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TREATED GRAVES DISEASE  The morphologic findings in treated Graves disease ...
Published: 01 November 2022
TREATED GRAVES DISEASE Figure 3-28 TREATED GRAVES DISEASE The morphologic findings in treated Graves disease are highly variable and dependent on both the duration of therapy and the type of treatment. A: In most cases, the follicles maintain their irregular contours, but with less marked colloi... More
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RATHKE CLEFT CYST  A: A simple Rathke cleft cyst is lined by cuboidal epith...
Published: 01 November 2022
RATHKE CLEFT CYST Figure 1-10 RATHKE CLEFT CYST A: A simple Rathke cleft cyst is lined by cuboidal epithelium with surrounding normal pituitary tissue. B: Higher power of the cyst shows cuboidal epithelium with admixed ciliated cells and goblet cells. C: A different case shows squamous metaplas... More
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GRANULOMATOUS THYROIDITIS  Left: In florid active granulomatous thyroiditis...
Published: 01 November 2022
GRANULOMATOUS THYROIDITIS Figure 3-14 GRANULOMATOUS THYROIDITIS Left: In florid active granulomatous thyroiditis, the granulomatous inflammation is widespread and not easily overlooked. Right: In the resolving (‘burnt out’) phase, the predominant low-power appearance is atrophy of the thyroid gl... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... and prognostication of pituitary tumors in clinical practice, particularly in cases with absent, low, or pluri-hormonal expression ( 32 ). Table 1-1 TRANSCRIPTION FACTORS IMPORTANT FOR PITUITARY DEVELOPMENT Factor Target Cells Pit-1/GHF1 a GH/PRL/TSH Thyrotroph embryonic factor (TEF) TSH...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... of cases of primary or secondary hyperparathyroidism ( 2 , 3 ). In addition to parathyroid autografts, ectopic or supranumerary parathyroid glands are a cause of persistent hyperparathyroidism in secondary hyperparathyroidism associated with renal disease ( 4 – 6 ). Ectopic parathyroid glands have been...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... reported in up to 69 percent of cases of hydrops fetalis in some series ( 106 , 108 , 110 , 113 ). Adrenal cytomegaly is also a well-known finding in Beckwith-Wiedemann syndrome and is often seen in cases with associated adrenal hemorrhage ( 108 , 110 , 114 , 115 ). Although the pathogenesis of adrenal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-3
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... project into the lumen of a larger follicle (known as Sanderson polster). This finding is more common in cases of hyperplasia. NORMAL ADULT THYROID GLAND Figure 3-2 NORMAL ADULT THYROID GLAND Histologic appearance of normal thyroid gland. The follicles are roughly round and lined by cuboidal cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-5
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... identified in 145 of 149 (97 percent) cases. In all cases, maternal transmission was excluded. Of the 122 diazoxide-unresponsive cases with diffuse hyperinsulinism, 109 (89 percent) had KATP mutations and 2 had GCK mutations ( 163 ). Of the 56 (47 percent) of children with mutation-positive...
Images
POSTPUBERTAL-TYPE TERATOMA  This highly unusual <span class="search-highlight">case</span> shows organoid cutaneo...
Published: 01 August 2022
POSTPUBERTAL-TYPE TERATOMA Figure 5-24 POSTPUBERTAL-TYPE TERATOMA This highly unusual case shows organoid cutaneous differentiation. There were typical features elsewhere, including GCNIS. More
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SPERMATOCYTIC TUMOR  Left: An unusual <span class="search-highlight">case</span> of an intratubular tumor consist...
Published: 01 August 2022
SPERMATOCYTIC TUMOR Figure 5-78 SPERMATOCYTIC TUMOR Left: An unusual case of an intratubular tumor consisting of few scattered cells, some near the tubule bases. Possible confusion as GCNIS may occur. Right: Higher power of the same case. (Case courtesy of Dr. M. Varma, Cardiff, Wales, UK) More
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SPERMATOCYTIC TUMOR  A rare <span class="search-highlight">case</span> shows a prominent granulomatous reaction a...
