ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA Figure 5-31 ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA A diagnosis of adrenal cortical carcinoma was suspected because of the presence of predominant oncocyti... More about this image found in ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOM...

UNDIFFERENTIATED NEUROBLASTOMA Figure 11-12 UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuroblasts form solid sheets. Patterns such as this may cause confusion with other childhood neoplasms such as malignant lymphoma. Most nuclei have a single, small nucleolus. The tumo... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuro...

DIFFERENTIATING NEUROBLASTOMA Figure 11-14 DIFFERENTIATING NEUROBLASTOMA This tumor shows areas of ganglion cell differentiation, which are still in an immature neuropil matrix, flanked by areas of schwannian stroma (upper right), but also by areas of immature neuroblasts (lower left). When there... More about this image found in DIFFERENTIATING NEUROBLASTOMA This tumor shows areas of ganglion cell diff...

UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION Figure 11-16 UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION This stage 3 NB in a 5-year-old girl was not pretreated and showed this peculiar undifferentiated spindle cell morphology without presence of neuropil, ga... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION This stag...

DIFFERENTIATING NEUROBLASTOMA Figure 11-18 DIFFERENTIATING NEUROBLASTOMA A: This 18-month-old boy with opsoclonus myoclonus syndrome had a paravertebral tumor, which was shown to be a neuroblastic tumor with more than 5 percent ganglion cell differentiation, classifying it as differentiating NB. ... More about this image found in DIFFERENTIATING NEUROBLASTOMA A: This 18-month-old boy with opsoclonus myo...

POORLY DIFFERENTIATED NEUROBLASTOMA Figure 11-28 POORLY DIFFERENTIATED NEUROBLASTOMA Very cellular tumor, composed of small blue round cells. The scattered small amount of neuropil indicates the neuroblastic nature of the lesion. More about this image found in POORLY DIFFERENTIATED NEUROBLASTOMA Very cellular tumor, composed of small...

DIFFERENTIATING NEUROBLASTOMA Figure 11-29 DIFFERENTIATING NEUROBLASTOMA Left adrenal biopsy of 13-month-old boy shows morphologically heterogeneous tumor with varying ganglion cell differentiation, next to areas with neuroblasts, separated by neuropil. More about this image found in DIFFERENTIATING NEUROBLASTOMA Left adrenal biopsy of 13-month-old boy show...

MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Figure 1-1 MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gonadal pathways are shown. Functions distinguishing the adrenal cortical zones from each other and from the gonads are determined by differential expression of steroi... More about this image found in MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gon...

SMALL BLUE ROUND CELL TUMOR Figure 11-11 SMALL BLUE ROUND CELL TUMOR Immunohistochemically, this tumor was shown to be undifferentiated NB. The cellular tumor is composed of undifferentiated cells with atypical nuclei and scant cytoplasm. No stroma or ganglion cell differentiation is present. More about this image found in SMALL BLUE ROUND CELL TUMOR Immunohistochemically, this tumor was shown to...

GANGLIONEUROBLASTOMA INTERMIXED Figure 11-30 GANGLIONEUROBLASTOMA INTERMIXED Biopsy of paravertebral mass in 11-year-old girl shows areas of schwannian stroma, intermingled with areas of immature stroma containing cells with varying differentiation toward ganglion cells, but also including neurob... More about this image found in GANGLIONEUROBLASTOMA INTERMIXED Biopsy of paravertebral mass in 11-year-ol...

VAGAL PARAGANGLIOMA Figure 9-16 VAGAL PARAGANGLIOMA A: The prominent blood vessels and a pericyte-like arrangement of tumor cells may suggest a vascular tumor in the differential diagnosis. B: A different area of the same tumor shows a solid growth pattern with prominent perivascular pseudoroset... More about this image found in VAGAL PARAGANGLIOMA A: The prominent blood vessels and a pericyte-like arr...

STROMA-POOR NEUROBLASTOMA Figure 11-8 STROMA-POOR NEUROBLASTOMA On cross section, a variation from hemorrhagic, bulging, irregular lobules to more pale, homogeneous foci is seen. Because of ganglion cell differentiation, this tumor in older terminology would be classified as a ganglioneuroblastom... More about this image found in STROMA-POOR NEUROBLASTOMA On cross section, a variation from hemorrhagic, ...

ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND Figure 12-24 ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND A: The pattern of growth shows a well-developed glandular arrangement of tumor cells. B: Metastatic poorly differentiated adenocarcinoma has a sinusoidal pattern, with growth as... More about this image found in ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND A: The pattern of gro...

STROMA-POOR NEUROBLASTOMA Figure 11-13 STROMA-POOR NEUROBLASTOMA A: The tumor cells are separated by pale pink fibrillary material representing neuritic cell processes. The tumor was largely undifferentiated, with only rare cells showing early ganglion cell differentiation. B: A different tumor ... More about this image found in STROMA-POOR NEUROBLASTOMA A: The tumor cells are separated by pale pink fi...

TYROSINE HYDROXYLASE IN DEVELOPING FETAL ADRENAL GLAND Figure 1-13 TYROSINE HYDROXYLASE IN DEVELOPING FETAL ADRENAL GLAND Most of the medullary progenitor cells in this image express TH. Because TH is a cytosolic enzyme, it can often detect ability to produce catecholamines in immature or poorly ... More about this image found in TYROSINE HYDROXYLASE IN DEVELOPING FETAL ADRENAL GLAND Most of the medulla...

UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY Figure 11-17 UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was originally diagnosed as malignant rhabdoid tumor on the basis of morphology and loss of BRG1 immunostaining, until resection showed foci of ganglion cell d... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was or...

GANGLIONEUROBLASTOMA INTERMIXED Figure 11-19 GANGLIONEUROBLASTOMA INTERMIXED This tumor had more than 50 percent of schwannian stroma and may be called stroma rich. A: There is a mixture of mature and immature elements with schwannian stroma to the lower left and upper right. B: Focus of neurob... More about this image found in GANGLIONEUROBLASTOMA INTERMIXED This tumor had more than 50 percent of sch...

HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-26 HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular carcinoma metastatic to the adrenal gland can simulate a primary adrenal cortical carcinoma. This metastasis has a prominent trabecular pattern with delicate si... More about this image found in HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular car...