WARTHIN-FINKELDEY GIANT CELL Figure 4-29 WARTHIN-FINKELDEY GIANT CELL The characteristic giant cell shows multiple compactly arranged and overlapping pale nuclei. (Courtesy of the CDC IDPB) More about this image found in WARTHIN-FINKELDEY GIANT CELL The characteristic giant cell shows multiple ...

MERKEL CELL CARCINOMA Figure 9-50 MERKEL CELL CARCINOMA A: At low power, the small round blue cell tumor is centered on the dermis. B: Higher power shows sheets of cells with a high nuclear to cytoplasmic ratio, prominent apoptosis, and brisk mitotic activity. C: Classic paranuclear “dot-like” ... More about this image found in MERKEL CELL CARCINOMA A: At low power, the small round blue cell tumor is ...

POLIOMYELITIS Figure 3-20 POLIOMYELITIS Single cell neuronal degeneration leads to an irregular distribution of the remaining neurons (top and right). More about this image found in POLIOMYELITIS Single cell neuronal degeneration leads to an irregular dist...

JC VIRUS GRANULE CELL NEURONOPATHY Figure 3-43 JC VIRUS GRANULE CELL NEURONOPATHY Coronal T1-weighted MRI scan shows less frequent type of PML, JC virus granule cell neuronopathy. Note the severe damage to the cerebellar hemisphere (lower right of the image). More about this image found in JC VIRUS GRANULE CELL NEURONOPATHY Coronal T1-weighted MRI scan shows less...

JC VIRUS GRANULE CELL NEURONOPATHY Figure 3-44 JC VIRUS GRANULE CELL NEURONOPATHY There is prominent involvement of cerebellar granule cell neurons (and not oligodendrocytes) on an SV40 immunostain. More about this image found in JC VIRUS GRANULE CELL NEURONOPATHY There is prominent involvement of cereb...

MERS-CoV MULTINUCLEATED SYNCYTIAL CELL Figure 4-8 MERS-CoV MULTINUCLEATED SYNCYTIAL CELL Lung history specimen. (Courtesy of the CDC PHIL) More about this image found in MERS-CoV MULTINUCLEATED SYNCYTIAL CELL Lung history specimen. (Courtesy of...

PARAINFLUENZA VIRUS Figure 4-31 PARAINFLUENZA VIRUS A: Multinucleated giant cell formation (due to fusion of infected cells) in lung infection. B: Viral particles were confirmed by appropriate immunohistochemistry. More about this image found in PARAINFLUENZA VIRUS A: Multinucleated giant cell formation (due to fusion ...

ACUTE VIRAL HEPATITIS Figure 5-2 ACUTE VIRAL HEPATITIS A: Single cell dropout (spotty necrosis) at left, and more extensive confluent necrosis at top right. Note the dark eosinophilic cytoplasm and pyknotic nuclei of the degenerated liver cells. B,C: Degeneration of large numbers of adjacent hep... More about this image found in ACUTE VIRAL HEPATITIS A: Single cell dropout (spotty necrosis) at left, an...

PLAQUE STAGE KAPOSI SARCOMA Figure 8-18 PLAQUE STAGE KAPOSI SARCOMA The early haphazard spindle cell proliferation, extravasated erythrocytes, and abundant extracellular and intracellular hyaline globules, representing effete red blood cells (arrows), are seen at high power. More about this image found in PLAQUE STAGE KAPOSI SARCOMA The early haphazard spindle cell proliferation...

EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA Figure 8-19 EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA There is a spindle cell proliferation with slit-like spaces, some containing erythrocytes. Note the cellular appearance and relatively scant mitotic activity. More about this image found in EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA There is a spindle cell pr...

PRIMARY EFFUSION LYMPHOMA (PEL) Figure 8-22 PRIMARY EFFUSION LYMPHOMA (PEL) A: Cytologic cell block preparation of pleural effusion fluid shows sheets of dyscohesive atypical lymphoid cells at low power. B: High power illustrates the typical high-grade cytomorphology, prominent single nucleoli, ... More about this image found in PRIMARY EFFUSION LYMPHOMA (PEL) A: Cytologic cell block preparation of ple...

LSIL Figure 9-36 LSIL A: A normal intermediate cell is indicated (arrow). Other cells show features of LSIL with nuclear enlargement, coarse chromatin, nuclear membrane irregularities, perinuclear halo (“koilocyte”), and multinucleation (SurePath cytology, Papanicolaou stain). B: Condyloma with ... More about this image found in LSIL A: A normal intermediate cell is indicated (arrow). Other cells show ...

DISSEMINATED TUBERCULOSIS TO LIVER Figure 12-61 DISSEMINATED TUBERCULOSIS TO LIVER A small epithelioid cell granuloma (A) and numerous scattered acid-fast bacilli (B). More about this image found in DISSEMINATED TUBERCULOSIS TO LIVER A small epithelioid cell granuloma (A) ...

TUBERCULOID LEPROSY Figure 15-19 TUBERCULOID LEPROSY Periadnexal epithelioid cell and focally granulomatous infiltrate. More about this image found in TUBERCULOID LEPROSY Periadnexal epithelioid cell and focally granulomatous...

CUTANEOUS YAWS Figure 15-37 CUTANEOUS YAWS A,B: Perivascular mononuclear inflammatory cell infiltrate (A) with only mildly associated endothelial cell swelling (B). C: Warthin-Starry stain demonstrates scattered intraepidermal spirochetes (arrows). D: Pronounced epidermal hyperplasia and hyperk... More about this image found in CUTANEOUS YAWS A,B: Perivascular mononuclear inflammatory cell infiltrate ...

INFECTIVE ENDOCARDITIS Figure 16-4 INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cells make up the valvular vegetation (A,B). A fungal Grocott methenamine silver (GMS) stain highlights scattered bacterial organisms (C), which may show altered morphologic and tinctorial cha... More about this image found in INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cell...

PRIMARY SYPHILIS Figure 18-2 PRIMARY SYPHILIS Typical endothelial cell swelling and proliferation are associated with a lymphoplasmacytic perivascular infiltrate and interspersed neutrophils. More about this image found in PRIMARY SYPHILIS Typical endothelial cell swelling and proliferation are a...

SYPHILIS Figure 18-3 SYPHILIS Pronounced and deep plasma cell infiltration. More about this image found in SYPHILIS Pronounced and deep plasma cell infiltration.

SECONDARY SYPHILIS INVOLVING A LYMPH NODE Figure 18-7 SECONDARY SYPHILIS INVOLVING A LYMPH NODE Endothelial cell swelling, plasma cell infiltration (A), and early granuloma formation (B). More about this image found in SECONDARY SYPHILIS INVOLVING A LYMPH NODE Endothelial cell swelling, plasm...

GRANULOMA INGUINALE Figure 18-20 GRANULOMA INGUINALE A neutrophil-rich inflammatory cell infiltrate with interspersed macrophages containing Donovan bodies (arrow). (Courtesy of Dr. M. Sangueza, Obrero Hospital, La Paz, Bolivia) More about this image found in GRANULOMA INGUINALE A neutrophil-rich inflammatory cell infiltrate with in...