Search Results for cytoplasmic

LIPID DEPLETION IN CORTICAL CELLS NORMALLY RICH IN CYTOPLASMIC LIPID Figure 1-30 LIPID DEPLETION IN CORTICAL CELLS NORMALLY RICH IN CYTOPLASMIC LIPID There is distortion of the zona fasciculata caused by patchy lipid depletion. In some areas, lipid is absent in the outer cortex but prominent More about this image found in LIPID DEPLETION IN CORTICAL CELLS NORMALLY RICH IN CYTOPLASMIC LIPID There...

BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Figure 6-34 BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic beta-catenin expression in ACC may be focal with a “clonal” pattern or more frequently, diffuse as in the figure. Membrane pattern is visible in peritumoral non More about this image found in BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic...

PHEOCHROMOCYTOMA: NEUROENDOCRINE MARKERS Figure 8-37 PHEOCHROMOCYTOMA: NEUROENDOCRINE MARKERS The tumor cells express nuclear INSM1 (A), cytoplasmic synaptophysin (B), and cytoplasmic chromogranin A (C). These biomarkers indicate that this is a neuroendocrine neoplasm but are not specific More about this image found in PHEOCHROMOCYTOMA: NEUROENDOCRINE MARKERS The tumor cells express nuclear I...

UNDIFFERENTIATED NEUROBLASTOMA: IMMUNOHISTOCHEMISTRY Figure 11-35 UNDIFFERENTIATED NEUROBLASTOMA: IMMUNOHISTOCHEMISTRY A: Undifferentiated NB for which immunohistochemistry was needed for classification shows extensive cytoplasmic staining for synaptophysin with a slightly granular aspect. B More about this image found in UNDIFFERENTIATED NEUROBLASTOMA: IMMUNOHISTOCHEMISTRY A: Undifferentiated N...

ADRENAL CORTICAL CARCINOMA WITH HYALINE GLOBULES Figure 6-16 ADRENAL CORTICAL CARCINOMA WITH HYALINE GLOBULES This ACC is composed of cells with predominantly eosinophilic granular cytoplasm although some cells are vacuolated with pale-staining cytoplasm. Numerous intracytoplasmic hyaline More about this image found in ADRENAL CORTICAL CARCINOMA WITH HYALINE GLOBULES This ACC is composed of c...

CONGENITAL ADRENAL HYPERPLASIA Figure 2-12 CONGENITAL ADRENAL HYPERPLASIA A: Marked expansion of the zona fasciculata in an older child with congenital adrenal hyperplasia (CAH). Many cells have lipid-depleted cytoplasm due to sustained trophic stimulation by ACTH. B: Hyperplastic zona More about this image found in CONGENITAL ADRENAL HYPERPLASIA A: Marked expansion of the zona fasciculata...

ZONATION OF ADULT ADRENAL GLAND Figure 1-29 ZONATION OF ADULT ADRENAL GLAND An indistinct, discontinuous zona glomerulosa beneath the adrenal capsule has a ball-like arrangement of cells, with less abundant lipid-rich cytoplasm than cells of the zona fasciculata. Radial cords of zona fasciculata More about this image found in ZONATION OF ADULT ADRENAL GLAND An indistinct, discontinuous zona glomerul...

sinusoidal lining. B: This poorly differentiated hepatocellular carcinoma metastatic to adrenal gland (cortex at top of field) has abundant eosinophilic cytoplasm, prominent nucleoli, and numerous intracytoplasmic hyaline globules. The features suggest a high-grade adrenal cortical carcinoma. C More about this image found in HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular car...

nodules (small blue cells with sparse cytoplasm at center, larger pink cells with prominent cytoplasm). More about this image found in ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A A: The adrenal medul...

PHEOCHROMOCYTOMA Figure 8-20 PHEOCHROMOCYTOMA The tumor cells are large and polygonal, with abundant granular basophilic cytoplasm and indistinct cell borders. More about this image found in PHEOCHROMOCYTOMA The tumor cells are large and polygonal, with abundant gr...

PHEOCHROMOCYTOMA Figure 8-21 PHEOCHROMOCYTOMA Large and polygonal tumor cells have pale eosinophilic cytoplasm and indistinct cell borders. More about this image found in PHEOCHROMOCYTOMA Large and polygonal tumor cells have pale eosinophilic cy...

PHEOCHROMOCYTOMA Figure 8-22 PHEOCHROMOCYTOMA The tumor cells are round and regular, with abundant cytoplasm, resembling cells of an epithelial neuroendocrine tumor. More about this image found in PHEOCHROMOCYTOMA The tumor cells are round and regular, with abundant cyto...

BIOMARKERS OF PHEOCHROMOCYTOMA Figure 8-38 BIOMARKERS OF PHEOCHROMOCYTOMA The most specific biomarkers of pheochromocytoma are nuclear GATA3 (A) and cytoplasmic tyrosine hydroxylase (B). More about this image found in BIOMARKERS OF PHEOCHROMOCYTOMA The most specific biomarkers of pheochromoc...

CUSHING DISEASE Figure 3-7 CUSHING DISEASE Under the trophic influence of ACTH, much of the zona fasciculata is converted to cells with lipid-depleted, compact, eosinophilic cytoplasm. More about this image found in CUSHING DISEASE Under the trophic influence of ACTH, much of the zona fasc...

PHEOCHROMOCYTOMA: INTRACYTOPLASMIC HYALINE GLOBULES Figure 8-30 PHEOCHROMOCYTOMA: INTRACYTOPLASMIC HYALINE GLOBULES Scattered tumor cells harbor large round cytoplasmic globules with a hyaline appearance. More about this image found in PHEOCHROMOCYTOMA: INTRACYTOPLASMIC HYALINE GLOBULES Scattered tumor cells ...

SPIRONOLACTONE BODIES Figure 4-31 SPIRONOLACTONE BODIES Numerous spironolactone bodies are seen in the cytoplasm of zona glomerulosa cells in this adrenal gland from a patient treated with spironolactone for primary hyperaldosteronism. More about this image found in SPIRONOLACTONE BODIES Numerous spironolactone bodies are seen in the cytop...

MIDDLE EAR (JUGULOTYMPANIC) PARAGANGLIOMA Figure 9-23 MIDDLE EAR (JUGULOTYMPANIC) PARAGANGLIOMA The presence of nuclear pleomorphism, together with artifactual cytoplasmic vacuolization and clearing in this paraganglioma, may suggest adenocarcinoma as a diagnosis. More about this image found in MIDDLE EAR (JUGULOTYMPANIC) PARAGANGLIOMA The presence of nuclear pleomorp...

ABDOMINAL PARAGANGLIOMA Figure 9-25 ABDOMINAL PARAGANGLIOMA This tumor is composed of monomorphic cells with slightly eosinophilic cytoplasm and prominent vacuoles creating a pseudoacinar appearance. This appearance is often associated with SDHB mutation. More about this image found in ABDOMINAL PARAGANGLIOMA This tumor is composed of monomorphic cells with s...

CYTOMEGALY IN REGRESSING FETAL CORTEX FROM A STILLBORN Figure 1-27 CYTOMEGALY IN REGRESSING FETAL CORTEX FROM A STILLBORN The nuclei are extremely large and occasional nuclear pseudoinclusions are formed by invagination of cytoplasm (arrow). More about this image found in CYTOMEGALY IN REGRESSING FETAL CORTEX FROM A STILLBORN The nuclei are extr...

ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-25 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells have compact eosinophilic cytoplasm and contain eosinophilic hyaline globules. More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells ...