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Images
Published: 01 September 2024
LIVER IN EARLY HIV INFECTION Figure 9-21 LIVER IN EARLY HIV INFECTION A: Portal tract with a reactive lymphoid follicle. B: HIVp24 immunohistochemistry in liver portal tract lymphoid follicle shows virus in dendritic cells. More about this image found in LIVER IN EARLY HIV INFECTION A: Portal tract with a reactive lymphoid foll...
Images
Published: 01 September 2024
PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) Figure 9-2 PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregularly shaped reactive follicles. B: PGL lymph node follicle in center with macrophage phagocytosis and apoptotic debris. C: HIVp24 stains HIV virus in follicular dend... More about this image found in PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregul...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-10
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., including monocytes, macrophages, and dendritic cells (preferred replication sites), as well as lymphocytes, endothelial cells, fibroblasts, hepatocytes, adrenocortical cells, and other epithelial cells ( 8 ). The pathogenesis of both diseases is extremely complex. It includes activation of the mononuclear...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... damage cardiomyocytes. Influenza virus activates self-reactive T cells, which cause cardiomyocyte damage through molecular mimicry of viral and cardiac antigens. During the acute phase, many inflammatory cell subsets can be present, including lymphocytes, neutrophils, macrophages, and dendritic cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-23
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... binding proteins (CBP). The newly released fungal yeasts then infect other macrophages and the cycle is repeated. Other cells that can be infected by Histoplasma are dendritic cells, neutrophils, and natural killer cells, although the yeasts are unable to escape destruction in immunocompetent...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... inconspicuous mantle zones. The enlarged follicles extend throughout the entire lymph node, and germinal centers typically have irregular “geographic” (jigsaw-puzzle piece shape) outlines ( fig. 9-2A ). Follicle lysis may be prominent, with abundant follicular dendritic cells (FDC), as well as evident...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... the epithelial barrier, they enter macrophages and dendritic cells. This can occur through one of two mechanisms, depending on the bacterial cell surface lipopolysaccharide (smooth or rough) ( fig. 14-3 ). The bacteria then replicate extensively inside vacuoles (called brucellosomes) of macrophages, dendritic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... scattered prominent immunoblasts (C). (Courtesy of the CDC IDPB) Hantavirus antigens are demonstrated immunohistochemically in endothelial cells at many sites, including the lung, kidney, and spleen ( fig. 4-22 ), as well as in dendritic cells in the spleen and lymph nodes. In situ hybridization confirms...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... The cellular immune response against this spirochete is thought to underlie many of the clinical manifestations of syphilis. Infection further results in cytokine production, stimulation of dendritic cells and macrophages, and the development of antibodies. The adaptive immune response to the organism...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-26
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... cysts can result in infection, but is dependent on various intestinal intraluminal nutrient and microbiome factors. T-, B-mast, and dendritic cells are all involved in the host immune response, with IgA, nitric oxide, and interleukins 6 and 17 playing a pivotal role ( 23 ). LIFE CYCLE OF GIARDIA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., and arthropods. The flaviviruses cause disease by entering the blood stream of vertebrates and infecting a variety of cells including dendritic cells, neutrophils, macrophages (including placental Hofbauer cells), and endothelial cells ( 1 ). A conserved portion of the envelope (E) protein of the virus attaches...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., and are phagocytized by alveolar macrophages, and dendritic cells and neutrophils (in lymph nodes). Mycobacteria are found in membrane-bound cell compartments and free in the cytosol of these cells, where replication appears to take place, irrespective of whether the phagocytic cell is dead or alive ( 94...
Images
Published: 01 February 2024
COMMON BLUE NEVUS Figure 8-2 COMMON BLUE NEVUS There is a small collection of fusiform and dendritic melanocytes with a few melanophages in the superficial reticular dermis. More about this image found in COMMON BLUE NEVUS There is a small collection of fusiform and dendritic me...
Images
Published: 01 February 2024
COMMON BLUE NEVUS Figure 8-3 COMMON BLUE NEVUS Small lesion of pigmented fusiform and dendritic melanocytes and scattered melanophages. These cells are present in the superficial reticular dermis in association with pilar erector smooth muscle bundles. More about this image found in COMMON BLUE NEVUS Small lesion of pigmented fusiform and dendritic melanoc...
Images
Published: 01 February 2024
COMMON BLUE NEVUS Figure 8-6 COMMON BLUE NEVUS A: Papular exophytic silhouette of a pigmented intradermal melanocytic nevus. B: Slender fusiform and dendritic melanocytes wrap around collagen bundles. C: Dendritic melanocytes carry fine melanin granules in the cytoplasm in contrast to the large... More about this image found in COMMON BLUE NEVUS A: Papular exophytic silhouette of a pigmented intraderm...
Images
Published: 01 February 2024
PLAQUE-TYPE BLUE NEVUS INVOLVING BREAST TISSUE Figure 8-23 PLAQUE-TYPE BLUE NEVUS INVOLVING BREAST TISSUE A: Diffuse involvement of the stroma of the breast by pigmented melanocytes. B: The melanocytes display spindle, epithelioid, and dendritic features and are cytologically bland. More about this image found in PLAQUE-TYPE BLUE NEVUS INVOLVING BREAST TISSUE A: Diffuse involvement of t...
Images
Published: 01 February 2024
ACRAL MELANOMA Figure 14-1 ACRAL MELANOMA A: There is a large pigmented patch on the heel. B: There is a proliferation of predominantly solitary units of melanocytes at the dermoepidermal junction and focally above. It is associated with junctional hyperpigmentation. C: Some of the melanocytes ... More about this image found in ACRAL MELANOMA A: There is a large pigmented patch on the heel. B: There ...
Images
Published: 01 February 2024
BLUE NEVUS WITH EPITHELIOID CELL FEATURES Figure 8-10 BLUE NEVUS WITH EPITHELIOID CELL FEATURES A: Heavily pigmented intradermal melanocytic nevus. B,C: Most of the pigmented tumor cells are epithelioid in appearance. A minor population of melanocytes displays conventional BN-like fusiform and d... More about this image found in BLUE NEVUS WITH EPITHELIOID CELL FEATURES A: Heavily pigmented intradermal...
Images
Published: 01 February 2024
COMBINED BLUE NEVUS Figure 10-10 COMBINED BLUE NEVUS A: Intradermal melanocytic nevus with a superficial dermal population of small epithelioid melanocytes (arrow) overlying a proliferation of pigmented fusiform and dendritic cells (*). B: Juxtaposition of conventional small epithelioid melanocy... More about this image found in COMBINED BLUE NEVUS A: Intradermal melanocytic nevus with a superficial de...
Images
Published: 01 February 2024
CELLULAR BLUE NEVUS Figure 8-13 CELLULAR BLUE NEVUS A: Pigmented melanocytic nevus with fibrotic bulbous tongue-like extensions into the subcutis. Hypercellular nodules are present in the deep portion of the tumor. B: Densely cellular spindle cell nodule is surrounded by heavily pigmented fusifo... More about this image found in CELLULAR BLUE NEVUS A: Pigmented melanocytic nevus with fibrotic bulbous t...
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