ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-45 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A: The tumor cells contain small to medium-sized electron-dense granules, which represent lipofuscin. Some cells contain sparse lipid droplets. B: Stacks of rough endoplasmic reticulum and promi... More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A: The tumor cells contain sm...

“BLACK” ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-49 “BLACK” ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells contain abundant lipofuscin and have only sparse lipid droplets. Microvillous projections are seen along the cytoplasmic borders. More about this image found in “BLACK” ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells contain a...

ADRENAL CORTICAL CARCINOMA: ULTRASTRUCTURE Figure 6-29 ADRENAL CORTICAL CARCINOMA: ULTRASTRUCTURE A: Tumor cells contain sparse lipid droplets; some have small, irregular microvillous extensions of cytoplasm along the cell border. The cells contain ample mitochondria and smooth endoplasmic reticu... More about this image found in ADRENAL CORTICAL CARCINOMA: ULTRASTRUCTURE A: Tumor cells contain sparse l...

GANGLIONEUROMA Figure 11-43 GANGLIONEUROMA The ganglion cells contain abundant granular pigment consistent with lipofuscin or neuromelanin. Mature ganglion cells are encircled by satellite cells. More about this image found in GANGLIONEUROMA The ganglion cells contain abundant granular pigment consis...

COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROMA Figure 8-56 COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROMA This unusual tumor contains a pheochromocytoma and clusters of large mature neurons that are “naked,” that is, devoid of schwannian stroma. More about this image found in COMPOSITE PHEOCHROMOCYTOMA AND GANGLIONEUROMA This unusual tumor contains ...

GANGLIONEUROMA Figure 11-42 GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelinated nerve is present at one pole of a ganglion. The ganglion is probably incorporated secondarily in the tumor. B: A large bundle of myelinated nerve is present in this GN and is most likely se... More about this image found in GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelin...

PHEOCHROMOCYTOMA: CYSTIC DEGENERATION Figure 8-9 PHEOCHROMOCYTOMA: CYSTIC DEGENERATION The large cyst at bottom of this 15-cm tumor most likely results from old hemorrhage or infarction and contains only thin blood-tinged fluid. The small cyst to its right contains degenerating blood. More about this image found in PHEOCHROMOCYTOMA: CYSTIC DEGENERATION The large cyst at bottom of this 15-...

INTRACORTICAL LEYDIG CELLS Figure 1-38 INTRACORTICAL LEYDIG CELLS A solitary cluster of Leydig (or hilus) cells with numerous Reinke crystalloids were noted incidentally in the normal part of an adrenal gland removed because of an aldosterone-secreting cortical adenoma. Most of the Leydig cells a... More about this image found in INTRACORTICAL LEYDIG CELLS A solitary cluster of Leydig (or hilus) cells w...

ULTRASTRUCTURAL CORRELATES OF CORTICAL ZONATION Figure 1-47 ULTRASTRUCTURAL CORRELATES OF CORTICAL ZONATION At low magnification, cells of the zona glomerulosa (A) contain sparse lipid and have round to oval mitochondria with lamellar cristae. Cells of the zona fasciculata (B) contain many large ... More about this image found in ULTRASTRUCTURAL CORRELATES OF CORTICAL ZONATION At low magnification, cell...

CHROMAFFIN CELLS IN ADRENAL MEDULLA Figure 1-49 CHROMAFFIN CELLS IN ADRENAL MEDULLA Portions of adjacent chromaffin cells with heterogeneous secretory granules. With fixation in glutaraldehyde and postfixation in osmium ( 58 ), norepinephrine-containing granules have small, uniformly dark dense c... More about this image found in CHROMAFFIN CELLS IN ADRENAL MEDULLA Portions of adjacent chromaffin cells ...

PHEOCHROMOCYTOMA IN NEUROFIBROMATOSES TYPE 1 (NF1) Figure 10-3 PHEOCHROMOCYTOMA IN NEUROFIBROMATOSES TYPE 1 (NF1) A: The adrenal gland contains a pheochromocytoma. B: The morphology of the tumor is not distinct from sporadic pheochromocytomas. More about this image found in PHEOCHROMOCYTOMA IN NEUROFIBROMATOSES TYPE 1 (NF1) A: The adrenal gland co...

ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-25 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells have compact eosinophilic cytoplasm and contain eosinophilic hyaline globules. More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells ...

INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Figure 1-40 INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Globules are present in several chromaffin cells. A few cells contain numerous small globules. More about this image found in INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Globules are p...

TUBULAR DEGENERATION OF OUTER ZONA FASCICULATA Figure 1-33 TUBULAR DEGENERATION OF OUTER ZONA FASCICULATA Solid columns and cords of lipid-depleted cells are con verted into hollow tubules containing occasional degenerating cortical cells. More about this image found in TUBULAR DEGENERATION OF OUTER ZONA FASCICULATA Solid columns and cords of ...

ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY Figure 2-6 ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY This dysplastic kidney removed from a 5-week-old girl contains a prominent focus of benign immature adrenal cortex. More about this image found in ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY This dysplastic ...

PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Figure 4-26 PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Micronodules (arrows) are present at the corticomedullary junction on either side of the medulla. The nodules contain cells with compact, eosinophilic cytoplasm and focally prominent pigm... More about this image found in PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Micronodules (arrows) are...

GANGLIONEUROBLASTOMA INTERMIXED Figure 11-30 GANGLIONEUROBLASTOMA INTERMIXED Biopsy of paravertebral mass in 11-year-old girl shows areas of schwannian stroma, intermingled with areas of immature stroma containing cells with varying differentiation toward ganglion cells, but also including neurob... More about this image found in GANGLIONEUROBLASTOMA INTERMIXED Biopsy of paravertebral mass in 11-year-ol...

TESTICULAR TUMOR IN CONGENITAL ADRENAL HYPERPLASIA Figure 2-16 TESTICULAR TUMOR IN CONGENITAL ADRENAL HYPERPLASIA Individual cells have distinct cell borders and rounded nuclei, often with one or two eccentric nucleoli. Many cells contain coarse, granular pigment, which is lipofuscin. More about this image found in TESTICULAR TUMOR IN CONGENITAL ADRENAL HYPERPLASIA Individual cells have d...

MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 8-13 MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) The adrenal gland contains a dominant pheochromocytoma as well as two smaller nodules (top) and an expanded pal... More about this image found in MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TY...

ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-23 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged pleomorphic nuclei are seen in some cells, which are markedly different than the nuclei of adjacent tumor cells. A few cells also contain finely granula... More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged...