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cardiomyocyte

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., and nutritional status ( 8 ). The pathogenesis of infectious, and in particular viral, myocarditis is complex since the different microorganisms primarily affect different cells: cardiomyocytes, endothelial cells, or inflammatory cells ( Table 7-2 ). As depicted in figure 7-1 , the pathogenesis of viral...
Images
MYOCARDIAL COMPONENTS  Left ventricular <span class="search-highlight">cardiomyocytes</span> are considerably lar...
Published: 15 November 2023
MYOCARDIAL COMPONENTS Figure 4-6 MYOCARDIAL COMPONENTS Left ventricular cardiomyocytes are considerably larger than interstitial cells, but interstitial cells appreciably outnumber the myocytes, as seen in this case with early fibrosis. Also, note the typical variation in nuclear size in adjacent... More about this image found in MYOCARDIAL COMPONENTS Left ventricular cardiomyocytes are considerably lar...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch04
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... MYOCARDIAL COMPONENTS Left ventricular cardiomyocytes are considerably larger than interstitial cells, but interstitial cells appreciably outnumber the myocytes, as seen in this case with early fibrosis. Also, note the typical variation in nuclear size in adjacent myocytes. INTERSTITIAL FIBROSIS: SPECTRUM...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch25
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... occur in an isolated fashion or as an extension of annular calcification. Extranodal Atrioventricular Connections. Historically termed “Mahaim fibers,” connections of cardiomyocytes between the atrium and ventricle as seen in sections of the AV nodal area have been implicated in sudden death...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-appendix01
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... in the previous row) Cell number (ventricles) ( 11 ) By cell volume:  75% myocytes  25% interstitial cells This seeming paradox exists because cardiomyocytes are substantially larger than the more numerous interstitial cells (see fig. 4-6 ) By cell number:  20-25% myocytes  75-80% interstitial cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch13
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...), mitochondrial diseases, storage diseases, RASopathies (e.g., Noonan syndrome), and Marfan syndrome, also often exhibit significant cardiac disease resulting from intrinsic disease of the cardiomyocyte. These are therefore considered in the context of cardiomyopathies. Rarely, some cardiomyopathies have mixed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch43
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... glycogen vacuoles ( 12 ). These findings, together the lack of developed T tubules, led the authors to conclude that rhabdomyomas are the result of localized arrests in cardiomyocyte cell development ( 12 ). Molecular Genetic Findings. No molecular genetic abnormalities have been reported outside...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch23
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Sudarikova Yu   V , Bakeeva   LE , Tsiplenkova   VG.   Ultrastructure of mitochondrial reticulum of human cardiomyocytes in alcohol cardiomyopathy . Biochemistry (Mosc)   1997 ; 62 : 989 - 1002 . 41. Mashimo   K , Sato   S , Ohno   Y . Chronic effects of ethanol on cultured...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch14
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... , Taylor   MR , et al . Truncations of titin causing dilated cardiomyopathy . N Engl J Med   2012 ; 366 : 619 - 28 . 28. Takemura   G , Miyata   S , Kawase   Y , Okada   H , Maruyama   R , Fujiwara   H . Autophagic degeneration and death of cardiomyocytes in heart failure...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch15
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... . Hum Mol Genet   2008 ; 17 : 2753 - 65 . 79. Haywood   NJ , Wolny   M , Rogers   B , et al . Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation . Biochem J   2016 ; 473 : 2485 - 93 . 80...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch21
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... , Pimentel   DR , et al . Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress . Circ Res   2004 ; 94 : 1008 - 10 . 59. Collins   AB , Smith   RN , Stone   JR . Classification of amyloid deposits in diagnostic cardiac...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch01
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... by cardiomyocytes. The anterior aspect has a muscular wall, reflecting its origin from the embryonic atrium. Internally, a prominent C-shaped ridge of muscle, the crista terminalis (terminal crest or ridge), separates the two regions ( fig. 1-8A ). Pectinate muscles arise perpendicularly from the crista terminalis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch19
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... from those with Danon disease ( 48 ). Immunohistochemistry with antibodies directed against mitochondrial antigens (MTCO2) is positive within the areas of sarcoplasmic clearing ( 33 ). Frozen tissue evaluated for COX/SDH activities shows a large proportion of COX-deficient cardiomyocytes, a finding...