ISLET CELL HYPERPLASIA Figure 5-8 ISLET CELL HYPERPLASIA Islet cell tumor and adjacent islet cell hyperplasia. (Left: H&E; right: chromogranin immunohistochemistry.) More

CLEAR CELL PARATHYROID HYPERPLASIA Figure 2-11 CLEAR CELL PARATHYROID HYPERPLASIA Clear cell parathyroid hyperplasia is an absolute increase in parathyroid parenchymal cells with abundant clear cytoplasm involving multiple parathyroid glands in the absence of a known stimulus for parathyroid horm... More

SOLID CELL NEST Figure 3-5 SOLID CELL NEST Solid cell nest in a thyroglossal duct cyst. These ultimobranchial body rests are made up of polygonal to oval cells with oval nuclei and granular chromatin. More

HASHIMOTO THYROIDITIS Figure 3-21 HASHIMOTO THYROIDITIS Hurthle cell (oxyphil cell) metaplasia is usually a prominent feature in Hashimoto thyroiditis. More

C-CELL HYPERPLASIA Figure 3-38 C-CELL HYPERPLASIA Physiologic C-cell hyperplasia shows increased numbers of calcitonin-positive C cells. More

C-CELL HYPERPLASIA Figure 3-39 C-CELL HYPERPLASIA C-cell hyperplasia and microscopic medullary thyroid carcinoma in a patient with multiple endocrine neoplasia (MEN) type 2B. After calcitonin immunostaining, the increased numbers of C cells are readily appreciated. More

ZOLLINGER-ELLISON SYNDROME/ECL CELL HYPERPLASIA Figure 5-9 ZOLLINGER-ELLISON SYNDROME/ECL CELL HYPERPLASIA ECL cell hyperplasia can be seen in Zollinger-Ellison syndrome (ZES) and primary gastrin cell hyperplasia (Left: H&E stain; right: chromogranin immunohistochemistry). More

ANTERIOR PITUITARY GLAND: NORMAL HISTOLOGY Figure 1-2 ANTERIOR PITUITARY GLAND: NORMAL HISTOLOGY Clusters of various cell types are present. A: Reticulin stain highlights the acinar clusters. B: The hematoxylin and eosin (H&E)-stained section shows a mixture of various cell types in the aci... More

HASHIMOTO THYROIDITIS Figure 3-23 HASHIMOTO THYROIDITIS A mixed B (CD20-positive) cell (A) and T (CD3-positive) cell infiltrate (B) is present. The T cells infiltrate the follicular epithelium (B). Immunostaining for kappa (C) and lambda (D) light chains of immunoglobulin shows polyclonal B cells... More

PANCREATIC ISLET CELL AGGREGATION Figure 5-1 PANCREATIC ISLET CELL AGGREGATION Left: Low-power view of pancreatic islet cell aggregation in which the pancreatic islet volume may appear increased in diabetes and pancreatitis, but the volume is similar to that of normal pancreas. Right: The appear... More

ISLET CELL HYPERPLASIA IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN1) Figure 5-7 ISLET CELL HYPERPLASIA IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN1) Islet cell hyperplasia is seen in MEN1 and von Hippel-Lindau disease. (Left: H&E; right: chromogranin immunohistochemistry.) More

DIFFUSE IDIOPATHIC PULMONARY NEUROENDOCRINE CELL HYPERPLASIA (DIPNECH) Figure 5-11 DIFFUSE IDIOPATHIC PULMONARY NEUROENDOCRINE CELL HYPERPLASIA (DIPNECH) Pulmonary neuroendocrine cells forming a single layer or small aggregates protrude into the lumen. (Left: H&E; right: chromogranin immunohi... More

LUTEINIZING HORMONE (LH) CELLS: IMMUNOHISTOCHEMISTRY Figure 1-6 LUTEINIZING HORMONE (LH) CELLS: IMMUNOHISTOCHEMISTRY Gonadotroph cells in the anterior pituitary immunostain for LH. These cells make up about 10 percent of anterior pituitary cells. Follicle-stimulating hormone (FSH) and LH are pres... More

FOLLICULOSTELLATE CELLS Figure 1-7 FOLLICULOSTELLATE CELLS Folliculostellate cells are highlighted by immunohistochemistry for S-100 protein. These cells have cytoplasmic processes that extend between the hormone-producing cells. More

NORMAL C CELLS Figure 3-4 NORMAL C CELLS Left: Normal C cells are inconspicuous on routine hematoxylin and eosin (H&E) staining. In this section, a few clusters of C cells have somewhat pale cytoplasm. Right: Immunohistochemistry for calcitonin readily identifies C cells. More

PROLACTIN (PRL) CELLS: IMMUNOHISTOCHEMISTRY Figure 1-3 PROLACTIN (PRL) CELLS: IMMUNOHISTOCHEMISTRY Immunohistochemical staining for PRL in the anterior pituitary. These cells constitute 10 to 30 percent of anterior pituitary cells. More

THYROID-STIMULATING HORMONE (TSH) CELLS: IMMUNOHISTOCHEMISTRY Figure 1-5 THYROID-STIMULATING HORMONE (TSH) CELLS: IMMUNOHISTOCHEMISTRY TSH-producing cells in the anterior pituitary are highlighted by specific immunohistochemistry. These angular cells comprise less than 5 percent of anterior pitui... More

PARATHYROID GLAND Figure 2-1 PARATHYROID GLAND Parathyroid glands are composed of parenchymal cells and adipose tissue. Parenchymal cells include chief cells, oncocytic/oxyphilic cells, transitional cells, and clear (water clear) cells; mixtures of cell types can be seen (A–D). Parathyroid parenc... More

ONCOCYTIC/OXYPHILIC PARATHYROID PARENCHYMAL CELLS Figure 2-2 ONCOCYTIC/OXYPHILIC PARATHYROID PARENCHYMAL CELLS Oncocytic/oxyphilic parathyroid parenchymal cells are not present in young children. These cells become apparent with increasing age. In older patients, oncocytic/oxyphil parathyroid par... More

PARATHYROID CYST Figure 2-18 PARATHYROID CYST Left: Parathyroid cysts may have parathyroid cells in the cyst wall. Right: The cyst wall is usually thin and fibrous, but may also contain other elements such lymphoid, muscular, thymic, salivary, adipose, and mesenchymal tissue. More