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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Acquired melanocytic nevi are benign melanocytic neoplasms not present at birth. They develop during childhood, adolescence, or any time during adulthood. The annotations “common,” “ordinary,” “conventional,” or “banal” refer to the spectrum of acquired nevi most frequently encountered...
Images
<span class="search-highlight">COMMON</span> BLUE NEVUS  <span class="search-highlight">Common</span> blue nevus (BN), uniformly pigmented, extends thr...
Published: 01 February 2024
COMMON BLUE NEVUS Figure 8-5 COMMON BLUE NEVUS Common blue nevus (BN), uniformly pigmented, extends through the entire dermis into the superficial subcutis. There is associated mild stromal fibrosis. More about this image found in COMMON BLUE NEVUS Common blue nevus (BN), uniformly pigmented, extends thr...
Images
<span class="search-highlight">COMMON</span> BLUE NEVUS  There is a small collection of fusiform and dendritic me...
Published: 01 February 2024
COMMON BLUE NEVUS Figure 8-2 COMMON BLUE NEVUS There is a small collection of fusiform and dendritic melanocytes with a few melanophages in the superficial reticular dermis. More about this image found in COMMON BLUE NEVUS There is a small collection of fusiform and dendritic me...
Images
<span class="search-highlight">COMMON</span> BLUE NEVUS  Small lesion of pigmented fusiform and dendritic melanoc...
Published: 01 February 2024
COMMON BLUE NEVUS Figure 8-3 COMMON BLUE NEVUS Small lesion of pigmented fusiform and dendritic melanocytes and scattered melanophages. These cells are present in the superficial reticular dermis in association with pilar erector smooth muscle bundles. More about this image found in COMMON BLUE NEVUS Small lesion of pigmented fusiform and dendritic melanoc...
Images
<span class="search-highlight">COMMON</span> BLUE NEVUS  A: Variably dense aggregates of pigmented melanocytes ar...
Published: 01 February 2024
COMMON BLUE NEVUS Figure 8-4 COMMON BLUE NEVUS A: Variably dense aggregates of pigmented melanocytes are distributed around follicular units occupying a larger area in the reticular dermis. B: There are slender fusiform melanocytes with finely granular cytoplasmic melanin pigment and small oval ... More about this image found in COMMON BLUE NEVUS A: Variably dense aggregates of pigmented melanocytes ar...
Images
<span class="search-highlight">COMMON</span> BLUE NEVUS  A: Papular exophytic silhouette of a pigmented intraderm...
Published: 01 February 2024
COMMON BLUE NEVUS Figure 8-6 COMMON BLUE NEVUS A: Papular exophytic silhouette of a pigmented intradermal melanocytic nevus. B: Slender fusiform and dendritic melanocytes wrap around collagen bundles. C: Dendritic melanocytes carry fine melanin granules in the cytoplasm in contrast to the large... More about this image found in COMMON BLUE NEVUS A: Papular exophytic silhouette of a pigmented intraderm...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., but unlike other nevi, are also usually positive for gp100 (HMB-45) ( 3 , 4 ). Most harbor mutations in GNAQ and GNA11, while mutations of CYSTLTR2 or PLCB4 or gene fusions involving GRIM1 or PRKCA are less common ( 2 , 5 – 11 ). DERMAL MELANOCYTOSES Dermal melanocytoses...
Images
Images
COMBINED BLUE NEVUS  Biphenotypic intradermal melanocytic nevus with a mixe...
Published: 01 February 2024
COMBINED BLUE NEVUS Figure 8-11 COMBINED BLUE NEVUS Biphenotypic intradermal melanocytic nevus with a mixed population of conventional small epithelioid melanocytes and a pigmented population with fusiform melanocytes with common BN-like features. More about this image found in COMBINED BLUE NEVUS Biphenotypic intradermal melanocytic nevus with a mixe...
Images
PLAQUE-TYPE BLUE NEVUS  A: A broad plaque of pigmented melanocytes in the d...
Published: 01 February 2024
PLAQUE-TYPE BLUE NEVUS Figure 8-22 PLAQUE-TYPE BLUE NEVUS A: A broad plaque of pigmented melanocytes in the dermis and subcutis involves the skin of the scalp. B: Individual tumor cells show features typical of common BN. They follow neurovascular bundles. More about this image found in PLAQUE-TYPE BLUE NEVUS A: A broad plaque of pigmented melanocytes in the d...
Images
PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES  A: Plaque-like multinodular g...
Published: 01 February 2024
PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES Figure 8-24 PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES A: Plaque-like multinodular growth of melanocytes involving the eyelid. B: The superficial portion of the lesion shows features of pigmented and paucimelanotic common BN. C: The deeper portion ... More about this image found in PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES A: Plaque-like multinodular g...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanoma ( 1 – 4 ). Some acral melanomas have different growth patterns. EPIDEMIOLOGY While acral melanoma likely has a similar incidence across different ethnicities ( 5 ), it is the most common variant of melanoma affecting individuals of Asian, Hispanic, or African ethnic origin ( 6 – 10...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... characterized by the presence of junctional nests and individual melanocytes displayed in a pagetoid and/or lentiginous pattern. EPIDEMIOLOGY SSM is the most common melanoma variant affecting young to middle-aged adults with lighter skin color. The trunk and extremities are most often affected. Risk factors...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... features, and dysplastic, blue, Spitz, or other nevi may also involve these sites. Also, atypical features said to be related to a “special site” are not site specific: they can be seen in melanocytic nevi anywhere. ACRAL NEVI Clinical Features.  Acral melanocytic nevi are common, especially...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... or mid-dermis only  Plexiform growth pattern common  Usually pigmented  Range of cytologic features (spindle, ovoid, and epithelioid)  Random nuclear atypia (enlarged nuclei, hyperchromatism, pseudoinclusions)  Curvilinear spindle cells around groups of melanocytes  Mitoses rare...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... deeply and was broadly transected or not. It is most common after a shave biopsy ( 6 – 12 ). Persistent nevi typically appear in adolescents or young adults, especially females ( 12 – 14 ), and on the back ( 12 , 13 , 15 ). The nevi tend to reappear within a few weeks to months, most commonly within...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... ). They tend to affect middle-aged or elderly individuals of a median age around 50 years. More than half of the reported cases have occurred in the head and neck region, but these melanomas also affect the trunk and extremities. A common clinical history is that of a blue nevus that has changed. Most tumors...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... present Inflammation Common Less common There are exceptions to the above features. On occasion, the area of the epidermis colonized by metastatic melanoma extends peripheral to the dermal melanoma deposit (see fig. 22-7 ). In exceptionally rare cases, metastatic melanoma is only seen...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... to be of small size and sharply circumscribed, but there are exceptions. Some vulvar lesions form large patches. Microscopically, solitary units of melanocytes are distributed at a normal or only slightly increased cell density. Melanotic macules are a common clinical presentation. They are benign and do...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...The melanocytic nevus commonly referred to as dysplastic is a fairly common acquired lesion with clinical and pathologic features intermediate between an ordinary nevus and superficial spreading melanoma. Other terms for this nevus include melanocytic nevus with architectural disorder...