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cardiomyopathy

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch14
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... ordinary activity such as walking short distances Class IV Severe limitations including symptoms at rest Table 14-2 ADVERSE PROGNOSTIC FACTORS IN DILATED CARDIOMYOPATHY Severe symptoms Left ventricular remodeling (including degree of dilatation) Impaired ventricular contractility...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch15
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 15-1 MAJOR RISK FACTORS ASSOCIATED WITH SUDDEN DEATH IN HYPERTROPHIC CARDIOMYOPATHY (HCM) Family history of HCM-related sudden death Unexplained syncope Multiple episodes of nonsustained ventricular tachycardia Significant left ventricular hypertrophy (wall thickness >3.0...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch16
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 16-1 GENES IMPLICATED IN PRIMARY RESTRICTIVE CARDIOMYOPATHY Gene Protein MYH7 Myosin-7 DES Desmin FLNC Filamen C MYBPC3 Myosin-binding protein C, cardiac type TNNI3 Troponin I, cardiac type JUP Junction...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch17
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 17-1 GENES IMPLICATED IN ARRHYTHMOGENIC CARDIOMYOPATHY Gene Protein Frequency Identified Reference PKP2 Plakophilin-2 34%-74% ( 47 ) DSP Desmoplakin 2%-39% ( 47 ) DSG2 Desmoglein-2 5%-26% ( 47 ) DSC2 Desmocollin-2 1%-2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch18
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 18-1 DIAGNOSTIC CRITERIA FOR STRESS CARDIOMYOPATHY a All four of the following features are required for the diagnosis:  Transient left ventricular systolic dysfunction  Absence of obstructive coronary artery disease or evidence of plaque rupture  New...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch19
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 19-1 MUSCULAR DYSTROPHY AND CONGENITAL MYOPATHY-ASSOCIATED CARDIOMYOPATHIES Cardiomyopathy Gene Inheritance Cardiac Phenotype Dystrophin-associated (Duchenne and Becker muscular dystrophies) DMD X-linked Dilated Emery-Dreifuss muscular dystrophy EMD, FHL1...
Images
DILATED <span class="search-highlight">CARDIOMYOPATHY</span>: MOLECULAR MECHANISMS  Dilated <span class="search-highlight">cardiomyopathy</span> is a p...
Published: 15 November 2023
DILATED CARDIOMYOPATHY: MOLECULAR MECHANISMS Figure 14-1 DILATED CARDIOMYOPATHY: MOLECULAR MECHANISMS Dilated cardiomyopathy is a polygenic disease that can result from mutation in genes encoding for structural (intermediate filaments or nuclear envelope), sarcomeric, desmosomal, ion channel, or ... More about this image found in DILATED CARDIOMYOPATHY: MOLECULAR MECHANISMS Dilated cardiomyopathy is a p...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch13
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 13-1 CARDIOMYOPATHY DEFINITIONS WHO/ISFC a 1980 Heart muscle diseases of unknown cause WHO/ISFC 1995 Diseases of the myocardium associated with cardiac dysfunction AHA 2006 A heterogeneous group of diseases of the myocardium associated with mechanical...
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MITOCHONDRIAL <span class="search-highlight">CARDIOMYOPATHIES</span>: HYPERTROPHIC PHENOTYPE  Mitochondrial cardi...
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Figure 19-5 MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Mitochondrial cardiomyopathy in an infant produces symmetric left ventricular hypertrophy. More about this image found in MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Mitochondrial cardi...
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<span class="search-highlight">CARDIOMYOPATHIES</span>: MOLECULAR MECHANISMS  The schematic shows the regions wit...
Published: 15 November 2023
CARDIOMYOPATHIES: MOLECULAR MECHANISMS Figure 13-1 CARDIOMYOPATHIES: MOLECULAR MECHANISMS The schematic shows the regions within the myocyte in which protein mutations have been shown to result in cardiomyopathy. More about this image found in CARDIOMYOPATHIES: MOLECULAR MECHANISMS The schematic shows the regions wit...
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ARRHYTHMOGENIC <span class="search-highlight">CARDIOMYOPATHY</span>: INFLAMMATION  Inflammation is frequently see...
Published: 15 November 2023
ARRHYTHMOGENIC CARDIOMYOPATHY: INFLAMMATION Figure 17-12 ARRHYTHMOGENIC CARDIOMYOPATHY: INFLAMMATION Inflammation is frequently seen throughout the myocardium in arrhythmogenic cardiomyopathy and may be one of the inciting events for fibrofatty replacement. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY: INFLAMMATION Inflammation is frequently see...
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HYPERTROPHIC <span class="search-highlight">CARDIOMYOPATHY</span>: ULTRASTRUCTURAL DISORGANIZATION  Like the disa...
