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carotid
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Images
Published: 01 December 2024
NORMAL CAROTID BODY Figure 9-7 NORMAL CAROTID BODY A: This developing carotid body in an early second trimester stillborn fetus (same case as in figs. 9-3 and 9-4 ), shows more complex architecture and greater admixture of cell types than the abdominal paraganglia. B: Tyrosine hydroxylase exp... More about this image found in NORMAL CAROTID BODY A: This developing carotid body in an early second tri...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA WITH ADJACENT NORMAL CAROTID BODY Figure 9-21 CAROTID BODY PARAGANGLIOMA WITH ADJACENT NORMAL CAROTID BODY The neoplastic cells in this tumor are larger, more spindled, and clearer than the normal carotid body chief cells (at right). More about this image found in CAROTID BODY PARAGANGLIOMA WITH ADJACENT NORMAL CAROTID BODY The neoplasti...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-37 CAROTID BODY PARAGANGLIOMA Immunohistochemical stains for S-100 protein and SOX10 outline the nested architecture in carotid body paraganglioma. More about this image found in CAROTID BODY PARAGANGLIOMA Immunohistochemical stains for S-100 protein an...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-12 CAROTID BODY PARAGANGLIOMA The tumor is completely encapsulated and has protruding segments of nerve and artery (top left). The cut surface shows focal cystic degeneration and prominent cavernous blood vessels. A distinct large fleshy nodule is present at lo... More about this image found in CAROTID BODY PARAGANGLIOMA The tumor is completely encapsulated and has pr...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed fleshy... More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed fleshy... More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...
Images
Published: 01 December 2024
CAROTID BODY SCLEROSING PARAGANGLIOMA Figure 9-19 CAROTID BODY SCLEROSING PARAGANGLIOMA A: Sclerosing paragangliomas have been reported as a distinct entity that can mimic infiltrating carcinoma. This sharply circumscribed example shows extensive sclerosis, which is very dense at top right. B: S... More about this image found in CAROTID BODY SCLEROSING PARAGANGLIOMA A: Sclerosing paragangliomas have be...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-20 CAROTID BODY PARAGANGLIOMA Areas of sclerosis encroach on the tumor capsule and tumor blood vessels. The presence of hemosiderin suggests repeated ischemia and infarction as possible factors contributing to the development of sclerosis in this case. More about this image found in CAROTID BODY PARAGANGLIOMA Areas of sclerosis encroach on the tumor capsul...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-24 CAROTID BODY PARAGANGLIOMA A: The almost entirely spindle cell composition of this paraganglioma raises the possibility of mesenchymal and other spindle cell neoplasms. B: Reticulin stain highlights the spindle cell pattern. More about this image found in CAROTID BODY PARAGANGLIOMA A: The almost entirely spindle cell composition...
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Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-29 CAROTID BODY PARAGANGLIOMA Extensive necrosis resulted from preoperative embolization performed to reduce bleeding. Embolic foreign material is present in blood vessel at top right. More about this image found in CAROTID BODY PARAGANGLIOMA Extensive necrosis resulted from preoperative e...
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Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-30 CAROTID BODY PARAGANGLIOMA Preoperative embolization of this tumor was performed with gel beads, which are seen occluding cavernous blood vessels. There is no postembolic necrosis in this case, probably reflecting a shorter interval between embolization and ... More about this image found in CAROTID BODY PARAGANGLIOMA Preoperative embolization of this tumor was per...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Figure 9-36 CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Focal anomalous immunoreactivity for keratins is present in this paraganglioma stained with antibody cocktail AE1/AE3. The tumor was diffusely positive for synapto... More about this image found in CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Focal anomalo...
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Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-38 CAROTID BODY PARAGANGLIOMA Immunohistochemical stain for CD163 shows macro phages in a paraganglioma that closely mimic the distribution of sustentacular cells. More about this image found in CAROTID BODY PARAGANGLIOMA Immunohistochemical stain for CD163 shows macro...
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in Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE Figure 10-1 MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE A: This patient, with a documented pathogenic germline SDHB variant, was diagnosed with a right carotid body tumor. B,C: 68Ga-DOTATATE PET/CT also showed multiple lesions in his retroperitoneum. (A–C: courtesy of Dr. S. Ezzat, Toronto, Canada) More about this image found in MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE A: This patient, with a document...
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Published: 01 December 2024
NORMAL PERITHYROIDAL PARAGANGLION Figure 9-10 NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered incidentally in peri-thyroidal soft tissue in an adult patient with a multinodular goiter, is architecturally similar to the carotid body in figure 9-7 . The intimate association of n... More about this image found in NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered inciden...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... paragangliomas reported up to 1965 (B) in a classic illustration. Arrow added in A indicates the organ of Zuckerkandl. The two hot spots for paragangliomas in the neck are based in part on carotid body paragangliomas, which occasionally produce significant amounts of norepinephrine or dopamine. Since its initial...
Images
Published: 01 December 2024
SITES OF PARAGANGLIOMA DEVELOPMENT Figure 9-1 SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distribution of extra-adrenal chromaffin tissue in neonates (A) and prevalent sites of sympathetic paragangliomas reported up to 1965 (B) in a classic illustration. Arrow added in A indic... More about this image found in SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distributi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... with a right carotid body tumor. B,C: 68Ga-DOTATATE PET/CT also showed multiple lesions in his retroperitoneum. (A–C: courtesy of Dr. S. Ezzat, Toronto, Canada) The hereditary syndromes usually give rise to multifocal neoplasms, including multiple paragangliomas, but also, as documented in Table...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ). Comparable axonally guided migration of neural crest progenitors along nerves near the superior cervical ganglion has been proposed for development of carotid body chief cells ( 30 ). CURRENT CONCEPT OF NEURAL CREST CELL MIGRATION Figure 1-8 CURRENT CONCEPT OF NEURAL CREST CELL MIGRATION A: Neural crest...
Images
Published: 15 November 2023
CAROTID ATHEROSCLEROSIS: RESTENOSIS Figure 29-14 CAROTID ATHEROSCLEROSIS: RESTENOSIS A segment of this carotid artery was removed and a graft placed. An endarterectomy had been performed 2 years prior. This area of restenosis is composed of smooth muscle cells with little inflammation or lipid, h... More about this image found in CAROTID ATHEROSCLEROSIS: RESTENOSIS A segment of this carotid artery was r...
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