CALRETININ IN NORMAL ADRENAL GLAND Figure 1-54 CALRETININ IN NORMAL ADRENAL GLAND Calretinin typically shows diffuse strong expression throughout the cortex (negative medulla at bottom of field). More about this image found in CALRETININ IN NORMAL ADRENAL GLAND Calretinin typically shows diffuse stro...

CUSHING DISEASE WITH DIFFUSE AND MICRONODULAR HYPERPLASIA Figure 3-5 CUSHING DISEASE WITH DIFFUSE AND MICRONODULAR HYPERPLASIA Transverse sections of adrenal gland in a patient with pituitary ACTH-dependent hypercortisolism (Cushing disease). The adrenal gland was only mildly enlarged and shows b... More about this image found in CUSHING DISEASE WITH DIFFUSE AND MICRONODULAR HYPERPLASIA Transverse secti...

ECTOPIC ACTH SYNDROME Figure 3-11 ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia from an adrenal metastasis of an ACTH-secreting lung neuroendocrine tumor. More about this image found in ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia fr...

SPORADIC ADRENAL CORTICAL DISEASE Figure 4-5 SPORADIC ADRENAL CORTICAL DISEASE Diffuse and pseudonodular enlargement of the adrenal gland. More about this image found in SPORADIC ADRENAL CORTICAL DISEASE Diffuse and pseudonodular enlargement of...

SPORADIC ADRENAL CORTICAL DISEASE Figure 4-8 SPORADIC ADRENAL CORTICAL DISEASE Diffuse and pseudonodular enlargement of the adrenal gland showing a predominant lipid-rich cell component. The adrenal medulla is not altered. More about this image found in SPORADIC ADRENAL CORTICAL DISEASE Diffuse and pseudonodular enlargement of...

DIFFUSE ALDOSTERONE-PRODUCING HYPERPLASIA Figure 4-30 DIFFUSE ALDOSTERONE-PRODUCING HYPERPLASIA A continuous zone of hyperplastic zona glomerulosa is present in non-neoplastic adrenal gland. More about this image found in DIFFUSE ALDOSTERONE-PRODUCING HYPERPLASIA A continuous zone of hyperplasti...

ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-51 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Diffuse nonpolarized CYP11B2-positive immunohistochemistry is compared to adjacent cortex devoid of aldosterone-producing cells. More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Diffuse nonpolarized CYP11B...

SF1 IN ADRENAL CORTICAL CARCINOMA Figure 6-30 SF1 IN ADRENAL CORTICAL CARCINOMA Diffuse SF1-positive nuclear staining (A) highlights single neoplastic cells invading the periadrenal adipose tissue (B). More about this image found in SF1 IN ADRENAL CORTICAL CARCINOMA Diffuse SF1-positive nuclear staining (A...

PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-43 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1 (A). Ki-67 index (B) was 5 percent, whereas p53 was expressed in rare nuclei (C). (Same case as figs. 6-40 and 6-41 .) More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1...

ABDOMINAL PARAGANGLIOMA Figure 9-13 ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mutation of the SDHB gene (same specimen as in fig. 9-11 ), has mixed nested and trabecular architecture and is composed of monomorphic cells with slightly eosinophilic cytoplasm. This appearance is often associated with SDHB mutation. B: The strong, diffuse expression of synaptophysin highlights a mixed pattern of nested, trabecular, and diffuse histoarchitecture. C: Immunohistochemical stain for tyrosine hydroxylase shows intratumoral heterogeneity at the functional level, with abrupt transition from strong, diffuse expression to absent expression in a small region of the tumor. D: Immunohistochemical stain for S-100 protein shows heterogeneous distribution of sustentacular cells in adjacent areas of tumor. E: Immunohistochemical stain for glial fibrillary acidic protein (GFAP) shows a small focus of GFAP-positive sustentacular cells in a tumor in which S-100 protein-positive cells were much more numerous. More about this image found in ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mut...

ADRENAL MEDULLARY HYPERPLASIA Figure 8-59 ADRENAL MEDULLARY HYPERPLASIA Adrenal glands from patients with MEN2 (A) and SDHB-related disease (B) show diffuse expansion of the medulla that is much larger than the adrenal cortex on either side. While this is considered to be diffuse hyperplasia, the... More about this image found in ADRENAL MEDULLARY HYPERPLASIA Adrenal glands from patients with MEN2 (A) a...

ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 10-2 ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A: The adrenal gland has diffuse medullary hyperplasia as well as multiple nodules that represent pheochromocytomas. B,C: The nodules of adr... More about this image found in ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A:...

ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A Figure 8-60 ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A A: The adrenal medulla is mildly, diffusely thickened and extends into the alae of the gland. A single grossly discernible nodule (arrow) is the clue to the hereditary disease. ... More about this image found in ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A A: The adrenal medul...

MESENTERIC PARAGANGLIOMA Figure 9-14 MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and clear cells was incidentally discovered in an asymptomatic patient with no other tumors. Fat invasion, poorly defined irregular cell nests, and diffuse growth are putative risk factors f... More about this image found in MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and ...

ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Figure 5-39 ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Deeply eosinophilic large cells in a diffuse pattern of growth with prominent nucleoli. More about this image found in ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Deeply eosinophilic large cells i...

VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING Figure 8-45 VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associated with VHL-related disease; it may be diffuse or focal as in this case. More about this image found in VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associat...

MELAN-A IN ADRENAL CORTICAL CARCINOMA Figure 6-32 MELAN-A IN ADRENAL CORTICAL CARCINOMA Melan-A expression in ACC is usually heterogeneous, either diffuse (A) or focal (B) even within the same lesion. More about this image found in MELAN-A IN ADRENAL CORTICAL CARCINOMA Melan-A expression in ACC is usually...

CHROMOGRANIN A IN NORMAL ADRENAL GLAND Figure 1-56 CHROMOGRANIN A IN NORMAL ADRENAL GLAND Chromaffin cells in the adrenal medulla characteristically show diffuse, intense immunoreactivity for chromogranin A. There is no staining in the adrenal cortex or in perivascular cuffs of cortical tissue wi... More about this image found in CHROMOGRANIN A IN NORMAL ADRENAL GLAND Chromaffin cells in the adrenal med...

ADRENAL INVOLVEMENT BY LYMPHOMA Figure 12-28 ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, replaces much of the adrenal gland, with only a few small nests of pale-staining cortical cells present in this field. B: Immunostain for CD20 is diffusely positive. More about this image found in ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, rep...

PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS Figure 8-39 PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS A: Antibodies to S-100 protein show strong nuclear and cytoplasmic positivity in sustentacular cells, identified easily even if the tumor cells also show diffuse reactivity. B: The nuclei of sustentacular cel... More about this image found in PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS A: Antibodies to S-100 protein show ...