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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nodular aggregates of atypical melanocytes with nuclear atypia, high mitotic rate, and/or necrosis) Molecular Genetic Findings  Somatic NRAS mutation (codon 61) most commonly  Somatic BRAF mutation (codon V600) more commonly in small CMN  Multiple CMN and NCM caused...
Images
CHRONIC ISCHEMIC HEART DISEASE  Remote MIs <span class="search-highlight">cause</span> thinning and global dilata...
Published: 15 November 2023
CHRONIC ISCHEMIC HEART DISEASE Figure 8-14 CHRONIC ISCHEMIC HEART DISEASE Remote MIs cause thinning and global dilatation of the left ventricle, which, apart from the myocardial scarring, may mimic dilated cardiomyopathy. More about this image found in CHRONIC ISCHEMIC HEART DISEASE Remote MIs cause thinning and global dilata...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... causes, such as site-related exposure to mechanical trauma. Miscellaneous site-related changes have been reported for acral skin, genital skin, and nevi on the milk line, umbilicus, ear, scalp, and flexural sites. Most melanocytic nevi anywhere, including these “special sites,” display conventional...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Disord   2016 ; 17 : 381 - 8 . 9. Zhang   J , Cheng   R , Liang   J , Ni   C , Li   M , Yao   Z . Lentiginous phenotypes caused by diverse pathogenic genes (SASH1 and PTPN11): clinical and molecular discrimination . Clin Genet   2016 ; 90 : 372 - 7 . 10. Veraldi   S...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and pathologically as melanoma . Pathology   2004 ; 36 : 419 - 27 . 8. Yeh   I , Lang   UE , Durieux   E , Tee   MK , et al . Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi . Nat Commun   2017 ; 8 : 644 . 9. de la Fouchardière...
Images
MYOFIBROBLASTOMA  A: At low power, this well-circumscribed lesion composed ...
Published: 01 January 2024
MYOFIBROBLASTOMA Figure 11-7 MYOFIBROBLASTOMA A: At low power, this well-circumscribed lesion composed of spindle cells with admixed adipose tissue and collagen is compatible with myofibroblastoma. B: At high power, scattered atypical nuclei and multinucleated giant cells are seen. Their presenc... More about this image found in MYOFIBROBLASTOMA A: At low power, this well-circumscribed lesion composed ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... mutant nevus cell that has acquired a second genetic hit of tumor progression causing the loss of function of PRKAR1A. In this case, the PEM may be part of a combined melanocytic nevus. Other cases have gene fusions involving PRKCA located on chromosome 17 with various partners...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and mainly seen as metastatic lesions. In additional to displaying peculiar microscopic features, melanomas can cause diagnostic confusion by colliding with a squamous cell or basal cell carcinoma. Such collision scenarios may lead to erroneous interpretations of a biphenotypic (e.g., combined epithelial...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanosis are caused by postzygotic mutations in codon 61 of NRAS . J Invest Dermatol   2013 ; 133 : 2229 - 36 . 32. Bastian   BC , Xiong   J , Frieden   IJ , et al . Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... the wall. If found in association with a banal nevus, this finding should not be a cause of concern. The “shedding” of nevus cells into vascular lumens and subsequent transport to the regional lymph node likely plays a role in the formation of nodal nevi. MELANOCYTIC NEVUS WITH INTRALYMPHATIC NEST Figure 3...
Images
EPICARDIAL CORONARY ARTERY DYSPLASIA  Marked intimal fibroplasia <span class="search-highlight">causes</span> sig...
Published: 15 November 2023
EPICARDIAL CORONARY ARTERY DYSPLASIA Figure 6-21 EPICARDIAL CORONARY ARTERY DYSPLASIA Marked intimal fibroplasia causes significant luminal compromise. More about this image found in EPICARDIAL CORONARY ARTERY DYSPLASIA Marked intimal fibroplasia causes sig...
Images
ALCOHOL SEPTAL ABLATION PROCEDURE  Left: Alcohol septal ablation <span class="search-highlight">causes</span> a l...
