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Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...Acinar differentiation in pancreatic neoplasms is defined as the production of exocrine enzymes by the neoplastic cells, best demonstrated using specific immunohistochemical labeling ( 1 – 4 ). Although acinar cells constitute most of the pancreatic parenchyma, pancreatic neoplasms...
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Published: 01 March 2023
ACINAR CELL NODULE Figure 1-21 ACINAR CELL NODULE Acinar cell nodules are defined as aggregates of enlarged non-neoplastic acinar cells that are distinguished from the surrounding acinar cells by the pale tinctorial staining qualities of the cytoplasm. More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-3 ACINAR CELL CARCINOMA A: Acinar cell carcinoma arising in the head of the pancreas with polypoid extension into the duodenum. B: The neoplasm is tan to pink and circumscribed, and shows focal hemorrhage. C: This 15-cm tumor shows a central degenerative cyst. More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-5 ACINAR CELL CARCINOMA Top: At low power, acinar cell carcinomas are circumscribed and surrounded by a fibrous pseudocapsule into which mushroom-like projections may grow. Bottom: Rarely, there is polypoid growth into the pancreatic ducts; non-neoplastic ductal ep... More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-18 ACINAR CELL CARCINOMA Spindle cell features are rare. More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-27 ACINAR CELL CARCINOMA Neoplastic acinar cell clusters appear more hyperchromatic than non-neoplastic acinar cells because of the increased nuclear to cytoplasmic ratio (left). The vaguely lobulated architecture of acinar cell carcinoma is more disorganized and cr... More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-29 ACINAR CELL CARCINOMA Acinar cell carcinomas can lack nucleoli and show anisonucleosis and rare signet ring-like cells (Papanicolaou stain). More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-31 ACINAR CELL CARCINOMA Immunolabeling for trypsin in a smear of acinar cell carcinoma. More
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Published: 01 March 2023
METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Figure 14-2 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Histology of a nodular metastasis of renal cell carcinoma (left). Nests of clear cell carcinoma extend adjacent to non-neoplastic islet cells (right). More
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Published: 01 March 2023
METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Figure 14-3 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Cytologically, characteristic round nuclei and prominent, central nucleoli are in cells with abundant clear cytoplasm on fixed smears (left: Thinprep; right: Hematoxylin and eosin [H&... More
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Published: 01 March 2023
METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Figure 14-4 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Air-dried Romanowsky-stained smears enhance the appearance of microvesicles in the abundant cytoplasm of renal cell carcinoma (left), juxtaposed with comparatively small non-neoplastic ac... More
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Published: 01 March 2023
METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR Figure 14-6 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR The renal cell carcinoma (top) has clear cell features whereas the neuroendocrine t... More
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Published: 01 March 2023
ACINAR EPITHELIAL CELL Figure 1-10 ACINAR EPITHELIAL CELL Electron micrograph of acinar cells (right) juxtaposed with centroacinar cells (left). Acinar cells have luminal edge microvilli and round, electron-dense zymogen granules, whereas centroacinar cells have luminal microvilli and no zymogen ... More
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Published: 01 March 2023
DUCTAL ADENOCARCINOMA Figure 7-24 DUCTAL ADENOCARCINOMA Prominent clear cell change can mimic a metastasis of a renal cell carcinoma. More
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Published: 01 March 2023
DUCTAL ADENOCARCINOMA Figure 7-34 DUCTAL ADENOCARCINOMA Foamy cell variant. Diff Quik (A), Papanicolaou stain (B), cell block (C). More
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Published: 01 March 2023
SIGNET RING CELL CARCINOMA Figure 8-15 SIGNET RING CELL CARCINOMA Noncohesive cells with intracellular mucin that displaces the nuclei. More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-2 ACINAR CELL CARCINOMA Left: Computerized tomography (CT) shows a small neoplasm in the head of the pancreas that is hypodense compared to the pancreatic tissue. Right: Larger neoplasms are well circumscribed; central cystic degeneration is present. More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-4 ACINAR CELL CARCINOMA The neoplasm in the pancreatic tail directly extends into the spleen. More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-6 ACINAR CELL CARCINOMA A: Most cases are hypercellular at low power, with minimal fibrous stroma. B: Sometimes, fibrous bands separate the neoplasm into hyper-cellular islands. C: Only rarely are the individual neoplastic glands surrounded by stroma. More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-7 ACINAR CELL CARCINOMA Neoplastic cells are arranged in solid nests and acinar structures (left); some of these are slightly dilated (right). More
