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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... While many are no different from banal nevi described in chapter 3 , some are “atypical,” often displaying mixed features of “dysplastic” nevi (e.g., junctional shoulder, fusion of junctional nests, variable atypia, lamellar fibroplasia, associated inflammation) and superficial small congenital nevi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with no evidence of maturation. Spitz and Spitzoid Melanomas. Spitz and spitzoid melanomas are rare variants of melanoma characterized by a resemblance to Spitz nevi microscopically and by the associated molecular pathways (see chapter 19 ) ( 25 – 29 ). A number of conventional microscopic features are used...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... fig. 9-4 ), the latter may be a compound or intradermal nevus. The associated nevus may be a congenital or acquired nevus. For additional information on DPN as part of a combined nevus, see chapter 10 . An incompletely removed, persistent, or clinically recurrent DPN manifests as an intradermal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...This chapter discusses unusual morphologic variants of primary cutaneous melanomas that have not been discussed elsewhere in the Fascicle. The purpose of commenting on these variants is for the practicing pathologist to be aware of the morphologic spectrum of melanomas, and to consider...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and/or hair follicles is called lentigo maligna (LM) or lentigo maligna melanoma in situ (LM-MIS). Some pathologists have proposed to distinguish LM from LM-MIS ( 5 ), applying the term LM for an “earlier” stage in the evolution of melanoma in situ. In this chapter, LM is used synonymously...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of different phenotypes within a nevus, may be confused with nodular melanoma. The distinction of these lesions from miscellaneous variants of melanoma is discussed in other chapters of this book. Nodular Melanoma versus Clear Cell Sarcoma or Other Fusion Tumors. Dermal-based variants of clear cell sarcoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of metastatic disease. Their outlook for 10-year survival ranges from 75 percent to nearly 100 percent depending on associated clinical and pathologic factors. To best stratify risk assessment for patients, it is important to carefully assess and record these parameters. This chapter focuses on the prognostic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...This chapter addresses the histopathologic changes associated with persistent melanocytic nevi presenting with repigmentation after prior surgery and nevi changing in response to nonsurgical mechanical trauma or biochemical injury, such as effects from cancer treatment. Knowledge of the effects...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... proliferations are not “true” Spitz lesions ( 26 , 27 ). They are often part of a combined nevus and are discussed in more detail under combined BAP1-inactivated lesions in chapter 10 . However, some BAP1-inactivated nevi are “pure,” i.e., the entire lesion displays epithelioid cell features accompanied by loss...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... heterogeneous group of pigmented melanomas with significant interobserver variability as to whether a tumor has blue nevus-like features or not. This chapter focuses on melanomas related to blue nevi, either by documentation of a shared molecular pathway or strong evidence indicating that the melanoma is most...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... complex or are sporadic ( 24 , 25 ). They are discussed in more detail in a separate chapter. Epithelioid BN can also be confused with pigmented Spitz nevi or combined nevi ( 26 ). BLUE NEVUS WITH EPITHELIOID CELL FEATURES Figure 8-10 BLUE NEVUS WITH EPITHELIOID CELL FEATURES A: Heavily pigmented...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , 22 ). The pathology of such melanomas is discussed in more detail in chapter 20 . TREATMENT AND PROGNOSIS The incidence of melanoma associated with CMN varies greatly, depending on the CMN phenotype. The lifetime risk of melanoma in a CMN is proportional to the size and melanocyte mass of the nevus...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-03
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...The intraductal proliferative lesions of the breast are legion; this chapter is confined to columnar cell lesions, usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS). By definition, intraductal proliferations are bound by a myoepithelial cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... that are specific to the mammary gland, and these are the focus of this chapter. MAMMARY DUCT ECTASIA Definition.  Mammary duct ectasia is an inflammatory condition of the proximal breast ducts affecting perimenopausal and postmenopausal women. Clinical Features. The typical presentation is of a non...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-15
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of breast cancer biomarker studies. It is also essential to be aware of the clinical and imaging findings, as well as the results of any prior biopsies, or prior history of breast cancer and associated treatment, so as to guide tissue sampling. This chapter covers the handling and processing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-01
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., in particular, can be used to establish breast origin in meta-static carcinomas (see chapter 8 ), although sensitivity and specificity among these antibodies also varies ( 13 , 14 ). It has been proposed that both the epithelial and myoepithelial cell lines derive from a common precursor that displays...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... mesenchymal lesions presented. As was discussed in chapter 8 , there are several subtypes of metaplastic carcinoma, with a wide spectrum of morphologies, and therefore, many of the lesions in this chapter may be mimics ( Table 11-1 ). Also, in the setting of a core needle biopsy sample, it is prudent...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-10
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... encountered in the male breast include intraductal papilloma, fibroepithelial lesions, lymphocytic/diabetic mastopathy, duct ectasia, and pseudoangiomatous stromal hyperplasia. Gynecomastia is exclusive to the male breast, and that is the focus of this chapter along with the particular features of carcinomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-06
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...Sclerosing adenosis and other adenoses discussed in this chapter are a collection of benign breast lesions characterized by an increase in the number of acini above physiologic norms, such as during pregnancy and lactation. In most types of adenosis, the lobulocentric growth pattern is maintained...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-14
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... are discussed in chapter 15 . METASTATIC MICROPAPILLARY CARCINOMA Figure 14-1 METASTATIC MICROPAPILLARY CARCINOMA A: This low-power image shows scattered foci of carcinoma in a core needle biopsy sample of a lymph node. B: On higher power, the cytologic atypia of the metastatic micropapillary carcinoma...