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fibroblastic

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... suppressor gene . Science   1993 ; 260 : 1317 - 20 . 43. Kaelin   WG   Jr . Molecular basis of the VHL hereditary cancer syndrome . Nat Rev Cancer   2002 ; 2 : 673 - 82 . 44. Maher   PA . Identification and characterization of a novel, intracelllular isoform of fibroblast growth...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cortical zonation and cell replenishment ( 2 , 13 , 22 ). Signaling by numerous other ligands, including corticotrophin-releasing hormone (CRH), ACTH, angiotensin 2, fibroblast growth factor (FGF), and insulin-like growth factor (IGF) 1 and 2 is involved at various stages of cortical zonation ( 2 , 13 , 22...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., fibroblast, endothelium Parvovirus B19 Cardiomyocyte, endothelium SARS-CoV-2 Likely cardiomyocyte Epstein-Barr virus Lymphocyte Human herpesvirus 6 Endothelium Rickettsiae Endothelium Meningococci Endothelium, macrophage THE DIFFERENT STAGES OF MYOCARDITIS Figure 7-1 THE DIFFERENT...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-23
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... This can be complicated by mediastinal granuloma formation and secondary fistulation. Mediastinal fibrosis, the result of an exuberant fibroblastic and collagenous response to the Histoplasma yeasts, is another complication and can lead to secondary compression and obstruction of various...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-10
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., including monocytes, macrophages, and dendritic cells (preferred replication sites), as well as lymphocytes, endothelial cells, fibroblasts, hepatocytes, adrenocortical cells, and other epithelial cells ( 8 ). The pathogenesis of both diseases is extremely complex. It includes activation of the mononuclear...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-22
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... also be seen basally in enterocytes as well as in macrophages, fibroblasts, and endothelium. The latter organisms readily disseminate to other organs. SMALL INTESTINAL INFECTION BY ENCEPHALITOZOON INTESTINALIS Figure 22-16 SMALL INTESTINAL INFECTION BY ENCEPHALITOZOON INTESTINALIS...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-25
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... such as monkey kidney cell lines, human brain microvascular endothelial cells, or lung fibroblasts, as this FLA cannot be cultured on laboratory agar. Naegleria are diagnosed by visualizing moving trophozoites in the CSF; Acanthamoeba and Balamuthia are not readily observed in the CSF...
Images
PN WITH MESENCHYMAL FEATURES  A: An amelanotic nodule is present within a C...
Published: 01 February 2024
PN WITH MESENCHYMAL FEATURES Figure 2-19 PN WITH MESENCHYMAL FEATURES A: An amelanotic nodule is present within a CMN. B: The nodule is composed of fibroblast-like cells and myxoid stroma. The tumor cells within the nodule were immunohistochemically negative for melanocyte differentiation antige... More about this image found in PN WITH MESENCHYMAL FEATURES A: An amelanotic nodule is present within a C...
Images
SCLEROSING BLUE NEVUS  A: Small amelanotic fibrosing spindle cell lesion in...
Published: 01 February 2024
SCLEROSING BLUE NEVUS Figure 8-8 SCLEROSING BLUE NEVUS A: Small amelanotic fibrosing spindle cell lesion in the superficial dermis. B: The spindle cells are strongly and diffusely immunoreactive for Melan-A. C: The tumor cells display cytologically bland fibroblast-like features, simulating a f... More about this image found in SCLEROSING BLUE NEVUS A: Small amelanotic fibrosing spindle cell lesion in...
Images
<span class="search-highlight">FIBROBLASTS</span> OF CARDIAC FIBROMA  Left: Bland, spindle-shaped <span class="search-highlight">fibroblasts</span> are...
Published: 15 November 2023
FIBROBLASTS OF CARDIAC FIBROMA Figure 42-4 FIBROBLASTS OF CARDIAC FIBROMA Left: Bland, spindle-shaped fibroblasts are the lesional cells. Right: Dense pink collagen is often visible in and among the fibroblasts. More about this image found in FIBROBLASTS OF CARDIAC FIBROMA Left: Bland, spindle-shaped fibroblasts are...
Images
PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH)  A: Low-power image shows irre...
