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VHL-ASSOCIATED SEROUS CYSTADENOMA AND NEUROENDOCRINE TUMOR Both small sero...

VHL-ASSOCIATED SEROUS CYSTADENOMA AND NEUROENDOCRINE TUMOR Both small sero...

in Serous Cystic Neoplasms > Tumors of the Pancreas
Published: 01 March 2023
VHL-ASSOCIATED SEROUS CYSTADENOMA AND NEUROENDOCRINE TUMOR Figure 4-19 VHL-ASSOCIATED SEROUS CYSTADENOMA AND NEUROENDOCRINE TUMOR Both small serous neoplasms (A, top) and a neuroendocrine tumor (A, bottom) are present in this patient with VHL. The serous neoplasms are microcystic (B) and some are... More about this image found in VHL-ASSOCIATED SEROUS CYSTADENOMA AND NEUROENDOCRINE TUMOR Both small sero...
Book Chapter

Classification of Pancreatic Tumors

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-02
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... as non-neoplastic; it is now designated “acinar cystic transformation” and is included in the chapter on non-neoplastic tumor-like changes ( 21 ). Although technically not part of the classification system, the staging criteria for both neuroendocrine and exocrine neoplasms have changed (discussed...
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Book Chapter

Staging

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-03
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... margins in pancreatoduodenectomy specimens include the bile duct, pancreatic neck, uncinate process (retroperitoneal), soft tissue, and proximal and distal bowel margins (see chapter 16 ). Carcinoma frequently extends to involve the retroperitoneal resection margin, and care should be taken to identify...
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Book Chapter

Adenocarcinoma Variants

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... neoplasms lack intracellular mucin, express CD10, and have a nuclear pattern of labeling for β-catenin ( 93 ). Staging. The staging of signet ring cell carcinoma should follow the staging for carcinomas of the exocrine pancreas (see chapter 3 ). Prognosis. Because of the rarity of this entity it is hard...
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Book Chapter

Intraductal Neoplasms

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... with an associated invasive carcinoma depends primarily on the type of carcinoma ( 47 , 110 ). As discussed in chapter 8 , the prognosis for patients with an IPMN with an associated invasive colloid carcinoma is significantly better than it is for patients with an IPMN with an associated invasive tubular carcinoma...
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Book Chapter

Dissection and Reporting of Pancreatic Resection Specimens

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-16
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... Knowing where to look for nodes is helpful (see chapter 1 ). A useful hint is that lymph nodes often sit in the groove created by the junction of the pancreas and bowel wall (“pancreatoduodenal lymph nodes”). It is not necessary to report the nodal groups separately. All nodes should be submitted...
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Book Chapter

Ductal Adenocarcinoma and Pancreatic Intraepithelial Neoplasia

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... an infiltrating adenocarcinoma of the pancreas, and molecular analyses of PanINs demonstrating that PanINs harbor many of the same genetic alterations found in infiltrating ductal adenocarcinoma ( 206 , 411 ). As described in detail in chapter 1 , the epithelium lining the pancreatic ducts is normally a flat...
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Book Chapter

Non-Neoplastic Lesions Mimicking Pancreatic Neoplasms

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-15
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... Langerhans (see chapter 1 ). However, in the inferior portion of the pancreatic head, most of the islets are of the reticulated trabecular “diffuse” type, consisting mainly of PP cells (PP islets). β cells, δ (somatostatin) cells, and α (glucagon) cells account for only 20 percent of the cells of the PP...
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Book Chapter

Acinar Cell Carcinoma and Variants

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of these mixed neoplasms have an acinar component and are therefore discussed below; mixed ductal neuroendocrine carcinomas are discussed in chapter 12 . In most cases of mixed neoplasms containing an acinar component, that element predominates and appears to drive the clinical behavior and genomics...
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Book Chapter

