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Figure 7-34
Published: 01 June 2025
METASTATIC EBV-ASSOCIATEDNASOPHARYNGEAL CARCINOMA Figure 7-34 METASTATIC EBV-ASSOCIATEDNASOPHARYNGEAL CARCINOMA The aspirate contains crowded cells with enlarged ovoid nuclei, a distinct nucleolus, and scant cytoplasm. (Diff-Quik preparation) More about this image found in METASTATIC EBV-ASSOCIATEDNASOPHARYNGEAL CARCINOMA The aspirate contains cr...
Images
Figure 1-34
Published: 01 June 2025
nasopharyngeal carcinoma. B: This tumor type is positive for Epstein-Barr virus (EBV), best demonstrated by in situ hybridization for EBV-encoded small RNA (EBER). More about this image found in SINONASAL LYMPHOEPITHELIAL CARCINOMA A: Tumor cells have ill-defined cell ...
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Figure 3-11
Published: 01 June 2025
KERATINIZING NASOPHARYNGEAL CARCINOMA Figure 3-11 KERATINIZING NASOPHARYNGEAL CARCINOMA A,B: Keratinizing nasopharyngeal carcinomas are often Epstein-Barr virus (EBV) negative and show similar histologic features to keratinizing squamous cell carcinomas in other head and neck anatomic sites. More about this image found in KERATINIZING NASOPHARYNGEAL CARCINOMA A,B: Keratinizing nasopharyngeal car...
Images
Figure 4-78
Published: 01 June 2025
plasmablasts with pleomorphism and atypical mitoses. C: EBV encoding region (EBER) staining is positive in most HIV-associated cases. D: The Ki-67 index is usually more than 80 percent. More about this image found in PLASMABLASTIC LYMPHOMA OF THE ORAL CAVITY A: A 32-year-old HIV-positive ma...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
... year, with approximately 73,000 deaths ( 36 ). In most parts of the world where EBV is nonendemic, NPC is a rare cancer with an estimated incidence of less than 1 per 100,000 ( 37 , 38 ). However, in selected endemic geographic areas, including several provinces in southern China, southeast Asia...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
...-Barr virus (EBV) ( 116 , 117 ). Despite the ubiquity of EBV, malignancies associated with it are most common in certain Asian populations, suggesting that genotypes underlying viral-host immune interactions more common in these populations leave those patients more susceptible ( 118 ). Clinical...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... to nasopharyngeal carcinoma and despite its relative proximity to the nasopharynx, oropharyngeal lymphoepithelial carcinoma is almost always HPV associated and Epstein-Barr virus (EBV) negative ( 30 , 31 ). LYMPHOEPITHELIAL (OR UNDIFFERENTIATED) CARCINOMA Figure 2-17 LYMPHOEPITHELIAL (OR UNDIFFERENTIATED...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... cavity Submucosal infiltrative neoplastic proliferation with varied growth patterns, including trabeculae, cords, islands, lobules, and sheets, often without desmoplastic stromal reaction, EBV+ a WHO = World Health Organization; SCC = squamous cell carcinoma; H&N = head and neck; EBV...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... as a discrete neck mass and where the luminal contents (fluid, necrotic material, degenerated cells) predominate. Most are metastatic SCCs, and many of these are related to high-risk HPV or less commonly, Epstein-Barr virus (EBV). General Features. Cervical nodal metastases are incredibly common in head...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... a relatively nonspecific name, and has a biology that is very dependent on viral status, specifically HPV for tumors of the oropharynx, nasopharynx, and sinonasal tract ( 131 , 132 ) and Epstein-Barr virus (EBV) for tumors of the nasopharynx ( 133 ). It also has a morphology that overlaps with many nonsquamous...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... decreases, there is an inverse relationship to the degree of pleomorphism and tumor grade. In poorly differentiated, nonkeratinizing, and basaloid tumors ( fig. 8-49 ), the possibility of viral-induced (human papillomavirus [HPV], Epstein-Barr virus [EBV]) or translocation driven etiology (BRD4...
Images
Images
Figure 8-5
Published: 01 September 2024
EPSTEIN-BARR VIRUS (EBV) PATHOGENESIS Figure 8-5 EPSTEIN-BARR VIRUS (EBV) PATHOGENESIS More about this image found in EPSTEIN-BARR VIRUS (EBV) PATHOGENESIS
Images
Figure 8-6
Published: 01 September 2024
EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Figure 8-6 EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Usually, there is a peripheral lymphocytosis and atypical lymphocytes (A,B) are seen on the peripheral blood smear. More about this image found in EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Usually, there is a peripheral lym...
Images
Figure 8-8
Published: 01 September 2024
EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Figure 8-8 EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural distortion (A) with focal capsular permeation by lymphoid cells (top), a polymorphic mononuclear infiltrate (B) with associated plasma cells (C) and focal mitotic activity More about this image found in EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural dist...
Images
Figure 8-9
Published: 01 September 2024
EBV-ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Figure 8-9 EBV-ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Bone marrow trephine biopsy (A,B) and aspirate (C,D). More about this image found in EBV-ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Bone marrow trephine bio...
Images
Figure 8-11
Published: 01 September 2024
EBV-ASSOCIATED NASOPHARYNGEAL CARCINOMA Figure 8-11 EBV-ASSOCIATED NASOPHARYNGEAL CARCINOMA Desmoplastic stroma (A) and associated lymphocyte infiltrate (B), with pancytokeratin immunohistochemistry (C) confirm the epithelial nature of the neoplasm. More about this image found in EBV-ASSOCIATED NASOPHARYNGEAL CARCINOMA Desmoplastic stroma (A) and associ...
Images
Figure 8-12
Published: 01 September 2024
NASOPHARYNGEAL CARCINOMA Figure 8-12 NASOPHARYNGEAL CARCINOMA Strong epithelial positivity is seen on EBV-encoded small RNA (EBER) in situ hybridization (ISH), confirming the EBV association of the tumor. More about this image found in NASOPHARYNGEAL CARCINOMA Strong epithelial positivity is seen on EBV-encod...
Images
Figure 8-13
Published: 01 September 2024
IMMUNOBLASTIC CELLS IN EBV INFECTION Figure 8-13 IMMUNOBLASTIC CELLS IN EBV INFECTION A Hodgkin-like (mononuclear) and Reed-Sternberg-like (binuclear) morphology. These B cells typically possess a postgerminal center phenotype on immunohistochemistry. (Courtesy of Dr. E. A. Dent, Emory More about this image found in IMMUNOBLASTIC CELLS IN EBV INFECTION A Hodgkin-like (mononuclear) and Reed...
Images
Figure 8-14
Published: 01 September 2024
POST-TRANSPLANT EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE (PTLD) OF THE MONOMORPHIC TYPE Figure 8-14 POST-TRANSPLANT EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE (PTLD) OF THE MONOMORPHIC TYPE Low-power view (A) plasmacytoma-like features (B) and positivity for EBER ISH (C). (Courtesy of Dr. S More about this image found in POST-TRANSPLANT EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE (PTLD) OF THE MO...