Published: 01 January 2024
PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) Figure 11-14 PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) A: Low-power image shows irregular slit-like spaces lined by spindle cells embedded in a dense collagenous stroma, characteristic of PASH. B: Intermediate-power view of the myofibroblasts and f... More about this image found in PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) A: Low-power image shows irre...
Images
NONBACTERIAL THROMBOTIC ENDOCARDITIS: ORGANIZATION  <span class="search-highlight">Fibroblasts</span> and histioc...
Published: 15 November 2023
NONBACTERIAL THROMBOTIC ENDOCARDITIS: ORGANIZATION Figure 11-7 NONBACTERIAL THROMBOTIC ENDOCARDITIS: ORGANIZATION Fibroblasts and histiocytes move into the thrombus and begin to organize it. More about this image found in NONBACTERIAL THROMBOTIC ENDOCARDITIS: ORGANIZATION Fibroblasts and histioc...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Some fusiform variants of PN show neural (schwannian) or mesenchymal (fibroblastic or chondroid) features (see fig. 2-19 ) ( 14 ). CMN WITH SUPERFICIAL DERMAL PROLIFERATIVE NODULE (PN) Figure 2-15 CMN WITH SUPERFICIAL DERMAL PROLIFERATIVE NODULE (PN) There is a dense nodular aggregate...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... angiotropism. Pure Desmoplastic Melanoma In pure DM, the tumor is overall cell poor (low melanocyte cell density) and stroma rich (abundant collagenous stroma). Melanocytes are predominantly dispersed as solitary units in a fibrous stroma ( figs. 16-1 , 16-5 ). They typically have a fibroblast-like...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... fibrosis parallel to the epidermis, with often prominent fibroblasts and vertically oriented vessels. The epidermis may show attenuation of rete ridges, acanthosis, and hyperkeratosis ( 6 ). By contrast, regressing melanoma typically shows epidermal thinning ( 6 ). Below the scar, a nevus remnant may...
Images
ORGANIZING THROMBUS  A: This low-power photomicrograph shows alternating ar...
Published: 15 November 2023
ORGANIZING THROMBUS Figure 51-19 ORGANIZING THROMBUS A: This low-power photomicrograph shows alternating areas of fibrin and variably cellular zones. B: This high-power view shows fibroblasts moving into dense fibrin at the leading edge of organization. C: The fibroblasts are embedded within a ... More about this image found in ORGANIZING THROMBUS A: This low-power photomicrograph shows alternating ar...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and diffusely immunoreactive for Melan-A. C: The tumor cells display cytologically bland fibroblast-like features, simulating a fibroma. SCLEROSING AND CELLULAR BLUE NEVUS Figure 8-9 SCLEROSING AND CELLULAR BLUE NEVUS A: Sclerosing spindle cell nodule is in the dermis. Most of the superficial part...
Images
SUBACUTE MYOCARDIAL INFARCTION: GRANULATION TISSUE  Small capillaries and f...
Published: 15 November 2023
SUBACUTE MYOCARDIAL INFARCTION: GRANULATION TISSUE Figure 7-16 SUBACUTE MYOCARDIAL INFARCTION: GRANULATION TISSUE Small capillaries and fibroblasts indicate the healing phase is now occurring. More about this image found in SUBACUTE MYOCARDIAL INFARCTION: GRANULATION TISSUE Small capillaries and f...
Images
CARCINOID DISEASE VALVULOPATHY  The fibroproliferative plaques contain blan...
Published: 15 November 2023
CARCINOID DISEASE VALVULOPATHY Figure 10-21 CARCINOID DISEASE VALVULOPATHY The fibroproliferative plaques contain bland fibroblasts within a prominent myxoid backdrop seen on both H&E (left), and Masson trichrome (right) staining. More about this image found in CARCINOID DISEASE VALVULOPATHY The fibroproliferative plaques contain blan...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... fibromatosis is a fibroblastic/myofibroblastic neoplasm of soft tissue. It is considered to be a benign neoplasm, although in about 25 percent of cases, there is local recurrence. Clinical Features. Desmoid fibromatosis typically presents as a slow-growing, ill-defined, firm mass in the breast parenchyma...