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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...PROGNOSTIC FACTORS Once a diagnosis of melanoma has been established, it is important for the pathologist to provide prognostic information for patients and their clinical care team. At the time of diagnosis approximately 90 percent of individuals with primary cutaneous melanoma have no evidence...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... is found between the primary site and regional lymph nodes, it is classified as a locoregional “in-transit” metastasis ( fig. 22-1 ). Cutaneous metastases located farther away beyond the regional node of the primary melanoma site are called “distant” metastases. MELANOMA IN-TRANSIT METASTASIS Figure 22-1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... tumors . Philadelphia : Elsevier ; 2019 . 4. Busam   KJ , Mujumdar   U , Hummer   AJ , et al . Cutaneous desmoplastic melanoma: reappraisal of morphologic heterogeneity and prognostic factors . Am J Surg Pathol   2004 ; 28 : 1518 - 25 . 5. Hawkins   WG , Busam   KJ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...This chapter discusses unusual morphologic variants of primary cutaneous melanomas that have not been discussed elsewhere in the Fascicle. The purpose of commenting on these variants is for the practicing pathologist to be aware of the morphologic spectrum of melanomas, and to consider...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... at or near mucosal sites, such as the lip or anogenital region ( fig. 1-6 ). They may be reported as melanotic macule or lentigo. Similar lesions located on the nail, manifesting as melanonychia striata, may be referred to as subungual lentigo or melanotic macule ( 3 ). As with other cutaneous lesions...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of special sites . Clin Lab Med   2011 ; 31 : 229 - 42 . 4. Hosler   GA , Moresi   JM , Barrett   TL . Nevi with site-related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site . J Cutan Pathol   2008 ; 35 : 889 - 98 . 5. Van Scott   EJ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanoma” or “epithelioid blue nevus” ( 3 , 4 ). The term animal-type melanoma referred to pigmented tumors that microscopically resembled melanotic disease of gray horses ( 3 ). Epithelioid blue nevus was reported in 1996 as a cutaneous manifestation of Carney complex ( 2 ), but it also occurs...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are affected ( 13 ). It is less common in other ethnic groups. There is a predilection for women. In contrast to Mongolian spots, nevus of Ota usually does not fade with time, but tends to persist throughout life, and may enlarge and darken. Cutaneous melanoma may arise in a nevus of Ota, but this is rare ( 14...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Metcalf   JS , Maize   JC . Clark’s nevus . Semin Cutan Med Surg   1999 ; 18 : 43 - 6 . 5. Clark   WH   Jr , Reimer   RR , Greene   M , Ainsworth   AM , Mastrangelo   MJ . Origin of familial malignant melanomas from heritable melanocytic lesions. The “B-K mole syndrome...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanocytes. Strong and diffuse immunoreactivity for PRAME can assist in establishing a diagnosis of melanoma. FISH may also be useful. Primary Nevoid Melanoma versus Cutaneous Metastasis. On rare occasion, a melanoma metastasis to the dermis is confused with a primary nevoid melanoma. Clinical context...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , Jorgensen   C . Sun exposure and risk of melanoma . Arch Dis Child   2006 ; 91 : 131 - 8 . 10. Berg   P , Wennberg   AM , Tuominen   R , et al . Germline CDKN2A mutations are rare in child and adolescent cutaneous melanoma . Melanoma Res   2004 ; 14 : 251 - 5 . 11. Lange   JR...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... ). In Southeast Asia, for example, more than half of the primary cutaneous melanomas occur at acral sites, with subungual melanoma accounting for 10 to 20 percent ( 11 – 13 ). In the United States, 2 to 3 percent of melanomas are acral ( 11 ). CLINICAL FEATURES Acral melanoma occurs across a wide age range...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... a  One BAP1-TPDS tumor and first- or second-degree relative with BAP1-TPDS Confirmed BAP1-TPDS–associated neoplasms (in descending order of association with the syndrome):  BAP1-inactivated melanocytic tumors (BIMT)  Uveal melanoma  Mesothelioma  Cutaneous melanoma  Renal cell carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in histological types and sites of origin of cutaneous melanoma: a meta-analysis . Br J Dermatol   2011 ; 164 : 776 - 84 . 11. Thomas   NE , Edmiston   SN , Alexander   A , et al . Association between NRAS and BRAF mutational status and melanoma-specific survival among patients with higher-risk...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...   B , Calonje   E . Deep penetrating nevus: a review . Arch Pathol Lab Med   2011 ; 135 : 321 - 6 . 5. Cooper   PH . Deep penetrating (plexiform spindle cell) nevus. A frequent participant in combined nevus . J Cutan Pathol   1992 ; 19 : 172 - 80 . 6. Strazzula   L...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in conventional melanocytic nevi . J Cutan Pathol   2007 ; 34 : 713 - 5 . 16. Kerl   H , Wolf   IH , Kerl   K , Cerroni   L , Kutzner   H , Argenyi   ZB . Ancient melanocytic nevus: a simulator of malignant melanoma . Am J Dermatopathol   2011 ; 33 : 127 - 30 . 17. Fernandez...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (cutaneous or ocular) melanoma, as well as pigmented melanotic schwannian neoplasms. Blue Melanoma versus Blue Nevus. Confusion between a melanoma and blue nevus is rare, but may occur, especially in the setting of a cellular blue nevus with atypical features (e.g., nuclear atypia, a few mitotic figures...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... requires a multidisciplinary approach ( 2 , 26 , 27 ). Early and complete surgical excision is considered ( 28 ). Complete removal, however, is rarely feasible, especially for giant CMNs, where melanoma risk is also highest. Furthermore, removal of cutaneous CMN does not eliminate the risk of melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in melanocytic proliferations with intermediate histopathologic or spitzoid features . J Cutan Pathol   2020 ; 47 : 1123 - 31 . 11. Lazova   R , Pornputtapong   N , Halaban   R , et al . Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Sommer   LL , Barcia   SM , Clarke   LE , Helm   KF . Persistent melanocytic nevi: a review and analysis of 205 cases . J Cutan Pathol   2011 ; 38 : 503 - 7 . 13. King   R , Hayzen   BA , Page   RN , Googe   PB , Zeagler   D , Mihm   MC   Jr . Recurrent nevus...