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Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... S , et al Cytotoxic tumour-infiltrating T lymphocytes influence outcome in resected pancreatic ductal adenocarcinoma . Eur J Cancer 2017 ; 83 : 290 - 301 . 260. Nielsen MF , Mortensen MB , Detlefsen S . Key players in pancreatic cancer-stroma interaction: cancer...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI:
10.55418/9781933477251-3
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... that the disorder results from a subclinical viral infection that provides an antigen, either of viral origin or resulting from virus-induced host tissue damage, that uniquely binds to HLA-B35 molecules on macrophages. The resulting antigen-HLA-B35 complex activates cytotoxic T lymphocytes that then damage thyroid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI:
10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... of the glands in Cushing syndrome. Lymphocytic infiltrates of mixed, cytotoxic, and T-helper cells ( 662 ) are often present. Immunohistochemical Findings. Diffuse synaptophysin expression in PPNAD nodules suggests a neuroendocrine phenotype ( 633 , 642 , 666 ). Studies by Sasano et al. ( 667 , 668...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI:
10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... secondary to cytotoxic T-lymphocyte-associated protein 4 blockade: insights into pathogenesis from an autopsy series . Am J Pathol 2016 ; 186 : 3225 - 35 . 110. Barnard ZR , Walcott BP , Kahle KT , Nahed BV , Coumans JV . Hyponatremia associated with Ipilimumab-induced...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI:
10.55418/9781933477220-09
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
.... This neoplasm is related to Epstein-Barr virus (EBV) infection; in situ hybridization for EBV early RNA (EBER) is uniformly positive ( 54 ). Positive immunostains include those for cytotoxic granule markers (TIA-1 [100 percent], perforin [100 percent], granzyme B [89 percent]), CD2, CD56 (92 percent), CD30 (30...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI:
10.55418/9781933477220-04
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... the metastatic sites being favored because of their routine exposure to cytotoxic chemotherapy, with consequent selection of the less proliferative cell population. Clinical Features. The lesion was first described in postchemotherapy resections; since then primary testicular and nonchemotherapy-related cases...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
DOI:
10.55418/9781933477183-13
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... Hepatol 2008 ; 48 : 74 – 82 . 10. Szablewski V , René C , Costes V . Indolent cytotoxic T cell lymphoproliferation associated with nodular regenerative hyperplasia: a common liver lesion in the context of common variable immunodeficiency disorder . Virchows Arch 2015 ; 467...
Images
Published: 01 September 2021
PRIMARY CUTANEOUS CD8-POSITIVE AGGRESSIVE EPIDERMOTROPIC CYTOTOXIC T-CELL LYMPHOMA Figure 3-71 PRIMARY CUTANEOUS CD8-POSITIVE AGGRESSIVE EPIDERMOTROPIC CYTOTOXIC T-CELL LYMPHOMA Left: There is prominent epidermotropism with a somewhat pagetoid appearance. Right: Epidermal necrosis is adjacent to... More about this image found in PRIMARY CUTANEOUS CD8-POSITIVE AGGRESSIVE EPIDERMOTROPIC CYTOTOXIC T-CELL L...
Images
Published: 01 September 2021
PRIMARY CUTANEOUS CD8-POSITIVE AGGRESSIVE EPIDERMOTROPIC CYTOTOXIC T-CELL LYMPHOMA Figure 3-72 PRIMARY CUTANEOUS CD8-POSITIVE AGGRESSIVE EPIDERMOTROPIC CYTOTOXIC T-CELL LYMPHOMA By definition, the tumor cells are positive for CD8. More about this image found in PRIMARY CUTANEOUS CD8-POSITIVE AGGRESSIVE EPIDERMOTROPIC CYTOTOXIC T-CELL L...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
DOI:
10.55418/9781933477183-11
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... by the portal inflammatory infiltrate. Perivenular injury with endotheliitis may also be seen in approximately 8 percent of cases ( 203 ), although it is unclear whether the endothelium is injured primarily in GVHD or is damaged secondarily from cytotoxic T cells or inflammatory cytokines ( 195 ). If treatment...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
DOI:
10.55418/9781933477183-10
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... by the skin and blood vessels and photoactivated by sunlight, resulting in photosensitivity. Increased protoporphyrin changes the composition of bile, with alterations in bile acids and phospholipids, leading to cytotoxicity ( 49 ). The genetic alteration in XLP, clinically indistinguishable from EPP...
