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Images
Figure 1-14
Published: 01 June 2025
RHINOSCLEROMA Figure 1-14 RHINOSCLEROMA A: The diagnostic microscopic finding of rhinoscleroma is the “Mikülicz cell,” large histiocytes with ample clear, vacuolated cytoplasm. B: Rod-shaped bacilli are demonstrated by Warthin-Starry staining. More about this image found in RHINOSCLEROMA A: The diagnostic microscopic finding of rhinoscleroma is th...
Images
Figure 5-65
Published: 01 June 2025
ADENOMATOID ODONTOGENIC TUMOR Figure 5-65 ADENOMATOID ODONTOGENIC TUMOR Diagnostic areas of nodular swirls of epithelium with duct-like spaces. More about this image found in ADENOMATOID ODONTOGENIC TUMOR Diagnostic areas of nodular swirls of epithe...
Images
Figure 5-151
Published: 01 June 2025
ODONTOGENIC KERATOCYST Figure 5-151 ODONTOGENIC KERATOCYST Diagnostic features of odontogenic keratocyst: the basal cells are palisaded and hyperchromatic, and range from cuboidal to columnar, with luminal corrugated parakeratin. There can be some limited reverse nuclear polarity. More about this image found in ODONTOGENIC KERATOCYST Diagnostic features of odontogenic keratocyst: the ...
Images
Figure 5-176
Published: 01 June 2025
CALCIFYING ODONTOGENIC CYST Figure 5-176 CALCIFYING ODONTOGENIC CYST The diagnostic ghost cells are enlarged, and ovoid to more elongated. They retain cellular outlines and have characteristic nuclei displaying karyolysis. More about this image found in CALCIFYING ODONTOGENIC CYST The diagnostic ghost cells are enlarged, and o...
Images
Figure 5-114
Published: 01 June 2025
CEMENTOBLASTOMA Figure 5-114 CEMENTOBLASTOMA “Active” areas of cementoblastoma with hypercellularity and immature matrix, suggesting the diagnostic possibility of osteosarcoma. More about this image found in CEMENTOBLASTOMA “Active” areas of cementoblastoma with hypercellularity an...
Images
Figure 5-49
Published: 01 June 2025
DESMOPLASTIC AMELOBLASTOMA Figure 5-49 DESMOPLASTIC AMELOBLASTOMA The tumor is characterized by a desmoplastic stromal response, compression of the tumor islands, and loss of diagnostic ameloblastic features. More about this image found in DESMOPLASTIC AMELOBLASTOMA The tumor is characterized by a desmoplastic st...
Images
Figure 5-152
Published: 01 June 2025
ODONTOGENIC KERATOCYST Figure 5-152 ODONTOGENIC KERATOCYST The cyst on the left merges with significant inflammation below to produce reactive changes and the loss of diagnostic features of odontogenic keratocyst. More about this image found in ODONTOGENIC KERATOCYST The cyst on the left merges with significant inflam...
Images
Figure 3-26
Published: 01 June 2025
NASOPHARYNGEAL ANGIOFIBROMA: SUBTRACTION ANGIOGRAM Figure 3-26 NASOPHARYNGEAL ANGIOFIBROMA: SUBTRACTION ANGIOGRAM The intense vascularity of this angiofibroma is evident in a subtraction angiogram. This finding is virtually diagnostic, and allows planning for surgery and embolization. More about this image found in NASOPHARYNGEAL ANGIOFIBROMA: SUBTRACTION ANGIOGRAM The intense vascularity...
Images
Figure 1-35
Published: 01 June 2025
NUT CARCINOMA Figure 1-35 NUT CARCINOMA A: Rounded, anastomosing nests of nonkeratinizing cells invade sinonasal submucosa. B: Nuclear monotony is typical, and abrupt keratinization is a useful diagnostic clue, seen in about a third of cases. More about this image found in NUT CARCINOMA A: Rounded, anastomosing nests of nonkeratinizing cells inva...
Images
Figure 1-122
Published: 01 June 2025
ALVEOLAR RHABDOMYOSARCOMA Figure 1-122 ALVEOLAR RHABDOMYOSARCOMA Desmin (A) and myogenin (B) are diffusely positive. Aberrant staining for other markers, such as CD56 (C) and S-100 protein (D) is common, and can present a significant diagnostic pitfall. More about this image found in ALVEOLAR RHABDOMYOSARCOMA Desmin (A) and myogenin (B) are diffusely positi...
Images
Figure 7-9
Published: 01 June 2025
SCLEROSING PARAGANGLIOMA Figure 7-9 SCLEROSING PARAGANGLIOMA Some paragangliomas have dense, collagenized stroma relative to the amount of actual tumor cells. This can lead to diagnostic challenges given the similarity to other lesions. The stroma obscures the typical nested pattern More about this image found in SCLEROSING PARAGANGLIOMA Some paragangliomas have dense, collagenized stro...
Images
Images
Figure 1-37
Published: 01 June 2025
SMARCB1-DEFICIENT SINONASAL CARCINOMA Figure 1-37 SMARCB1-DEFICIENT SINONASAL CARCINOMA A: The tumor is an infiltrative epithelioid proliferation of undifferentiated-appearing cells. B: Empty vacuoles are often seen, which can be a helpful diagnostic clue. C: The tumor cells have More about this image found in SMARCB1-DEFICIENT SINONASAL CARCINOMA A: The tumor is an infiltrative epit...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... of the tumors and their relationships to vessels, nerves, and skull base, including possible bone erosion. Since the imaging findings are usually diagnostic, biopsy is rarely indicated ( 18 ). Gross Findings. Tumors are ovoid to fusiform and firm, with highly variable cut surfaces that are light brown to tan...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... odontogenic epithelium is genetically programmed to become ameloblasts and secrete enamel matrix, when it becomes neoplastic, it may recapitulate odontogenesis and become enamel organs. That is the hallmark diagnostic feature of ameloblastoma where the peripheral cells of the tumor islands appear...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... layers thick to thin low-cuboidal layers. Mucosal areas of transition between respiratory epithelium and squamous epithelium result in small regions of immature squamous metaplastic mucosa. The latter sometimes presents a diagnostic challenge, being misinterpreted as dysplasia or carcinoma in situ...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... cytoplasmic inclusions composed of immunoglobulin, are frequent, as is true in any condition with abundant plasma cells. The diagnostic microscopic finding of rhinoscleroma is the of Mikülicz cell, large histiocytes with ample clear, vacuolated cytoplasm ( fig. 1-14A ). As the condition progresses, biopsies...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... the skull. These complexities contribute to the generally limited understanding of the diseases that affect this organ. However, a basic familiarity with the anatomy and histology, within the context of embryologic development, allows for a reasonable diagnostic approach. Normal findings are covered...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
... identified in a majority of NPCs, and homozygous deletions in MTAP are present in approximately one third of cases ( 72 ). Differential Diagnosis. While the keratinizing type of NPC shows the classic histologic features of invasive SCC and does not present a diagnostic problem, nonkeratinizing NPC...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... carcinoma. Molecular Genetic Findings. Although not used for diagnostic purposes, emerging data on HPV-associated SCC show that the tumors most frequently harbor PIK3CA, NOTCH-1, and PTEN mutations ( 43 ). There are no consistent translocations, deletions, or amplifications...