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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... intratumoral heterogeneity, with double- or triple-positive hybrid cells, especially occurring in cases with cortisol co-secretion ( 57 ). 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) immunoreactivity is more abundant than type 1 (HSD3B1) in aldosterone-producing adenomas, but the status of HSD3B1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... is unusually slow compared to many other neoplasms. The median volume doubling times have been calculated as 5.44 years for head and neck paragangliomas, 6.94 years for abdominal paragangliomas, and 11.8 years for thoracic paragangliomas with succinate dehydrogenase mutations in one recent study ( 65...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...   A , et al . Characteristics of adrenocortical carcinoma associated with Lynch syndrome . J Clin Endocrinol Metab   2021 ; 106 : 318 - 25 . 93. Raygada   M , Raffeld   M , Bernstein   A , et al . Case report of adrenocortical carcinoma associated with double germline mutations in MSH2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-genome doubling. The second class includes high-risk ACC cases with frequent TP53 and Wnt pathway gene mutations, an expression pattern often associated with worse outcome, CIMP-high phenotype, and numerous nonrecurrent alterations with potential whole-genome doubling. This integrated approach...
Images
<em>PNEUMOCYSTIS</em> SPP ON A CYTOLOGY SPECIMEN  The characteristi...
Published: 01 September 2024
PNEUMOCYSTIS SPP ON A CYTOLOGY SPECIMEN Figure 21-25 PNEUMOCYSTIS SPP ON A CYTOLOGY SPECIMEN The characteristic cyst morphology and multiple intracytoplasmic double dots are seen. More about this image found in PNEUMOCYSTIS SPP ON A CYTOLOGY SPECIMEN The characteristi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-06
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...HUMAN HERPESVIRUS 1, 2, AND 3 INFECTIONS General Considerations, Including Etiology and Synonyms Human herpesviruses (HHV) 1, 2, and 3 are neurotropic double-stranded DNA viruses of the alpha Herpesviridae family, which most frequently infect the skin but can also affect...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-19
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... the separating wall (which is typically double the thickness) ( fig. 19-7 ) ( 3 ). DISSEMINATED TALAROMYCES MARNEFFEI INFECTION Figure 19-6 DISSEMINATED TALAROMYCES MARNEFFEI INFECTION A: The gut in an immunocompromised individual shows a histiocytic infiltrate with multiple intracellular...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-30
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... infections globally in individuals aged 15 to 49 years, with a prevalence of 5.3 percent in women worldwide ( 2 ). Some estimates put the global annual incidence at almost double, however, with almost 90 percent of infections occurring in people living in resource-limited settings ( 3 ). This is because many...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... (HHV4), is a lymphotropic, enveloped, double-stranded DNA virus belonging to the Herpesviridae family and Gammaherpesvirinae subfamily. It is considered the most frequent cause of infectious mononucleosis. The virus remains latent in B lymphocytes lifelong after primary infection and has...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Paracoccidioides spp, including enzyme immunoassays, double immunodiffusion, counterimmunoelectrophoresis, and immunoblots ( 39 ). The serologic tests are primarily laboratory-developed tests and there is thus high variability between them. These methods are also used to follow-up patients during therapy...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...) are icosahedral, nonenveloped, double-stranded, linear DNA viruses that measure 60 to 90 nm. They are named after adenoid tissue, the surgical specimen in which they were first discovered by Rowe et al. in 1953 ( 32 ). To date, more than 80 human AdV types have been identified by means of both serology and whole...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... viruses that can infect the skin and mucous membranes of a wide variety of mammals and other animals. Each virus type and subtype is species specific; the family Papillomaviridae currently consists of 39 genera ( 34 ). Human papillomaviruses (HPV) are nonenveloped, double-stranded, circular DNA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-05
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... <5 years) Acute self-limited hepatitis (more frequent in older children/adults) Fulminant acute hepatitis with liver failure Severer course in those with HBV or HCV infection Recurrent disease in up to 20% Supportive Hepatitis B (HBV) Hepadnaviridae Partially double-stranded DNA 42 nm...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... diagnosis of human brucellosis . Int J Antimicrob Agents   2010 ; 36 ( Suppl 1 ): S12 - 7 . 10. Solera   J , Geijo   P , Largo   J , et al . A randomized, double-blind study to assess the optimal duration of doxycycline treatment for human brucellosis . Clin Infect Dis   2004 ; 39 : 1776...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Considerations, Including Etiology and Synonyms Progressive multifocal leukoencephalopathy (PML) is a rare brain infection caused by JC virus, a double-stranded DNA polyomavirus that affects immunosuppressed individuals. JC virus is genetically related to BK virus and simian virus 40 (SV40). PML...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... whipplei PCR testing is used in problematic cases and in localized disease, where duodenal biopsy material is not available. Although the organism was recently successfully propagated in culture, it has a long doubling time and this methodology is thus mostly of value in epidemiologic studies. Prevention...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Right angle Acute angle No branching Depends on the fungus; can be acute or right angle Septation Absent Absent Division by fission may lead to separation of bacteria by a double cell wall Present; pauciseptate or septate, depending on organism Gram stain Positive, beaded Positive, beaded...
Images
MYXOMATOUS MITRAL VALVE DISEASE  The spongy layer (<span class="search-highlight">double</span>-headed arrow) is ...
Published: 15 November 2023
MYXOMATOUS MITRAL VALVE DISEASE Figure 10-8 MYXOMATOUS MITRAL VALVE DISEASE The spongy layer (double-headed arrow) is expanded so that it is thicker than the two adjacent fibrous layers combined, along with focal extension of the spongy tissue into the fibrosa (ventricularis) (black arrowhead). (... More about this image found in MYXOMATOUS MITRAL VALVE DISEASE The spongy layer (double-headed arrow) is ...
Images
MYXOMATOUS AORTIC VALVE DISEASE  The spongy layer is expanded (<span class="search-highlight">double</span>-heade...
Published: 15 November 2023
MYXOMATOUS AORTIC VALVE DISEASE Figure 10-9 MYXOMATOUS AORTIC VALVE DISEASE The spongy layer is expanded (double-headed arrow) and thicker than the two adjacent fibrous layers combined. The spongy tissue extends focally into the fibrosa (ventricularis) (black arrowhead), seen with Verhoeff-van Gi... More about this image found in MYXOMATOUS AORTIC VALVE DISEASE The spongy layer is expanded (double-heade...
Images
LEFT VENTRICULAR NONCOMPACTION  The trabeculated layer (<span class="search-highlight">double</span>-headed yello...
Published: 15 November 2023
LEFT VENTRICULAR NONCOMPACTION Figure 19-6 LEFT VENTRICULAR NONCOMPACTION The trabeculated layer (double-headed yellow arrow) is more than twice as thick as the compact layer (double-headed white arrow). Although a nonspecific finding, noncompaction can be seen in the setting of mitochondrial car... More about this image found in LEFT VENTRICULAR NONCOMPACTION The trabeculated layer (double-headed yello...