TENOFOVIR TOXICITY Figure 9-20 TENOFOVIR TOXICITY Tubular epithelial damage and eosinophilic cytoplasmic inclusions. More about this image found in TENOFOVIR TOXICITY Tubular epithelial damage and eosinophilic cytoplasmic ...

HSIL/LSIL Figure 9-40 HSIL/LSIL A: HSIL with diffuse, strong cytoplasmic and nuclear (“block”) staining for p16, interpreted as a positive result. B: LSIL on the right (short arrow), while the differential diagnosis for the area on the left (long arrow) includes immature squamous metaplasia and ... More about this image found in HSIL/LSIL A: HSIL with diffuse, strong cytoplasmic and nuclear (“block”) s...

CYTOMEGALOVIRUS COLITIS Figure 5-18 CYTOMEGALOVIRUS COLITIS A: The colonic ulcer shows granulation tissue with prominent mixed inflammatory cell infiltration. B,C: Enlarged infected stromal and endothelial cells are present in the ulcer base, with nuclear and cytoplasmic inclusion material. D: ... More about this image found in CYTOMEGALOVIRUS COLITIS A: The colonic ulcer shows granulation tissue with...

MERKEL CELL CARCINOMA Figure 9-50 MERKEL CELL CARCINOMA A: At low power, the small round blue cell tumor is centered on the dermis. B: Higher power shows sheets of cells with a high nuclear to cytoplasmic ratio, prominent apoptosis, and brisk mitotic activity. C: Classic paranuclear “dot-like” ... More about this image found in MERKEL CELL CARCINOMA A: At low power, the small round blue cell tumor is ...

HSIL AND CARCINOMA Figure 9-37 HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, with high nuclear to cytoplasmic ratio, coarse chromatin, and nuclear irregularity (SurePath cytology, Papanicolaou stain). B: HSIL with acanthosis, hyperkeratosis (at left), parakeratosis (a... More about this image found in HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, ...

HSIL AND CARCINOMA Figure 9-37 HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, with high nuclear to cytoplasmic ratio, coarse chromatin, and nuclear irregularity (SurePath cytology, Papanicolaou stain). B: HSIL with acanthosis, hyperkeratosis (at left), parakeratosis (a... More about this image found in HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, ...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-30 SUBACUTE SCLEROSING PANENCEPHALITIS Brain parenchymal and perivascular space macrophages (arrowheads) in SSPE, with reactive astrocytes showing an eosinophilic cytoplasm and tapering processes (arrow). More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS Brain parenchymal and perivascular spa...

LSIL, NEGATIVE p16 IMMUNOHISTOCHEMISTRY Figure 9-41 LSIL, NEGATIVE p16 IMMUNOHISTOCHEMISTRY A: Total absence of p16 staining (negative) in LSIL. B: Negative p16, showing only focal cytoplasmic and nuclear staining. More about this image found in LSIL, NEGATIVE p16 IMMUNOHISTOCHEMISTRY A: Total absence of p16 staining (...

LEISHMANIA AMASTIGOTES Figure 28-8 LEISHMANIA AMASTIGOTES A Giemsa stain demonstrates multiple Leishmania amastigotes within the cytoplasm of histiocytes. (Courtesy of Dr. L. E. Botero, Pontificia Bolivariana University, Medellín, Colombia) More about this image found in LEISHMANIA AMASTIGOTES A Giemsa stain demonstrates multip...

MICROSPORIDIOSIS Figure 22-17 MICROSPORIDIOSIS High-power view of a modified Gram stain highlighting numerous microsporidian spores in the upper cytoplasm of an enterocyte. (Courtesy of Dr. J. Greenson, University of Michigan, Ann Arbor, MI) More about this image found in MICROSPORIDIOSIS High-power view of a modified Gram stain highlighting num...

MENINGOCOCCAL (BACTERIAL) MYOCARDITIS Figure 7-4 MENINGOCOCCAL (BACTERIAL) MYOCARDITIS A: There is a pronounced interstitial neutrophil infiltrate in a patient with meningococcemia. B: Red Neisseria meningitidis cytoplasmic positivity is seen on immunohistochemistry in many of the phagocytic and inflammatory cells. (Courtesy of the CDC IDPB) More about this image found in MENINGOCOCCAL (BACTERIAL) MYOCARDITIS A: There is a pronounced interstitia...

