CUTANEOUS NOCARDIOSIS Figure 12-22 CUTANEOUS NOCARDIOSIS Clinical features of primary cutaneous nocardiosis (A), including Nocardia (bacterial) “mycetoma” (B). (Courtesy of the CDC PHIL) More about this image found in CUTANEOUS NOCARDIOSIS Clinical features of primary cutaneous nocardiosis (...

CUTANEOUS LEISHMANIASIS Figure 28-6 CUTANEOUS LEISHMANIASIS Cutaneous epithelioid cell granulomas have giant cells and a rim of lymphocytes. Giant cell intracytoplasmic parasites are abundant. (Courtesy of the Armed Forces Institute of Pathology) More about this image found in CUTANEOUS LEISHMANIASIS Cutaneous epithelioid cell granulomas have giant c...

ACUTE PARVOVIRUS B19 INFECTION Figure 8-2 ACUTE PARVOVIRUS B19 INFECTION The characteristic cutaneous erythema of “slapped cheek disease” is seen in a child. (Courtesy of the CDC PHIL) More about this image found in ACUTE PARVOVIRUS B19 INFECTION The characteristic cutaneous erythema of “s...

PATCH STAGE OF CUTANEOUS KAPOSI SARCOMA Figure 8-17 PATCH STAGE OF CUTANEOUS KAPOSI SARCOMA The dermis appears “busy,” with a subtle vasoformative proliferation composed of somewhat jagged vessels, usually most obvious in the vicinity of native blood vessels and skin appendages. More about this image found in PATCH STAGE OF CUTANEOUS KAPOSI SARCOMA The dermis appears “busy,” with a ...

EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA Figure 8-19 EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA There is a spindle cell proliferation with slit-like spaces, some containing erythrocytes. Note the cellular appearance and relatively scant mitotic activity. More about this image found in EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA There is a spindle cell pr...

CUTANEOUS NOCARDIA SULFUR GRANULE Figure 12-24 CUTANEOUS NOCARDIA SULFUR GRANULE Peripheral Splendore-Hoeppli phenomenon on H&E (A) and modified AFB (B) staining. (B: courtesy of the CDC PHIL) More about this image found in CUTANEOUS NOCARDIA SULFUR GRANULE Peripheral Splendore-Ho...

DISSEMINATED ACTINOMYCOSIS Figure 12-29 DISSEMINATED ACTINOMYCOSIS A: Multiple draining cutaneous sinuses are on the legs. (Courtesy of the CDC PHIL) B: Skin histology shows drainage of a typical actinomycotic (sulfur) granule. (Courtesy of Prof. W. Grayson, Ampath Pathology Laboratories, Johann... More about this image found in DISSEMINATED ACTINOMYCOSIS A: Multiple draining cutaneous sinuses are on t...

ANTHRAX Figure 14-8 ANTHRAX A: Clinical features of cutaneous anthrax include a large black necrotic lesion on the forearm. B: Chest X-ray image of inhalation anthrax, with early mediastinal widening (the main site of pathology in this disease form), associated pleural effusion, and minimal lung... More about this image found in ANTHRAX A: Clinical features of cutaneous anthrax include a large black ne...

CUTANEOUS ANTHRAX Figure 14-9 CUTANEOUS ANTHRAX The typical necrosis and ulceration (A) are seen, with predominantly perivascular inflammation, dermal edema, and hemorrhage (B). (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in CUTANEOUS ANTHRAX The typical necrosis and ulceration (A) are seen, with p...

CUTANEOUS YAWS Figure 15-37 CUTANEOUS YAWS A,B: Perivascular mononuclear inflammatory cell infiltrate (A) with only mildly associated endothelial cell swelling (B). C: Warthin-Starry stain demonstrates scattered intraepidermal spirochetes (arrows). D: Pronounced epidermal hyperplasia and hyperk... More about this image found in CUTANEOUS YAWS A,B: Perivascular mononuclear inflammatory cell infiltrate ...

