TREATED GRAVES DISEASE Figure 3-28 TREATED GRAVES DISEASE The morphologic findings in treated Graves disease are highly variable and dependent on both the duration of therapy and the type of treatment. A: In most cases, the follicles maintain their irregular contours, but with less marked colloi... More

RATHKE CLEFT CYST Figure 1-10 RATHKE CLEFT CYST A: A simple Rathke cleft cyst is lined by cuboidal epithelium with surrounding normal pituitary tissue. B: Higher power of the cyst shows cuboidal epithelium with admixed ciliated cells and goblet cells. C: A different case shows squamous metaplas... More

GRANULOMATOUS THYROIDITIS Figure 3-14 GRANULOMATOUS THYROIDITIS Left: In florid active granulomatous thyroiditis, the granulomatous inflammation is widespread and not easily overlooked. Right: In the resolving (‘burnt out’) phase, the predominant low-power appearance is atrophy of the thyroid gl... More

POSTPUBERTAL-TYPE TERATOMA Figure 5-24 POSTPUBERTAL-TYPE TERATOMA This highly unusual case shows organoid cutaneous differentiation. There were typical features elsewhere, including GCNIS. More

SPERMATOCYTIC TUMOR Figure 5-78 SPERMATOCYTIC TUMOR Left: An unusual case of an intratubular tumor consisting of few scattered cells, some near the tubule bases. Possible confusion as GCNIS may occur. Right: Higher power of the same case. (Case courtesy of Dr. M. Varma, Cardiff, Wales, UK) More

SPERMATOCYTIC TUMOR Figure 5-79 SPERMATOCYTIC TUMOR A rare case shows a prominent granulomatous reaction and lymphocytic infiltrate. More

LEYDIG CELL TUMOR Figure 6-21 LEYDIG CELL TUMOR The spindled cells in this case cause it to resemble a tumor of soft tissue type. More

SERTOLI-STROMAL CELL TUMOR Figure 6-114 SERTOLI-STROMAL CELL TUMOR This case shows prominent entrapment of spermatogonia, some retaining their preexisting tubular shape and others in small clusters or in isolation. More

ADENOCARCINOMA OF RETE TESTIS Figure 8-63 ADENOCARCINOMA OF RETE TESTIS This metastatic case forms stubby papillae with hyalinized cores that resemble the normal chordae retis. More

MYELOID SARCOMA OF TESTIS Figure 9-24 MYELOID SARCOMA OF TESTIS This case shows a predominant population of myeloblastic cells with scant cytoplasm, vesicular nuclei, and prominent nucleoli. More

ADENOCARCINOMA OF COLON METASTATIC TO TESTIS Figure 10-8 ADENOCARCINOMA OF COLON METASTATIC TO TESTIS This case shows the characteristic sheets of cribriform glands with columnar, eosinophilic cells. More

SERTOLI CELL NODULE Figure 11-9 SERTOLI CELL NODULE Left: A grossly evident case shows confluent trabeculae of immature-appearing Sertoli cells and germ cells with numerous interconnecting basement membrane deposits. There are affected tubules at the periphery (right). Right: At high magnificati... More

SERTOLI CELL NODULE Figure 11-10 SERTOLI CELL NODULE Left: The cellular elements in this case have been entirely replaced by basement membrane matrix. Right: A macroscopic lesion has a multinodular/lobulated configuration. More

MUMPS ORCHITIS Figure 11-122 MUMPS ORCHITIS This case, from a teenage boy, was resected for a clinical suspicion of neoplasm. At scanning magnification there is evident segmental involvement of the testis. More

EXTENSION OF GCNIS INTO THE RETE TESTIS IN CASES OF SEMINOMA Figure 4-61 EXTENSION OF GCNIS INTO THE RETE TESTIS IN CASES OF SEMINOMA Left: GCNIS extends into the rete testis, admixed with intact rete testis epithelium. Right: There is prominent intra-rete extension of GCNIS cells, with expansio... More