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TREATED GRAVES <span class="search-highlight">DISEASE</span>  The morphologic findings in treated Graves <span class="search-highlight">disease</span> ...
Published: 01 November 2022
TREATED GRAVES DISEASE Figure 3-28 TREATED GRAVES DISEASE The morphologic findings in treated Graves disease are highly variable and dependent on both the duration of therapy and the type of treatment. A: In most cases, the follicles maintain their irregular contours, but with less marked colloi... More
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MULTIGLANDULAR PARATHYROID <span class="search-highlight">DISEASE</span> IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (...
Published: 01 November 2022
MULTIGLANDULAR PARATHYROID DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN1) Figure 2-3 MULTIGLANDULAR PARATHYROID DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN1) Hyperparathyroidism is the most common manifestation of MEN1. The parathyroid glands can have a diffuse or nodular growth pa... More
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UNTREATED GRAVES <span class="search-highlight">DISEASE</span>  The follicles have convoluted and irregular conto...
Published: 01 November 2022
UNTREATED GRAVES DISEASE Figure 3-26 UNTREATED GRAVES DISEASE The follicles have convoluted and irregular contours. There is extensive colloid scalloping. More
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GRAVES <span class="search-highlight">DISEASE</span>  There may be such marked papillary hyperplasia that the dia...
Published: 01 November 2022
GRAVES DISEASE Figure 3-27 GRAVES DISEASE There may be such marked papillary hyperplasia that the diagnosis of papillary thyroid carcinoma is considered. Careful attention to the nuclear features helps avoid this pitfall. More
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HASHITOXICOSIS  Features of both Graves <span class="search-highlight">disease</span> and Hashimoto thyroiditis, ...
Published: 01 November 2022
HASHITOXICOSIS Figure 3-29 HASHITOXICOSIS Features of both Graves disease and Hashimoto thyroiditis, with lymphoid follicles and germinal centers, are present. More
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SECONDARY PARATHYROID HYPERPLASIA WITH DIFFUSE GROWTH  Secondary parathyroi...
Published: 01 November 2022
SECONDARY PARATHYROID HYPERPLASIA WITH DIFFUSE GROWTH Figure 2-12 SECONDARY PARATHYROID HYPERPLASIA WITH DIFFUSE GROWTH Secondary parathyroid hyperplasia is an increase in parathyroid hormone secretion and an adaptive increase in parathyroid parenchymal mass involving multiple parathyroid glands ... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-3
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... with the activity of the follicles, i.e., active follicles usually have weakly eosinophilic and flocculent colloid while inactive follicles tend to have more eosinophilic colloid ( fig. 3-3 ). Birefringent calcium oxalate crystals are often found in the colloid of normal or diseased thyroid glands ( 17 ). NORMAL...
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HYPERCELLULAR PARATHYROID GLAND: CYSTIC CHANGE  The parathyroid glands can ...
Published: 01 November 2022
HYPERCELLULAR PARATHYROID GLAND: CYSTIC CHANGE Figure 2-8 HYPERCELLULAR PARATHYROID GLAND: CYSTIC CHANGE The parathyroid glands can show hemorrhage and cystic change, particularly in larger glands and in those with hyperparathyroidism-jaw tumor–associated disease more so than sporadic hyperparath... More
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ISLET CELL HYPERPLASIA IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN1)  Islet...
Published: 01 November 2022
ISLET CELL HYPERPLASIA IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN1) Figure 5-7 ISLET CELL HYPERPLASIA IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN1) Islet cell hyperplasia is seen in MEN1 and von Hippel-Lindau disease. (Left: H&E; right: chromogranin immunohistochemistry.) More
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ONCOCYTIC/OXYPHILIC PARATHYROID PARENCHYMAL CELLS  Oncocytic/oxyphilic para...
Published: 01 November 2022
ONCOCYTIC/OXYPHILIC PARATHYROID PARENCHYMAL CELLS Figure 2-2 ONCOCYTIC/OXYPHILIC PARATHYROID PARENCHYMAL CELLS Oncocytic/oxyphilic parathyroid parenchymal cells are not present in young children. These cells become apparent with increasing age. In older patients, oncocytic/oxyphil parathyroid par... More
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SECONDARY PARATHYROID HYPERPLASIA  Although the parathyroid glands in secon...
