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VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA Figure 1-44 VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure shows a single VIP-expressing neuron, a myelinated nerve containing VIP-positive axons (arrow), and branching VIP-positive terminal fibers between More about this image found in VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure s...

IMMUNOHISTOCHEMISTRY WITH PHOX2B Figure 11-36 IMMUNOHISTOCHEMISTRY WITH PHOX2B The same tumor as figure 11-35 shows nuclear reactivity for PHOX2B, a nuclear transcription factor specific for sympathetic neurons and chromaffin cells. More about this image found in IMMUNOHISTOCHEMISTRY WITH PHOX2B The same tumor as figure 11-35 shows nu...

ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES Figure 6-19 ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES A–C: Atypical mitotic figures in varied shapes are a pathologic hallmark of ACC. More about this image found in ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES A–C: Atypical mitotic figures...

NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Figure 11-34 NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Area of undifferentiated NB with numerous apoptotic bodies and a few potential mitotic figures, illustrating the approach to mitosis karyorrhexis counting. More about this image found in NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Area of undiffer...

PRIMARY ADRENAL LEIOMYOMA Figure 12-12 PRIMARY ADRENAL LEIOMYOMA Primary adrenal leiomyoma is composed of interlacing fascicles of spindle cells in various planes of section. No mitotic figures were identified and there is no necrosis. More about this image found in PRIMARY ADRENAL LEIOMYOMA Primary adrenal leiomyoma is composed of interla...

PHEOCHROMOCYTOMA: PERIPHERY Figure 8-17 PHEOCHROMOCYTOMA: PERIPHERY The periphery of these tumors is extremely variable, with some showing clear encapsulation (A) and others lacking a capsule, and instead showing interdigitation with the surrounding adrenal cortex (B). Both patterns are seen More about this image found in PHEOCHROMOCYTOMA: PERIPHERY The periphery of these tumors is extremely var...

BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Figure 6-34 BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic beta-catenin expression in ACC may be focal with a “clonal” pattern or more frequently, diffuse as in the figure. Membrane pattern is visible in peritumoral non More about this image found in BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic...

PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Figure 4-16 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Heterogeneous architectural patterns with diffuse and pseudonodular lesions from the adrenal More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTI...

ADRENAL CORTICAL CARCINOMA Figure 6-2 ADRENAL CORTICAL CARCINOMA This adrenal cortical carcinoma shows a gross nodule-in-nodule appearance (A). Peripheral areas are well circumscribed with oncocytic features (B). A thin capsule (C) separates the peripheral areas from a central component More about this image found in ADRENAL CORTICAL CARCINOMA This adrenal cortical carcinoma shows a gross n...

PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Figure 4-17 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Heterogeneity of cellular features from the same adrenal lesion seen in figures 4-12 and 4-16 More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTI...

PEDIATRIC ADRENAL CORTICAL CARCINOMA Figure 6-42 PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and vascular invasion (B,C). Increased mitotic activity and rare atypical mitotic figures were also found. Cytologic atypia was mild as it is usually in pediatric adrenal cortical More about this image found in PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and va...

PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Figure 8-53 PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Immunohistochemical stain for S-100 protein shows intratumoral variation in density of sustentacular cells in a pheochromocytoma from a patient with MEN2A (same patient as figure 8 More about this image found in PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Immunohistochemical sta...

NORMAL PERITHYROIDAL PARAGANGLION Figure 9-10 NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered incidentally in peri-thyroidal soft tissue in an adult patient with a multinodular goiter, is architecturally similar to the carotid body in figure 9-7 . The intimate association More about this image found in NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered inciden...

SITES OF PARAGANGLIOMA DEVELOPMENT Figure 9-1 SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distribution of extra-adrenal chromaffin tissue in neonates (A) and prevalent sites of sympathetic paragangliomas reported up to 1965 (B) in a classic illustration. Arrow added More about this image found in SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distributi...

BECKWITH-WIEDEMANN SYNDROME Figure 2-18 BECKWITH-WIEDEMANN SYNDROME A: Transverse sections of adrenal gland from a 3-week-old infant with Beckwith-Wiedemann syndrome are enlarged and show redundant cerebriform folds of cortex with demarcation between adult or definitive cortex and regressing More about this image found in BECKWITH-WIEDEMANN SYNDROME A: Transverse sections of adrenal gland from a...

MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA Figure 11-44 MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at 13 months as an unresectable abdominal NB and was treated with abdominal mega-voltage irradiation. At age 17 years, the patient presented again with an abdominal More about this image found in MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at...

NORMAL ABDOMINAL PARAGANGLION Figure 9-5 NORMAL ABDOMINAL PARAGANGLION A: Low magnification shows proximity of this paraganglion to adjacent developing ganglia, adrenal gland, and kidney in a mid-second trimester fetus. B: Higher magnification of paraganglion in a mid-second trimester fetus More about this image found in NORMAL ABDOMINAL PARAGANGLION A: Low magnification shows proximity of this...

ABDOMINAL PARAGANGLIOMA Figure 9-39 ABDOMINAL PARAGANGLIOMA Immunohistochemical staining for somatostatin receptor 2A, an inexpensive stain, can triage patients for somatostatin receptor imaging and peptide receptor radionuclide therapy (PRRT). This very sensitive positron emission tomography More about this image found in ABDOMINAL PARAGANGLIOMA Immunohistochemical staining for somatostatin rece...

COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROBLASTOMA Figure 8-57 COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROBLASTOMA More about this image found in COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROBLASTOMA

CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...