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MELANOCYTIC NEVUS WITH <span class="search-highlight">CLEAR</span> BALLOON CELL CHANGES  The melanocytes display ...
Published: 01 February 2024
MELANOCYTIC NEVUS WITH CLEAR BALLOON CELL CHANGES Figure 3-16 MELANOCYTIC NEVUS WITH CLEAR BALLOON CELL CHANGES The melanocytes display large epithelioid cell features with abundant clear cytoplasm (arrows). More about this image found in MELANOCYTIC NEVUS WITH CLEAR BALLOON CELL CHANGES The melanocytes display ...
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DERMAL <span class="search-highlight">CLEAR</span> CELL SARCOMA  There is a nodule in the dermis, which simulates...
Published: 01 February 2024
DERMAL CLEAR CELL SARCOMA Figure 15-9 DERMAL CLEAR CELL SARCOMA There is a nodule in the dermis, which simulates the appearance of a nodular melanoma, but molecular analysis revealed a EWSR1-ATF1 gene fusion. More about this image found in DERMAL CLEAR CELL SARCOMA There is a nodule in the dermis, which simulates...
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COMBINED BALLOON CELL NEVUS  A: A conventional melanocytic nevus contains a...
Published: 01 February 2024
COMBINED BALLOON CELL NEVUS Figure 10-14 COMBINED BALLOON CELL NEVUS A: A conventional melanocytic nevus contains a second population of epithelioid cells with clear cytoplasm (arrow). B: Juxtaposition of the epithelioid cells with abundant clear cytoplasm and small conventional melanocytes. All... More about this image found in COMBINED BALLOON CELL NEVUS A: A conventional melanocytic nevus contains a...
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BALLOON CELL COMPOUND MELANOCYTIC NEVUS  A dominant population of melanocyt...
Published: 01 February 2024
BALLOON CELL COMPOUND MELANOCYTIC NEVUS Figure 2-10 BALLOON CELL COMPOUND MELANOCYTIC NEVUS A dominant population of melanocytes displays abundant cytoplasm with clear cell (balloon cell) features. More about this image found in BALLOON CELL COMPOUND MELANOCYTIC NEVUS A dominant population of melanocyt...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-like melanoma   Neurotropic and/or desmoplastic melanoma   Spitzoid melanoma   Nevoid melanoma  Misc. primary malignant tumors with neurocristic/melanocytic differentiation   Clear cell sarcoma   Dermal melanocytic tumor with CRTC1-TRIM11 fusion  Metastatic melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...), but can be supported by molecular methods (e.g., same mutation profile as the primary tumor). Metastatic Melanoma versus Clear Cell Sarcoma (Melanoma of Soft Parts). Most textbooks classify clear cell sarcoma as a soft tissue neoplasm of uncertain histogenesis. It is a malignant tumor usually presenting...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... the diagnosis of melanoma even when presented with unusual features. BALLOON CELL/CLEAR CELL MELANOMA Balloon cell/clear cell melanoma is characterized by the presence of tumor cells with distinct cytoplasmic features ( 1 ). On hematoxylin and eosin (H&E)-stained sections, the tumor cells usually...
Images
PREGNANCY-LIKE HYPERPLASIA  Cells with <span class="search-highlight">clear</span>, vacuolated cytoplasm fill the...
Published: 01 January 2024
PREGNANCY-LIKE HYPERPLASIA Figure 1-7 PREGNANCY-LIKE HYPERPLASIA Cells with clear, vacuolated cytoplasm fill the lobules (A) and in other areas eosinophilic secretions are present in the acini (B). More about this image found in PREGNANCY-LIKE HYPERPLASIA Cells with clear, vacuolated cytoplasm fill the...
Images
<span class="search-highlight">CLEAR</span> CELL CHANGE  Low- (A) and high- (B) power images of two examples of c...
Published: 01 January 2024
CLEAR CELL CHANGE Figure 1-8 CLEAR CELL CHANGE Low- (A) and high- (B) power images of two examples of clear cell change in lobules. More about this image found in CLEAR CELL CHANGE Low- (A) and high- (B) power images of two examples of c...