Published: 01 November 2022
SECONDARY PARATHYROID HYPERPLASIA Figure 2-13 SECONDARY PARATHYROID HYPERPLASIA Although the parathyroid glands in secondary hyperparathyroidism may show diffuse growth early in disease, they become more nodular over time. A,B: Nodular growth of secondary parathyroid hyperplasia. C,D: Hypercell... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... such as Parkinson disease ( 20 ). NORMAL ADRENAL MEDULLA Figure 4-7 NORMAL ADRENAL MEDULLA Left: The central adrenal vein in the medulla has a thick wall of smooth muscle. Right: The smooth muscle wall surrounding the central adrenal vein is characteristically incomplete in areas. NORMAL ADRENAL MEDULLA Figure...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... of cases of primary or secondary hyperparathyroidism ( 2 , 3 ). In addition to parathyroid autografts, ectopic or supranumerary parathyroid glands are a cause of persistent hyperparathyroidism in secondary hyperparathyroidism associated with renal disease ( 4 – 6 ). Ectopic parathyroid glands have been...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... common reactive changes are pituitary cell hyperplasias, such as those seen in Addison disease and Schmidt syndrome ( 76 , 77 ). This is discussed later in the chapter. Most of the anterior pituitary cells producing trophic hormones directed at specific organs can be affected via a direct feedback effect...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-5
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... more strongly than parathyroid oxyphil cells; normal rims of parathyroid tissue may stain more intensely than parathyroid adenomas ( 79 ). The distribution and functions of granin-derived peptides is of increasing interest in physiology and medicine, and these peptides have been studied as disease...
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ROSAI-DORFMAN <span class="search-highlight">DISEASE</span>  The parenchyma is replaced by yellow, bulging tissue...
Published: 01 August 2022
ROSAI-DORFMAN DISEASE Figure 11-65 ROSAI-DORFMAN DISEASE The parenchyma is replaced by yellow, bulging tissue but retains the lobular configuration of the testis. (Fig. 1 from Azoury FJ, Reed RJ. Histiocytosis: report of an unusual case. N Engl J Med 1966;274:928-30.) (Courtesy of Dr. R. J. Reed,... More
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ROSAI-DORFMAN <span class="search-highlight">DISEASE</span>  Left: Large, eosinophilic histiocytic cells and lymp...
Published: 01 August 2022
ROSAI-DORFMAN DISEASE Figure 11-66 ROSAI-DORFMAN DISEASE Left: Large, eosinophilic histiocytic cells and lymphocytes infiltrate between atrophic seminiferous tubules. Right: The characteristic emperipolesis is seen at higher magnification (arrow). (Figs. 1E and 1F from Wang CC, Al-Hussain TO, Se... More
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ROSAI-DORFMAN <span class="search-highlight">DISEASE</span>  The large histiocytic cells are positive for S-100 p...
Published: 01 August 2022
ROSAI-DORFMAN DISEASE Figure 11-67 ROSAI-DORFMAN DISEASE The large histiocytic cells are positive for S-100 protein. (Fig. 2A from Wang CC, Al-Hussain TO, Serrano-Olmo J, Epstein JI. Rosai-Dorfman disease of the genito-urinary tract: analysis of six cases from the testis and kidney. Histopatholog... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-03
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...  Rete testis hyperplasia and other non-neoplastic rete lesions  Steroid cell nodular hyperplasia associated with adreno-genital syndrome (TTAGS), Nelson syndrome, and other disorders (Carney complex)  Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy)  Reactive fibrous...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-09
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... ). Bilateral testicular involvement ( fig. 9-1 ) occurs in about 15 percent of cases ( 32 ). Clinical staging, using the Ann Arbor system, shows 70 to 88 percent of cases in stages I and II ( 32 , 36 , 37 ). “B” symptoms correlate with advanced clinical stage disease ( 36 ). DIFFUSE LARGE B-CELL LYMPHOMA...