Published: 01 August 2022
SPERMATOCYTIC TUMOR Figure 5-79 SPERMATOCYTIC TUMOR A rare case shows a prominent granulomatous reaction and lymphocytic infiltrate. More
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LEYDIG CELL TUMOR  The spindled cells in this <span class="search-highlight">case</span> cause it to resemble a t...
Published: 01 August 2022
LEYDIG CELL TUMOR Figure 6-21 LEYDIG CELL TUMOR The spindled cells in this case cause it to resemble a tumor of soft tissue type. More
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SERTOLI-STROMAL CELL TUMOR  This <span class="search-highlight">case</span> shows prominent entrapment of spermat...
Published: 01 August 2022
SERTOLI-STROMAL CELL TUMOR Figure 6-114 SERTOLI-STROMAL CELL TUMOR This case shows prominent entrapment of spermatogonia, some retaining their preexisting tubular shape and others in small clusters or in isolation. More
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ADENOCARCINOMA OF RETE TESTIS  This metastatic <span class="search-highlight">case</span> forms stubby papillae w...
Published: 01 August 2022
ADENOCARCINOMA OF RETE TESTIS Figure 8-63 ADENOCARCINOMA OF RETE TESTIS This metastatic case forms stubby papillae with hyalinized cores that resemble the normal chordae retis. More
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MYELOID SARCOMA OF TESTIS  This <span class="search-highlight">case</span> shows a predominant population of myel...
Published: 01 August 2022
MYELOID SARCOMA OF TESTIS Figure 9-24 MYELOID SARCOMA OF TESTIS This case shows a predominant population of myeloblastic cells with scant cytoplasm, vesicular nuclei, and prominent nucleoli. More
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ADENOCARCINOMA OF COLON METASTATIC TO TESTIS  This <span class="search-highlight">case</span> shows the character...
Published: 01 August 2022
ADENOCARCINOMA OF COLON METASTATIC TO TESTIS Figure 10-8 ADENOCARCINOMA OF COLON METASTATIC TO TESTIS This case shows the characteristic sheets of cribriform glands with columnar, eosinophilic cells. More
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SERTOLI CELL NODULE  Left: A grossly evident <span class="search-highlight">case</span> shows confluent trabecula...
Published: 01 August 2022
SERTOLI CELL NODULE Figure 11-9 SERTOLI CELL NODULE Left: A grossly evident case shows confluent trabeculae of immature-appearing Sertoli cells and germ cells with numerous interconnecting basement membrane deposits. There are affected tubules at the periphery (right). Right: At high magnificati... More
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SERTOLI CELL NODULE  Left: The cellular elements in this <span class="search-highlight">case</span> have been ent...
Published: 01 August 2022
SERTOLI CELL NODULE Figure 11-10 SERTOLI CELL NODULE Left: The cellular elements in this case have been entirely replaced by basement membrane matrix. Right: A macroscopic lesion has a multinodular/lobulated configuration. More
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MUMPS ORCHITIS  This <span class="search-highlight">case</span>, from a teenage boy, was resected for a clinical ...
Published: 01 August 2022
MUMPS ORCHITIS Figure 11-122 MUMPS ORCHITIS This case, from a teenage boy, was resected for a clinical suspicion of neoplasm. At scanning magnification there is evident segmental involvement of the testis. More
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EXTENSION OF GCNIS INTO THE RETE TESTIS IN <span class="search-highlight">CASES</span> OF SEMINOMA  Left: GCNIS e...
Published: 01 August 2022
EXTENSION OF GCNIS INTO THE RETE TESTIS IN CASES OF SEMINOMA Figure 4-61 EXTENSION OF GCNIS INTO THE RETE TESTIS IN CASES OF SEMINOMA Left: GCNIS extends into the rete testis, admixed with intact rete testis epithelium. Right: There is prominent intra-rete extension of GCNIS cells, with expansio... More