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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch35
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Elevated right atrial pressure, as in pulmonary hypertension, increases the likelihood of a right-to-left shunt. Pathology of Interventions. Closure may be performed in the setting of cryptogenic stroke, migraine with aura, paradoxical embolization, platypnea orthodeoxia syndrome, or decompression...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-14
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
...Cryptogenic cirrhosis has been an important challenge in surgical pathology for more than 100 years. As new etiologies of cirrhosis were identified over time, cases of liver cirrhosis of unknown etiology diminished considerably, yet this continues to be a major diagnostic challenge today ( 1...
Images
Published: 01 January 2022
CRYPTOGENIC CIRRHOSIS PATTERN Figure 5-18 CRYPTOGENIC CIRRHOSIS PATTERN This cirrhotic liver shows mild ongoing portal and septalchronic inflammation. There is focal interface activity, but no plasma cell enrichment and no significant lobular hepatitis. More about this image found in CRYPTOGENIC CIRRHOSIS PATTERN This cirrhotic liver shows mild ongoing port...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
10.55418/9781933477190-8
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
.... Buchanan DR , Johnston ID , Kerr IH , Hetzel MR , Corrin B , Turner-Warwick M . Cryptogenic bilateral fibrosing pleuritis . Br J Dis Chest 1988 ; 82 : 186 - 93 . 20. Derakhshan F , Ionescu D , Cheung S , Churg A . Use of programmed death ligand...
Images
Published: 01 January 2022
ALPHA-1-ANTITRYPSIN GLOBULES Figure 1-43 ALPHA-1-ANTITRYPSIN GLOBULES Periportal hepatocytes have eosinophilic cytoplasmic globules. This biopsy is from a patient with cryptogenic cirrhosis; mutational status was unknown at the time of sign-out ( figures 1-43 and 1-44 are from the same case). More about this image found in ALPHA-1-ANTITRYPSIN GLOBULES Periportal hepatocytes have eosinophilic cyto...
Images
Published: 01 January 2022
CIRRHOSIS ASSOCIATED WITH THE METABOLIC SYNDROME Figure 9-32 CIRRHOSIS ASSOCIATED WITH THE METABOLIC SYNDROME Left: In this cirrhotic liver, focal changes of active steatohepatitis are present. Right: This cryptogenic cirrhotic liver shows minimal macrovesicular steatosis, no significant inflamm... More about this image found in CIRRHOSIS ASSOCIATED WITH THE METABOLIC SYNDROME Left: In this cirrhotic l...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-9
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... by various professional groups. As one example of medication therapy, pioglitazone, an insulin sensitizer, is recommend by the American Association for the Study of Liver Disease (AASLD) in selected cases ( 7 ). CRYPTOGENIC CIRRHOSIS The fat in NAFLD can diminish or disappear by the time cirrhosis develops...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-5
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... of the degree of active injury, these are: massive necrosis (associated with fulminant hepatitis presentation); subacute necrosis; acute hepatitis with moderate to marked lobular inflammation; chronic hepatitis with mild to moderate portal and lobular inflammation; and cirrhosis, often clinically cryptogenic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-6
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
..., pruritus, failure to thrive Jaundice, pruritus, failure to thrive Young adult presentations Rare Rare Cryptogenic biliary disease or cryptogenic cirrhosis Extrahepatic findings Diarrhea, pancreatic disease, hearing loss None None Increased risk for cholelithiasis None reported to date Yes...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-13
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... Hepatopulmonary syndrome secondary to cryptogenic liver disease Portal hypertension, generally due to nodular regenerative hyperplasia (NRH) Cirrhosis Liver failure Portal hypertension in CVID is generally associated with autoimmune diseases and azathioprine therapy in one series ( 9 ), and polyclonal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-3
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
...: biliary tract obstruction, phlebitis of portal vein, direct extension, hepatic artery seeding, penetrating liver trauma, and cryptogenic causes( 3 ). Biliary tract disease (usually obstructive) is the most common direct cause, found in 30 to 60 percent of cases. Another 25 percent of cases result from...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-10
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... allele (PI*MZ individuals) have increased risk of chronic liver disease in the setting of concomitant liver diseases such as nonalcoholic steatohepatitis, for which the Z allele is considered a “second hit” ( 87 , 88 ). The PI*MZ phenotype is also associated with cryptogenic cirrhosis ( 88 ). PI*SZ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-1
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
...-ANTITRYPSIN GLOBULES Periportal hepatocytes have eosinophilic cytoplasmic globules. This biopsy is from a patient with cryptogenic cirrhosis; mutational status was unknown at the time of sign-out ( figures 1-43 and 1-44 are from the same case). ALPHA-1-ANTITRYPSIN GLOBULES Figure 1-44 ALPHA-1...
