent in this tumor.
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