Published: 15 November 2023
HYPERTROPHIC CARDIOMYOPATHY: ULTRASTRUCTURAL DISORGANIZATION Figure 15-20 HYPERTROPHIC CARDIOMYOPATHY: ULTRASTRUCTURAL DISORGANIZATION Like the disarray seen at the cellular level, sarcomeres also exhibit a nonparallel arrangement in hypertrophic cardiomyopathy. More about this image found in HYPERTROPHIC CARDIOMYOPATHY: ULTRASTRUCTURAL DISORGANIZATION Like the disa...
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HYPERTROPHIC <span class="search-highlight">CARDIOMYOPATHY</span>: CHRONIC ISCHEMIC INJURY  Sarcoplasmic vacuoliz...
Published: 15 November 2023
HYPERTROPHIC CARDIOMYOPATHY: CHRONIC ISCHEMIC INJURY Figure 15-11 HYPERTROPHIC CARDIOMYOPATHY: CHRONIC ISCHEMIC INJURY Sarcoplasmic vacuolization may be seen in the subendocardium of hearts with hypertrophic cardiomyopathy, as a result of chronic ischemic injury. More about this image found in HYPERTROPHIC CARDIOMYOPATHY: CHRONIC ISCHEMIC INJURY Sarcoplasmic vacuoliz...
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PRIMARY RESTRICTIVE <span class="search-highlight">CARDIOMYOPATHY</span>  This 4-chamber view exhibits the promin...
Published: 15 November 2023
PRIMARY RESTRICTIVE CARDIOMYOPATHY Figure 16-1 PRIMARY RESTRICTIVE CARDIOMYOPATHY This 4-chamber view exhibits the prominent biatrial dilatation seen in primary restrictive cardiomyopathy as well as the normal ventricular wall thicknesses and chamber dimensions. More about this image found in PRIMARY RESTRICTIVE CARDIOMYOPATHY This 4-chamber view exhibits the promin...
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ARRHYTHMOGENIC <span class="search-highlight">CARDIOMYOPATHY</span>: MOLECULAR MECHANISMS  Arrhythmogenic cardiom...
Published: 15 November 2023
ARRHYTHMOGENIC CARDIOMYOPATHY: MOLECULAR MECHANISMS Figure 17-1 ARRHYTHMOGENIC CARDIOMYOPATHY: MOLECULAR MECHANISMS Arrhythmogenic cardiomyopathy most commonly results from mutations in the genes encoding for desmosomal proteins and Ca2+ handling proteins in the sarcoplasmic reticulum. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY: MOLECULAR MECHANISMS Arrhythmogenic cardiom...
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HYPERTROPHIC <span class="search-highlight">CARDIOMYOPATHY</span> (HCM): MOLECULAR MECHANISM  HCM is a disease of...
Published: 15 November 2023
HYPERTROPHIC CARDIOMYOPATHY (HCM): MOLECULAR MECHANISM Figure 15-1 HYPERTROPHIC CARDIOMYOPATHY (HCM): MOLECULAR MECHANISM HCM is a disease of the sarcomere. More about this image found in HYPERTROPHIC CARDIOMYOPATHY (HCM): MOLECULAR MECHANISM HCM is a disease of...
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HYPERTROPHIC <span class="search-highlight">CARDIOMYOPATHY</span>: MYOCYTE DISARRAY  The cardiac myocytes are arr...
Published: 15 November 2023
HYPERTROPHIC CARDIOMYOPATHY: MYOCYTE DISARRAY Figure 15-13 HYPERTROPHIC CARDIOMYOPATHY: MYOCYTE DISARRAY The cardiac myocytes are arranged in a nonparallel arrangement. More about this image found in HYPERTROPHIC CARDIOMYOPATHY: MYOCYTE DISARRAY The cardiac myocytes are arr...
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ARRHYTHMOGENIC <span class="search-highlight">CARDIOMYOPATHY</span>  The admixture of fat and fibrosis throughout...
Published: 15 November 2023
ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-9 ARRHYTHMOGENIC CARDIOMYOPATHY The admixture of fat and fibrosis throughout the wall is evident at high-power magnification. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY The admixture of fat and fibrosis throughout...
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STRESS <span class="search-highlight">CARDIOMYOPATHY</span>  There are confluent areas of necrosis with identifia...
Published: 15 November 2023
STRESS CARDIOMYOPATHY Figure 18-5 STRESS CARDIOMYOPATHY There are confluent areas of necrosis with identifiable contraction bands and a sparse inflammatory infiltrate. More about this image found in STRESS CARDIOMYOPATHY There are confluent areas of necrosis with identifia...