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Figure 1-11

ROSAI-DORFMAN DISEASE A: Alternating pale and dark areas at low power are ...

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in Sinonasal Cavity > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
ROSAI-DORFMAN DISEASE Figure 1-11 ROSAI-DORFMAN DISEASE A: Alternating pale and dark areas at low power are characteristic of this condition. B: The pale areas are made up of large histiocytes with abundant eosinophilic cytoplasm. Emperipolesis is the presence of lymphocytes within More about this image found in ROSAI-DORFMAN DISEASE A: Alternating pale and dark areas at low power are ...
Book Chapter

Oral Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... versus Black: 2.0/100,000) ( https://seer.cancer.gov/statfacts/html/oralcav.html ) ( 10 ). Carcinogen exposure, diet, and preexisting medical conditions may all play a role in tumor development. Tobacco is the most important risk factor for OSCC ( 3 , 13 ). A dose-response correlation of tobacco smoking...
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Book Chapter

Nasopharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
... pilosebaceous units (D). E: The stalk of the polyp contains muscle, collagen, and adjacent seromucinous glands and adipose tissue. Immunohistochemical Findings. Except perhaps for excluding other neoplastic conditions in the differential diagnosis, immunohistochemical stains are not useful for the diagnosis...
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Book Chapter

Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... inflammatory polyp. General Features. Inflammatory polyps are most often seen as the result of allergic rhinosinusitis, but may also occur in the setting of infection, asthma, aspirin intolerance, cystic fibrosis, diabetes mellitus, and other conditions. Inflammatory polyps are encountered most frequently...
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Book Chapter

Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... the specific anatomy and histology of the ear allows for accurate diagnosis and treatment of the conditions that affect these areas. External Ear and External Auditory Canal The external auricle develops from the dorsal aspect of the first branchial groove. The tragus arises from the first branchial arch...
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Book Chapter

Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... ). It is estimated that an even larger number of patients have subclinical disease affecting the larynx. Such lesions can be confused with a neoplastic condition ( 28 – 30 ). Clinical Features. The demographics of patients with rheumatoid nodules is the same as that of patients with rheumatoid disease, although...
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Book Chapter

Jaw

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... frequency at the apices of nonvital teeth: APCs, periapical granulomas, and periapical abscesses. These three conditions cannot be distinguished from one another based on radiographic features alone, particularly on plain films, but CTs and MRIs are more discerning ( 431 – 438 ). APICAL PERIODONTAL CYST...
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Images
Figure 6-28

ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin...

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in Adrenal Cortical Carcinoma > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
typical of benign conditions (A,B) or “qualitative” changes, in the form of thickened fibers embedding single cells or small clusters (C). More about this image found in ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin...
Book Chapter

Clinicopathologic Features of the Adrenal Cortex

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... features underpinning these conditions, with a critical role in the multidisciplinary team ( 1 ). CUSHING SYNDROME Cushing syndrome is a systemic disorder originally described by Harvey Cushing in 1932 ( 2 ) and caused by excess glucocorticoids that result in alterations in the structure...
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Book Chapter

Adrenal Cortical Nodular Diseases

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical hyperplasia is a general term for a condition characterized by an increased number of cortical cells leading to an increase in size and weight of the gland. However, this term is currently considered a misnomer for almost all diseases that are defined as primary of the adrenal...
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Book Chapter

Other Adrenal Neoplasms and Tumor-Like Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of adrenal enlargement include hemorrhages, cysts, amyloidosis, infections, and noninfectious inflammatory conditions. Each of these entities can be confusing both clinically and radiologically. In some cases, the clinical context and imaging characteristics allow for a presumptive diagnosis ( 1 – 3...
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Book Chapter

Hereditary Predisposition to Adrenal Cortical Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... adrenal lesion or in the context of Carney complex ( 9 ). These conditions can present as sporadic or familial forms, but familial PPNAD as part of the Carney complex is the most common presentation. Carney complex was first described in 1985 as a sporadic or familial disease with autosomal dominant...
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Book Chapter

Physiology, Development, and Anatomy of the Adrenal Glands

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... conditions of chronic stress increases the adrenal glands’ capacity to produce cortisol by exerting a trophic effect on the zona fasciculata. The fight or flight response is a function of adult adrenal glands, in which the chromaffin cell acts essentially as a modified postganglionic sympathetic neuron...
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Book Chapter

Familial and Syndrome-Related Pheochromocytoma and Paraganglioma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... is an E3 ubiq-uitin ligase that targets HIF1α for proteasomal degradation. In low oxygen conditions, down-regulation of pVHL allows HIF1α to dimerize with HIF1β, stimulating transcription of VEGF, PDGFβ, and erythropoietin; these are also activated in VHL-associated tumors that exhibit the hypoxia-mediated...
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Book Chapter

Adrenal Cortical Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...: ALTERED RETICULIN PATTERNS Figure 6-28 ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin pattern as highlighted by silver staining techniques, either in the form of “quantitative” changes (large nests disrupting the regular alveolar pattern typical of benign conditions (A,B...
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Book Chapter

Pheochromocytoma and Adrenal Medullary Hyperplasia

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ubiquitination of HIF2a, leading to its proteolytic degradation under normoxic conditions. Signaling pathways in pseudohypoxic tumors caused by VHL mutations therefore predominantly reflect a direct effect of the loss of function of VHL. In contrast, tumors caused by mutations of SDHx...
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Book Chapter

Congenital Disorders of the Adrenal Gland

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and a cytomegalic form ( 5 ). AHC can occur as an X-linked form due to DAX1 mutation, and is associated with a number of single gene disorders and various chromosomal abnormalities. Bilateral adrenal agenesis is a rare condition that is incompatible with postnatal life without hormone replacement ( 6...
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Book Chapter

Adrenal Cortical Adenoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... context of adrenal cortical adenoma is discussed separately in chapter 7 . No specific etiologic factors, including environmental and other predisposing conditions, are recognized in sporadic cases, although recently a population-based study identified an increased risk to develop adrenal cortical...
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Book Chapter

Paraganglia and Paragangliomas

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Dev   1998 ; 12 : 3320 - 4 . 21. Tella   SH , Taieb   D , Pacak   K . HIF-2alpha: Achilles’ heel of pseudohypoxic subtype paraganglioma and other related conditions . Eur J Cancer   2017 ; 86 : 1 - 4 . 22. Tischler   AS , Asa   SL . Paraganglia . In: Mills   SE...
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Book Chapter

Skin and Soft Tissue

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.../panamensis)  L. tropica  L. major a Adapted from reference 16 . Table 24-3 DERMATOPHYTIC CONDITIONS AND THEIR RESPECTIVE ETIOLOGIC AGENTS a Condition Causative Organism(s) Comment Tinea capitis Ringworm of the scalp  Endothrix infections...
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