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Figure 6-27
Published: 01 June 2025
SQUAMOUS PAPILLOMA Figure 6-27 SQUAMOUS PAPILLOMA Dysplastic features include epithelium showing hyperkeratosis and hyperchromatic basal cells with angulation and increased mitotic activity. More about this image found in SQUAMOUS PAPILLOMA Dysplastic features include epithelium showing hyperker...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... is intact squamous (rarely ulcerated), which can be normal, thickened with hyperkeratosis, or, on occasion, dysplastic. There are many histologic patterns, such as myxoid, fibrinous (or hyaline), vascular ( figs. 6-7 – 6-9 ), and fibrous, usually with little or no inflammation present ( 17 ). The abnormal...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... in both premalignant oral lesions and early carcinogenesis. These molecular alterations extend beyond the dysplastic epithelium and may account for field cancerization, a well-known occurrence in OSCC ( 34 – 36 ). Loss of heterozygosity (LOH) or deletions in chromosomal regions 3p, 9p, and 17p...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... and should be designated as such. When PIOCs arise in cysts, there may be histologic evidence of the preexisting cyst, which may or may not show varying degrees of dysplasia in the epithelial lining depending upon the section. When a cyst transforms, the first evidence is the premalignant dysplastic...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... frequently documented ( 992 – 1003 ). Patients with sinonasal tract mucosal melanomas do not seem to be part of dysplastic nevus syndrome or xeroderma pigmentosum kindreds ( 288 ). Melanoma is a common skin neoplasm, with about 25 percent of skin melanomas occurring in the head and neck. However, only about...
Images
Figure 2-6
Published: 01 December 2024
ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY Figure 2-6 ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY This dysplastic kidney removed from a 5-week-old girl contains a prominent focus of benign immature adrenal cortex. More about this image found in ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY This dysplastic ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...) and negative staining for PAX2 and PAX8 identifies adrenal tissue in most cases ( fig. 2-5 ) ( 16 ). An unusual example in a dysplastic pediatric kidney is shown in figure 2-6 . ADRENAL CORTICAL TISSUE IN A DONOR KIDNEY BIOPSY Figure 2-5 ADRENAL CORTICAL TISSUE IN A DONOR KIDNEY BIOPSY A: Uncircumscribed...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...DYSPLASTIC NEVUS Figure 4-1 DYSPLASTIC NEVUS A: Multiple red and brown lesions are present on the upper back shoulder. The arrow points to a lesion, which was excised, and the diagnosis histopathologically confirmed as dysplastic nevus. B: The lesion has a diameter of more than 4 mm...
Images
Figure 4-1
Published: 01 February 2024
DYSPLASTIC NEVUS Figure 4-1 DYSPLASTIC NEVUS A: Multiple red and brown lesions are present on the upper back shoulder. The arrow points to a lesion, which was excised, and the diagnosis histopathologically confirmed as dysplastic nevus. B: The lesion has a diameter of more than 4 mm More about this image found in DYSPLASTIC NEVUS A: Multiple red and brown lesions are present on the uppe...
Images
Figure 4-2
Published: 01 February 2024
DYSPLASTIC NEVUS Figure 4-2 DYSPLASTIC NEVUS A: Multiple pigmented lesions are present on the back. The lesion, which was biopsied and histologically confirmed, is highlighted. B: The lesion displays some asymmetry, has an irregular peripheral border, and has some variation in pigmentation More about this image found in DYSPLASTIC NEVUS A: Multiple pigmented lesions are present on the back. Th...
Images
Figure 4-3
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS Figure 4-3 COMPOUND DYSPLASTIC NEVUS A: Nests vary in size and shape. There is a band-like lymphocytic infiltrate. B: The melanocytic proliferation is predominantly junctional, but a few nests of melanocytes are seen in a fibrotic dermis. More about this image found in COMPOUND DYSPLASTIC NEVUS A: Nests vary in size and shape. There is a band...
Images
Figure 4-4
Published: 01 February 2024
PIGMENTED LENTIGINOUS COMPOUND DYSPLASTIC NEVUS Figure 4-4 PIGMENTED LENTIGINOUS COMPOUND DYSPLASTIC NEVUS A: The silhouette of a broad plaque-like lesion with epidermal hyperplasia. B: The epidermis shows lentigo-like hyperplasia. Melanin pigment is present in keratinocytes and melanocytes More about this image found in PIGMENTED LENTIGINOUS COMPOUND DYSPLASTIC NEVUS A: The silhouette of a bro...
Images
Figure 4-5
Published: 01 February 2024
LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Figure 4-5 LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Thin layers of fibrosis surround rete ridges, creating a zone separating junctional from dermal melanocytes. There is associated bland-like inflammation. More about this image found in LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Thin layers o...
Images
Figure 4-6
Published: 01 February 2024
INFLAMED DYSPLASTIC NEVUS Figure 4-6 INFLAMED DYSPLASTIC NEVUS The compound nevus displays features of a dysplastic nevus (e.g., fusion of junctional nests) and is associated with a dense band-like lymphocytic infiltrate involving the dermoepidermal junction and superficial dermis. More about this image found in INFLAMED DYSPLASTIC NEVUS The compound nevus displays features of a dyspla...
Images
Figure 4-7
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION Figure 4-7 COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION There is a gap (arrows) in the dermal melanocyte population, with inflammation and slightly hypervascular stroma separating dermal nevus cell aggregates. More about this image found in COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION There is a gap (arrows) ...
Images
Figure 4-8
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS Figure 4-8 COMPOUND DYSPLASTIC NEVUS Melanocyte nests vary in size and shape, and there is a lentiginous proliferation of solitary units of melanocytes. Some junctional melanocytes show slight nuclear enlargement and hyperchromatism. Mild lamellar fibrosis is present More about this image found in COMPOUND DYSPLASTIC NEVUS Melanocyte nests vary in size and shape, and the...
Images
Figure 4-9
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS Figure 4-9 COMPOUND DYSPLASTIC NEVUS There is architectural disorder of melanocytes at the dermoepidermal junction, with fusion of rete ridges. Many junctional melanocyte nuclei are larger than (some up to twice the size of) keratinocyte nuclei. More about this image found in COMPOUND DYSPLASTIC NEVUS There is architectural disorder of melanocytes a...
Images
Figure 4-10
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS Figure 4-10 COMPOUND DYSPLASTIC NEVUS Melanocytes are dispersed as solitary units and small nests at the dermoepidermal junction. Most melanocyte nuclei are larger than basilar keratinocyte nuclei. Some of the melanocytes display irregular nuclear contours More about this image found in COMPOUND DYSPLASTIC NEVUS Melanocytes are dispersed as solitary units and ...
Images
Figure 4-11
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES Figure 4-11 COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound dysplastic nevus (hematoxylin and eosin [H&E]-stain). B: Immunostain for PRAME. Most nuclei of junctional melanocytes (long arrow More about this image found in COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound...
Images
Figure 10-9
Published: 01 February 2024
COMBINED BAP1-INACTIVATED COMPOUND NEVUS WITH FEATURES OF A DYSPLASTIC NEVUS Figure 10-9 COMBINED BAP1-INACTIVATED COMPOUND NEVUS WITH FEATURES OF A DYSPLASTIC NEVUS A: The compound melanocytic proliferation is predominantly composed of small epithelioid melanocytes (arrows). Junctional nests More about this image found in COMBINED BAP1-INACTIVATED COMPOUND NEVUS WITH FEATURES OF A DYSPLASTIC NEVU...