CUTANEOUS LESION OF SECONDARY SYPHILIS Figure 18-4 CUTANEOUS LESION OF SECONDARY SYPHILIS Prominent psoriasiform epidermal hyperplasia and spongiosis are seen. (Courtesy of Dr. A. L. Canales, Harvard Medical School, Boston, MA) More about this image found in CUTANEOUS LESION OF SECONDARY SYPHILIS Prominent psoriasiform epidermal hy...

DISSEMINATED CUTANEOUS SPOROTRICHOSIS IN HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION Figure 24-3 DISSEMINATED CUTANEOUS SPOROTRICHOSIS IN HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION Crusted and ulcerated verrucous plaques are on the face and limbs; there was no concomitant visceral involvement.... More about this image found in DISSEMINATED CUTANEOUS SPOROTRICHOSIS IN HUMAN IMMUNODEFICIENCY VIRUS (HIV)...

DISSEMINATED CUTANEOUS SPOROTRICHOSIS Figure 24-8 DISSEMINATED CUTANEOUS SPOROTRICHOSIS The upper dermis contains large numbers of organisms, some of which have been engulfed by histiocytes. Polymerase chain reaction (PCR) studies confirmed the presence of Sporothrix schenckii. More about this image found in DISSEMINATED CUTANEOUS SPOROTRICHOSIS The upper dermis contains large numb...

DISSEMINATED CUTANEOUS SPOROTRICHOSIS Figure 24-9 DISSEMINATED CUTANEOUS SPOROTRICHOSIS A periodic acid-Schiff (PAS) stain highlights a large number of intradermal Sporothrix organisms and their divergent histomorphology, including round to ovoid yeasts undergoing narrow-based and tubular budding, occasional cigar-shaped forms, and the focal presence of early hyphal development. More about this image found in DISSEMINATED CUTANEOUS SPOROTRICHOSIS A periodic acid-Schiff (PAS) stain h...

CUTANEOUS BOTRYOMYCOSIS Figure 24-19 CUTANEOUS BOTRYOMYCOSIS A: There is marked swelling of the hand. (Courtesy of Division of Dermatology, University of the Witwatersrand, Johannesburg, South Africa) B: A Gram stain performed on a biopsy of the lesion revealed colonies of gram-positive bacteria... More about this image found in CUTANEOUS BOTRYOMYCOSIS A: There is marked swelling of the hand. (Courtesy...

CUTANEOUS AMEBIASIS Figure 26-9 CUTANEOUS AMEBIASIS A: Prominent epidermal hyperplasia with large numbers of intimately associated E. histolytica organisms. B: One trophozoite at higher power demonstrates the characteristic erythrophagocytosis (arrow). (Courtesy of Prof. P. McKee, Boussais, France) More about this image found in CUTANEOUS AMEBIASIS A: Prominent epidermal hyperplasia with large numbers ...

CUTANEOUS LEISHMANIASIS Figure 28-2 CUTANEOUS LEISHMANIASIS An ulcerated nodule has well-delineated elevated borders and a central depression. (Courtesy of Dr. L. M. Gomez, Pontificia Bolivariana University, Medellín, Colombia) More about this image found in CUTANEOUS LEISHMANIASIS An ulcerated nodule has well-delineated elevated b...

ULCERATED CUTANEOUS LEISHMANIASIS Figure 28-3 ULCERATED CUTANEOUS LEISHMANIASIS The ear pinna is involved (so called Chicleros ulcer). (Courtesy of the Department of Dermatology, Pablo Tobón Uribe Hospital, Medellín, Colombia) More about this image found in ULCERATED CUTANEOUS LEISHMANIASIS The ear pinna is involved (so called Chi...

CUTANEOUS LEISHMANIA ULCER Figure 28-5 CUTANEOUS LEISHMANIA ULCER Prominent peripheralization of amastigotes within macrophages, with prominent histiocytes and plasma cells (A,B). More about this image found in CUTANEOUS LEISHMANIA ULCER Prominent peripheralization of...

CHRONIC RELAPSING CUTANEOUS LEISHMANIASIS Figure 28-7 CHRONIC RELAPSING CUTANEOUS LEISHMANIASIS There is severe chronic inflammation with prominent pseudoepitheliomatous epidermal hyperplasia. More about this image found in CHRONIC RELAPSING CUTANEOUS LEISHMANIASIS There is severe chronic inflamma...