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Book Chapter
Ear and Temporal Bone
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... that develops and extends outward from the tympanic ring during childhood. The junction of the cartilage and bone is the narrowest part of the canal, called the isthmus, after which the floor dips down to the inferior margin of the annulus tympanicus, forming the tympanic recess. The external ear consists...
Book Chapter
Nasopharynx
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
.... Given that these lesions primarily appear in the newborn or in early childhood, even small tumors can have significant clinical effects. In the nasopharynx, where 60 percent of the tumors are located ( 13 ), the tumors arise in the lateral pharyngeal wall or posterior pharynx, and are more common...
Book Chapter
Neck
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... and are uncommon in the neck, representing less than 1 percent of all congenital neck cysts ( 107 ). Clinical Features. Bronchogenic cysts typically present in childhood, with only rare cases in adults ( 75 ). They are more common in men than women (3 to 1). They can present intraorally, particularly within...
Book Chapter
Sinonasal Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... of the inciting condition (e.g., allergies). Clinical Features. Inflammatory polyps are rare in childhood, with the exception of children with cystic fibrosis, where they are seen in up to 20 percent of patients ( 5 , 6 ). Uncommonly, inflammatory polyps are the presenting symptom. Accordingly, this condition...
Book Chapter
Oral Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... (myofibroma) or multicentric (myofibromatosis). General Features. Myofibromas are the most frequent fibrous tumors of infancy and early childhood. They occur as solitary myofibroma or multicentric myofibromatosis and generalized myofibromatosis. Most cases present before 2 years of age; however...
Book Chapter
Jaw
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... disease of bone ( 724 – 726 ). Clinical Features. The most distinctive clinical feature of GO is the age distribution. Conventional osteosarcoma typically affects the metaphysis of actively growing bones in childhood. GO is more evenly distributed throughout life, skewing the mean age of occurrence...
Images
UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuro...
Available to Purchase
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA Figure 11-12 UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuroblasts form solid sheets. Patterns such as this may cause confusion with other childhood neoplasms such as malignant lymphoma. Most nuclei have a single, small nucleolus More about this image found in UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuro...
Book Chapter
Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., both cell types, i.e., Schwann cell progenitor cells and neural crest progenitor cells, are potentially implicated as cells of origin. Epidemiology NBL and GNBL are the most common extracranial solid tumors in infancy and childhood, with an incidence of 9.7 cases per million in the entire pediatric...
Book Chapter
Hereditary Predisposition to Adrenal Cortical Lesions
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...) <1% Carcinomas in childhood, Wilms tumor, hepatoblastoma, rhabdomyosarcoma, neuroblastoma Primary macronodular adrenal disease (excluding MEN1 b , HLRCC, and FAP) ARMC5 (PDE11A rare) Primary macronodular adrenal disease <1% — Primary micronodular adrenal...
Book Chapter
Pheochromocytoma and Adrenal Medullary Hyperplasia
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... in the diagnosis of about 3 years ( 13 ). The old teaching that pheochromocytomas have a “ten percent” rule (10 percent bilateral, 10 percent malignant, and 10 percent familial, as well as other criteria such as 10 percent extra-adrenal and 10 percent in childhood) is no longer considered to be correct. While...
Book Chapter
Physiology, Development, and Anatomy of the Adrenal Glands
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ). Physical data regarding adrenal gland weights in infancy and childhood are based per force on postmortem studies ( 38 ). Figure 1-16 shows the average combined weights of meticulously dissected adrenal glands from 226 individuals ranging from 30 weeks’ gestational age to 35 years ( 38 ). AVERAGE COMBINED...
Book Chapter
Congenital Disorders of the Adrenal Gland
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of virilization with onset in childhood, suggesting untreated CAH ( 29 ). An increased incidence of incidental adrenal nodule(s) occurs in patients with homozygous (82 percent of patients; 2 cases were bilateral) and heterozygous (45 percent of patients) traits for CAH; the lesions were assumed to be adrenal...
Book Chapter
Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ). The features of these lesions are similar to those of other SDHx-related tumors. Beckwith-Wiedemann Syndrome Beckwith-Wiedemann syndrome is a disorder characterized by early childhood onset of clinical abnormalities, including omphalocele, umbilical hernia, hypoglycemia, and macrosomia...
Book Chapter
Adrenal Cortical Carcinoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., probably as the consequence of the prevalence of the TP53 p.R337H mutation in that population (see chapter 7 ) ( 232 ). Therefore, most data on the clinical and pathologic features of childhood adrenal cortical tumors derive from Brazilian cohorts of patients, even if there are no apparent...
Book Chapter
Lymph Nodes and Bone Marrow
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... lymphoma Chronic active EBV infection of T and NK cells (systemic and cutaneous) Hydroa-vacciniforme Severe mosquito bite allergy Systemic EBV-positive T-cell lymphoproliferative disease of childhood Hemophagocytic lymphocytosis NK/T-cell lymphomas (nodal and extranodal, including nasal type) Aggressive...
Book Chapter
Respiratory Tract
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... diagnosis of measles depends on the stage of the disease. In early infection (prior to the rash), other viral causes of upper respiratory tract infection may be considered. Once the rash appears, the differential diagnosis includes other childhood viral infections associated with a viral exanthem...
Book Chapter
Central Nervous System
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... is clearing, or even weeks/months after the rash has resolved ( 58 ). SSPE remains a challenging clinical diagnosis, especially in areas of the world where the incidence is decreasing. Although most childhood-onset cases are reasonably stereotypic in their features, symptoms may overlap with those...
Book Chapter
Gastrointestinal Tract
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Childhood asthma and other allergic disorders (such as eczema and rhinitis) Gastric B-cell non-Hodgkin (mucosal-associated lymphoid lymphoid tissue [MALT]) lymphoma Possibly: Metabolic syndrome/obesity Chronic inflammatory bowel disease, diarrheal disease, and tuberculosis Idiopathic...
Book Chapter
Skin and Soft Tissue
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-06
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... frequently acquired in childhood and remains lifelong. The age of first infection varies from country to country, with serologic studies demonstrating acquisition at a younger age in low- and middle-income countries ( 1 ). In the developing world, almost three quarters of individuals have been exposed to HSV...
Book Chapter
Sexually Transmitted Infections
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... trachomatis are presented in Table 18-3 . Trachoma is a chronic keratoconjunctivitis that results from recurrent eye infections by the bacterium ( 11 ). The disease is divided into active infection, which occurs in childhood and is characterized by collections of subepithelial lymphoid follicles ( fig. 18-12...
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