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Figure 2-30

COMBINED NEUROENDOCRINE CARCINOMA A: Needle core biopsy of a neck mass sho...

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in Oropharynx > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
COMBINED NEUROENDOCRINE CARCINOMA Figure 2-30 COMBINED NEUROENDOCRINE CARCINOMA A: Needle core biopsy of a neck mass shows a mixed oropharyngeal nonkeratinizing SCC (left) with tightly defined nests and larger cells with a little more cytoplasm and small cell carcinoma (center and right More about this image found in COMBINED NEUROENDOCRINE CARCINOMA A: Needle core biopsy of a neck mass sho...
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Figure 3-24

NASOPHARYNGEAL SALIVARY GLAND ANLAGE TUMOR A–C: The tumor is composed of a...

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in Nasopharynx > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
NASOPHARYNGEAL SALIVARY GLAND ANLAGE TUMOR Figure 3-24 NASOPHARYNGEAL SALIVARY GLAND ANLAGE TUMOR A–C: The tumor is composed of a combination of branching squamous (A), glandular (B), and tubular (C) elements. More about this image found in NASOPHARYNGEAL SALIVARY GLAND ANLAGE TUMOR A–C: The tumor is composed of a...
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Figure 6-88

MUCOEPIDERMOID CARCINOMA A: This intermediate-grade mucoepidermoid carcino...

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in Hypopharynx, Larynx, and Trachea > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
MUCOEPIDERMOID CARCINOMA Figure 6-88 MUCOEPIDERMOID CARCINOMA A: This intermediate-grade mucoepidermoid carcinoma is predominantly solid with a combination of epidermoid cells, intermediate cells, and rare mucinous cells. B: Some mucoepidermoid carcinomas have abundant cells with clear More about this image found in MUCOEPIDERMOID CARCINOMA A: This intermediate-grade mucoepidermoid carcino...
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Figure 3-22

MALIGNANT SALIVARY GLAND TUMORS OF THE NASOPHARYNX Adenoid cystic carcinom...

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in Nasopharynx > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
subtype of adenoid cystic carcinoma often presents in the nasopharynx at an advanced stage. B: Intermediate-grade mucoepidermoid carcinoma shows a combination of epidermoid, intermediate, and rare goblet-type mucinous epithelial cells. More about this image found in MALIGNANT SALIVARY GLAND TUMORS OF THE NASOPHARYNX Adenoid cystic carcinom...
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Oropharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... for neuroendocrine differentiation. However, recent reports have shown almost one third of oropharyngeal SCCs are positive, in the absence of other neuroendocrine marker expression, so INSM1 should be considered only in combination with other neuroendocrine marker expression ( 41 ). Solid adenoid cystic carcinoma...
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Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... patterns of these lesions. Most lesions are myxoid, but combinations of fibrinous material, hemorrhage, and small vessel or reendothelialized spaces are common. Clues that the lesion is not a true hemangioma are the heterogeneity of tissue patterns and the associated fibrin accumulation. For the occasional...
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Nasopharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
... of the nasopharynx is important since management considerations, which are in part influenced by advances in radiotherapy techniques, differ from other types of head and neck cancer ( 10 ). Nasopharyngeal carcinomas are treated principally by radiotherapy, with or without combined chemotherapy and without surgical...
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Neck

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... disease, metastatic cancers, and new and recurrent hematolymphoid tumors. For the latter, FNA, when combined with flow cytometry, cell block material, cytogenetics (in selected cases), and clinical findings can be sufficient for a definitive diagnosis and subclassification of many lymphomas. In most cases...
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Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... and contain predominantly acid mucin, which appears blue or purple-blue with a combined Alcian blue/periodic acid–Schiff (PAS) stain in contrast to the red or purple-red mucin in typical inflammatory polyps ( 13 ). CYSTIC FIBROSIS POLYP Figure 1-9 CYSTIC FIBROSIS POLYP Inflammatory polyps in patients...
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Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... type I anomalies are more common in adults (range, 13 to 81 years) ( 18 , 28 ). If the lesion is a fistula, it tends to present in younger patients as a cyst (birth to 13 years). Cysts are twice as common as sinuses and fistulas combined. Female patients are affected more often than males at a ratio...
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Jaw

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... neoplasms like ameloblastoma. Clinical Features. ACs have a strong predilection for the mandible, with roughly a 3 to 1 mandible to maxilla ratio. They have a 2 to 1 male predominance and affect all ages, with a mean in the mid 40s ( 26 , 27 ). ACs are aggressive neoplasms that present with combinations...
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Oral Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
...). The exophytic, nodular area (D) is carcinoma. Over time, the lesions become more exophytic, with erythema and ulceration ( fig. 4-25D ). The progression of early PVL without dysplasia to cancer can take decades. It is impossible to discuss PVL without combining both the clinical presentation and biopsy findings...
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Figure 1-16

AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY The...

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in Physiology, Development, and Anatomy of the Adrenal Glands > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY Figure 1-16 AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY The patients ranged from 30 weeks’ gestational age to 35 years. Vertical bars represent one standard deviation. There is a marked decrease More about this image found in AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY The...
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Physiology, Development, and Anatomy of the Adrenal Glands

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and reproductive development, but loss of SF1 function only rarely causes adrenal insufficiency, most often in combination with testicular dysgenesis, while X-linked adrenal hypoplasia congenita is associated with loss of DAX1 function ( 2 , 13 , 22 ). Wnt/β-catenin signaling is later involved in maintaining...
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Book Chapter

Adrenal Cortical Nodular Diseases

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cortical nodular diseases is covered in chapter 7 . Adrenal cortical proliferations, usually without clinical or biochemical evidence of hormone hypersecretion, have been described in the context of Carney triad ( 3 ). This is the combination of gastric gastrointestinal stromal tumor (GIST), pulmonary...
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Other Adrenal Neoplasms and Tumor-Like Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... adrenal calcifications have also been seen in metabolic diseases, including Wolman disease, a rare autosomal recessive disorder of lipid metabolism caused by deficiency of lysosomal acid lipase ( 12b , 12c ), and adenosine deaminase-deficient severe combined immunodeficiency. PRIMARY NONENDOCRINE TUMORS...
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Book Chapter

Adrenal Cortical Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-ACT prospective study enrolling an international cohort of 2,017 patients, including 98 ACC patients ( 77 ). In this study, the combination of tumor diameter, imaging characteristics, and urine steroid metabolomics demonstrated very high positive (76.5 percent) and negative (99.7 percent) predictive...
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Book Chapter

Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... (Ondine curse) Blueberry muffin baby a VIP = vasoactive intestinal protein. Patients with a primary tumor or tumor localization in the head and neck area may present with Horner syndrome due to involvement of the superior cervical ganglion. This syndrome consists of a combination of one or more...
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Book Chapter

Congenital Disorders of the Adrenal Gland

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Congenital adrenal gland abnormalities may manifest anatomically, hormonally, or as a combination of the two, and thus present challenges to pathologists and clinicians. A common occurrence is the need to distinguish ectopic cortical tissue from tumor in cancer staging, abdominal surgery...
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Book Chapter

Clinicopathologic Features of the Adrenal Cortex

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., and sex steroids. Excess glucocorticoids give rise to Cushing syndrome, mineralocorticoid excess causes Conn syndrome, and sex steroid excess results in virilization or more rarely, feminization. A mixed endocrine syndrome can result from a combination of glucocorticoid and sex steroid secretion...
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