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EPIDERMOTROPIC METASTATIC MELANOMA  A: Metastatic melanoma is present in th...
Published: 01 February 2024
EPIDERMOTROPIC METASTATIC MELANOMA Figure 22-7 EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in the epidermis and dermis. This metastasis simulates the appearance of a primary melanoma. The intraepidermal melanoma extends peripheral to the dermal tumor cells. Clinicopatholo... More about this image found in EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in th...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... pattern. Combinations of patterns may be seen within a single lesion. The parallel furrow correlates microscopically with nests of melanocytes under the surface sulci, with vertically oriented melanin pigment in the stratum corneum. In the lattice-like pattern, nests of melanocytes underlie the surface...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... by the biopsy sample greatly facilitates clinical correlation and rendering of a definitive diagnosis. For the distinction of a lentiginous junctional nevus from LM it helps to know whether or not a pigmented macule on the skin of an elderly individual is new or changing, whether the patient has additional...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... to the large epithelioid tumor cells of the melanoma. This category of nodular melanoma, i.e., the group of primary dermal melanomas, is relevant for the potential diagnostic confusion with locally recurrent or metastatic melanoma. This distinction often can only be made by clinicopathologic correlation...
Images
CYST WALL  On occasion, morphologic evidence of a mass is subtle, as in thi...
Published: 01 January 2024
CYST WALL Figure 15-5 CYST WALL On occasion, morphologic evidence of a mass is subtle, as in this case of a cyst. The attenuated epithelium at the edge of the core of tissue and the slightly denser fibrosis, are indicative of a cyst wall, which may be the pathologic correlate of an image-detected... More about this image found in CYST WALL On occasion, morphologic evidence of a mass is subtle, as in thi...
Images
USUAL DUCTAL HYPERPLASIA  In this case, usual ductal hyperplasia (UDH) repr...
Published: 01 January 2024
USUAL DUCTAL HYPERPLASIA Figure 3-6 USUAL DUCTAL HYPERPLASIA In this case, usual ductal hyperplasia (UDH) represented the pathologic correlate for a non-mass-enhancing lesion detected on magnetic resonance imaging (MRI). As is appreciated in this low-power image, the area of involvement by UDH is... More about this image found in USUAL DUCTAL HYPERPLASIA In this case, usual ductal hyperplasia (UDH) repr...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of the conjunctival mucosa in the absence of an associated melanocytic neoplasm. It is the conjunctival equivalent of a melanotic macule/lentigo. REFERENCES REFERENCES 1. Elgart   GW . Seborrheic keratoses, solar lentigines, and lichenoid keratoses. Dermatoscopic features and correlation to histology...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... inflammatory reaction pattern. Sometimes there is partial loss of melanocytes, a phenomenon referred to as “regression.” Inflammation or partial regression may correlate with a so-called “halo” phenomenon, which refers to the clinical finding of circumferential depigmentation or hypopigmentation around...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... immunoreactivity for HRAS protein ( fig. 7-24 ). Gene fusions involving ROS1, ALK, NTRK, or MET ( fig. 7-25 – 7-31 ) are usually associated with immunoreactivity for the respective protein ( 37 ). However, the reverse is not always the case. While in Spitz lesions there is a good correlation...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nodules. Correlation with other clinical findings is needed to determine whether a PEM is a manifestation of Carney complex. MICROSCOPIC FINDINGS PEM is typically an intradermal, heavily pigmented tumor ( figs. 11-1 , 11-2 ). Many lesions display a wedge-like silhouette (see fig. 11-1 ). PEM may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... label for S-100 protein or SOX10. Clinical correlation and mutation analysis are essential for the correct diagnosis. Sometimes a subsequent metastasis expresses S-100 protein or SOX10. Undifferentiated melanoma is usually a metastatic tumor. If a patient has a known prior melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... aberrations by cytogenetic methods, such as FISH, single nucleotide polymorphism (SNP), or comparative genomic hybridization (CGH) arrays, can be diagnostically helpful, but it is not without pitfalls. These are not stand-alone tests and need to be correlated with the histopathologic findings and results from...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... fluorescence in situ hybridization (FISH) test. Correlation with clinical and histopathologic findings, as well as results from other studies, such as immunoreactivity for PRAME, as applicable, is needed for the best diagnosis. DIFFERENTIAL DIAGNOSIS Dysplastic Nevus versus Melanocytic Nevus with Mild...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Histological diagnosis of nevi and melanoma . Heidelberg : Springer ; 2013 . 17. Tschandl   P . Recurrent nevi: report of three cases with dermatoscopic-dermatopathologic correlation . Dermatol Pract Concept   2013 ; 3 : 29 - 32 . 18. Botella-Estrada   R , Sanmartin   O , Sevila...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... METASTATIC MELANOMA A: Metastatic melanoma is present in the epidermis and dermis. This metastasis simulates the appearance of a primary melanoma. The intraepidermal melanoma extends peripheral to the dermal tumor cells. Clinicopathologic correlation is essential to establish the correct diagnosis. B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... For diagnostically difficult cases immunohistochemical (e.g., PRAME expression) and/or ancillary cytogenetic studies are used for further characterization. If the atypical cell population is small, FISH analysis is preferable to CGH or SNP array so that cytogenetic aberrations can be directly correlated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... presents as a dermal or subcutaneous nodule without an associated benign nevus cell population, it may be mistaken for metastatic melanoma (see fig. 18-7 ). Clinical correlation (e.g., prior history of a blue nevus versus a prior history of invasive conventional melanoma) and often also mutation analysis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-15
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... for identification of the calcifications. It is important that the pathologist have access to the specimen radiograph to permit radiologic-pathologic correlation, and to ensure that the microcalcifications identified on microscopic examination correspond in size and arrangement with those present in the specimen...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., and periductal (B-cell predominant) lymphoid infiltrates, as well as alterations of the collagenous stroma, keloidal-type collagen, and epithelioid myofibroblasts ( fig. 2-3 ) ( 6 ). The findings are subtle, but taken together, this constellation of features is sufficient to suggest the diagnosis. Correlation...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-04
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... diagnostic terms is now recommended ( 1 ). These variants are discussed separately from classic LCIS, and always require use of their qualifier. Clinical Features. There are no signs or symptoms associated with LCIS, and the classic form typically does not have an imaging correlate ( 2 ). Most often LCIS...