Published: 15 November 2023
ALCOHOL SEPTAL ABLATION PROCEDURE Figure 15-23 ALCOHOL SEPTAL ABLATION PROCEDURE Left: Alcohol septal ablation causes a localized infarction of the myocardium. Right: Granulomatous reactions can be encountered at the edge of the areas of myocardium infarcted by alcohol instillation. More about this image found in ALCOHOL SEPTAL ABLATION PROCEDURE Left: Alcohol septal ablation causes a l...
Images
PENETRATIVE INJURY: GUNSHOT WOUND  This high-velocity weapon <span class="search-highlight">caused</span> extensi...
Published: 15 November 2023
PENETRATIVE INJURY: GUNSHOT WOUND Figure 23-15 PENETRATIVE INJURY: GUNSHOT WOUND This high-velocity weapon caused extensive morcellation of the right and left ventricles. More about this image found in PENETRATIVE INJURY: GUNSHOT WOUND This high-velocity weapon caused extensi...
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ALLOGRAFT VASCULOPATHY  A,B: Intimal fibroplasia <span class="search-highlight">causing</span> somewhat concentri...
Published: 15 November 2023
ALLOGRAFT VASCULOPATHY Figure 24-10 ALLOGRAFT VASCULOPATHY A,B: Intimal fibroplasia causing somewhat concentric luminal narrowing (A) without disruption of the internal elastic membrane (B) (elastic stain). C: Vascular injury, in the form of small vessel vasculitis, may also be seen with thrombu... More about this image found in ALLOGRAFT VASCULOPATHY A,B: Intimal fibroplasia causing somewhat concentri...
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ANNULAR DILATATION <span class="search-highlight">CAUSING</span> AORTIC REGURGITATION  Ascending aortic dilatatio...
Published: 15 November 2023
ANNULAR DILATATION CAUSING AORTIC REGURGITATION Figure 28-19 ANNULAR DILATATION CAUSING AORTIC REGURGITATION Ascending aortic dilatation may cause the aortic valve annulus to dilate, which may stretch the valve cusps and lead to cusp malcoaptation (yellow arrow) and regurgitation. More about this image found in ANNULAR DILATATION CAUSING AORTIC REGURGITATION Ascending aortic dilatatio...
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VENOUS MALFORMATION  This cluster of malformed veins <span class="search-highlight">caused</span> a mass in the s...
Published: 15 November 2023
VENOUS MALFORMATION Figure 33-2 VENOUS MALFORMATION This cluster of malformed veins caused a mass in the soft tissue in the neck of a young woman. The vascular walls show short, duplicated elastic fibers typical of a vein visualized with an elastin stain. More about this image found in VENOUS MALFORMATION This cluster of malformed veins caused a mass in the s...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-09
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... affect postpubertal girls. The condition is extremely debilitating, causing back and neck pain, as well as being socially distressing. Circulating gonadal hormonal levels are normal and definitive risk factors have not been identified, although studies have hypothesized end-organ hypersensitivity...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-10
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., and BRIP1 ( 12 ). Between 5 and 10 percent of male BRCA2 mutation carriers develop breast cancer compared to only 1 to 2 percent for BRCA1 mutation carriers ( 13 ). Conditions causing elevations in estrogen, such as Klinefelter syndrome, obesity, liver cirrhosis, as well as radiation...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-13
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of the nipple surface. When the epidermal surface is involved, exudation and crusting may cause irritation and discomfort, raising clinical consideration of Paget disease. Nipple adenoma occurs in both women and men, with women in the fifth decade of life most commonly affected, although the reported age range...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... , Thai   TA , Lam   CC , et al . Granulomatous mastitis: the histological differentials . J Clin Pathol   2011 ; 64 : 405 - 11 . 28. Phelan   S , O’Doherty   A , Hill   A , Quinn   CM . Epithelial displacement during breast needle core biopsy causes diagnostic difficulties...