BACILLARY DYSENTERY Figure 13-4 BACILLARY DYSENTERY A,B: Later stage of a mild case of bacillary dysentery reveals crypt neutrophil exocytosis, superficial and midmucosal crypt abscess formation, and regenerative epithelial changes. More about this image found in BACILLARY DYSENTERY A,B: Later stage of a mild case of bacillary dysentery...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-28 SUBACUTE SCLEROSING PANENCEPHALITIS Many cases of viral encephalitis show more striking diffuse microgliosis than tight localized microglial clusters, as illustrated here in the cortex of an SSPE case at autopsy. More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS Many cases of viral encephalitis show ...

TUBERCULOSIS Figure 12-56 TUBERCULOSIS Acid-fast stain in two cases of tuberculosis shows a high organism burden and small clusters of positive bacilli (A), contrasted with a low organism burden demonstrating scant single bacilli (B) in areas of necrosis. More about this image found in TUBERCULOSIS Acid-fast stain in two cases of tuberculosis shows a high org...

ACANTHAMOEBA KERATITIS Figure 25-13 ACANTHAMOEBA KERATITIS Irregular opacification and discoloration of the cornea, which frequently has a ring-shaped appearance (absent in this case). More about this image found in ACANTHAMOEBA KERATITIS Irregular opacification and discol...

VIRAL ENCEPHALITIS Figure 3-52 VIRAL ENCEPHALITIS Immunohistochemical assays confirm the etiology of viral encephalitis, as in this case of enterovirus (A) and Nipah virus (B) infection. (Courtesy of the CDC IDPB) More about this image found in VIRAL ENCEPHALITIS Immunohistochemical assays confirm the etiology of vira...

CENTRAL NERVOUS SYSTEM TOXOPLASMOSIS Figure 25-3 CENTRAL NERVOUS SYSTEM TOXOPLASMOSIS A: Brain histology shows necrosis and prominent mononuclear inflammation. B: An autopsy case shows prominent necrosis with minimal inflammation. More about this image found in CENTRAL NERVOUS SYSTEM TOXOPLASMOSIS A: Brain histology shows necrosis and...

ELECTRON MICROSCOPY IN THE DIAGNOSIS OF BK NEPHROPATHY Figure 1-9 ELECTRON MICROSCOPY IN THE DIAGNOSIS OF BK NEPHROPATHY H&E-stained sections (A–C) and electron microphotographs at increasing magnifications (D–F) from a case of BK nephropathy. More about this image found in ELECTRON MICROSCOPY IN THE DIAGNOSIS OF BK NEPHROPATHY H&E-stained sec...

VIRAL ENCEPHALITIS Figure 3-49 VIRAL ENCEPHALITIS The histopathologic findings are nonspecific and include perivascular cuffing by mononuclear cells and glial nodules, as seen in this mild case of herpes simplex encephalitis (A: courtesy of the CDC PHIL) and enterovirus encephalitis (B: courtesy ... More about this image found in VIRAL ENCEPHALITIS The histopathologic findings are nonspecific and includ...

BABESIA SPP DIFFERENTIAL DIAGNOSIS WITH MALARIA Figure 27-11 BABESIA SPP DIFFERENTIAL DIAGNOSIS WITH MALARIA A peripheral blood smear shows a morphology indistinguishable from Plasmodium falciparum (malaria). In this case, babesiosis was suspected due to a negative rapid malaria test, and confirmed with in situ hybridization. More about this image found in BABESIA SPP DIFFERENTIAL DIAGNOSIS WITH MALARIA A periphe...

PENILE AND ESOPHAGEAL CANDIDIASIS Figure 22-4 PENILE AND ESOPHAGEAL CANDIDIASIS Prominent superficial squamous epithelial neutrophil infiltration (A) (courtesy of Prof. P. McKee, Boussais, France) is contrasted with a case of esophageal candidiasis (B), devoid of associated inflammation (periodic... More about this image found in PENILE AND ESOPHAGEAL CANDIDIASIS Prominent superficial squamous epithelia...

BRUCELLOSIS Figure 14-4 BRUCELLOSIS A: Brucellosis of the liver shows a small non-necrotizing granuloma. (Courtesy of Prof. S. Lucas, London, UK) B: Lymph node involvement shows extensive necrosis with surrounding histiocytes and scattered granulomas. C: Brucella spp organisms are highlighted by a modified Steiner silver stain. (Case courtesy of Dr. B. Pritt, Mayo Clinic, Rochester, MN) More about this image found in BRUCELLOSIS A: Brucellosis of the liver shows a small non-necrotizing gran...

PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) Figure 9-2 PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregularly shaped reactive follicles. B: PGL lymph node follicle in center with macrophage phagocytosis and apoptotic debris. C: HIVp24 stains HIV virus in follicular dend... More about this image found in PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregul...

INTESTINAL SPIROCHETOSIS Figure 13-9 INTESTINAL SPIROCHETOSIS EAEC findings on endoscopic biopsy are closely mimicked by Brachyspira spp organisms (A) and may be confused with an exaggerated colonic epithelial brush border in mild cases. The bacteria in intestinal spirochetosis are also gram negative (B), but unlike EAEC have a more wiry, spiralled morphology and are positive with silver staining (such as Warthin-Starry) (C). A novel finding is the cross reactivity of Brachyspira spp with T. pallidum immunohistochemistry (D). (Courtesy of Dr. E. Montgomery, University of Miami, Miami, FL) More about this image found in INTESTINAL SPIROCHETOSIS EAEC findings on endoscopic biopsy are closely mi...