MUCINOUS CYSTIC NEOPLASM WITH HIGH-GRADE DYSPLASIA AND ASSOCIATED INVASIVE CARCINOMA Figure 5-5 MUCINOUS CYSTIC NEOPLASM WITH HIGH-GRADE DYSPLASIA AND ASSOCIATED INVASIVE CARCINOMA A: Some cysts have a smooth lining but others contain fleshy mural nodules. B: An exophytic solid component is conf... More

MUCINOUS CYSTIC NEOPLASM WITH LOW- AND HIGH-GRADE DYSPLASIA Figure 5-8 MUCINOUS CYSTIC NEOPLASM WITH LOW- AND HIGH-GRADE DYSPLASIA A: Some cysts are lined by predominantly flat mucinous epithelium with only basal nuclear pseudostratification. B,C: Elsewhere the papillae are more prominent (B) an... More

MUCINOUS CYSTIC NEOPLASM Figure 5-9 MUCINOUS CYSTIC NEOPLASM A: In areas with low-grade dysplasia, the epithelium contains abundant apical mucinous cytoplasm and the nuclei are predominantly basally located and uniform. B: A few cells show loss of nuclear polarity. C: Full-thickness nuclear pse... More

MUCINOUS CYSTIC NEOPLASM Figure 5-10 MUCINOUS CYSTIC NEOPLASM Some locules have low-grade dysplasia (left), while adjacent locules have high-grade dysplasia (right). More

MUCINOUS CYSTIC NEOPLASM WITH LOW-GRADE DYSPLASIA Figure 5-28 MUCINOUS CYSTIC NEOPLASM WITH LOW-GRADE DYSPLASIA Low-grade mucinous epithelium with mild nuclear disorganization (Diff Quik stain). More

MUCINOUS CYSTIC NEOPLASM WITH HIGH-GRADE DYSPLASIA Figure 5-29 MUCINOUS CYSTIC NEOPLASM WITH HIGH-GRADE DYSPLASIA Cytologically, high-grade dysplasia is identical to adenocarcinoma (Thinprep). More

MUCINOUS CYSTIC NEOPLASM WITH HIGH-GRADE DYSPLASIA Figure 5-30 MUCINOUS CYSTIC NEOPLASM WITH HIGH-GRADE DYSPLASIA Necrosis in a mucinous cystic neoplasm with high-grade dysplasia (Thinprep). More

INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH LOW-GRADE DYSPLASIA Figure 6-20 INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH LOW-GRADE DYSPLASIA Tall columnar mucinous epithelium lines the papillae. In low-grade dysplasia, the nuclei are minimally to moderately atypical. They can be entirely basal p... More

INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH HIGH-GRADE DYSPLASIA Figure 6-21 INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH HIGH-GRADE DYSPLASIA A: High-grade dysplasia is associated with both cytologic atypia and architectural complexity, such as micropapillae with complete lack of epithelial pol... More

INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH HIGH-GRADE DYSPLASIA Figure 6-22 INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH HIGH-GRADE DYSPLASIA Regions with high-grade dysplasia (left) can occur in an IPMN pre dominantly showing low-grade dysplasia (right). More

GASTRIC-TYPE INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM Figure 6-25 GASTRIC-TYPE INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM A: Simple columnar epithelial cells have slightly eosinophilic cytoplasm and low-grade dysplasia. Papilla formation is limited. The underlying stroma contains pyloric-like glands.... More

MUCINOUS CYSTIC NEOPLASM Figure 5-3 MUCINOUS CYSTIC NEOPLASM Unilocular cyst with a solid mural nodule (top left), representing an area with high-grade dysplasia and associated invasive carcinoma. More

DUCTAL ADENOCARCINOMA Figure 7-12 DUCTAL ADENOCARCINOMA Cancerization of a preexisting duct. Note the adjacent invasive carcinoma (left, arrows) and the abrupt transition from normal epithelium (right, top) to neoplastic epithelium with significant dysplasia (right). More

PANCREATOBILIARY-TYPE INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM Figure 6-24 PANCREATOBILIARY-TYPE INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM A: Cuboidal epithelial cells form complex arborizing papillae with round, markedly atypical nuclei. B: Minimal intracellular mucin is evident. C: Columnar epit... More

SQUAMOUS INTRAEPITHELIAL LESION, DIFFICULT TO GRADE Figure 5-17 SQUAMOUS INTRAEPITHELIAL LESION, DIFFICULT TO GRADE This vulvar lesion, formerly with in the spectrum of the so-called “bowenoid dysplasia”, contains a cellular population of keratinocytes with apoptosis that suggests a high-grade le... More