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DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN  High-grade <span class="search-highlight">DCIS</span> undermin...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN Figure 3-25 DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN High-grade DCIS undermines an attenuated layer of residual normal epithelium with spindled nuclei. More about this image found in DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN High-grade DCIS undermin...
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DUCTAL CARCINOMA IN SITU (<span class="search-highlight">DCIS</span>) INVOLVING SCLEROSING ADENOSIS  In this case...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU (DCIS) INVOLVING SCLEROSING ADENOSIS Figure 6-6 DUCTAL CARCINOMA IN SITU (DCIS) INVOLVING SCLEROSING ADENOSIS In this case of high grade DCIS involving adenosis, the conformation of small highly atypical glands suggests invasive carcinoma. Recognition of the lobulocentric... More about this image found in DUCTAL CARCINOMA IN SITU (DCIS) INVOLVING SCLEROSING ADENOSIS In this case...
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INVASIVE DUCTAL CARCINOMA AND DUCTAL CARCINOMA IN SITU (<span class="search-highlight">DCIS</span>)  A: Frequentl...
Published: 01 January 2024
INVASIVE DUCTAL CARCINOMA AND DUCTAL CARCINOMA IN SITU (DCIS) Figure 8-17 INVASIVE DUCTAL CARCINOMA AND DUCTAL CARCINOMA IN SITU (DCIS) A: Frequently, DCIS is seen admixed and/or surrounding invasive breast carcinomas. The DCIS is recognizable as having more rounded tumor cell nests. B: High-pow... More about this image found in INVASIVE DUCTAL CARCINOMA AND DUCTAL CARCINOMA IN SITU (DCIS) A: Frequentl...
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DUCTAL CARCINOMA IN SITU INVOLVING LOBULES  <span class="search-highlight">DCIS</span> involving lobules can be a...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU INVOLVING LOBULES Figure 8-29 DUCTAL CARCINOMA IN SITU INVOLVING LOBULES DCIS involving lobules can be a mimic of invasive or microinvasive carcinoma. Observing the lobulocentric arrangement of the tumor cell nests and the presence of a myoepithelial cell layer aid in the... More about this image found in DUCTAL CARCINOMA IN SITU INVOLVING LOBULES DCIS involving lobules can be a...
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NIPPLE ADENOMA WITH DUCTAL CARCINOMA IN SITU (<span class="search-highlight">DCIS</span>)  A: At low power, the c...
Published: 01 January 2024
NIPPLE ADENOMA WITH DUCTAL CARCINOMA IN SITU (DCIS) Figure 13-9 NIPPLE ADENOMA WITH DUCTAL CARCINOMA IN SITU (DCIS) A: At low power, the characteristic features of a nipple adenoma can be seen: benign-appearing epithelial elements below the nipple surface with extension into the squamous epitheli... More about this image found in NIPPLE ADENOMA WITH DUCTAL CARCINOMA IN SITU (DCIS) A: At low power, the c...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-03
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...The intraductal proliferative lesions of the breast are legion; this chapter is confined to columnar cell lesions, usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS). By definition, intraductal proliferations are bound by a myoepithelial cell...
Images
DUCTAL CARCINOMA IN SITU MIMICKING USUAL DUCTAL HYPERPLASIA  A: At first gl...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU MIMICKING USUAL DUCTAL HYPERPLASIA Figure 3-35 DUCTAL CARCINOMA IN SITU MIMICKING USUAL DUCTAL HYPERPLASIA A: At first glance, nuclear variability and cellular heterogeneity can give the impression of UDH in some examples of DCIS. The presence of necrosis favors DCIS, but... More about this image found in DUCTAL CARCINOMA IN SITU MIMICKING USUAL DUCTAL HYPERPLASIA A: At first gl...
Images
PAGET DISEASE  A: Scanning magnification view illustrates the area of under...
Published: 01 January 2024
PAGET DISEASE Figure 13-15 PAGET DISEASE A: Scanning magnification view illustrates the area of underlying DCIS from which this Paget disease arose. B: Higher-power view of the epidermis overlying the DCIS shows the characteristic Paget cells, with large pleomorphic nuclei involving much of the ... More about this image found in PAGET DISEASE A: Scanning magnification view illustrates the area of under...
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DUCTAL CARCINOMA IN SITU WITH SPINDLE CELL FEATURES  In this example of int...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU WITH SPINDLE CELL FEATURES Figure 3-30 DUCTAL CARCINOMA IN SITU WITH SPINDLE CELL FEATURES In this example of intermediate nuclear grade DCIS, the cells have a spindled morphology, particularly in the central area. This pattern of DCIS is often associated with endocrine d... More about this image found in DUCTAL CARCINOMA IN SITU WITH SPINDLE CELL FEATURES In this example of int...