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ACINIC CELL CARCINOMA  A: These cells have more abundant <span class="search-highlight">clear</span> cytoplasm an...
Published: 01 January 2024
ACINIC CELL CARCINOMA Figure 8-70 ACINIC CELL CARCINOMA A: These cells have more abundant clear cytoplasm and eosinophilic luminal secretions. B: A lysozyme stain is strongly and diffusely positive, supporting the diagnosis of acinic cell carcinoma. More about this image found in ACINIC CELL CARCINOMA A: These cells have more abundant clear cytoplasm an...
Images
PAGET DISEASE  A: Low-power shows large cells with abundant <span class="search-highlight">clear</span> to pale e...
Published: 01 January 2024
PAGET DISEASE Figure 13-12 PAGET DISEASE A: Low-power shows large cells with abundant clear to pale eosinophilic cytoplasm present singly, in small and large clusters. Even at this power, the presence of intracytoplasmic mucin vacuoles is appreciated (near center of field). B: At higher power, t... More about this image found in PAGET DISEASE A: Low-power shows large cells with abundant clear to pale e...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., similar to plasma cells. Oncocytic change refers to swollen eosinophilic granular cytoplasm. When melanocytes have abundant clear cytoplasm, this phenotype is typically referred to as balloon cell change ( fig. 3-16 ). MELANOCYTIC NEVUS WITH FATTY METAPLASIA Figure 3-11 MELANOCYTIC NEVUS WITH FATTY...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...  Acral nevus  Acral lentigo  Clear cell sarcoma Molecular Genetic Findings  Genomic complexity common  BRAF, NRAS, NF1, TERT mutations less common than in sun-exposed melanomas ACRAL MELANOMA Figure 14-1 ACRAL MELANOMA A: There is a large pigmented patch on the heel. B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... may be poorly pigmented, but lack of melanin pigment is most often found in sclerosing BN. Blue Nevus with Clear Cell or Foam Cell Features. Melanocytes with a clear, balloon cell, or foamy appearance may on occasion be seen as a minor subpopulation within a lesion with otherwise typical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (arrow) and a deep dermal nodule of fusiform melanocytes with schwannian features (*). Combined Balloon Cell Nevus. Balloon cell melanocytes are characterized by the presence of abundant clear or pale, sometimes foamy, cytoplasm. They may constitute a minor or larger component of a combined melanocytic...
Images
TOKER CELLS  Intermediate- (A) and high-power (B) images of the nipple epid...
Published: 01 January 2024
TOKER CELLS Figure 13-19 TOKER CELLS Intermediate- (A) and high-power (B) images of the nipple epidermis depict scattered Toker cells with moderate amounts of clear cytoplasm and bland-appearing round nuclei. Clear keratinocytes are present in the more superficial epidermis. These cells have less... More about this image found in TOKER CELLS Intermediate- (A) and high-power (B) images of the nipple epid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are positive for BRAFV 600E or NRAS or diffusely express PRAME or HMB-45. AST versus Clear Cell Sarcoma versus Other Tumors. On occasion, a clear cell sarcoma (CCS) populates the epidermis and simulates the appearance of a Spitz tumor ( 51 ). Cytogenetic or mRNA sequence studies documenting...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are biphenotypic or multiphenotypic, with partial areas displaying features of Spitz nevus, blue nevus, pigmented epithelioid melanocytoma, neurotized nevus or neurofibroma ( fig. 2-9 ), or clear/balloon cell nevus ( fig. 2-10 ). CMNs may also display a desmoplastic stroma, with melanocytes aligned between...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... report should be designed so that the diagnosis and core data elements for clinical care are displayed in a clear and readily recognizable manner. A synoptic format improves consistency of reporting data elements and is therefore encouraged. When a comprehensive checklist, including optional data...
Images
ACINI OF THE BREAST  The inner epithelial cell layer and the outer myoepith...
Published: 01 January 2024
ACINI OF THE BREAST Figure 1-4 ACINI OF THE BREAST The inner epithelial cell layer and the outer myoepithelial cell layer are depicted. The myoepithelial cells can be variably prominent; in this case they have abundant clear cytoplasm. More about this image found in ACINI OF THE BREAST The inner epithelial cell layer and the outer myoepith...