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MYOCARDIAL COMPONENTS  Left ventricular cardiomyocytes are <span class="search-highlight">considerably</span> lar...
Published: 15 November 2023
MYOCARDIAL COMPONENTS Figure 4-6 MYOCARDIAL COMPONENTS Left ventricular cardiomyocytes are considerably larger than interstitial cells, but interstitial cells appreciably outnumber the myocytes, as seen in this case with early fibrosis. Also, note the typical variation in nuclear size in adjacent... More about this image found in MYOCARDIAL COMPONENTS Left ventricular cardiomyocytes are considerably lar...
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INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE  The nuclei are large, and var...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE Figure 8-38 INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE The nuclei are large, and vary considerably in size and shape, sufficient for a diagnosis of pleomorphic lobular carcinoma. More about this image found in INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE The nuclei are large, and var...
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MUCINOUS CARCINOMA, HYPERCELLULAR VARIANT  A: At low power, this mucinous c...
Published: 01 January 2024
MUCINOUS CARCINOMA, HYPERCELLULAR VARIANT Figure 8-48 MUCINOUS CARCINOMA, HYPERCELLULAR VARIANT A: At low power, this mucinous carcinoma is considerably more cellular than that seen in fig. 8-47 , with large sheets of tumor cells surrounded by stromal mucin. B: At higher power, the tumor cells ... More about this image found in MUCINOUS CARCINOMA, HYPERCELLULAR VARIANT A: At low power, this mucinous c...
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METASTATIC SEROUS CARCINOMA  A: Low-power view of a core needle biopsy with...
Published: 01 January 2024
METASTATIC SEROUS CARCINOMA Figure 7-36 METASTATIC SEROUS CARCINOMA A: Low-power view of a core needle biopsy with a papillary lesion, dense lymphocytic infiltrate, and microcalcifications. B,C: At intermediate (B) and high (C) power view, the cytologic atypia is striking. This constellation of ... More about this image found in METASTATIC SEROUS CARCINOMA A: Low-power view of a core needle biopsy with...
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FIBROADENOMA WITH INVASIVE LOBULAR CARCINOMA  A: The stroma of this fibroad...
Published: 01 January 2024
FIBROADENOMA WITH INVASIVE LOBULAR CARCINOMA Figure 5-9 FIBROADENOMA WITH INVASIVE LOBULAR CARCINOMA A: The stroma of this fibroadenoma is considerably more cellular than is usual, yet the areas around the ducts have the appearance of a typical fibroadenoma. B: At high power, the cellularity is ... More about this image found in FIBROADENOMA WITH INVASIVE LOBULAR CARCINOMA A: The stroma of this fibroad...
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MICROGLANDULAR ADENOSIS  A: On core needle biopsy, microglandular adenosis ...
Published: 01 January 2024
MICROGLANDULAR ADENOSIS Figure 6-21 MICROGLANDULAR ADENOSIS A: On core needle biopsy, microglandular adenosis may be misinterpreted as a low-grade invasive ductal carcinoma. B: The growth pattern and lack of myoepithelial cells do not differentiate one diagnosis over the other. The eosinophilic ... More about this image found in MICROGLANDULAR ADENOSIS A: On core needle biopsy, microglandular adenosis ...
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MALIGNANT PHYLLODES TUMOR  A: This section illustrates the heterogeneity th...
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR Figure 5-31 MALIGNANT PHYLLODES TUMOR A: This section illustrates the heterogeneity that can be encountered in phyllodes tumor, with a more hypocellular, myxoid-appearing area in the upper piece of tissue and a considerably more cellular section of tissue in the lower po... More about this image found in MALIGNANT PHYLLODES TUMOR A: This section illustrates the heterogeneity th...
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COMPLEX SCLEROSING LESION WITH FOCAL NECROSIS  A: Low power image of a comp...
Published: 01 January 2024
COMPLEX SCLEROSING LESION WITH FOCAL NECROSIS Figure 6-29 COMPLEX SCLEROSING LESION WITH FOCAL NECROSIS A: Low power image of a complex sclerosing lesion involved by a florid epithelial proliferation. At lower center are ducts entrapped in sclerotic stroma. B: Intermediate power image of a duct ... More about this image found in COMPLEX SCLEROSING LESION WITH FOCAL NECROSIS A: Low power image of a comp...
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PIGMENTED PAGET DISEASE  A: Clinical photograph illustrating a pigmented le...
Published: 01 January 2024
PIGMENTED PAGET DISEASE Figure 13-14 PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented lesion involving the nipple and areola, with concomitant scaling of the surface of the nipple. B: Punch biopsy of the pigmented lesion shows a population of atypical epithelioid cells inv... More about this image found in PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented le...
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PIGMENTED PAGET DISEASE  A: Clinical photograph illustrating a pigmented le...
Published: 01 January 2024
PIGMENTED PAGET DISEASE Figure 13-14 PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented lesion involving the nipple and areola, with concomitant scaling of the surface of the nipple. B: Punch biopsy of the pigmented lesion shows a population of atypical epithelioid cells inv... More about this image found in PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented le...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... resection are limited and need to be balanced against morbidity from surgery. Often, margins are suboptimal. When reviewing excisions of DM we recommend the documentation of features that are relevant for consideration of additional treatment (e.g., re-excision or radiation therapy), including depth...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... While the association of a LM with an invasive malignant neoplasm in the dermis with features compatible with melanoma is usually sufficient evidence to establish a diagnosis of LMM, consideration needs to be given to the possibility of a rare collision scenario (e.g., LM colliding with an atypical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of maturation). Test results from ancillary studies and clinical follow-up may be needed in some cases to provide convincing evidence of malignancy. There is considerable variation in the architecture (circumscribed versus infiltrative, degree of asymmetry); the cytologic features are also highly variable. Some...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... acquired nevus. The term dysplastic nevus was originally used to describe large irregular nevi in hereditary melanoma kindreds with the hypothesis that these lesions had considerable risk for transformation to melanoma ( 1 , 5 ). In analogy to concepts of tumor progression of epithelial neoplasms (e.g...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... There are no specific treatment guidelines for melanomas arising in congenital nevi. Since these tumors often carry NRAS mutations, consideration may be given to using mitogen-activated protein kinase (MEK) inhibitors as the adjuvant targeted therapy. For children or adolescents with a Spitz melanoma, complete...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , Laterza   AM , Duran   C . Giant pigmented nevi: clinical, histopathologic, and therapeutic considerations . J Pediatr   1992 ; 120 : 906 - 11 . ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... if atypical or unusual features are found, such as mitotic figures, which cannot readily be explained, such as in the context of pregnancy. Consideration is given to a re-excision for an unusual lesion on a case by case basis. REFERENCES REFERENCES 1. Schäfer   T , Merkl   J , Klemm   E...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... pathways characterized by the presence of various kinase fusions or HRAS aberrations ( 8 , 13 ). While pathologists commonly agree on a typical case, there is considerable interobserver variability regarding what microscopic findings are needed for a lesion to be designated as “spitzoid” versus...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... attest to the blue tumor lineage. Melanoma differs from CBN by a higher degree of cytologic atypia, mitotic activity (including atypical mitotic figures), and necrosis. There may be considerable heterogeneity within a lesion that represents melanoma arising in association with a CBN. The diagnosis may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-06
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., which can aid in diagnostic recognition of the entity as benign. However, some adenoses have a more haphazard or even infiltrative pattern of growth, or are associated with significant stromal sclerosis and distortion, raising consideration of malignancy. Microglandular adenosis is unique among...