BLASTOMYCOSIS Figure 21-3 BLASTOMYCOSIS Suppurative granulomas with isolated pale fungal yeasts in the cytoplasm of a giant cell (A), which are often identified due to their weakly birefringent cell wall and central nuclei on a hematoxylin and eosin (H&E) stain (B,C). More about this image found in BLASTOMYCOSIS Suppurative granulomas with isolated pale fungal yeasts in t...

ENTERIC CYCLOSPORIASIS Figure 26-42 ENTERIC CYCLOSPORIASIS Various C. cayetanensis parasite forms are seen at high power. Both sexual stages (arrow) and asexual stages (arrow-head shows elongated, “banana-shaped” merozoites) are visible in the enterocyte cytoplasm. More about this image found in ENTERIC CYCLOSPORIASIS Various C. cayetanensis parasite f...

AFRICAN TRYPANOSOME TRYPOMASTIGOTES Figure 25-9 AFRICAN TRYPANOSOME TRYPOMASTIGOTES On a blood smear, the central large dark nucleus, small dark basal kinetoplast, long flagellum, and scattered small granules in the organism’s pale cytoplasm are seen. (Giemsa stain; courtesy of the CDC PHIL) More about this image found in AFRICAN TRYPANOSOME TRYPOMASTIGOTES On a blood smear, the central large da...

E. HISTOLYTICA TROPHOZOITES Figure 26-10 E. HISTOLYTICA TROPHOZOITES The associated cell debris adjacent to colonic mucosa shows organisms with light eosinophilic granular cytoplasm, imparting a histiocyte-like morphology. (Courtesy of A. Cardona, Hospital Pablo Tobón Uribe, Medellín, Columbia) More about this image found in E. HISTOLYTICA TROPHOZOITES The associated cell debris ad...

NIPAH VIRUS INFECTION Figure 3-48 NIPAH VIRUS INFECTION Patterns of immunohistochemical staining in CNS neurons: abundant viral antigen in neurons and associated processes (A), discrete staining of intracytoplasmic viral inclusions (B), and fine granular cytoplasmic positivity in retracted neuron... More about this image found in NIPAH VIRUS INFECTION Patterns of immunohistochemical staining in CNS neur...

CYTOMEGALOVIRUS (CMV) Figure 4-34 CYTOMEGALOVIRUS (CMV) A: Congestion, early erythrocyte extravasation, and scattered enlarged cells with nucleomegaly in the lung. B: At high power, an enlarged cell demonstrates characteristic nuclear viral inclusions with surrounding halo, and basophilic cytopl... More about this image found in CYTOMEGALOVIRUS (CMV) A: Congestion, early erythrocyte extravasation, and ...

TROPHOZOITES IN COLONIC AMEBIASIS Figure 26-11 TROPHOZOITES IN COLONIC AMEBIASIS A: At high power, a round pale parasite nucleus (contrasting with the dark nuclei of surrounding inflammatory cells), central nuclear karyosome, and abundant vacuolated cytoplasm are seen. B: The granular intracytop... More about this image found in TROPHOZOITES IN COLONIC AMEBIASIS A: At high power, a round pale parasite ...

ENTERIC MICROSPORIDIOSIS Figure 22-14 ENTERIC MICROSPORIDIOSIS Prominent increase in lamina propria plasma cells, scattered intraepithelial lymphocytes, and surface epithelial disarray. Note the foci of granular supranuclear enterocyte cytoplasm (at top) due to the presence of microsporidian orga... More about this image found in ENTERIC MICROSPORIDIOSIS Prominent increase in lamina propria plasma cells...

TYPHOID FEVER Figure 13-17 TYPHOID FEVER A: Base of a cecal ulcer shows the characteristic predominance of histiocytes in the inflammatory infiltrate. B: The histiocytes (Mallory cells), which are also found in draining lymph nodes, have granular cytoplasm due to phagocytosis of necrotic debris ... More about this image found in TYPHOID FEVER A: Base of a cecal ulcer shows the characteristic predominan...