Images
Published: 01 September 2021
PRIMARY CUTANEOUS ACRAL CD8-POSITIVE T-CELL LYMPHOMA Figure 3-75 PRIMARY CUTANEOUS ACRAL CD8-POSITIVE T-CELL LYMPHOMA The tumor cells display a cytotoxic phenotype with uniform expression of CD8 (left) and TIA-1 (right). More about this image found in PRIMARY CUTANEOUS ACRAL CD8-POSITIVE T-CELL LYMPHOMA The tumor cells displ...
Images
Published: 01 September 2021
PRIMARY CUTANEOUS GAMMA-DELTA T-CELL LYMPHOMA Figure 3-81 PRIMARY CUTANEOUS GAMMA-DELTA T-CELL LYMPHOMA The neoplastic lymphocytes are typically negative for CD4 (A) and CD8 (B) but express cytotoxic molecules, in this case TIA-1 (C). More about this image found in PRIMARY CUTANEOUS GAMMA-DELTA T-CELL LYMPHOMA The neoplastic lymphocytes a...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 9
Published: 01 November 2021
DOI:
10.55418/9781933477176-2
ISBN-10: 1-933477-17-2
ISBN: 978-1-933477-17-6
... are less common than the Xp11 translocation renal cell carcinomas; fewer than 100 cases have been reported in the world literature. The mean and median patient age is 31 years ( 301 , 302 ). Exposure to cytotoxic chemotherapy is a risk factor for developing MITF family translocation renal cell carcinomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 7
Published: 01 September 2021
DOI:
10.55418/9781933477121-3
ISBN-10: 1-933477-12-1
ISBN: 978-1-933477-12-1
... is typically negative. In large cell transformation, there is more frequent loss of pan-T-cell antigens such as CD2, CD5, and CD7, and varying degrees of CD30 expression are seen in up to half of cases ( 159 , 163 , 164 ). Rare cases assume a cytotoxic phenotype with CD8 and/or cytotoxic molecule expression...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 6
Published: 01 August 2021
DOI:
10.55418/9781933477091-ch09
ISBN-10: 1-933477-09-1
ISBN: 978-1-933477-09-1
...) in the pregnant uterus to a TH1-dominant environment (the T-helper cell type 1 response induces cellular cytotoxicity and macrophage activation, effective against intracellular organisms; a proinflammatory reaction) similar to that seen in autoimmune disease ( 45 ). Preeclampsia is associated with chronic immune...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 6
Published: 01 August 2021
DOI:
10.55418/9781933477091-ch08
ISBN-10: 1-933477-09-1
ISBN: 978-1-933477-09-1
... cells, and cytotoxic T cells ( 63 ). The intervillositis should be present in at least two of the routine three sections of macroscopically normal placenta. If three sections are not available (as often in early gestations), then it has been recommended that at least 5 percent of the intervillous space...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 4
Published: 01 April 2021
DOI:
10.55418/9781933477930-03
ISBN-10: 1-933477-93-8
ISBN: 978-1-933477-93-0
... 2016 ; 61 : 175 - 9 . 195. Bergman MP , D’Elios MM . Cytotoxic T cells in H. Pylori-related gastric autoimmunity and gastric lymphoma . J Biomed Biotechnol 2010 ; 2010 : 104918 . 196. Pittman ME , Voltaggio L , Bhaijee F , Robertson SA , Montgomery EA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 4
Published: 01 April 2021
DOI:
10.55418/9781933477930-02
ISBN-10: 1-933477-93-8
ISBN: 978-1-933477-93-0
..., nonsteroidal anti-inflammatory drugs (NSAIDs), emepronium bromide, alendronate, ferrous sulfate, phenytoin, and, most recently, crizotinib ( 170 – 172 ). Drugs that alter the local pH, have cytotoxic effects, or decrease tissue perfusion produce characteristic patterns of injury, discussed below. Drug-induced...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 4
Published: 01 April 2021
DOI:
10.55418/9781933477930-04
ISBN-10: 1-933477-93-8
ISBN: 978-1-933477-93-0
... for histologic abnormalities to completely resolve ( 211 , 212 ). Medications that Affect the Cell Cycle Clinical Features. Colchicine and paclitaxel are alkaloid preparations that exert cytotoxic effects by inducing mitotic arrest during metaphase. Both agents can cause cytologic changes in the proliferative...
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