IMMUNOHISTOCHEMICAL STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASE Figure 1-4 IMMUNOHISTOCHEMICAL STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASE H&E (A–C) stains of colonic ulceration reveal scattered large atypical cells in the ulcer base. Cytomegalovirus (CMV) immunoperoxidase stain (D) s... More about this image found in IMMUNOHISTOCHEMICAL STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASE H&...

MAGNETIC RESONANCE IMAGE OF PATIENT WITH PRION DISEASE Figure 2-1 MAGNETIC RESONANCE IMAGE OF PATIENT WITH PRION DISEASE Magnetic resonance imaging (MRI) typically shows abnormal signal in the putamen and head of the caudate (arrows). More about this image found in MAGNETIC RESONANCE IMAGE OF PATIENT WITH PRION DISEASE Magnetic resonance ...

CREUTZFELDT-JAKOB DISEASE Figure 2-2 CREUTZFELDT-JAKOB DISEASE Whole brain specimen shows prominent cerebral and cerebellar atrophy. More about this image found in CREUTZFELDT-JAKOB DISEASE Whole brain specimen shows prominent cerebral an...

SPONGIFORM CHANGE IN CREUTZFELDT-JAKOB DISEASE Figure 2-3 SPONGIFORM CHANGE IN CREUTZFELDT-JAKOB DISEASE Striking spongiform change seen at low (A) and medium (B) power, with characteristic absence of associated inflammation. (Courtesy of Dr. R. McLendon, Duke University, Durham, NC) More about this image found in SPONGIFORM CHANGE IN CREUTZFELDT-JAKOB DISEASE Striking spongiform change ...

MICROVACUOLAR CHANGE IN KURU AND CREUTZFELDT-JAKOB DISEASE Figure 2-4 MICROVACUOLAR CHANGE IN KURU AND CREUTZFELDT-JAKOB DISEASE A: Brain tissue in kuru shows cerebellar atrophy, with neuronal loss and spongiform change. (Courtesy of Dr. J. Arango, University of Antioquia, Medellín, Colombia) B:... More about this image found in MICROVACUOLAR CHANGE IN KURU AND CREUTZFELDT-JAKOB DISEASE A: Brain tissue...

CREUTZFELDT-JAKOB DISEASE Figure 2-5 CREUTZFELDT-JAKOB DISEASE Microscopic vacuoles (A) intruding on neurons and their nuclei, with neuronal degeneration (B). (Courtesy of Dr. R. McLendon, Duke University, Durham, NC) More about this image found in CREUTZFELDT-JAKOB DISEASE Microscopic vacuoles (A) intruding on neurons an...

IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE Figure 2-7 IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE A: Positive amyloid plaque on immunohistochemical staining. (Courtesy of the Armed Forces Institute of Pathology) B: Synaptic pattern of PrP^SC immunohistochemical staining. More about this image found in IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE A: Positive amylo...

ZIKA CONGENITAL SYNDROME Figure 3-4 ZIKA CONGENITAL SYNDROME Microcephaly can be associated with this disease. (Courtesy of the CDC Zika Virus Webpage https://www.cdc.gov/zika/czs/index.html ) More about this image found in ZIKA CONGENITAL SYNDROME Microcephaly can be associated with this disease....

NEUROPATHIC FLAVIVIRUS DISEASE PREVENTION Figure 3-8 NEUROPATHIC FLAVIVIRUS DISEASE PREVENTION Inspector examining discarded tires, where stagnant water frequently collects and serves as a breeding place for mosquitos. (Courtesy of the CDC PHIL) More about this image found in NEUROPATHIC FLAVIVIRUS DISEASE PREVENTION Inspector examining discarded ti...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-24 SUBACUTE SCLEROSING PANENCEPHALITIS In late stages of disease, there is meningeal fibrosis and usually scanty mononuclear cells. More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS In late stages of disease, there is me...

POST-TRANSPLANT EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE (PTLD) OF THE MONOMORPHIC TYPE Figure 8-14 POST-TRANSPLANT EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE (PTLD) OF THE MONOMORPHIC TYPE Low-power view (A) plasmacytoma-like features (B) and positivity for EBER ISH (C). (Courtesy of Dr. S. As... More about this image found in POST-TRANSPLANT EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE (PTLD) OF THE MO...

HHV8-ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE IN HIV PATIENT Figure 8-23 HHV8-ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE IN HIV PATIENT A: An intra-abdominal lymph node shows an early germinal center and vascular hyalinization, surrounding concentric rims (“onion-skinning”) of lymphocytes and ass... More about this image found in HHV8-ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE IN HIV PATIENT A: An intra-...

MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Figure 8-24 MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Lymph node in patient with HIV where there is HHV8-associated Kaposi sarcoma (A) and Castleman disease (B). More about this image found in MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Lymph node in patient wi...

HIV CENTRAL NERVOUS SYSTEM DISEASE Figure 9-7 HIV CENTRAL NERVOUS SYSTEM DISEASE A: Brain in HIV-associated dementia syndrome (HAD), with ventricular dilatation and sulcal widening. B: HIV encephalitis shows cortical white matter with multinucleated giant cell encephalitis (MGCE). C: HIV enceph... More about this image found in HIV CENTRAL NERVOUS SYSTEM DISEASE A: Brain in HIV-associated dementia syn...

IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS), CRYPTOCOCCAL DISEASE Figure 9-30 IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS), CRYPTOCOCCAL DISEASE A: Cryptococcal CNS IRIS shows granulomatous meningitis with necrosis and giant cells. B: Grocott stain shows damaged fungal yeasts in gra... More about this image found in IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS), CRYPTOCOCCAL DISEASE A...

LEGIONNAIRES’ DISEASE Figure 12-7 LEGIONNAIRES’ DISEASE X-ray of 2 different patients with bilateral diffuse infiltrates (A,B) due to legionnaires’ disease. (Courtesy of the CDC PHIL) More about this image found in LEGIONNAIRES’ DISEASE X-ray of 2 different patients with bilateral diffuse...

LEGIONNAIRES’ DISEASE Figure 12-8 LEGIONNAIRES’ DISEASE A: Prominent intra-alveolar inflammatory infiltrate with fibrin is seen. (Courtesy of the CDC IDPB) B: High-power view of prominent intra-alveolar macrophages with ingested debris and bacterial organisms. (Courtesy of the CDC PHIL) More about this image found in LEGIONNAIRES’ DISEASE A: Prominent intra-alveolar inflammatory infiltrate ...

LEGIONNAIRES’ DISEASE Figure 12-9 LEGIONNAIRES’ DISEASE The etiologic bacterial organisms are seen with Steiner silver (A) and immunohistochemical (B) stains. (A: courtesy of the CDC IDPB; B: courtesy of the CDC PHIL) More about this image found in LEGIONNAIRES’ DISEASE The etiologic bacterial organisms are seen with Stei...