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NECROLYTIC MIGRATORY ERYTHEMA  The <span class="search-highlight">classic</span> rash of glucagonoma syndrome.
Published: 01 March 2023
NECROLYTIC MIGRATORY ERYTHEMA Figure 12-71 NECROLYTIC MIGRATORY ERYTHEMA The classic rash of glucagonoma syndrome. More
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METASTATIC MALIGNANT MELANOMA  Left: The <span class="search-highlight">classic</span> histologic features includ...
Published: 01 March 2023
METASTATIC MALIGNANT MELANOMA Figure 14-10 METASTATIC MALIGNANT MELANOMA Left: The classic histologic features include a diffuse pattern and epithelioid cells with abundant cytoplasm and prominent nucleoli. Right: Other cases are noncohesive and have little cytoplasm. More
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PANCREATOBLASTOMA  Treatment effects include fibrosis (left) and infiltrate...
Published: 01 March 2023
PANCREATOBLASTOMA Figure 10-16 PANCREATOBLASTOMA Treatment effects include fibrosis (left) and infiltrates of foamy histiocytes (right), which can obscure the classic histologic features. More
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PANCREATOBLASTOMA  In this patient with familial adenomatous polyposis (FAP...
Published: 01 March 2023
PANCREATOBLASTOMA Figure 10-13 PANCREATOBLASTOMA In this patient with familial adenomatous polyposis (FAP), a morphologically classic pancreatoblastoma (left) is present and a tubular adenoma also involves the ampulla of Vater (right). More
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<span class="search-highlight">CLASSIC</span> HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CERVICAL INTRAEPITHELIA...
Published: 01 February 2023
CLASSIC HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CERVICAL INTRAEPITHELIAL NEOPLASIA 3 [CIN3]) Figure 3-9 CLASSIC HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CERVICAL INTRAEPITHELIAL NEOPLASIA 3 [CIN3]) Decreased maturation, full thickness atypia with hyperchromasia, and evident variation in nu... More
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<span class="search-highlight">CLASSIC</span> HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CIN2-3)  Even though th...
Published: 01 February 2023
CLASSIC HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CIN2-3) Figure 3-10 CLASSIC HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CIN2-3) Even though the surface shows maturation in the form of more abundant cytoplasm and nuclear spacing, the entire population is atypical, with nuclear enlargement, hyp... More
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KERATOACANTHOMA  These lesions show a <span class="search-highlight">classic</span> cup-shaped architecture with ...
Published: 01 February 2023
KERATOACANTHOMA Figure 5-3 KERATOACANTHOMA These lesions show a classic cup-shaped architecture with central keratin accumulation. The basal layer has a bland appearance. More
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EXOPHYTIC LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CONDYLOMA)  This lesio...
Published: 01 February 2023
EXOPHYTIC LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CONDYLOMA) Figure 3-1 EXOPHYTIC LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CONDYLOMA) This lesion exhibits the classic papillary architecture of LSIL, with koilocytotic atypia (left), stains strongly for p16, indicating it is associated with a ... More
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MICROGLANDULAR HYPERPLASIA  A: This reactive proliferation is seen in the s...
Published: 01 February 2023
MICROGLANDULAR HYPERPLASIA Figure 3-84 MICROGLANDULAR HYPERPLASIA A: This reactive proliferation is seen in the superficial mucosa, and often involves endocervical polyps, as in this example. B: It features a crowded and confluent population of glands lined by bland endocervical mucinous epithel... More
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MICROGLANDULAR HYPERPLASIA  A: This reactive proliferation is seen in the s...
Published: 01 February 2023
MICROGLANDULAR HYPERPLASIA Figure 3-84 MICROGLANDULAR HYPERPLASIA A: This reactive proliferation is seen in the superficial mucosa, and often involves endocervical polyps, as in this example. B: It features a crowded and confluent population of glands lined by bland endocervical mucinous epithel... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-10
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... pancreatic tissue at 8 weeks of gestation ( 49 ). The histologic appearance of pancreatoblastoma differs somewhat between children and adults, with the more classic appearance occurring in pediatric cases. At low power, the lobulated pattern of pancreatoblastoma is clearly evident, and the periphery...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-14
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... and no known history of melanoma ( 68 ), increasing the likelihood of misdiagnosis as a primary pancreatic malignancy. Pancreatic metastasis from melanoma occurs at an earlier age (average age, 53 years) than other metastases to the pancreas and conventional ductal adenocarcinoma ( 62 , 69 ). The classic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
..., and the bile duct upstream from this area of stenosis is dilated and thickened. Dilatation of both pancreatic and bile ducts correlates with the classic “double-duct sign” seen radiographically. Fatty replacement of the pancreatic parenchyma upstream from cancers can also be seen ( fig. 7-5A,B ). Most...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-04
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...Serous cystic neoplasms (SCNs) collectively include the classic microcystic serous cystadenoma along with macrocystic and solid variants, and the rare malignant serous cystic neoplasms. Serous neoplasms are the few ductal-type neoplasms that do not produce mucin. Most (over 95 percent) are benign...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... presenting symptoms include abdominal pain, weight loss, nausea, and vomiting ( 2 , 22 , 35 ). Weakness, anorexia, melena, and diarrhea have also been reported. The classic syndrome of lipase hypersecretion due to massive amounts of lipase secreted into the blood by the neoplasm is likely overreported...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... NEUROENDOCRINE TUMOR There are spindle-shaped nuclei, some of which are enlarged and irregular. PANCREATIC NEUROENDOCRINE TUMOR Figure 12-26 PANCREATIC NEUROENDOCRINE TUMOR Mitotic figures are usually sparse in PanNETs. Classic argyrophil and argentaffin silver staining techniques previously used to identify...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ). Most adenosquamous carcinomas fall into the basal-like/squamous subtype based on gene expression profiling ( 21 – 25 ). Recent molecular analyses have suggested that the squamous component represents a subclonal population in an otherwise classic glandular neoplasm ( 26 ). There may also be significant...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... islets seem to consistently show a core of β cells closely associated with intra-islet capillaries and surrounded by a mantle of non-β cells, much like the classically described rodent islets ( 118 , 122 , 127 , 128 ). However, larger islets appear more complex, and several theories of cytoarchitectural...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ducts appear to communicate with the larger pancreatic ducts, but in other cases, it is challenging to distinguish branch duct IPMNs from true cystic lesions radiographically. Endoscopy classically reveals mucin excretion from a patulous ampulla of Vater when the main duct is involved ( fig. 6-2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... and classic morphology is seen, PNET still cannot be excluded, and additional molecular studies can be attempted because the fusions observed in PNETs can include EWSR1 (and FUS) fusions with various ETS partners ( 134 – 136 ). Other recurrent fusions (e.g., CIC-DUX4, BCOR...