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congenital

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Congenital melanocytic nevus (CMN) is a melanocytic nevus that is present at birth ( Table 2-1 ) ( 1 ). Nevi developing or becoming clinically apparent within the first 2 years of life share similar histopathologic features, and are called tardive CMN or congenital-like...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch35
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...,D: Verhoeff-van Gieson stains.) ATRIAL SEPTAL DEFECTS: FOUR CONGENITAL TYPES Figure 35-5 ATRIAL SEPTAL DEFECTS: FOUR CONGENITAL TYPES A: Secundum defect, in an elderly adult. B: Primum defect, in an infant. C: Sinus venosus defect, in an adult. The right pulmonary veins (arrows) join the right...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch36
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...CONGENITAL STENOSIS OF SEMILUNAR VALVES Figure 36-1 CONGENITAL STENOSIS OF SEMILUNAR VALVES Left: Aortic stenosis, with thickened cusps. Right: Pulmonary stenosis, with dome-shaped acommissural valve. The truncal valve may also be congenitally stenotic (see fig. 37-27 ). CONGENITAL SUBVALVULAR...
Images
SMALL <span class="search-highlight">CONGENITAL</span> MELANOCYTIC NODULE (CMN)  A: Well-demarcated brown plaque ...
Published: 01 February 2024
SMALL CONGENITAL MELANOCYTIC NODULE (CMN) Figure 2-1 SMALL CONGENITAL MELANOCYTIC NODULE (CMN) A: Well-demarcated brown plaque on the dorsum of the hand of a child. B: The color is uniformly dark brown. The periphery of the lesion is slightly irregular. (Courtesy of Dr. A. Marghoob, New York, NY... More about this image found in SMALL CONGENITAL MELANOCYTIC NODULE (CMN) A: Well-demarcated brown plaque ...
Images
COMBINED NEVUS  A: <span class="search-highlight">Congenital</span> nevus with “satellite” lesions, one of which ...
Published: 01 February 2024
COMBINED NEVUS Figure 10-1 COMBINED NEVUS A: Congenital nevus with “satellite” lesions, one of which has become darker (arrow). B: The dark papule (arrow) shows bluish discoloration. C: Dermoscopy of the nevus and separate dark papule (arrow). More about this image found in COMBINED NEVUS A: Congenital nevus with “satellite” lesions, one of which ...
Images
COMBINED DEEP PENETRATING NEVUS  A: Silhouette of a <span class="search-highlight">congenital</span> nevus with a...
Published: 01 February 2024
COMBINED DEEP PENETRATING NEVUS Figure 10-2 COMBINED DEEP PENETRATING NEVUS A: Silhouette of a congenital nevus with a dual population of conventional and pigmented melanocytes. B: Juxtaposition of the pigmented spindle and epithelioid melanocytes (*) and conventional type B (arrow) melanocytes ... More about this image found in COMBINED DEEP PENETRATING NEVUS A: Silhouette of a congenital nevus with a...
Images
COMBINED NEUROTIZED NEVUS  This biphenotypic <span class="search-highlight">congenital</span> nevus has a superfi...
Published: 01 February 2024
COMBINED NEUROTIZED NEVUS Figure 10-13 COMBINED NEUROTIZED NEVUS This biphenotypic congenital nevus has a superficial conventional nevus cell population (arrow) and a deep dermal nodule of fusiform melanocytes with schwannian features (*). More about this image found in COMBINED NEUROTIZED NEVUS This biphenotypic congenital nevus has a superfi...
Images
NODULAR MELANOMA ASSOCIATED WITH A LARGE <span class="search-highlight">CONGENITAL</span> MELANOCYTIC NEVUS  A: T...
Published: 01 February 2024
NODULAR MELANOMA ASSOCIATED WITH A LARGE CONGENITAL MELANOCYTIC NEVUS Figure 20-3 NODULAR MELANOMA ASSOCIATED WITH A LARGE CONGENITAL MELANOCYTIC NEVUS A: The tumor is characterized by asymmetric exophytic growth with various colors. B: Silhouette of the lesion shows expansile nodular growth sur... More about this image found in NODULAR MELANOMA ASSOCIATED WITH A LARGE CONGENITAL MELANOCYTIC NEVUS A: T...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... recognized: conventional adult-type melanoma, Spitz melanoma, and melanoma associated with a large or giant congenital melanocytic nevus ( 1 , 2 ). EPIDEMIOLOGY Less than 1 percent of all melanomas occur in the pediatric population ( 3 ). Factors associated with an increased risk...
Images
NODULAR MELANOMA WITH RHADOMYOSARCOMATOUS DIFFERENTIATION ASSOCIATED WITH A...