Serous Cystic Neoplasms

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-04
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... SEROUS CYSTADENOMA AND NEUROENDOCRINE TUMOR Both small serous neoplasms (A, top) and a neuroendocrine tumor (A, bottom) are present in this patient with VHL. The serous neoplasms are microcystic (B) and some are microscopic (C). The neuroendocrine tumor has clear cell features (D) (see chapter 12...
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Book Chapter

Nonepithelial and Miscellaneous Neoplasms

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of the periampullary duodenum, a few pancreatic cases have been reported and are discussed in chapter 12 . Histologically, the typical “zellballen” arrangement of chief cells in varying sized organoid nests is present, with an unpolarized, haphazard arrangement without acini or rosettes as might be observed...
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Book Chapter

Pancreatoblastoma

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-10
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... in pancreatoblastomas is much more restricted than in acinar cell carcinomas ( 67 ), which have a broad range of alterations involving multiple oncogenic pathways (see chapter 9 ). Clues to the most frequent genomic alterations in pancreatoblastoma come from its association with BWS and FAP ( fig. 10-13 ), which...
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Book Chapter

Mucinous Cystic Neoplasms

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-05
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... Staging of MCNs with an associated invasive carcinoma should follow the staging for carcinomas of the exocrine pancreas (see chapter 3 ). Invasive carcinomas may be limited to the septa of the cysts, or infiltrate into the pancreatic parenchyma and subsequently into the peripancreatic connective tissues...
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Book Chapter

Neuroendocrine Neoplasms

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
..., lack the triple cell type pattern of gangliocytic paragangliomas and are keratin negative (see chapter 13 ). In contrast to most cases arising in the duodenum, pancreatic gangliocytic paragangliomas can have malignant behavior, with lymph node or distant metastases ( 544 – 546 ). The large cell type...
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Book Chapter

The Normal Pancreas

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... such as PAS with diastase and Alcian blue at pH 2.5. Visible intracytoplasmic mucin is a pathologic change in the ductal epithelium (see chapter 7 ) ( 82 , 83 ). Ductal cells label with antibodies to high (AE1, AE3) and low (CAM5.2, CK7, CK19) molecular weight cytokeratins. Antibodies to CK20 and monoclonal...
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Book Chapter

Solid Pseudopapillary Neoplasm

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-11
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... pseudopapillary neoplasms follows the staging for carcinomas of the exocrine pancreas (see chapter 3 ). Complete surgical resection is the treatment of choice and is recommended even when there is local extension into adjacent structures ( 23 , 53 , 207 ). Resection of liver metastases and even liver...
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Book Chapter

Embryology and Anatomy of the Lower Female Genital Tract

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-1
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... differences in susceptibility to cancer following infection by high-risk HPV. Although the vaginal mucosa is normally committed to squamous differentiation, in certain instances aberrant differentiation occurs (see chapter 4 ). It may also take the form of spontaneous localized metaplasia, resembling Skene...
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Book Chapter

Classification and Biomarkers of Lower Female Genital Tract Neoplasia

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-2
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... markers commonly considered in female lower genital tract pathology. Other potentially useful markers not listed here are covered in the following chapters with entities in which they have a clinical application. Vimentin. Although often used in the past, vimentin is now relegated to a few specific...
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Book Chapter

Tumors and Tumor-Like Lesions of the Vagina

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... is discussed in detail in chapter 5 . Patients tend to present with vaginal MTMF in their fifth to eighth decades with a solitary mass or nodule. The differential diagnosis includes other benign spindle cell tumors, such as cellular angiofibroma, but also entities with malignant potential such as solitary...
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Book Chapter

Tumors and Tumor-Like Lesions of the Vulva

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... ). As mentioned in chapter 4 , vaginal melanoma appears to confer a worse prognosis than vulvar melanoma. Tumor stage, as per the American Joint Committee on Cancer (AJCC) system for cutaneous melanoma, is predictive of outcome in patients with vulvar and vaginal melanomas ( 447 , 463 ). Survival is also...
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