ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY Figure 2-6 ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY This dysplastic kidney removed from a 5-week-old girl contains a prominent focus of benign immature adrenal cortex. More about this image found in ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY This dysplastic ...

INFLAMED DYSPLASTIC NEVUS Figure 4-6 INFLAMED DYSPLASTIC NEVUS The compound nevus displays features of a dysplastic nevus (e.g., fusion of junctional nests) and is associated with a dense band-like lymphocytic infiltrate involving the dermoepidermal junction and superficial dermis. More about this image found in INFLAMED DYSPLASTIC NEVUS The compound nevus displays features of a dyspla...

DYSPLASTIC NEVUS Figure 4-1 DYSPLASTIC NEVUS A: Multiple red and brown lesions are present on the upper back shoulder. The arrow points to a lesion, which was excised, and the diagnosis histopathologically confirmed as dysplastic nevus. B: The lesion has a diameter of more than 4 mm and displays... More about this image found in DYSPLASTIC NEVUS A: Multiple red and brown lesions are present on the uppe...

DYSPLASTIC NEVUS Figure 4-2 DYSPLASTIC NEVUS A: Multiple pigmented lesions are present on the back. The lesion, which was biopsied and histologically confirmed, is highlighted. B: The lesion displays some asymmetry, has an irregular peripheral border, and has some variation in pigmentation, with... More about this image found in DYSPLASTIC NEVUS A: Multiple pigmented lesions are present on the back. Th...

COMPOUND DYSPLASTIC NEVUS Figure 4-3 COMPOUND DYSPLASTIC NEVUS A: Nests vary in size and shape. There is a band-like lymphocytic infiltrate. B: The melanocytic proliferation is predominantly junctional, but a few nests of melanocytes are seen in a fibrotic dermis. More about this image found in COMPOUND DYSPLASTIC NEVUS A: Nests vary in size and shape. There is a band...

PIGMENTED LENTIGINOUS COMPOUND DYSPLASTIC NEVUS Figure 4-4 PIGMENTED LENTIGINOUS COMPOUND DYSPLASTIC NEVUS A: The silhouette of a broad plaque-like lesion with epidermal hyperplasia. B: The epidermis shows lentigo-like hyperplasia. Melanin pigment is present in keratinocytes and melanocytes. Sol... More about this image found in PIGMENTED LENTIGINOUS COMPOUND DYSPLASTIC NEVUS A: The silhouette of a bro...

LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Figure 4-5 LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Thin layers of fibrosis surround rete ridges, creating a zone separating junctional from dermal melanocytes. There is associated bland-like inflammation. More about this image found in LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Thin layers o...

COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION Figure 4-7 COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION There is a gap (arrows) in the dermal melanocyte population, with inflammation and slightly hypervascular stroma separating dermal nevus cell aggregates. More about this image found in COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION There is a gap (arrows) ...

COMPOUND DYSPLASTIC NEVUS Figure 4-8 COMPOUND DYSPLASTIC NEVUS Melanocyte nests vary in size and shape, and there is a lentiginous proliferation of solitary units of melanocytes. Some junctional melanocytes show slight nuclear enlargement and hyperchromatism. Mild lamellar fibrosis is present (ar... More about this image found in COMPOUND DYSPLASTIC NEVUS Melanocyte nests vary in size and shape, and the...

COMPOUND DYSPLASTIC NEVUS Figure 4-9 COMPOUND DYSPLASTIC NEVUS There is architectural disorder of melanocytes at the dermoepidermal junction, with fusion of rete ridges. Many junctional melanocyte nuclei are larger than (some up to twice the size of) keratinocyte nuclei. More about this image found in COMPOUND DYSPLASTIC NEVUS There is architectural disorder of melanocytes a...

COMPOUND DYSPLASTIC NEVUS Figure 4-10 COMPOUND DYSPLASTIC NEVUS Melanocytes are dispersed as solitary units and small nests at the dermoepidermal junction. Most melanocyte nuclei are larger than basilar keratinocyte nuclei. Some of the melanocytes display irregular nuclear contours and/or hyperch... More about this image found in COMPOUND DYSPLASTIC NEVUS Melanocytes are dispersed as solitary units and ...

COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES Figure 4-11 COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound dysplastic nevus (hematoxylin and eosin [H&E]-stain). B: Immunostain for PRAME. Most nuclei of junctional melanocytes (long arrow) and intrade... More about this image found in COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound...

COMBINED BAP1-INACTIVATED COMPOUND NEVUS WITH FEATURES OF A DYSPLASTIC NEVUS Figure 10-9 COMBINED BAP1-INACTIVATED COMPOUND NEVUS WITH FEATURES OF A DYSPLASTIC NEVUS A: The compound melanocytic proliferation is predominantly composed of small epithelioid melanocytes (arrows). Junctional nests var... More about this image found in COMBINED BAP1-INACTIVATED COMPOUND NEVUS WITH FEATURES OF A DYSPLASTIC NEVU...

SCALP NEVUS Figure 5-9 SCALP NEVUS A: The compound nevus displays plaque-like growth and has a junctional shoulder. B: It contains areas displaying features of a dysplastic nevus with fusion of nests, random atypia, and stromal fibrosis. More about this image found in SCALP NEVUS A: The compound nevus displays plaque-like growth and has a ju...

ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER Figure 3-23 ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER A: The lesion is small and circumscribed. It displays minor asymmetry. B: This compound nevus has a shoulder, but lacks other features of a dysplastic nevus. More about this image found in ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER A: The lesion ...

NEVUS CHANGING UNDER BRAF INHIBITOR THERAPY Figure 6-9 NEVUS CHANGING UNDER BRAF INHIBITOR THERAPY A: The nevus shows features of an inflamed dysplastic nevus. B: Junctional nests at the tips of rete ridges vary in size and shape. A few suprabasilar melanocytes are seen in the center of the lesi... More about this image found in NEVUS CHANGING UNDER BRAF INHIBITOR THERAPY A: The nevus shows features of...