Published: 01 February 2024
NODULAR MELANOMA WITH RHADOMYOSARCOMATOUS DIFFERENTIATION ASSOCIATED WITH A GIANT MELANOCYTIC NEVUS Figure 20-6 NODULAR MELANOMA WITH RHADOMYOSARCOMATOUS DIFFERENTIATION ASSOCIATED WITH A GIANT MELANOCYTIC NEVUS A: A large nodular mass is associated with a congenital compound nevus. B: The invas... More about this image found in NODULAR MELANOMA WITH RHADOMYOSARCOMATOUS DIFFERENTIATION ASSOCIATED WITH A...
Images
NEVOID MELANOMA  A: Plaque-like silhouette of the tumor simulates the appea...
Published: 01 February 2024
NEVOID MELANOMA Figure 17-6 NEVOID MELANOMA A: Plaque-like silhouette of the tumor simulates the appearance of a small congenital nevus. Several thin elongated rete ridges are present. B: The papillary dermis contains dense aggregates of melanocytes, some of which have enlarged nuclei. C: Mitot... More about this image found in NEVOID MELANOMA A: Plaque-like silhouette of the tumor simulates the appea...
Images
NODULAR MELANOMA ASSOCIATED WITH A NEVUS  A: The melanoma is an entirely in...
Published: 01 February 2024
NODULAR MELANOMA ASSOCIATED WITH A NEVUS Figure 15-7 NODULAR MELANOMA ASSOCIATED WITH A NEVUS A: The melanoma is an entirely intradermal nodular tumor (*). There is an associated congenital melanocytic nevus (arrow in inset). B: Close-up of the area within the inset of A. There is a dual populat... More about this image found in NODULAR MELANOMA ASSOCIATED WITH A NEVUS A: The melanoma is an entirely in...
Images
NODULAR MELANOMA ASSOCIATED WITH A GIANT MELANOCYTIC NEVUS  A: In an infant...
Published: 01 February 2024
NODULAR MELANOMA ASSOCIATED WITH A GIANT MELANOCYTIC NEVUS Figure 20-4 NODULAR MELANOMA ASSOCIATED WITH A GIANT MELANOCYTIC NEVUS A: In an infant a large nodular melanoma mass is located in the deep soft tissue in association with a congenital compound nevus. B: The melanocytes of the nevus show... More about this image found in NODULAR MELANOMA ASSOCIATED WITH A GIANT MELANOCYTIC NEVUS A: In an infant...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in growth, as in the case of combined BAP1-inactivated nevi. The change in color and shape contribute to clinical asymmetry worrisome for a possible melanoma. COMBINED NEVUS Figure 10-1 COMBINED NEVUS A: Congenital nevus with “satellite” lesions, one of which has become darker (arrow). B: The dark...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... refers to a melanoma simulating, at first glance, the appearance of an ordinary acquired or small congenital melanocytic nevus ( Table 17-1 ). However, as any type of nevus can be mistaken for melanoma, the annotation “nevoid” may also be applied to melanomas simulating a Spitz nevus (spitzoid melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... to approximately 1 in 200,000 in the general population ( 15 ). Leptomeningeal melanoma has also been found on rare occasion ( 16 ). Nevus of Ito (“Nevus Fuscocaeruleus Acromiodeltoideus”) Nevus of Ito, also known as nevus fuscocaeruleus acromiodeltoideus, is a unilateral usually congenital...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nevi on the other hand are more frequent in older individuals. It is likely that acquired nevi displaying a predominantly intradermal growth pattern (sometimes referred to as “congenital pattern”) result from an initiating oncogenic event in a dermal melanocyte, and are of dermal origin. Recent...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... fig. 9-4 ), the latter may be a compound or intradermal nevus. The associated nevus may be a congenital or acquired nevus. For additional information on DPN as part of a combined nevus, see chapter 10 . An incompletely removed, persistent, or clinically recurrent DPN manifests as an intradermal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with an acquired or congenital melanocytic nevus ( fig. 15-7 ). There is a range of growth patterns and cytologic features. NODULAR MELANOMA WITH NO ASSOCIATED MELANOMA IN SITU Figure 15-6 NODULAR MELANOMA WITH NO ASSOCIATED MELANOMA IN SITU A: Nodular silhouette of the tumor with a collarette on one side. B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., blue, congenital or other)  Desmoplastic carcinoma  Sarcoma with desmoplasia (AFX, DFSP, leiomyosarcoma, MPNST) a Molecular Genetic Findings  High mutation burden in elderly and in association with solar elastosis  Common mutations include: NF1, TP53, NFkappaB inhibitor...