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PIGMENTED PAGET DISEASE  A: <span class="search-highlight">Clinical</span> photograph illustrating a pigmented le...
Published: 01 January 2024
PIGMENTED PAGET DISEASE Figure 13-14 PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented lesion involving the nipple and areola, with concomitant scaling of the surface of the nipple. B: Punch biopsy of the pigmented lesion shows a population of atypical epithelioid cells inv... More about this image found in PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented le...
Images
PIGMENTED PAGET DISEASE  A: <span class="search-highlight">Clinical</span> photograph illustrating a pigmented le...
Published: 01 January 2024
PIGMENTED PAGET DISEASE Figure 13-14 PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented lesion involving the nipple and areola, with concomitant scaling of the surface of the nipple. B: Punch biopsy of the pigmented lesion shows a population of atypical epithelioid cells inv... More about this image found in PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented le...
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NEVOID MELANOMA IN SITU  A: Junctional proliferation of nests and solitary ...
Published: 01 February 2024
NEVOID MELANOMA IN SITU Figure 17-9 NEVOID MELANOMA IN SITU A: Junctional proliferation of nests and solitary units of melanocytes. B: Image of the clinical lesion, from which the biopsy was taken. The clinical context proves that the junctional melanocytic proliferation must be melanoma in situ... More about this image found in NEVOID MELANOMA IN SITU A: Junctional proliferation of nests and solitary ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... to be of small size and sharply circumscribed, but there are exceptions. Some vulvar lesions form large patches. Microscopically, solitary units of melanocytes are distributed at a normal or only slightly increased cell density. Melanotic macules are a common clinical presentation. They are benign and do...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nevus-like, other a DPN = deep penetrating nevus. While nodular melanoma is not a distinct pathologic-genomic entity, it is clinically a very useful melanoma subcategory. Nodular melanomas are more difficult to diagnose clinically than other conventional melanomas, especially in the absence...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...PROGNOSTIC FACTORS Once a diagnosis of melanoma has been established, it is important for the pathologist to provide prognostic information for patients and their clinical care team. At the time of diagnosis approximately 90 percent of individuals with primary cutaneous melanoma have no evidence...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...The melanocytic nevus commonly referred to as dysplastic is a fairly common acquired lesion with clinical and pathologic features intermediate between an ordinary nevus and superficial spreading melanoma. Other terms for this nevus include melanocytic nevus with architectural disorder...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... features, and dysplastic, blue, Spitz, or other nevi may also involve these sites. Also, atypical features said to be related to a “special site” are not site specific: they can be seen in melanocytic nevi anywhere. ACRAL NEVI Clinical Features.  Acral melanocytic nevi are common, especially...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of trauma and treatment is important because sometimes the associated microscopic features simulate the appearance of a melanoma ( 1 – 5 ). Awareness of the clinical context, and in the case of a prior surgical procedure knowledge of the prior pathology, are essential to avoid misdiagnoses. TRAUMATIZED...
Images
PRIMARY BLUE MELANOMA  An expansile tumor nodule is present in the subcutis...
Published: 01 February 2024
PRIMARY BLUE MELANOMA Figure 18-7 PRIMARY BLUE MELANOMA An expansile tumor nodule is present in the subcutis. The tumor carried a GNAQ 209L mutation. By clinical history, the patient had a blue nevus for many years, which had changed. More about this image found in PRIMARY BLUE MELANOMA An expansile tumor nodule is present in the subcutis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Melanoma can affect the skin not only as a primary tumor, but also as a metastatic tumor deposit. Metastatic melanoma has not originated at the site where it is found, but represents secondary growth after intravascular, intralymphatic or potentially perivascular spread. CLINICAL FEATURES Melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... ). In Southeast Asia, for example, more than half of the primary cutaneous melanomas occur at acral sites, with subungual melanoma accounting for 10 to 20 percent ( 11 – 13 ). In the United States, 2 to 3 percent of melanomas are acral ( 11 ). CLINICAL FEATURES Acral melanoma occurs across a wide age range...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Deep penetrating nevus (DPN) typically displays an inverted triangle-like downward architecture. It is composed of pigmented melanocytes with distinctive cytologic features ( Table 9-1 ). Table 9-1 FEATURES OF DEEP PENETRATING NEVUS Clinical Features  Brown or bluish-black...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Nevoid melanoma is a melanoma that closely resembles a melanocytic nevus microscopically. It is not a distinct clinical, microscopic, or molecular entity. The term nevoid melanoma refers to a diagnostic pitfall: “a diagnosis of a nevus that you later regret” ( 1 ). Most often the term...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Blue nevus (BN) and dermal melanocytosis share clinical, histopathologic, immunohistochemical, and molecular features ( 1 , 2 ). Clinically, most lesions are characterized by bluish discoloration. Histologically, there is an intrastromal proliferation of slender fusiform...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Congenital melanocytic nevus (CMN) is a melanocytic nevus that is present at birth ( Table 2-1 ) ( 1 ). Nevi developing or becoming clinically apparent within the first 2 years of life share similar histopathologic features, and are called tardive CMN or congenital-like...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with LM-MIS, recognizing that over time or within the same clinical lesion, LM-MIS may be associated with a spectrum of morphologic changes from low melanocyte cell density and relatively bland cytology to high tumor cell density, disordered growth, including pagetoid melanocytes, and marked cytologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...The term spitzoid melanoma is used for a melanoma bearing some resemblance to a Spitz nevus ( 1 ). It is a diagnostic pitfall ( 2 ): a melanocytic neoplasm may at first glance look like an atypical Spitz nevus or Spitz tumor, but is eventually diagnosed as melanoma based on clinical follow...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Combined melanocytic nevi are benign melanocytic proliferations that display two (or more) histopathologic nevus phenotypes within the same clinical lesion. Their relevance lies in the fact that they may both clinically and histopathologically be confused with melanoma. In some combined...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... likely derived from a blue nevus, such as histopathologic confirmation of a residual blue nevus associated with the melanoma or a clinical history of a blue nevus at the same site. For the sake of brevity, the term blue melanoma is used here. CLINICAL FEATURES Blue melanomas are rare ( 1 – 7...