CUSHING DISEASE Figure 3-3 CUSHING DISEASE Bilateral adrenal hyperplasia is seen by computerized tomography (CT) in a patient with an ACTH-dependent, recurrent ACTH-secreting pituitary tumor. (Courtesy of Prof. A. Veltri and Dr. F. Solitro, San Luigi Hospital, Turin, Italy) More about this image found in CUSHING DISEASE Bilateral adrenal hyperplasia is seen by computerized tomo...

CUSHING DISEASE WITH DIFFUSE AND MICRONODULAR HYPERPLASIA Figure 3-5 CUSHING DISEASE WITH DIFFUSE AND MICRONODULAR HYPERPLASIA Transverse sections of adrenal gland in a patient with pituitary ACTH-dependent hypercortisolism (Cushing disease). The adrenal gland was only mildly enlarged and shows b... More about this image found in CUSHING DISEASE WITH DIFFUSE AND MICRONODULAR HYPERPLASIA Transverse secti...

CUSHING DISEASE Figure 3-7 CUSHING DISEASE Under the trophic influence of ACTH, much of the zona fasciculata is converted to cells with lipid-depleted, compact, eosinophilic cytoplasm. More about this image found in CUSHING DISEASE Under the trophic influence of ACTH, much of the zona fasc...

CUSHING DISEASE Figure 3-8 CUSHING DISEASE Histology of left (upper panels) and right (lower panels) adrenal glands from a patient with a recurrent ACTH-secreting pituitary tumor (same case as fig. 3-3 ). Both glands show a similar morphologic appearance, with a homogeneous increase of cortical ... More about this image found in CUSHING DISEASE Histology of left (upper panels) and right (lower panels) ...

CUSHING DISEASE Figure 3-12 CUSHING DISEASE Bilateral adrenal hyperplasia in a patient with ACTH-secreting pituitary tumor. There is mild and micronodular increase in size in the left (A) and right (B) adrenal glands. The right gland also has a macronodule (over 1 cm). More about this image found in CUSHING DISEASE Bilateral adrenal hyperplasia in a patient with ACTH-secre...

ORIGINAL DESCRIPTION OF ADDISON DISEASE BY THOMAS ADDISON Figure 3-14 ORIGINAL DESCRIPTION OF ADDISON DISEASE BY THOMAS ADDISON A: The liver of H. P., with the diseased supra-renal capsules in situ. B,C: Sections of the diseased supra-renal capsules. (From his monograph, On the Constitutional an... More about this image found in ORIGINAL DESCRIPTION OF ADDISON DISEASE BY THOMAS ADDISON A: The liver of ...

SPORADIC ADRENAL CORTICAL NODULAR DISEASE Figure 4-3 SPORADIC ADRENAL CORTICAL NODULAR DISEASE Multiple homogeneous yellow nodules are visible, with a size ranging from a few millimeters to about 1 cm. More about this image found in SPORADIC ADRENAL CORTICAL NODULAR DISEASE Multiple homogeneous yellow nodu...

SPORADIC ADRENAL CORTICAL NODULAR DISEASE Figure 4-4 SPORADIC ADRENAL CORTICAL NODULAR DISEASE An incidental pigmented macronodule is associated with a few subcentimetric nodules in the adjacent cortex visible on transverse section. More about this image found in SPORADIC ADRENAL CORTICAL NODULAR DISEASE An incidental pigmented macronod...

SPORADIC ADRENAL CORTICAL DISEASE Figure 4-5 SPORADIC ADRENAL CORTICAL DISEASE Diffuse and pseudonodular enlargement of the adrenal gland. More about this image found in SPORADIC ADRENAL CORTICAL DISEASE Diffuse and pseudonodular enlargement of...

SPORADIC ADRENAL CORTICAL DISEASE Figure 4-6 SPORADIC ADRENAL CORTICAL DISEASE Nodular enlargement of the adrenal gland without encapsulation. More about this image found in SPORADIC ADRENAL CORTICAL DISEASE Nodular enlargement of the adrenal gland...

SPORADIC ADRENAL CORTICAL DISEASE Figure 4-7 SPORADIC ADRENAL CORTICAL DISEASE Nodular enlargement of the adrenal gland (less than 1 cm in size). At variance with adrenal cortical adenoma, there is absence of clear demarcation/encapsulation. More about this image found in SPORADIC ADRENAL CORTICAL DISEASE Nodular enlargement of the adrenal gland...

SPORADIC ADRENAL CORTICAL DISEASE Figure 4-8 SPORADIC ADRENAL CORTICAL DISEASE Diffuse and pseudonodular enlargement of the adrenal gland showing a predominant lipid-rich cell component. The adrenal medulla is not altered. More about this image found in SPORADIC ADRENAL CORTICAL DISEASE Diffuse and pseudonodular enlargement of...

SPORADIC ADRENAL CORTICAL DISEASE Figure 4-9 SPORADIC ADRENAL CORTICAL DISEASE Nodular enlargement of the adrenal gland (less than 1 cm) incidentally found in a patient with a large renal cyst. Clear cell features are predominant. A and B show low and high magnifications of the same area, illustr... More about this image found in SPORADIC ADRENAL CORTICAL DISEASE Nodular enlargement of the adrenal gland...

SPORADIC ADRENAL CORTICAL DISEASE Figure 4-10 SPORADIC ADRENAL CORTICAL DISEASE Nodular enlargement of the adrenal gland (less than 1 cm) with predominant oncocytic features and diffuse and intense Melan-A positivity (C) (same cases as in fig. 4-2 ). Oncocytic features are responsible for the at... More about this image found in SPORADIC ADRENAL CORTICAL DISEASE Nodular enlargement of the adrenal gland...

SPORADIC ADRENAL CORTICAL DISEASE WITH PIGMENTATION Figure 4-11 SPORADIC ADRENAL CORTICAL DISEASE WITH PIGMENTATION A: Incidental pigmented nodule has its epicenter in the zona reticularis and expansile borders impinging slightly on the outer cortex and medulla. B: Cortical cells contain a varia... More about this image found in SPORADIC ADRENAL CORTICAL DISEASE WITH PIGMENTATION A: Incidental pigmente...

PRIMARY BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE Figure 4-12 PRIMARY BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE A 43-year-old male patient with marked hypercortisolism. CT scan (different levels shown in A and B) shows bilateral enlargement of the adrenal glands with both a diffuse an... More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE A 43-year-old male...

MACRONODULAR ADRENAL CORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Figure 4-13 MACRONODULAR ADRENAL CORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Multiple macronodules in transverse section, with a thin rim of residual adrenal cortex. More about this image found in MACRONODULAR ADRENAL CORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETIO...

BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE Figure 4-14 BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE Transverse sections of both adrenal glands (shown separately in A and B) show marked thickening and nodularity of the golden yellow cortex. The nodules have ill-defined borders. The medulla... More about this image found in BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE Transverse sections of bot...

PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Figure 4-15 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Irregular extrusions of cortical cells into the periadrenal fat without any encapsulation. More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Irregular extrusions...