Images
DUCTAL CARCINOMA IN SITU WITH MUCIN PRODUCTION  A: At intermediate power, m...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU WITH MUCIN PRODUCTION Figure 3-31 DUCTAL CARCINOMA IN SITU WITH MUCIN PRODUCTION A: At intermediate power, mucin is seen within this duct involved by DCIS. B: At higher power, the cytologic atypia of the DCIS cells is better appreciated, as well as the mucin present betw... More about this image found in DUCTAL CARCINOMA IN SITU WITH MUCIN PRODUCTION A: At intermediate power, m...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-07
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... in the the PIK3CA/AKT pathway Papilloma with DCIS + + Heterogeneous expression; negative in DCIS Heterogeneous expression; strongly and diffusely positive in DCIS Alterations in the PIK3CA/AKT pathway Papillary DCIS + - Negative Strongly and diffusely positive No specific molecular alterations...
Images
COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE...
Published: 01 January 2024
COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE MIMICKING ADH AND LOW NUCLEAR GRADE DCIS Figure 3-21 COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE MIMICKING ADH AND LOW NUCLEAR GRADE DCIS A: At scanning magnification, the TDLU appears expa... More about this image found in COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-10
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...-appearing nuclei, raising consideration for atypical ductal hyperplasia (ADH) or even low-grade ductal carcinoma in situ (DCIS) ( fig. 10-3 ), however, a high threshold for rendering a diagnosis of low-grade DCIS in this setting is generally advised ( 7 , 8 ). In later lesions, the periductal stromal...
Images
DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE  Lobular involvement b...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Figure 3-26 DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Lobular involvement by DCIS. More about this image found in DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Lobular involvement b...
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DUCTAL CARCINOMA IN SITU: MICROCALCIFICATIONS AND NECROSIS  Many cases of D...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: MICROCALCIFICATIONS AND NECROSIS Figure 3-24 DUCTAL CARCINOMA IN SITU: MICROCALCIFICATIONS AND NECROSIS Many cases of DCIS are detected through screening mammography due to the presence of microcalcifications. More about this image found in DUCTAL CARCINOMA IN SITU: MICROCALCIFICATIONS AND NECROSIS Many cases of D...
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DUCTAL CARCINOMA IN SITU: COMEDO NECROSIS  A large proportion of the center...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: COMEDO NECROSIS Figure 3-23 DUCTAL CARCINOMA IN SITU: COMEDO NECROSIS A large proportion of the center of this duct is filled with necrotic material. The DCIS cells at the periphery of the space are of intermediate nuclear grade. More about this image found in DUCTAL CARCINOMA IN SITU: COMEDO NECROSIS A large proportion of the center...
Images
PAPILLARY DUCTAL CARCINOMA IN SITU WITH GLOBOID CELLS  On occasion, a secon...
Published: 01 January 2024
PAPILLARY DUCTAL CARCINOMA IN SITU WITH GLOBOID CELLS Figure 7-21 PAPILLARY DUCTAL CARCINOMA IN SITU WITH GLOBOID CELLS On occasion, a second population of epithelial cells with relatively abundant clear cytoplasm is seen in papillary DCIS, as illustrated in the center of the field. More about this image found in PAPILLARY DUCTAL CARCINOMA IN SITU WITH GLOBOID CELLS On occasion, a secon...
Images
APOCRINE DUCTAL CARCINOMA IN SITU  A: A duct is filled with highly atypical...
Published: 01 January 2024
APOCRINE DUCTAL CARCINOMA IN SITU Figure 3-29 APOCRINE DUCTAL CARCINOMA IN SITU A: A duct is filled with highly atypical epithelial cells with abundant granular eosinophilic cytoplasm. B: At high power, the nuclear pleomorphism and prominent nucleoli so characteristic of apocrine DCIS are readil... More about this image found in APOCRINE DUCTAL CARCINOMA IN SITU A: A duct is filled with highly atypical...
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SOLID PAPILLARY CARCINOMA  Solid papillary carcinomas may retain a peripher...
Published: 01 January 2024
SOLID PAPILLARY CARCINOMA Figure 7-28 SOLID PAPILLARY CARCINOMA Solid papillary carcinomas may retain a peripheral myoepithelial cell layer, as in this example. In such cases, it is appropriate to classify the lesion as DCIS, solid papillary pattern, or solid papillary carcinoma in situ. (A: H&am... More about this image found in SOLID PAPILLARY CARCINOMA Solid papillary carcinomas may retain a peripher...
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DUCTAL CARCINOMA IN SITU WITH SIGNET RING CELL FEATURES  A: Intermediate-po...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU WITH SIGNET RING CELL FEATURES Figure 3-32 DUCTAL CARCINOMA IN SITU WITH SIGNET RING CELL FEATURES A: Intermediate-power image of an area of DCIS in which many of the cells have large vacuoles. B: At higher power, the displacement of the nuclei to the periphery of the si... More about this image found in DUCTAL CARCINOMA IN SITU WITH SIGNET RING CELL FEATURES A: Intermediate-po...