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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... that approximately 90 percent of the human population has been infected with EBV. The virus is primarily transmitted via oral secretions/saliva, but can also be acquired through blood products and organ transplantation, and possibly, sexual contact ( 15 ). Seroconversion typically occurs in childhood...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of AdV on a negative stain (A) and schematic of viral components (B). (A: courtesy of the CDC PHIL) Epidemiology AdV has a worldwide distribution and most individuals are infected during childhood. The virus can be transmitted through aerosolized droplets and infects the respiratory tract or conjunctiva...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... invariably fatal (over 95 percent) 1 to 3 years after symptoms begin ( 46 ). Clinical manifestations typically develop 6 to 11 years after the initial measles virus infection, but occasionally the interval is shorter or much longer. Most cases begin in childhood ( 57 ). In adult-onset disease, where...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in childhood and persists for many years (frequently for life). High-income countries have seen a steady decrease in the prevalence of H. pylori infection over the last few decades, largely due to improved sanitation and increased use of antibiotics for other infectious conditions. In these regions...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-06
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of transmission, however, is greater in the former. Initial HSV infection, which may be asymptomatic, is most frequently acquired in childhood and remains lifelong. The age of first infection varies from country to country, with serologic studies demonstrating acquisition at a younger age in low- and middle...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... into active infection, which occurs in childhood and is characterized by collections of subepithelial lymphoid follicles ( fig. 18-12 ). The disease is asymptomatic or accompanied by redness, discomfort, tearing, discharge, or photophobia. The cicatricial phase is characterized by entropion, trichiasis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-05
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... cause of childhood and adult diarrhea, but also often affects the immunocompromised ( 33 ). The latter includes individuals with bone marrow and solid organ transplants, as well as congenital immune deficiencies (such as severe combined immunodeficiency [SCID]). Gastroenteritis due to cytomegalovirus...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., peripheral vascular disease, cirrhosis, renal failure, malignancy, and corticosteroid use. In children, predisposing factors include childhood rashes (especially varicella); infections such as omphalitis, balanitis, and mastitis; and other conditions such as diaper rash and necrotizing enterocolitis (NEC...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in childhood, with seropositivity in over 85 percent of the adult population. The mode of transmission is not yet completely understood, although main proposed routes include orofecal and respiratory. Close contact with an infected person is usually necessary. Other described transmission routes include organ...
Images
Published: 01 February 2024
SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-4 SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B: The tumor cells display severe nuclear atypia. The tumor was associated with homozygous deletions of p16 (not shown). C: Metastatic melanoma in the regional lymph node. More about this image found in SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B...
Images
Published: 01 February 2024
SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-6 SPITZOID MELANOMA (OF CHILDHOOD) A: The tumor is densely cellular with lack of maturation and tongue-like projections at the base. B: The tumor is composed of fusiform melanocytes, many of which are in mitosis. C: Tumor cells are present in the subca... More about this image found in SPITZOID MELANOMA (OF CHILDHOOD) A: The tumor is densely cellular with lac...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Pediatric melanomas encompass melanomas that affect individuals before they reach adulthood (usually prior to age 18 years). They are further subdivided into early childhood (prepubescent) and adolescent (postpubescent) melanomas. Three groups of pediatric melanomas are currently...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... number aberrations. SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-4 SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B: The tumor cells display severe nuclear atypia. The tumor was associated with homozygous deletions of p16 (not shown). C: Metastatic melanoma in the regional...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... A large PN typically occurs in the setting of a giant CMN during infancy or early childhood; small PNs occur at any age and in any size of CMN. CMN, especially those located on the head, neck, or trunk of young patients, have a globular dermoscopic pattern, while CMNs on the extremities are often...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Acquired melanocytic nevi are benign melanocytic neoplasms not present at birth. They develop during childhood, adolescence, or any time during adulthood. The annotations “common,” “ordinary,” “conventional,” or “banal” refer to the spectrum of acquired nevi most frequently encountered...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... “rhabdoid” alludes to the cytologic resemblance to a “rhabdoid tumor,” a term originally coined by Haas et al. ( 6 ) in 1981 for an aggressive childhood renal tumor. Rhabdoid melanoma was first reported by Bittenesi et al. ( 7 ) in 1992. Rhabdoid cytology is more often seen in metastatic tumors, but on rare...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... as of the trigeminal nerve (periorbital region, forehead, temple, cheek, and nose), as well as conjunctiva, retina, periorbital soft tissue, and nasal mucosa. The condition usually presents unilaterally at birth or in childhood, but delayed onset in adolescence may occur. Approximately 0.01 to 0.03 percent of Asians...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., the presence of pure versus mixed desmoplastic melanoma should be documented, since it affects prognosis and discussions on the value of a sentinel lymph node biopsy. We also believe that subclassification of unusual melanomas, such as Spitz melanoma of childhood or blue nevus-associated melanomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., the histopathologic and genomic features of the primary tumor, and the volume, distribution, and cytology of the intranodal melanocytes. REFERENCES REFERENCES 1. Spitz S . Melanomas of childhood . Am J Pathol 1948 ; 24 : 591 - 609 . 2. Allen AC , Spitz S . Malignant melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch42
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... (sheet-like) calcification of the falx Minor Diagnostic Criteria Cardiac or ovarian fibroma Lymphomesenteric or pleural cysts Childhood medulloblastoma Cleft lip/palate Macrocephaly Bifid ribs or extra ribs Polydactyly Ocular anomalies (e.g., cataract, pigmentary...
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