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CARCINOID DISEASE AND <span class="search-highlight">DRUG</span> VALVULOPATHY  Left: Carcinoid disease thickens a...
Published: 15 November 2023
CARCINOID DISEASE AND DRUG VALVULOPATHY Figure 10-19 CARCINOID DISEASE AND DRUG VALVULOPATHY Left: Carcinoid disease thickens and distorts the right-sided valves by plaque forming on valve surfaces. Right: Ergot-induced mitral stenosis looks similar to carcinoid disease grossly, with extensive t... More about this image found in CARCINOID DISEASE AND DRUG VALVULOPATHY Left: Carcinoid disease thickens a...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-10
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... levels, drugs (including antidepressants, antipsychotics, and marijuana, among others) ( 3 , 4 ). Most cases, however, have no known underlying etiologic factors ( 5 ). Imaging studies demonstrate a retroareolar area of dense tissue ( 6 ). Gross Findings. There are no specific gross findings associated...
Images
NONTHROMBOEMBOLIC PULMONARY EMBOLI  A: Metastatic breast carcinoma.  B: Fat...
Published: 15 November 2023
NONTHROMBOEMBOLIC PULMONARY EMBOLI Figure 32-21 NONTHROMBOEMBOLIC PULMONARY EMBOLI A: Metastatic breast carcinoma. B: Fat, following hip fracture (oil-red O staining). C: Microcrystalline cellulose in drug abuse. D: Pulmonary schistosomiasis with ova present within the pulmonary artery (elasti... More about this image found in NONTHROMBOEMBOLIC PULMONARY EMBOLI A: Metastatic breast carcinoma. B: Fat...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... bed (upper left of field). B: High power shows the small dark nuclei of the histiocytes and the abundant foamy cytoplasm. In the presence of residual carcinoma, there may be a greater degree of nuclear pleomorphism than was present in the original tumor due to the effect of the drugs on tumor cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of tumor cells with incomplete, barely perceptible membrane staining; “HER2 ultralow”) demonstrate any response to these newer drug antibody conjugate therapies ( 47e ). HER2 in situ hybridization, either fluorescent or chromogenic (FISH or CISH) testing, may utilize either a single or dual probe assay...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch30
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... with rheumatologic diseases, drug reactions Anti-GBM disease Small vessels Pulmonary hemorrhage with minimal inflammation of capillaries, glomerulonephritis Immunofluorescence required for diagnosis Cryoglobulinemic vasculitis Small vessels Small vessel inflammation, fibrinoid necrosis not invariable...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch23
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... 23-3 RECREATIONAL DRUGS ASSOCIATED WITH MYOCARDIAL INJURY Drug Cardiotoxicity Amphetamines, cocaine, and ecstasy (3,4-Methylendixoymethamphetamine) Sympathetic activation Catecholamine depletion Direct myocytotoxicity Lysergic acid diethylamide Tachycardia, vasospasm...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch10
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... to pulmonary regurgitation in left-sided heart failure. CARCINOID DISEASE AND DRUG VALVULOPATHY Figure 10-19 CARCINOID DISEASE AND DRUG VALVULOPATHY Left: Carcinoid disease thickens and distorts the right-sided valves by plaque forming on valve surfaces. Right: Ergot-induced mitral stenosis looks similar...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch22
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... Viral infection Hypersensitivity (including drug) reaction Autoimmune (collagen/vascular) disorder Helminth infection Drug reaction Hypereosinophilic syndrome Spirochete sp infection Mycoplasma sp infection Rickettsial sp infection Allergy/asthma Giant...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch12
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 12-1 RISK FACTORS FOR INFECTIVE ENDOCARDITIS Male sex Age >60 years Intravenous drug use Structural heart disease Poor dental hygiene Prosthetic cardiac device or leads Intravascular device Malignancy Immunosuppression Chronic hemodialysis Table 12-2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch32
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...) Pulmonary schistosomiasis Drugs (appetite suppressants, amphetamines) Denatured rapeseed oil (toxic oil syndrome) Table 32-3 CAUSES OF HYPOXIC PULMONARY HYPERTENSION High altitude Chronic upper airway obstruction  Sleep apnea  Enlarged tonsils Kyphoscoliosis Muscular dystrophy...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch27
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... or refute IgG4-related disease as an etiology. The clinical findings of pericardial IgG4-related processes are supportive of the diagnosis ( 63 , 64 ). Pericarditis with significant numbers of eosinophils is rare. Their presence is suggestive of an underlying drug reaction, parasitic infection...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch21
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... protein accumulation. Radionuclide bone scintigraphy with technetium-labeled bisphosphonates (99mTc-labeled pyrophosphate [PYP]) is sensitive and specific for identifying ATTR-type amyloidosis, although false positive results occur with drug toxicities, including hydroxychloroquine ( 38...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch29
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... of cardiovascular disease risk than diastolic blood pressure ( 48 ). The pathogenesis of hypertension is variable. Occasionally, anatomic lesions (such as renal artery stenosis or aortic coarctation) account for the findings of hypertension. Additionally, medications or drugs may play a role in the development...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch18
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... percent complete recovery rate in a population without frequent comorbidities. However, a more recent study with an expanded view of stress cardiomyopathy revealed that nearly 90 percent of patients may have some permanent decline in ejection fraction ( 27 ). In a large clinical series, an inotropic drug...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch26
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...% Tuberculosis <1% Drug induced <1% Asbestosis <1% Other 6% a Data from references 3 and 23 . PERICARDIAL CONSTRICTION Figure 26-2 PERICARDIAL CONSTRICTION Both specimens were resected from patients with hemodynamic constriction, but only the top specimen exhibits thickening...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch25
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
..., for example, ion channel disease, or by an arrhythmogenic focus located in the ventricles caused by underlying myocardial disease. Metabolic factors (especially acidosis and alterations in serum electrolytes) and drugs may lower the arrhythmogenic threshold for arrhythmogenic foci. In virtually all cases...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch14
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... developed. Drugs that are aimed at mitigating additional fibrosis, targeting the angiotensin II-galectin-3-IL-6 axis, are employed. Even with optimum therapy, however, it is common for patients to progress, even if therapy has altered the trajectory of the disease. Ultimately, many DCM patients still...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch16
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... hypereosinophilic syndrome Secondary  Infectious disease  Allergy/asthma  Autoimmune disorders, especially eosinophilic granulomatosis with polyangiitis  Toxins/drugs  Metabolic  Nonhematopoietic neoplasms a Primary, secondary per World Health Organization (WHO) classification. PRIMARY...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch20
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 20-1 CAUSES OF SYSTEMIC HYPERTENSION Primary hypertension Secondary hypertension Chronic kidney disease Renal artery stenosis Hyperaldosteronism Drugs Cushing syndrome Aortic coarctation Pheochromocytoma Hypothyroidism Obstructive sleep apnea Primary...