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Book Chapter

Oral Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
...-differentiated squamous epithelium. D: Neutrophilic abscesses are associated with the keratin (arrow) and stromal inflammation. ORAL POTENTIALLY MALIGNANT DISORDERS AND ORAL EPITHELIAL DYSPLASIA Definition.  Oral epithelial dysplasia (OED) refers to abnormal architectural and cytologic changes...
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Book Chapter

Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
...) is a non-neoplastic inflammatory degenerative process of the external ear characterized by necrobiotic changes in the dermis and perichondrium, with associated alterations in the cartilaginous plate ( 60 , 61 ). It does not seem that the cartilage is the primary source of the disorder, since similar...
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Book Chapter

Neck

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... by tissue sampling such as by FNA. While a detailed discussion of the cytologic evaluation of lymphomas is complex and well beyond the scope of this chapter, some general comments can be made. Among the most common causes of cervical lymphadenopathy raising concern for a lymphoproliferative disorder...
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Book Chapter

Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... features in the form of lymphovascular invasion, perineural invasion, atypical mitoses, pleomorphism, desmoplastic stromal reaction, bone invasion, architectural disorder, tumor necrosis, and increased mitoses (over 25/2 mm2) ( 52 ). If only areas of carcinoma in situ are detected in a papilloma...
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Book Chapter

Nasopharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
..., cytogenetic analysis, and review of the literature . BMC Ear Nose Throat Disord   2008 ; 8 : 8 . 123. Mogensen   MA , Lin   AC , Chang   KW , Berry   GJ , Barnes   PD , Fischbein   NJ . Salivary gland anlage tumor in a neonate presenting with respiratory distress: radiographic...
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Book Chapter

Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... and neck region affected by rheumatoid arthritis is the larynx ( 26 ). Approximately 20 to 25 percent of patients with rheumatoid arthritis develop rheumatoid nodules, including those affecting the larynx, leading to disorders of arytenoid movement as well as other aspects of laryngeal function ( 27 , 28...
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Images
Figure 3-1

CUSHING SYNDROME The clinical features of this disorder (left) can be caus...

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in Clinicopathologic Features of the Adrenal Cortex > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
CUSHING SYNDROME Figure 3-1 CUSHING SYNDROME The clinical features of this disorder (left) can be caused by pituitary adrenocorticotropic hormone (ACTH) excess (top right), ectopic ACTH causing massive adrenal hyperplasia (right middle), or primary adrenal disease (bottom right). (From Netter FH More about this image found in CUSHING SYNDROME The clinical features of this disorder (left) can be caus...
Book Chapter

Congenital Disorders of the Adrenal Gland

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., or assessment of donor organs for transplantation. In other situations, an underlying genetic disorder affecting hormone synthesis may alter adrenal anatomy or a functional tumor may arise in ectopic or malformed adrenal tissue. ADRENAL ADHESION, UNION, AND FUSION Adrenal adhesion and adrenal...
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Book Chapter

Clinicopathologic Features of the Adrenal Cortex

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... features underpinning these conditions, with a critical role in the multidisciplinary team ( 1 ). CUSHING SYNDROME Cushing syndrome is a systemic disorder originally described by Harvey Cushing in 1932 ( 2 ) and caused by excess glucocorticoids that result in alterations in the structure...
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Book Chapter

Familial and Syndrome-Related Pheochromocytoma and Paraganglioma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ). The genetic alterations are most often hereditary, giving rise to familial disease that can involve only PPGL formation, but usually is associated with other disorders. Some are nonhereditary disorders that cause syndromic manifestations. At least 20 genes have been implicated in familial disorders...
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Book Chapter

Other Adrenal Neoplasms and Tumor-Like Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... adrenal calcifications have also been seen in metabolic diseases, including Wolman disease, a rare autosomal recessive disorder of lipid metabolism caused by deficiency of lysosomal acid lipase ( 12b , 12c ), and adenosine deaminase-deficient severe combined immunodeficiency. PRIMARY NONENDOCRINE TUMORS...
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Book Chapter

Adrenal Cortical Nodular Diseases

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... on studies of nonfunctioning lesions larger than 1 cm, thus simulating an adrenal cortical adenoma. Currently, this disorder is usually detected as an incidental finding on high-resolution CT scan, magnetic resonance imaging (MRI), or during ultrasound examination for an unrelated problem or during...
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Book Chapter

Hereditary Predisposition to Adrenal Cortical Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of the nonhereditary McCune-Albright syndrome, a germline disorder caused by postzygotic somatic GNAS mutation mosaicism ( 1 ). Heterozygous germline mutations of the armadillo repeat containing 5 (ARMC5) gene are the most frequent molecular alterations associated with hypercortisolism caused...
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Book Chapter

Adrenal Cortical Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and a sensitivity of 86 percent have been reported in diagnosing adrenal masses ( 208 ), the major role of preoperative diagnosis in adrenal lesions is to diagnose adrenal metastases of a known primary, to confirm a clinical suspicion of a hematologic disorder, or to exclude non-neoplastic conditions...
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Book Chapter

Pheochromocytoma and Adrenal Medullary Hyperplasia

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... is most often due to germline disorders and reflects a spectrum from hyperplasia to neoplasia. To this point, molecular studies in patients with MEN2 have shown genetic abnormalities in both diffuse and nodular “hyperplasia” that were identical to those in pheochromocytoma ( 118 ). Adrenal medullary...
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Book Chapter

Physiology, Development, and Anatomy of the Adrenal Glands

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... age group. They have been reported with increased frequency in patients with chronic neurologic disorders such as Parkinson disease ( 59 ), and are common with some pheochromocytomas. INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Figure 1-40 INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL...
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Book Chapter

Adrenal Cortical Adenoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-secreting adrenal adenoma in a postmenopausal elderly woman . BMC Endocr Disord   2019 ; 19 : 14 . 24. Fassnacht   M , Tsagarakis   S , Terzolo   M , et al . European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration...
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Images
Figure 17-5

BARTONELLA-ASSOCIATED PELIOSIS In the liver (A) and bone ...

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in Lymph Nodes and Bone Marrow > Pathology of Non-Helminth Infectious Diseases
Published: 01 September 2024
BARTONELLA-ASSOCIATED PELIOSIS Figure 17-5 BARTONELLA-ASSOCIATED PELIOSIS In the liver (A) and bone marrow (B) characteristic randomly distributed and cystic, blood-filled cavities are seen, which typify this disorder. Warthin-Starry silver stain (C) demonstrates numerous More about this image found in BARTONELLA-ASSOCIATED PELIOSIS In the liver (A) and bone ...
Book Chapter

Prion Diseases

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-02
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... as a spongiform encephalopathy. Table 2-1 outlines the epidemiology of the different human prion diseases ( 3 , 4 ). Animal prion disorders include scrapie in goats and sheep, bovine spongiform encephalopathy (BSE, also known as “mad cow disease”) in cattle, chronic wasting disease in deer, and spongiform...
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Book Chapter

Lymph Nodes and Bone Marrow

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...), with EBV-encoded small RNA (EBER) Highly immunogenic, triggering a strong T-cell response In immune suppressed individuals: post-transplant lymphoproliferative disorder (PTLD), diffuse large B-cell lymphoma II EBNA1 and LMP1, 2, with EBERs Intermediate between latency type III and I EBV-positive...
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