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in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY Figure 1-16 AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY The patients ranged from 30 weeks’ gestational age to 35 years. Vertical bars represent one standard deviation. There is a marked decrease in c... More about this image found in AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY The...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and reproductive development, but loss of SF1 function only rarely causes adrenal insufficiency, most often in combination with testicular dysgenesis, while X-linked adrenal hypoplasia congenita is associated with loss of DAX1 function ( 2 , 13 , 22 ). Wnt/β-catenin signaling is later involved in maintaining...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cortical nodular diseases is covered in chapter 7 . Adrenal cortical proliferations, usually without clinical or biochemical evidence of hormone hypersecretion, have been described in the context of Carney triad ( 3 ). This is the combination of gastric gastrointestinal stromal tumor (GIST), pulmonary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... adrenal calcifications have also been seen in metabolic diseases, including Wolman disease, a rare autosomal recessive disorder of lipid metabolism caused by deficiency of lysosomal acid lipase ( 12b , 12c ), and adenosine deaminase-deficient severe combined immunodeficiency. PRIMARY NONENDOCRINE TUMORS...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-ACT prospective study enrolling an international cohort of 2,017 patients, including 98 ACC patients ( 77 ). In this study, the combination of tumor diameter, imaging characteristics, and urine steroid metabolomics demonstrated very high positive (76.5 percent) and negative (99.7 percent) predictive...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... (Ondine curse) Blueberry muffin baby a VIP = vasoactive intestinal protein. Patients with a primary tumor or tumor localization in the head and neck area may present with Horner syndrome due to involvement of the superior cervical ganglion. This syndrome consists of a combination of one or more...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Congenital adrenal gland abnormalities may manifest anatomically, hormonally, or as a combination of the two, and thus present challenges to pathologists and clinicians. A common occurrence is the need to distinguish ectopic cortical tissue from tumor in cancer staging, abdominal surgery...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., and sex steroids. Excess glucocorticoids give rise to Cushing syndrome, mineralocorticoid excess causes Conn syndrome, and sex steroid excess results in virilization or more rarely, feminization. A mixed endocrine syndrome can result from a combination of glucocorticoid and sex steroid secretion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and paraganglioma collectively are estimated to occur per year in the United States ( 38 ). A 2018 analysis of a comprehensive national pathology database in the Netherlands showed an annual combined incidence of pheochromocytoma and sympathetic paraganglioma of 0.6 per 100,000 person years ( 39 ), consistent...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... affected by Li-Fraumeni syndrome. Cancers at an earlier stage of disease and with improved long-term survival have been identified using a combined multimodal radiologic and biochemical screening program ( 80 ). No studies specifically compared the clinical and pathologic features of adrenal cortical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... combined annual incidence rates that varied from 0.04 to 0.21 per 100,000 person-years. With new technologies and the recognition of familial predisposition syndromes, the profile of this disease has changed: more are being discovered as incidental adrenal masses during imaging and during surveillance...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-promoting genes, including CDKN1C, H19, IGF2, and KCNQ1OT1. The hereditary combination of paraganglioma solely with GIST, known as Carney-Stratakis dyad or Carney-Stratakis syndrome, may not be a distinct entity and can be associated with any of the germline SDHx gene mutations...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... RB , Drachenberg CB , Sasano H , Papadimitriou JC . Adrenal cortical adenoma with excess black pigment deposition, combined with myelolipoma and clinical Cushing’s syndrome . Int J Surg Pathol 2004 ; 12 : 57 - 61 . 45. Kameyama K , Takami H . Pigmented granules...
Images
Published: 01 September 2024
LYMPHOID INTERSTITIAL PNEUMONITIS (LIP) Figure 9-12 LYMPHOID INTERSTITIAL PNEUMONITIS (LIP) A: Chest computerized tomography (CT) scan showing widespread nodularity. B: There is a diffuse and nodular lymphocytic infiltration. C: Peribronchial and perivascular lymphocytic aggregates are seen. D... More about this image found in LYMPHOID INTERSTITIAL PNEUMONITIS (LIP) A: Chest computerized tomography (...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-25
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... muscle are sometimes examined. Irrespective of the site, the histologic features typically include various combinations of necrosis, predominantly mononuclear inflammation, vasculitis, fibrosis, and associated parasitic organisms. In immunocompetent individuals, pathology is most often identified...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-17
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... not specific for Bartonella spp. Immunohistochemistry, on the other hand, is usually specific for the genus and can be used to confirm infection. The combined application of a Warthin-Starry stain and immunohistochemistry may further improve the organism detection rate in histologic sections ( 7...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-28
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... limited sensitivity in cutaneous and mucocutaneous leishmaniasis, however, and a combination approach is recommended. Liver biopsy and splenic aspirate are of great value in diagnosing visceral leishmaniasis, but can be complicated by catastrophic intra-abdominal hemorrhage. Bone marrow aspiration...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... spectrum has evolved. Introduction of combination highly active antiretroviral therapy (HAART) in the mid-1990s has enabled HIV-infected persons to live nearly normally with chronic infection, but is associated with drug-induced pathology and, sometimes, reactions due to the immune reconstitution...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-27
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... there is parasite resistance to chloroquine. In the United States, artemisinin-based combination treatments are currently the therapy of choice. Antimalarial drugs are associated with significant adverse effects (including cardio- and hepatotoxicity, hypoglycemia, cutaneous hypersensitivity, and neuropsychiatric...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-02
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... insertions, and possibly, deletions) have been found in codon 129 of PRNP gene, which encodes for either methionine or valine ( 8 ). Another classification is based on the different amino acid combinations in the PrP gene and includes homozygosity for methionine (MM) and valine (VV...
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